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Total 208 results found since Jan 2013.
European Stroke Organisation (ESO) guidelines for the management of spontaneous intracerebral hemorrhage
ConclusionThese guidelines inform the management of ICH based on evidence for the effects of treatments in RCTs. Outcome after ICH remains poor, prioritizing further RCTs of interventions to improve outcome.
Source: International Journal of Stroke - August 1, 2014 Category: Neurology Authors: Thorsten Steiner, Rustam Al‐Shahi Salman, Ronnie Beer, Hanne Christensen, Charlotte Cordonnier, Laszlo Csiba, Michael Forsting, Sagi Harnof, Catharina J. M. Klijn, Derk Krieger, A. David Mendelow, Carlos Molina, Joan Montaner, Karsten Overgaard, Jesper Tags: Guidelines Source Type: research
Tocilizumab for Treating Takayasu's Arteritis and Associated Stroke: A Case Series and Updated Review of the Literature
Takayasu's arteritis (TA) is a rare inflammatory disease that can result in stroke. Treatment of patients with TA requires prolonged use of corticosteroids (CS). We assessed the effectiveness of tocilizumab (TCZ) in inducing disease remission and reducing CS doses in patients with TA.
Source: Journal of Stroke and Cerebrovascular Diseases - April 10, 2015 Category: Neurology Authors: Mohammed Osman, Derek Emery, Elaine Yacyshyn Source Type: research
Focal Cerebral Arteriopathy Clinical Sciences
Conclusions—Corticosteroid treatment may provide additional benefit over AT for improved neurological outcome in childhood AIS because of focal cerebral arteriopathy. Larger prospective studies are warranted to further investigate these differences and understand mechanisms by which steroids modify outcome.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Maȷa Steinlin, Sandra Bigi, Belinda Stoȷanovski, Jay Gaȷera, Maria Regenyi, Marwan El–Koussy, Mark T. Mackay Tags: Ischemic Stroke Original Contributions Source Type: research
Differential effects of sympathetic nervous system and hypothalamic-pituitary-adrenal axis on systemic immune cells after severe experimental stroke.
In conclusion, mediators of the SNS and the HPA axis differentially affect the systemic immune system after stroke. Moreover, our findings suggest a negative-feedback of corticosteroids on the sympathetic axis which may control the post-stroke stress-reaction. This complex interplay between the HPA and the SNS after stroke has to be considered when targeting the neurohormonal systems in the post acute phase of severe stroke. PMID: 24886966 [PubMed - as supplied by publisher]
Source: Brain, Behavior, and Immunity - May 30, 2014 Category: Neurology Authors: Mracsko E, Liesz A, Karcher S, Zorn M, Bari F, Veltkamp R Tags: Brain Behav Immun Source Type: research
Increased Stroke Risk Among Adult Asthmatic Patients
ConclusionAsthma may be an independent risk factor for stroke, and its severity exhibits a dose response of stroke development.This article is protected by copyright. All rights reserved.
Source: European Journal of Clinical Investigation - September 10, 2014 Category: Journals (General) Authors: Wei‐Sheng Chung, Cheng‐Li Lin, Yung‐Fu Chen, Feng‐Ming Ho, Wu‐Huei Hsu, Chia‐Hung Kao Tags: Original Article Source Type: research
Listeria monocytogenes Meningoencephalitis Mimicking Stroke in a Patient with Chronic Lymphocytic Leukemia
Conclusion The supratentorial focal lesions secondary to Listeria meningoencephalitis are rare. The cases with focal neurological signs without fever at onset can resemble stroke.
Source: Neurology and Therapy - December 1, 2013 Category: Neurology Source Type: research
Aggressive Medical Care in Young Chinese Patients with Ischemic Stroke of Undetermined Etiology: A Retrospective Study
This study aimed to investigate the clinical and angiographic characteristics of ischemic stroke of undetermined etiology in young Chinese adults and to observe the effects of medication on their long-term outcomes. Methods: A total of 179 consecutive young patients with ischemic stroke of undetermined etiology were retrospectively analyzed for clinical and angiographic characteristics, laboratory tests, the choice of drug treatment, and follow-up outcomes. Any predictive power for recurrent stroke and new lesions or aggravated stenosis was analyzed. Results: 170 patients were clinically followed up for a median of 25 mont...
Source: Interventional Neurology - December 8, 2014 Category: Neurology Source Type: research
SMART syndrome: Stroke-like migraine attack after radiation therapy
A 57-year-old woman presented with intense headache 13 years after cranioplasty and radiation treatment for occipital osteosarcoma. Examination showed anomia and paraphasic errors, right homonymous hemianopia, and dysmetria of the right arm. MRI during hospitalization demonstrated diffuse pathologic enhancement in the left parieto-occipital lobe (figure, A) and extensive gyral edema (figure, B and C). EEG while she was symptomatic showed left-predominant posterior quadrant slowing without epileptiform abnormalities. She was diagnosed with stroke-like migraine attacks after radiation therapy (SMART) syndrome and treated wit...
Source: Nature Clinical Practice - December 8, 2014 Category: Neurology Authors: Wang, N., Prasad, S. Tags: All Headache, MRI, Radiation therapy-tumor Cases Source Type: research
Changing course of Multiple Sclerosis (MS) after stroke: Excessive disease activity in a MS patient after cerebral infarction (P1.122)
CONCLUSIONS: This is a rare case of MS exacerbation after stroke in a patient with long-standing MS. The clear temporal relation with an increase of MS disease activity after stroke suggests possible interactions. One explanation could be an opening of the blood brain barrier after stroke with influx of activated immune cells into the central nervous system and consecutive MS exacerbation.Disclosure: Dr. Poellmann has received personal compensation for activities with Pfizer Inc., Novartis, Biogen Idec, and Merck Serono. Dr. Starck has nothing to disclose. Dr. Kümpfel has received personal compensation for activities ...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Poellmann, W., Starck, M., Kuempfel, T., Koehler, J. Tags: MS and CNS Inflammatory Diseases: Symptoms, Specific Symptomatic Treatment, Co-morbidities, and Costs Source Type: research
Steroid responsive encephalopathy associated with autoimmune thyroiditis (SREAT) with stroke like symptoms. A case report. (P5.104)
Conclusion: Clinicians should consider SREAT in the differential diagnosis of patients presenting with stroke like symptoms/vasculitis especially if investigations fail to establish a diagnosis.Disclosure: Dr. Javalkar has nothing to disclose. Dr. Abbas has nothing to disclose. Dr. Harris has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Javalkar, V., Abbas, S., Harris, M. Tags: Edema, Encephalopathy, and Encephalitis Source Type: research
P-006 evaluation of baseline ct aspects and admission neutrophil-lymphocyte ratio in perfusion-guided selected ica/mca stroke patients for endovascular reperfusion therapy
ConclusionsIn our cohort, baseline CT ASPECTS inversely correlated with admission NLR in anterior circulation AIS patients who had favorable perfusion imaging profile for IA reperfusion therapy. Additionally, in this subgroup of patients, NLR of 5 or less discriminated favorable from unfavorable ASPECTS.DisclosuresA. Honarmand: None. A. Shaibani: None. F. Syed: None. A. Elmokadem: None. M. Hurley: None. S. Ansari: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Honarmand, A., Shaibani, A., Syed, F., Elmokadem, A., Hurley, M., Ansari, S. Tags: SNIS 12th Annual Meeting Oral Poster Abstracts Source Type: research
Prevention of Stroke in Rheumatoid Arthritis
Abstract The risk of cerebrovascular disease is increased among rheumatoid arthritis (RA) patients and remains an underserved area of medical need. Only a minor proportion of RA patients achieve suitable stroke prevention. Classical cardiovascular risk factors appear to be under-diagnosed and undertreated among patients with RA. Reducing the inflammatory burden is also necessary to lower the cardiovascular risk. An adequate control of disease activity and cerebrovascular risk assessment using national guidelines should be recommended for all patients with RA. For patients with a documented history of cerebrovascu...
Source: Current Neurology and Neuroscience Reports - October 20, 2015 Category: Neuroscience Source Type: research
Traditional Chinese Medicine Decreases the Stroke Risk of Systemic Corticosteroid Treatment in Dermatitis: A Nationwide Population-Based Study.
This study identified 235,220 dermatitis patients and same comorbidity matched subjects between 2000 and 2009 from database of NHRI in Taiwan. The two cohorts were followed until December 31, 2011. The primary outcome of interest was new diagnosis of stroke. The crude hazard ratio (HR) for future stroke among dermatitis patients treated with systemic corticosteroid was 1.40 (95% CI, 1.34-1.45; P < 0.0001) and TCM was 1.09 (95% CI, 1.05-1.13; P < 0.0001). The log-rank test showed a higher cumulative incidence of ischemic stroke in the patient treated with only systemic corticosteroid group than that treated with syste...
Source: Evidence-based Complementary and Alternative Medicine - November 1, 2015 Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Report of cold agglutinins in a patient with acute ischemic stroke
Conclusion: We report here the first case of cerebral infarction probably due to the cold agglutinin disease. The underlying mechanism of cold agglutinins in the pathogenesis of acute ischemic stroke needs to be investigated further.
Source: BMC Neurology - October 30, 2015 Category: Neurology Authors: Haiqiang JinWei SunYongan SunYining HuangYunchuang Sun Source Type: research
Ultrasound-guided corticosteroid injections for adhesive capsulitis more effective than placebo
Commentary on: Prestgaard T, Wormgoor ME, Haugen S, et al.. Ultrasound-guided intra-articular and rotator interval corticosteroid injections in adhesive capsulitis of the shoulder: a double-blind, sham-controlled randomized study. Pain 2015;156:1683–91. Context Adhesive capsulitis (frozen shoulder or painful stiff shoulder) is relatively common. It is idiopathic: known associated factors include trauma, diabetes, prolonged immobilisation, age, stroke and autoimmune disease. While self-limited, pain and decreased range of motion can last up to 2–3 years. Therefore, there is practical value in therapeutic in...
Source: Evidence-Based Medicine - March 21, 2016 Category: Internal Medicine Authors: Lebrun, C. M. Tags: Rehabilitation medicine, Immunology (including allergy), Pain (neurology), Stroke, Radiology, Degenerative joint disease, Musculoskeletal syndromes, Osteoarthritis, Sports and exercise medicine, Clinical diagnostic tests, Radiology (diagnostics), Screenin Source Type: research
Neutrophils/Lymphocytes Ratio and Platelets/Lymphocytes Ratio and Its Relationship with Severity and Functional Prognosis in Patients with Acute Ischemic Stroke (P5.235)
CONCLUSIONS N/L ratio and P/L ratio at hospital admission have a positive correlation with the severity and functional prognosis of patients with Acute Ischemic Stroke. Due to its simple determination, affordable and safe, they could become severity and functional prognostic parameters in the initial evaluation of patients with Acute Ischemic Stroke in the future.Disclosure: Dr. Perez has nothing to disclose. Dr. Casas has nothing to disclose. Dr. Tourreilles has nothing to disclose. Dr. Gonzalez has nothing to disclose. Dr. Gimenez has nothing to disclose. Dr. Cabrera has nothing to disclose. Dr. Mattiazzi has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Perez, A., Casas, S., Tourreilles, M., Gonzalez, C., Gimenez, J., Cabrera, L., Mattiazzi, M. Tags: Cerebrovascular Disease: Biomarkers Source Type: research
Prophylactic antibiotic treatment in severe acute ischemic stroke: the A ntimicrobial chemop R rophylaxis for I schemic ST rok E I n Mace D on I a –Thrace S tudy (ARISTEIDIS)
AbstractInfections represent a leading cause of mortality in patients with acute ischemic stroke, but it is unclear whether prophylactic antibiotic treatment improves the outcome. We aimed to evaluate the effects of this treatment on infection incidence and short-term mortality. This was a pragmatic, prospective multicenter real-world analysis of previously independent consecutive patients with acute ischemic stroke who were>18 years, and who had at admission National Institutes of Health Stroke Scale (NIHSS)>11. Patients with infection at admission or during the preceding month, with axillary temperature at admiss...
Source: Internal and Emergency Medicine - September 21, 2016 Category: Emergency Medicine Source Type: research
Neurotoxocariasis, a treatable infectious etiology of Stroke (P3.318)
Conclusions:Toxocara infection is an uncommon but treatable etiology of stroke, and should be particularly considered in patients with eosinophilia, positive serology, myocarditis and embolic strokes.Disclosure: Dr. Garcia Monco has nothing to disclose. Dr. Azkune Calle has nothing to disclose. Dr. Ruisanchez nieva has nothing to disclose. Dr. Anguizola Tamayo has nothing to disclose. Dr. Pardina Vilella has nothing to disclose. Dr. Bocos Portillo has nothing to disclose. Dr. Gomez-Beldarrain has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Monco, J. G., Calle, I. A., nieva, A. R., Tamayo, D. A., Vilella, L. P., Portillo, J. B., Gomez-Beldarrain, M. Tags: Fungal and Parasitic Disease of the Nervous System Source Type: research
Recognition of giant cell arteritis in patients with polymyalgia rheumatica who have a stroke: a cautionary tale
Abstract An 82‐year‐old woman with polymyalgia rheumatica (PMR) on prednisone 7 mg daily was admitted to an acute stroke unit with a right homonymous hemianopia, a left posterior cerebral artery occlusion and occipital lobe infarct. She had raised inflammatory markers, did not have a temporal artery biopsy, and was discharged on the same dose of prednisone. After 21 months, off prednisone, her ophthalmologist, concerned about giant cell arteritis (GCA), restarted prednisone 40 mg daily, with rapid, profound visual improvement. After 3 days her general practitioner, noting normal baseline inflammatory markers, stopp...
Source: Internal Medicine Journal - October 9, 2017 Category: Internal Medicine Authors: Donald H. Gutteridge, Frank L. Mastaglia Tags: Brief Communication Source Type: research
Idiopathic Intracranial Hypertension Progressing to Venous Sinus Thrombosis, Subarachnoid Hemorrhage, and Stroke
We describe a young woman with typical IIH who underwent lumbar puncture and was treated with a short course of high-dose corticosteroids followed by acetazolamide. She subsequently developed CVST, subarachnoid hemorrhage, and stroke. Risk factors that may have resulted in CVST are discussed.
Source: Journal of Neuro-Ophthalmology - February 21, 2018 Category: Opthalmology Tags: Clinical Observation Source Type: research
Effect of the asthma-chronic obstructive pulmonary disease syndrome on the stroke, Parkinson's disease, and dementia: a national cohort study.
Conclusions: The ACOS cohort had a higher risk of the neurodegenerative diseases. The lower dose of the inhaler corticosteroids with cumulative dose ≧0.13 gram have the less risk of stroke and dementia. PMID: 29552322 [PubMed]
Source: Oncotarget - March 20, 2018 Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Stroke and temporal arteritis: A study of 6 cases
ConclusionsStroke caused by giant cell arteritis is a serious and potentially severe condition which requires a high level of suspicion and early treatment with corticosteroids. New diagnostic techniques contribute to refining patient assessment and identifying the optimal treatment. Endovascular treatment may be a valid therapeutic option in selected patients.ResumenIntroducciónAunque la asociación de arteritis de la temporal e ictus isquémico no es frecuente, su diagnóstico y su manejo posterior plantean serias dificultades, requiriendo un alto índice de sospecha.MétodosAnalizamos una serie de 6 pacientes con arter...
Source: Neurologia - April 13, 2019 Category: Neurology Source Type: research
Getting the Right Care for Painful Autoimmune Conditions
A corticosteroid can quickly relieve symptoms of both polymyalgia rheumatica and temporal arteritis. But a delay could cause vision loss, a stroke or even death.
Source: NYT Health - August 19, 2019 Category: Consumer Health News Authors: Jane E. Brody Tags: Stroke Steroids Autoimmune Diseases Immune System Source Type: news
Acute bacterial meningitis and stroke.
Abstract INTRODUCTION: Acute bacterial meningitis remains a common disease, especially in developing countries. Although advances over the last century have improved mortality and morbidity, the neurological adverse effects remain high. Specifically, acute ischaemic stroke is a serious comorbidity that represents both disease severity and poor prognosis. This review presents the clinical connection between meningitis and stroke, and discusses the neuroinflammatory components that have direct ties between these diseases. STATE OF THE ART: Ischaemic stroke is the direct result of the inflammatory response produ...
Source: Neurologia i Neurochirurgia Polska - August 22, 2019 Category: Neurology Authors: Siegel J Tags: Neurol Neurochir Pol Source Type: research
Effect of Bronchodilator and Steroid Use on Heart Disease and Stroke Risks in a Bronchiectasis –Chronic Obstructive Pulmonary Disease Overlap Cohort: A Propensity Score Matching Study
Conclusions: Compared with patients without bronchiectasis and COPD, BCOS patients with recent SABAs, past ICSs, and past anti-arrhythmia drugs use; a low or medium SABAs ICSs, and OSs dose; and a low SAMAs dose had a higher risk of HDS. LAMAs were not associated with HDS.
Source: Frontiers in Pharmacology - November 26, 2019 Category: Drugs & Pharmacology Source Type: research
An unusual cause of acute ischemic stroke: Adult Onset Still ’s Disease
We present a case where acute ischemic stroke secondary to a floating internal carotid artery thrombus was an early manifestation of AOSD. The patient also had prolonged high spiking fevers, sign ificant leucocytosis, arthralgias and transaminitis. He responded well to a high dose of oral corticosteroids and was eventually started on anticoagulation for secondary stroke prevention. To our knowledge, this is the first described case of arterial thrombosis associated with AOSD. We postulate th at thrombocytosis, vasculitis and hypercoagulability from the underlying inflammatory state may have contributed to the ischemic stroke.
Source: Journal of Thrombosis and Thrombolysis - December 1, 2019 Category: Hematology Source Type: research
Stroke-like migraine attacks after radiation therapy (SMART) syndrome —a case series and review
ConclusionOur extensive review favors MRI, CT, and prolonged EEG monitoring to rule out other differentials and showed that initiation of corticosteroid therapy and antiepileptic treatment were helpful in the resolution of symptoms and prevent recurrences. Therefore, future studies should be focused on early identification and management guidelines for SMART syndrome.
Source: Neurological Sciences - July 12, 2020 Category: Neurology Source Type: research
A case of inflammatory cerebral amyloid angiopathy after ischemic stroke - a potential risk factor related to blood-brain barrier disruption
We present a patient with history of CAA who developed probable CAA-ri/ABRA three months after an acute ischemic stroke.
Source: Clinical Imaging - November 19, 2021 Category: Radiology Authors: Dora Chen, Michelle Roytman, Kyriakos A. Kirou, Babak B. Navi, Andrew D. Schweitzer Tags: Neuroradiology Source Type: research
FDA Orders New Warning for Epidural Steroids
(MedPage Today) -- Injectable corticosteroids must now carry a new label warning about the risks of severe adverse effects from epidural injections including death, stroke, and permanent blindness and paralysis, the FDA said.
Source: MedPage Today Geriatrics - April 24, 2014 Category: Geriatrics Source Type: news
Spinal Corticosteroids Run Risk of Severe Neuro EffectsSpinal Corticosteroids Run Risk of Severe Neuro Effects
The FDA has announced that injections given to treat neck and back pain and radiating pain in the arms and legs may result, on rare occasions, in blindness, stroke, paralysis, and death. News Alerts
Source: Medscape Neurology and Neurosurgery Headlines - April 24, 2014 Category: Neurology Tags: Neurology & Neurosurgery News Alert Source Type: news
Epidural Corticosteroid Injections Pose Risk for Neurological Problems (FREE)
By Kristin J. Kelley Injectable corticosteroids given via epidural to treat back and neck pain may cause "rare but serious" complications — paralysis, stroke, vision loss, and death …
Source: Physician's First Watch current issue - April 24, 2014 Category: Primary Care Source Type: news
Epidural Corticosteroid Injection: Drug Safety Communication - Risk of Rare But Serious Neurologic Problems
Injection of corticosteroids into the epidural space of the spine may result in loss of vision, stroke, paralysis, and death.
Source: FDA MedWatch - April 23, 2014 Category: American Health Source Type: news
Study shows insufficient decrease in wound complications with sutured versus stapled skin closure in gastrointestinal operations
Commentary on: Tsujinaka T, Yamamoto K, Fujita J, et al.. Subcuticular sutures versus staples for skin closure after open gastrointestinal surgery: a phase 3, multicentre, open-label, randomised controlled trial. Lancet 2013;382:1105–12. Context Postoperative wound complications can occur in 9–26% of gastrointestinal operations.1–3 Skin closure with subcuticular sutures in clean operations, such as caesarean sections, are associated with decreased wound complications and increased patient satisfaction when compared with skin closure using staples.4 5 Whether these results are applicable to clean–con...
Source: Evidence-Based Medicine - May 19, 2014 Category: Internal Medicine Authors: Vo, H., Kin, C. Tags: Patients, Clinical trials (epidemiology), Immunology (including allergy), Drugs: cardiovascular system, Stroke, Dermatology, Diabetes, Injury Therapeutics Source Type: research
Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis
This article is protected by copyright. All rights reserved.
Source: British Journal of Dermatology - July 24, 2014 Category: Dermatology Authors: A. Fukunaga, M. Hatakeyama, M. Tsujimoto, Y. Oda, K. Washio, C. Nishigori Tags: Correspondence Source Type: research
Steroid treatment can improve the impaired quality of life of patients with acquired idiopathic generalized anhidrosis.
This article is protected by copyright. All rights reserved. PMID: 25060903 [PubMed - as supplied by publisher]
Source: The British Journal of Dermatology - July 24, 2014 Category: Dermatology Authors: Fukunaga A, Hatakeyama M, Tsujimoto M, Oda Y, Washio K, Nishigori C Tags: Br J Dermatol Source Type: research
Treating gerstmann's syndrome with natalizumab
We present video, MRI and pathological evidence of the case of a 30 year old woman who developed Gerstmann's syndrome as a result of a tumefactive multiple sclerosis (MS) lesion affecting the left cerebral hemisphere. Intravenous corticosteroids failed to stop rapid enlargement of the index lesion and occurrence of additional hemispheric lesions leading to clinical deterioration. Brain biopsy confirmed the diagnosis of MS. Strong contrast enhancement of the lesions prompted us to start treatment with natalizumab 300 mg i.v. every four weeks leading to sustained disease remission over a 14 month follow-up period though comp...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Gnanapavan, S., Zane, J., Kelly, P., Sakthivel, G., Klaus, S. Tags: Abstracts Source Type: research
Incidence, risk factors and outcomes of stroke post‐transplantation in patients receiving a steroid sparing immunosuppression protocol
This article is protected by copyright. All rights reserved.
Source: Clinical Transplantation - September 1, 2014 Category: Transplant Surgery Authors: Michelle Willicombe, Nicola Kumar, Dawn Goodall, Candice Clarke, Adam G McLean, Albert Power, David Taube Tags: Original Article Source Type: research
Acute bacterial infection negatively impacts cancer specific survival of colorectal cancer patients.
CONCLUSION: Infection and high neutrophil counts are associated with a poorer cancer-specific survival in colorectal cancer patients. PMID: 25320529 [PubMed - in process]
Source: World Journal of Gastroenterology : WJG - October 14, 2014 Category: Gastroenterology Authors: Attiê R, Chinen LT, Yoshioka EM, Silva MC, de Lima VC Tags: World J Gastroenterol Source Type: research
Mystery Case: Cerebral amyloid angiopathy-related inflammation
A 59-year-old man was arrested for unruly public behavior. He was subsequently found unresponsive with bilateral upper extremity extensor posturing and lower extremity triple flexion when stimulated. Over the next 48 hours, he awoke and became belligerent. MRI revealed innumerable cortical microhemorrhages on susceptibility-weighted imaging (figure, A) and asymmetric subcortical T2 hyperintensities (figure, B) consistent with cerebral amyloid angiopathy–related inflammation (CAA-ri).1 With corticosteroid treatment, he rapidly became calm and conversant, returning to near his premorbid baseline with only mild residual...
Source: Neurology - October 27, 2014 Category: Neurology Authors: Berkowitz, A. L., Baker, J. M., Miller, J. J., Greenberg, S. M. Tags: MRI, All Immunology, All Cerebrovascular disease/Stroke RESIDENT AND FELLOW SECTION Source Type: research
Hashimoto's encephalopathy: Report of three cases
Publication date: November 2014 Source:Journal of the Formosan Medical Association, Volume 113, Issue 11 Author(s): Jan-Shun Chang , Tien-Chun Chang Both severe thyrotoxicosis and hypothyroidism may affect brain function and cause a change in consciousness, as seen with a thyroid storm or myxedema coma. However, encephalopathy may also develop in patients with autoimmune thyroid diseases independent of actual thyroid function level, and this is known as Hashimoto's encephalopathy. Although most patients are found to have Hashimoto's thyroiditis, less frequently they have Graves' disease. Clinical manifestations include e...
Source: Journal of the Formosan Medical Association - November 9, 2014 Category: Journals (General) Source Type: research
A case of PRES in an active lupus nephritis patient after treatment of corticosteroid and cyclophosphamide
Abstract Posterior reversible encephalopathy syndrome (PRES) is primarily a radiological diagnosis. The syndrome is characterized by headache, altered mental status, seizures, and bilateral posterior white matter edema in a nonvascular distribution on neuroimaging with resolution of findings usually in 7–14 days (Casey et al. in AJNR Am J Neuroradiol 21:1199–1206, 2000). In most cases, computed tomography of the brain will show hypodense lesions in the parieto-occipital lobe. Although this syndrome is uncommon, prompt and accurate recognition allows early treatment, which has been shown to produce favorable o...
Source: Rheumatology International - November 12, 2014 Category: Rheumatology Source Type: research
In search of a treatment for radiation-induced optic neuropathy
Opinion statement Radiation-induced optic neuropathy (RON) is an iatrogenic complication that causes severe, irreversible vision loss in one or both eyes within the months to years following radiation therapy. Posterior RON is a rare but devastating toxicity of radiation applied to the visual pathways to treat paranasal sinus and skull base tumors. Anterior RON is an unavoidable consequence of proton beam irradiation or ophthalmic plaque treatment of orbital, choroidal, or retinal tumors. Various treatments aimed at stabilizing and ideally reversing vision loss have been investigated but only in small cases serie...
Source: Current Treatment Options in Neurology - November 8, 2014 Category: Neurology Source Type: research
Incidence, risk factors, and outcomes of stroke post‐transplantation in patients receiving a steroid sparing immunosuppression protocol
This study has identified subgroups of patients who are at increased risk of CVA post‐transplant in patients otherwise receiving a steroid sparing immunosuppression protocol.
Source: Clinical Transplantation - November 19, 2014 Category: Transplant Surgery Authors: Michelle Willicombe, Nicola Kumar, Dawn Goodall, Candice Clarke, Adam G. McLean, Albert Power, David Taube Tags: Original Article Source Type: research
Hashimoto's encephalopathy: Report of three cases.
Abstract Both severe thyrotoxicosis and hypothyroidism may affect brain function and cause a change in consciousness, as seen with a thyroid storm or myxedema coma. However, encephalopathy may also develop in patients with autoimmune thyroid diseases independent of actual thyroid function level, and this is known as Hashimoto's encephalopathy. Although most patients are found to have Hashimoto's thyroiditis, less frequently they have Graves' disease. Clinical manifestations include epilepsy, disturbance of consciousness, cognitive impairment, memory loss, myoclonus, hallucinations, stroke-like episodes, tremor, in...
Source: J Formos Med Assoc - November 1, 2014 Category: Journals (General) Authors: Chang JS, Chang TC Tags: J Formos Med Assoc Source Type: research
Hashimoto encephalopathy with angiographic CNS vasculitis
Hashimoto encephalopathy (HE)—also known as steroid-responsive encephalopathy associated with autoimmune thyroiditis—is a rare syndrome loosely associated with Hashimoto thyroiditis. HE mostly affects middle-aged women; is characterized by delirium, seizures, and myoclonus; and is thought to be an immune-mediated disorder. The pathophysiology of HE is not entirely understood. Most cases appear to be due to autoimmune vasculitis or an immune complex deposition that disrupts the cerebral microvasculature. This immunologic phenomenon has been observed on brain biopsy with a lymphocytic infiltration around small ar...
Source: Nature Clinical Practice - December 8, 2014 Category: Neurology Authors: Al-Wafai, A., Wahba, M., Doss, V. T., Elijovich, L. Tags: Other cerebrovascular disease/ Stroke, Autoimmune diseases, Vasculitis Cases Source Type: research
Epidural Steroid Injections are Safe and Effective: Multisociety Letter in Support of the Safety and Effectiveness of Epidural Steroid Injections
Abstract Background: In April 2014, the Food and Drug Administration (FDA) issued a Drug Safety Communication requesting that corticosteroid labeling include warnings that injection of corticosteroids into the epidural space of the spine may result in rare but serious adverse events, including loss of vision, stroke, paralysis, and death. Results: The International Spine Intervention Society spearheaded a collaboration of more than a dozen other medical societies in submitting the letter below to the FDA on November 7, 2014. We are publishing the letter to ensure that the readership of Pain Medicine is aware of the multiso...
Source: Pain Medicine - January 13, 2015 Category: Anesthesiology Authors: , David J. Kennedy, Joshua Levin, Richard Rosenquist, Virtaj Singh, Clark Smith, Milan Stojanovic, Yakov Vorobeychik Tags: Other Source Type: research
Twenty-year brain magnetic resonance imaging follow-up study in Systemic Lupus Erythematosus: Factors associated with accrual of damage and central nervous system involvement
Conclusion This study shows that MRI brain damage in SLE patients progresses independently from NP involvement as an effect of potentially modifiable risk factors and it is associated with increased risk of new NP events.
Source: Autoimmunity Reviews - January 27, 2015 Category: Allergy & Immunology Source Type: research
Eosinophilic CNS vasculitis can mimic demyelinating disease of the brain and spinal cord
A 61-year-old man developed progressive ascending sensory loss to T8 and paraparesis over 4 weeks. MRI revealed ovoid T2-hyperintense lesions in juxtacortical and periventricular areas, and in the T7-T10 spinal segment, with varying degrees of peripheral gadolinium enhancement (figure 1). He received 5 days of high-dose corticosteroids and plasmapheresis for presumed demyelination, without clinical response. Brain biopsy showed vasculitis involving small arteries with transmural inflammatory cell infiltrates including numerous eosinophils (figure 2). Eosinophilic vasculitis can cause ischemic strokes1; it rarely involves t...
Source: Neurology - February 2, 2015 Category: Neurology Authors: Schneider, R., Tsai, J. P., Munoz, D. G., Selchen, D. H. Tags: Vasculitis, All Cerebrovascular disease/Stroke NEUROIMAGES Source Type: research
Protective effects of corticosteroids in coronary artery bypass graft surgery alone or combined with valvular surgery: an updated and comprehensive meta-analysis and systematic review.
Abstract This systematic review with meta-analysis sought to determine the protective effects of corticosteroids on clinical outcomes following coronary artery bypass grafting (CABG). Medline, Embase, Elsevier and Sciences online database as well as Google scholar literature were used for selecting appropriate studies with randomized controlled design. The effect sizes measured were odds ratio (OR) for categorical variables and weighted mean difference with 95% confidence interval (CI) for calculating differences between mean values of duration of hospitalization in intervention and control groups. Values of P <...
Source: Hand Surgery - March 3, 2015 Category: Surgery Authors: Ali-Hassan-Sayegh S, Mirhosseini SJ, Haddad F, Karimi-Bondarabadi AA, Shahidzadeh A, Weymann A, Popov AF, Sabashnikov A Tags: Interact Cardiovasc Thorac Surg Source Type: research
Disease activity in rheumatoid arthritis and the risk of cardiovascular events
Conclusions: Reduced time‐averaged disease activity in RA is associated with fewer CV events. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - March 16, 2015 Category: Rheumatology Authors: D.H. Solomon, G Reed, J.M. Kremer, J.R. Curtis, M.E. Farkouh, L.R. Harrold, M.C. Hochberg, P Tsao, J Greenberg Tags: Full Length Source Type: research