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Total 1370 results found since Jan 2013.

Paediatric arterial ischaemic stroke and cerebral sinovenous thrombosis. First report from the Italian Registry of Pediatric Thrombosis (R. I. T. I., Registro Italiano Trombosi Infantili).
I. T. I. (Registro Italiano Trombosi Infantili) Abstract Data from large case series of children with cerebral thrombotic events are pivotal to improve prevention, early recognition and treatment of these conditions. The Italian Registry of Pediatric Thrombosis (R. I. T. I.) was established in 2007 by a multidisciplinary team, aiming for a better understanding of neonatal and paediatric thrombotic events in Italy and providing a preliminary source of data for the future development of specific clinical trials and diagnostic-therapeutic protocols. We analysed data relative to the paediatric cerebral throm...
Source: Thrombosis and Haemostasis - March 12, 2015 Category: Hematology Authors: Suppiej A, Gentilomo C, Saracco P, Sartori S, Agostini M, Bagna R, Bassi B, Giordano P, Grassi M, Guzzetta A, Lasagni D, Luciani M, Molinari AC, Palmieri A, Putti MC, Ramenghi LA, Rota LL, Sperlì D, Laverda AM, Simioni P, Stroke working group of the R. Tags: Thromb Haemost Source Type: research

Factor XIII-A subunit Val34Leu polymorphism in fatal atherothrombotic ischemic stroke
Factor XIII (FXIII) is a regulator of fibrinolysis and clot firmness. Val34Leu polymorphism of its potentially active A subunit (FXIII-A) leads to faster activation of FXIII, influences clot structure and provides a moderate protection against coronary artery disease. The effect of FXIII-A Val34Leu polymorphism on the risk of atherothrombotic ischemic stroke (AIS) has been investigated in a few studies with contradictory results. In all previous studies, only patients surviving AIS were enrolled and sex-specific effects were not explored. In this retrospective multicenter cohort, we investigated the effect of FXIII-A Val34...
Source: Blood Coagulation and Fibrinolysis - May 1, 2014 Category: Hematology Tags: Original Articles Source Type: research

Influence of the β-fibrinogen-455G/A polymorphism on development of ischemic stroke and coronary heart disease
Conclusion: Our meta-analysis suggests that the FGB-455G/A polymorphism contributes to susceptibility to IS and CHD.
Source: Thrombosis Research - January 21, 2014 Category: Hematology Authors: Lian Gu, Wenhui Liu, Yan Yan, Li Su, Guangliang Wu, Baoyun Liang, Jinjing Tan, Guihua Huang Tags: Clinical Studies Source Type: research

Circulating desphospho‐uncarboxylated matrix Gla protein and the risk of coronary heart disease and stroke
This study could not confirm that high dp‐ucMGP concentrations, reflecting a poor vitamin K status, are associated with increased CHD or stroke risk in the general population.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - April 1, 2014 Category: Hematology Authors: Geertje W. Dalmeijer, Yvonne T. Schouw, Elke J. Magdeleyns, Cees Vermeer, W.M. Monique Verschuren, Jolanda M.A. Boer, Joline W.J. Beulens Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Circulating desphospho-uncarboxylated matrix Gla protein and the risk of coronary heart disease and stroke.
CONCLUSION: The average follow-up was 11.5 years. Dp-ucMGP concentrations were not associated with CHD risk with a HR per SD of 1.00 (95% CI: 0.93-1.07) and a HR Q4 vs Q1 of 0.94 (95% CI: 0.79-1.13) after adjustment for cardiovascular risk factors. Dp-ucMGP was not associated with stroke risk (HRSD 0.98;95% CI: 0.90-1.08 and a HR Q4 vs Q1 of 1.09;95% CI: 0.78-1.51). This study could not confirm that high dp-ucMGP concentrations, reflecting a poor vitamin K status, are associated with increased CHD or stroke risk in the general population. This article is protected by copyright. All rights reserved. PMID: 24826813 [Pub...
Source: Thrombosis and Haemostasis - May 15, 2014 Category: Hematology Authors: Dalmeijer GW, van der Schouw YT, Magdeleyns EJ, Vermeer C, Verschuren WM, Boer JM, Beulens JW Tags: J Thromb Haemost Source Type: research

Antigen levels of coagulation factor XII, coagulation factor XI and prekallikrein, and the risk of myocardial infarction and ischemic stroke in young women
ConclusionIncreased levels of FXI antigen were associated with an increase in IS risk, whereas they showed only a marginal association with MI risk. FXII antigen and PK antigen levels were not substantially associated with MI risk and IS risk.
Source: Journal of Thrombosis and Haemostasis - May 22, 2014 Category: Hematology Authors: B. Siegerink, F. R. Rosendaal, A. Algra Tags: Original Article Source Type: research

Reticulocytosis and anemia are associated with an increased risk of death and stroke in the newborn cohort of the Cooperative Study of Sickle Cell Disease
Abstract Prior analyses of the Cooperative Study of Sickle Cell Disease (CSSCD) newborn cohort identified elevated white blood cell (WBC) count, low baseline hemoglobin and dactylitis between the age 1 and 2 years as markers of severe disease. Reticulocytosis was also associated with severe disease. Here we further analyzed data collected on enrolled CSSCD infants for the predictive value of those markers for stroke and death later in life. Three hundred fifty‐four CSSCD subjects were identified who had absolute reticulocyte counts (ARC) measured during infancy (2 to 6 months of age). Infants with higher ARC had signific...
Source: American Journal of Hematology - May 31, 2014 Category: Hematology Authors: Emily Riehm Meier, Elizabeth C. Wright, Jeffery L. Miller Tags: Research Article Source Type: research

Improving prediction of recanalization in acute large‐vessel occlusive stroke
ConclusionsAcute endovascular treatment is the single most important factor promoting recanalization in acute ischemic stroke. The presence of extracranial vessel stenosis or occlusion decreases recanalization rates. In patients with intracranial occlusions, higher NIHSS score and ASPECTS and normal vigilance facilitate recanalization. Clinical use of these predictors could influence recanalization strategies in individual patients.
Source: Journal of Thrombosis and Haemostasis - June 10, 2014 Category: Hematology Authors: P. Vanacker, D. Lambrou, A. Eskandari, P. Maeder, R. Meuli, G. Ntaios, P. Michel Tags: Original Article Source Type: research

Circulating desphospho‐uncarboxylated matrix γ‐carboxyglutamate protein and the risk of coronary heart disease and stroke
This study could not confirm that high dp‐ucMGP levels, reflecting poor vitamin K status, are associated with increased CHD or stroke risk in the general population.
Source: Journal of Thrombosis and Haemostasis - June 19, 2014 Category: Hematology Authors: G. W. Dalmeijer, Y. T. Schouw, E. J. Magdeleyns, C. Vermeer, W. M. M. Verschuren, J. M. A. Boer, J. W. J. Beulens Tags: Original Article Source Type: research

The clinical utility of Multiplate analyser measurement in platelet function testing following stroke and transient ischaemic attack
ConclusionThe Multiplate device gives reproducible, precise results in volunteers and stroke/TIA patients.This article is protected by copyright. All rights reserved.
Source: European Journal of Haematology - June 30, 2014 Category: Hematology Authors: Gurdeep S. Mannu, Alistair Macartney, Jonathan R. A. Lambert, Joao H. Bettencourt‐Silva, Mark Lawn, Hamish Lyall, Anthony Kneale Metcalf, John F Potter, John Wood, Allan Clark, Trevor Baglin, Phyo Kyaw Myint, Kristian M. Bowles Tags: Original Article Source Type: research

Evidence for the Prevention and Treatment of Stroke in Dialysis Patients
Abstract The risks of both ischemic and hemorrhagic stroke are particularly high in dialysis patients of any age and outcomes are poor. It is therefore important to identify strategies that safely minimize stroke risk in this population. Observational studies have been unable to clarify the relative importance of traditional stroke risk factors such as blood pressure and cholesterol in those on dialysis, and are affected by biases that usually make them an inappropriate source of data on which to base therapeutic decisions. Well‐conducted randomized trials are not susceptible to such biases and can reliably investigate t...
Source: Seminars In Dialysis - May 1, 2014 Category: Hematology Authors: William Herrington, Richard Haynes, Natalie Staplin, Jonathan Emberson, Colin Baigent, Martin Landray Tags: Review Source Type: research

Elevated levels of D-dimers increase the risk of ischaemic and haemorrhagic stroke. Findings from the EPICOR Study.
In conclusion, our data provide clear evidence that elevated levels of D-dimers are potential risk factors not only for ischaemic but also for haemorrhagic strokes. PMID: 25030937 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - July 17, 2014 Category: Hematology Authors: Di Castelnuovo A, Agnoli C, de Curtis A, Giurdanella MC, Sieri S, Mattiello A, Matullo G, Panico S, Sacerdote C, Tumino R, Vineis P, de Gaetano G, Donati MB, Iacoviello L Tags: Thromb Haemost Source Type: research

Differential impact of unrecognised brain infarction on stroke outcome in non-valvular atrial fibrillation.
This study enrolled 631 patients with NVAF having no clinical stroke history. UBIs were categorised into three types as territorial, lacunar, or subcortical. We collected stroke severity, functional outcome at three months, and the total volume of UBIs and acute infarction lesions. We investigated the association between clinical outcome and the type or volume of UBI, using a linear mixed model and logistic regression analysis. UBIs were detected in 285 (45.2 %) patients; territorial UBIs were observed in 24.4 % of patients (154/631), lacunar UBIs in 25 % (158/631), and subcortical UBIs in 15.7 % (99/631). Although...
Source: Thrombosis and Haemostasis - September 18, 2014 Category: Hematology Authors: Song TJ, Kim J, Lee HS, Nam CM, Nam HS, Kim EH, Lee KJ, Song D, Heo JH, Kim YD Tags: Thromb Haemost Source Type: research

Cytoprotective-selective activated protein C therapy for ischaemic stroke.
Abstract Despite years of research and efforts to translate stroke research to clinical therapy, ischaemic stroke remains a major cause of death, disability, and diminished quality of life. Primary and secondary preventive measures combined with improved quality of care have made significant progress. However, no novel drug for ischaemic stroke therapy has been approved in the past decade. Numerous studies have shown beneficial effects of activated protein C (APC) in rodent stroke models. In addition to its natural anticoagulant functions, APC conveys multiple direct cytoprotective effects on many different cell t...
Source: Thrombosis and Haemostasis - September 18, 2014 Category: Hematology Authors: Mosnier LO, Zlokovic BV, Griffin JH Tags: Thromb Haemost Source Type: research

Direct penetrating and indirect neck trauma as a cause of internal carotid artery thrombosis and secondary ischemic stroke
Abstract The following manuscript presents two cases of ischemic stroke secondary to traumatic internal carotid artery thrombosis with concomitant middle cerebral artery thrombosis occurring very rarely in the medico-legal practice. Penetrating neck trauma due to an occupational accident and multiple head and neck trauma secondary to battery were described. The autopsy and histopathological examination as well as the analysis of available medical records, including radiological examinations, and records of investigation indicated the sustained trauma to be the cause of the thrombosis.
Source: Journal of Thrombosis and Thrombolysis - September 25, 2014 Category: Hematology Source Type: research

Efficacy and safety of thrombolysis for stroke of unknown onset time: a meta-analysis
Abstract Current stroke treatment guidelines exclude unknown onset stroke (UOS) patients from thrombolytic therapy even though several studies have reported significant treatment efficacy and safety. We performed a meta-analysis of relevant studies retrieved by systematic searches of the PubMed, Embase, and Cochrane databases up to December 31, 2013. Dichotomized modified Rankin Scale (mRS) scores 0–1 at 90 days, mRS 0–2 at 90 days, overall mortality, and symptomatic intracranial hemorrhage (sICH) incidence were collected as primary outcome measures. Fixed effects meta-analytical models were used, and betwe...
Source: Journal of Thrombosis and Thrombolysis - October 2, 2014 Category: Hematology Source Type: research

Hyperfibrinogenemia predicts long-term risk of death after ischemic stroke
Abstract In stroke patients higher levels of plasma fibrinogen are associated with increased risk of unfavourable functional outcome and short-term mortality. The aim of our study was to determine the relationship between plasma fibrinogen level and long-term risk of death in ischemic stroke patients. Seven hundred thirty six patients (median age 71; 47.1 % men) admitted to the stroke unit within 24 h after stroke were included. Plasma fibrinogen level was measured on day 1 of hospitalisation. Hyperfibrinogenemia was defined as plasma fibrinogen concentration >3.5 g/L. The maximal follow-up period was 84 ...
Source: Journal of Thrombosis and Thrombolysis - October 2, 2014 Category: Hematology Source Type: research

Acute ischemic stroke patients with diabetes should not be excluded from intravenous thrombolysis
Abstract The benefit of intravenous thrombolysis (IVT) has been questioned for patients with diabetes mellitus (DM) in cases of acute ischemic stroke (IS). Our objective was to analyze the differences in outcome according to prior diagnosis of DM and the use or not of IVT. Observational study with inclusion of consecutive IS patients admitted to an stroke unit. Demographic data, vascular risk factors, comorbidity, stroke severity and 3-month follow-up outcome (modified Rankin Scale) were compared according to prior diagnosis of DM and the use or not of IVT. A total of 1,139 IS patients were admitted; 283 (24.8 %...
Source: Journal of Thrombosis and Thrombolysis - October 2, 2014 Category: Hematology Source Type: research

Association between NINJ2 gene polymorphisms and ischemic stroke: a family-based case–control study
Abstract Novel susceptibility genes related to ischemic stroke (IS) are proposed in recent literatures. Population-based replicate studies would cause false positive results due to population stratification. 229 recruit IS patients and their 229 non-IS siblings were used in this study to avoid population stratification. The family-based study was conducted in Beijing from June 2005 to June 2012. Association between SNPs and IS was found in the sibship discordant tests, and the conditional logistic regression was performed to identify effect size and explore gene–environment interactions. Significant allelic ass...
Source: Journal of Thrombosis and Thrombolysis - October 2, 2014 Category: Hematology Source Type: research

Consensus statement: stroke prevention in nonvalvular atrial fibrillation in special consideration of the new direct oral anticoagulants.
sterreichische Gesellschaft für Hämatologie & Medizinische Onkologie (OeGHO), Österreichische Schlaganfall-Gesellschaft (ÖGSF), Österreichische Gesellschaft für Innere Medizin (ÖGIM), Österreichische Gesellschaft für Anästhesiologie, Reanimation und Intensivmedizin (ÖGARI), Österreichische Gesellschaft für Allgemein- und Familienmedizin (ÖGAM) Abstract The introduction of new direct oral anticoagulants has changed the treatment of nonvalvular atrial fibrillation. However, these changes are not yet fully reflected in current guidelines.This consensus statement, endorsed by six Austrian medical so...
Source: Hamostaseologie - October 3, 2014 Category: Hematology Authors: Pabinger I, Lang W, Roithinger FX, Weidinger F, Eichinger-Hasenauer S, Glehr R, Halbmayer WM, Haring HP, Jilma B, Korninger HC, Kozek-Langenecker S, Kyrle P, Watzke H, Weltermann A, Willeit J, Huber K, Österreichische Kardiologische Gesellschaft (ÖKG), Tags: Wien Klin Wochenschr Source Type: research

Inflammation Markers and Incident Venous Thromboembolism: the REasons for Geographic And Racial Differences in Stroke (REGARDS) Cohort
ConclusionHigher CRP and lower serum albumin were associated with increased VTE risk, and statistically mediated part of the association of BMI with VTE. These data suggest inflammation may be a potential mechanism underlying the relationship of obesity and VTE risk.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - October 7, 2014 Category: Hematology Authors: Nels C. Olson, Mary Cushman, Pamela L. Lutsey, Leslie A. McClure, Suzanne Judd, Russell P. Tracy, Aaron R. Folsom, Neil A. Zakai Tags: Original Article ‐ Clinical Haemostasis and Thrombosis Source Type: research

Inflammation Markers and Incident Venous Thromboembolism: the REasons for Geographic And Racial Differences in Stroke (REGARDS) Cohort.
CONCLUSION: Higher CRP and lower serum albumin were associated with increased VTE risk, and statistically mediated part of the association of BMI with VTE. These data suggest inflammation may be a potential mechanism underlying the relationship of obesity and VTE risk. This article is protected by copyright. All rights reserved. PMID: 25292154 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - October 7, 2014 Category: Hematology Authors: Olson NC, Cushman M, Lutsey PL, McClure LA, Judd S, Tracy RP, Folsom AR, Zakai NA Tags: J Thromb Haemost Source Type: research

VASP phosphorylation and genetic polymorphism for clopidogrel resistance in Chinese patients with non-cardioembolic ischemic stroke
Clopidogrel resistance(CR)is found in non-cardioembolic ischemic stroke (NCIS) patients. However, it is still largely unknown how to identify CR in NCIS patients by laboratory and genetic characteristics.
Source: Thrombosis Research - October 10, 2014 Category: Hematology Authors: Shijun Zhang, Xinqiang Lai, Wenxian Li, Zhen Jing, Zhilin Xiong, Anding Xu, Yiwen Ruan, Li'an Huang Tags: Regular Article Source Type: research

Patent foramen ovale increases the risk of acute ischemic stroke in patients with acute pulmonary embolism leading to right ventricular dysfunction
Patent foramen ovale (PFO) is an established risk factor for ischemic stroke. Since acute right ventricular dysfunction (RVD) observed in patients with PE can lead to right-to-left inter-atrial shunt via PFO, we hypothesized that PFO is a risk factor for ischemic stroke in PE with significant right ventricular dysfunction.
Source: Thrombosis Research - September 18, 2014 Category: Hematology Authors: Sylwia Goliszek, Małgorzata Wiśniewska, Katarzyna Kurnicka, Barbara Lichodziejewska, Michał Ciurzyński, Maciej Kostrubiec, Marek Gołębiowski, Marek Babiuch, Marzanna Paczynska, Marcin Koć, Piotr Palczewski, Anna Wyzgał, Piotr Pruszczyk Tags: Regular Article Source Type: research

Comparison of costs and discharge outcomes for patients hospitalized for ischemic or hemorrhagic stroke with or without atrial fibrillation in the United States
Abstract This retrospective analysis investigated the impact of baseline clinical characteristics, including atrial fibrillation (AF), on hospital discharge status (to home or continuing care), mortality, length of hospital stay, and treatment costs in patients hospitalized for stroke. The analysis included adult patients hospitalized with a primary diagnosis of ischemic or hemorrhagic stroke between January 2006 and June 2011 from the premier alliance database, a large nationally representative database of inpatient health records. Patients included in the analysis were categorized as with or without AF, based on...
Source: Journal of Thrombosis and Thrombolysis - November 5, 2014 Category: Hematology Source Type: research

Ischemic stroke associated with immune thrombocytopenia
The objective of this study was to review all cases in literature in which the clinical manifestations of ischemic stroke and immune thrombocytopenia (ITP) were presented in the same patient including a new case of our own and discuss the possible mechanism and management of this syndrome. We reviewed 12 reports in which 18 cases were diagnosed as ischemic stroke and ITP. The clinical manifestations and ischemic lesion patterns of the 18 cases and our new case were analyzed in detail to elucidate the characteristics and management of this kind of syndrome. Of all the cases, 8 females and 10 males, 10 of them were Koreans; ...
Source: Journal of Thrombosis and Thrombolysis - November 8, 2014 Category: Hematology Source Type: research

Multidisciplinary Stepwise Management Strategy for Acute Superior Mesenteric Venous Thrombosis: An Intestinal Stroke Center Experience
BackgroudAcute superior mesenteric venous thrombosis (ASMVT) is an uncommon but catastrophic abdominal vascular emergency with high rate of intestinal failure and mortality. The retrospective pilot study was performed to assess the effect of a multidisciplinary stepwise management strategy on survival and mesenteric recanalization in an integrated intestinal stroke center (ISC).
Source: Thrombosis Research - November 10, 2014 Category: Hematology Authors: Shuofei Yang, Xinxin Fan, Weiwei Ding, Baochen Liu, Jiaxiang Meng, Dandan Xu, Changsheng He, Wenkui Yu, Xingjiang Wu, Jieshou Li Tags: Regular article Source Type: research

Determinants of premature familial arterial thrombosis in patients with juvenile ischaemic stroke. The Italian Project on Stroke in Young Adults (IPSYS).
In conclusion, young IS patients with FH of premature arterial thrombosis exhibit a distinct risk-factor profile, an underlying procoagulant state and have worse vascular prognosis than those with no FH of juvenile thrombotic events. PMID: 25413729 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - November 20, 2014 Category: Hematology Authors: Pezzini A, Grassi M, Lodigiani C, Patella R, Gandolfo C, Zini A, DeLodovici ML, Paciaroni M, Del Sette M, Toriello A, Musolino R, Calabrò RS, Bovi P, Adami A, Silvestrelli G, Sessa M, Cavallini A, Marcheselli S, Bonifati DM, Checcarelli N, Tancredi L, Ch Tags: Thromb Haemost Source Type: research

SLAP/SLAP2 prevent excessive platelet (hem)ITAM signaling in thrombosis and ischemic stroke in mice
In this study, we show that platelets expressed both SLAP isoforms and that overexpression of either protein in a heterologous cell line almost completely inhibited glycoprotein VI and C-type lectin-like receptor 2 signaling. In mice, single deficiency of SLAP or SLAP2 had only moderate effects on platelet function, whereas double deficiency of both adapters resulted in markedly increased signal transduction, integrin activation, granule release, aggregation, procoagulant activity, and thrombin generation in response to (hem)ITAM-coupled, but not G protein-coupled, receptor activation. In vivo, constitutive SLAP/SLAP2 knoc...
Source: Blood - January 1, 2015 Category: Hematology Authors: Cherpokova, D., Bender, M., Morowski, M., Kraft, P., Schuhmann, M. K., Akbar, S. M., Sultan, C. S., Hughes, C. E., Kleinschnitz, C., Stoll, G., Dragone, L. L., Watson, S. P., Tomlinson, M. G., Nieswandt, B. Tags: Free Research Articles, Platelets and Thrombopoiesis, Thrombosis and Hemostasis Source Type: research

Safety of venous thromboembolism prophylaxis with fondaparinux in ischemic stroke
We examined adverse event frequency in hospitalized patients with ischemic stroke who received VTE prophylaxis with fondaparinux versus UFH.
Source: Thrombosis Research - December 13, 2014 Category: Hematology Authors: C.T. Hackett, R.S. Ramanathan, K. Malhotra, M.R. Quigley, K.M. Kelly, M. Tian, J. Protetch, C. Wong, D.G. Wright, A.H. Tayal Tags: Regular Article Source Type: research

Metabolic syndrome, platelet activation and the development of transient ischemic attack or thromboembolic stroke
Stroke is the second most common cause of mortality in the world today, where transient ischemic attack (TIA) is a period of focal ischemia, the symptoms of which resemble a thromboembolic stroke. Contrary to stroke, TIA symptoms typically last less than one hour and necrosis is absent. Stroke is often preceded by TIA, making it an important predictor of future ischemic events. The causal role of atherosclerosis in the development of TIA is well established, however, research indicates that the atherosclerotic process begins years earlier with the development of metabolic syndrome, which affects approximately 45% of the ad...
Source: Thrombosis Research - January 16, 2015 Category: Hematology Authors: Mia-Jeanne van Rooy, Etheresia Pretorius Tags: Review Article Source Type: research

ASTRAL-R score predicts non-recanalisation after intravenous thrombolysis in acute ischaemic stroke.
In conclusion, the 5-item ASTRAL-R score moderately predicts non-recanalisation at 24 hours in thrombolysed ischaemic strokes. If its performance can be confirmed by external validation and its clinical usefulness can be proven, the score may influence patient selection for more aggressive revascularisation strategies in routine clinical practice. PMID: 25589216 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - January 15, 2015 Category: Hematology Authors: Vanacker P, Heldner MR, Seiffge D, Mueller H, Eskandari A, Traenka C, Ntaios G, Mosimann PJ, Sztajzel R, Mendes Pereira V, Cras P, Engelter S, Lyrer P, Fischer U, Lambrou D, Arnold M, Michel P Tags: Thromb Haemost Source Type: research

Risk of ischaemic stroke associated with non‐steroidal antiinflammatory drugs and paracetamol: a population‐based case‐control study
ConclusionsDiclofenac and aceclofenac increase the risk of ischaemic stroke while ibuprofen and naproxen do not. Dose, duration and baseline CV risk, but not aspirin use, appear to modulate the risk. Paracetamol does not increase the risk, even in patients at high background CV risk.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - January 22, 2015 Category: Hematology Authors: Patricia García‐Poza, Francisco J. Abajo, Miguel J. Gil, Ana Chacón, Verónica Bryant, Luis A. García‐Rodríguez Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

Risk of ischaemic stroke associated with non-steroidal antiinflammatory drugs and paracetamol: a population-based case-control study.
CONCLUSIONS: Diclofenac and aceclofenac increase the risk of ischaemic stroke while ibuprofen and naproxen do not. Dose, duration and baseline CV risk, but not aspirin use, appear to modulate the risk. Paracetamol does not increase the risk, even in patients at high background CV risk. This article is protected by copyright. All rights reserved. PMID: 25611553 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - January 22, 2015 Category: Hematology Authors: García-Poza P, de Abajo FJ, Gil MJ, Chacón A, Bryant V, García-Rodríguez LA Tags: J Thromb Haemost Source Type: research

Association of selenoprotein S gene polymorphism with ischemic stroke in a Chinese case–control study
Previous studies showed that selenoprotein S (SELS) was associated with a range of inflammatory markers, and its gene expression was influenced by a polymorphism in the promoter region. The genetic basis of the ischemic stroke has now been largely determined, so the aim of the study was to examine the role of SELS genetic variants in the ischemic stroke risk in a Chinese population. We conducted a case–control study with 239 ischemic stroke patients and 240 controls. Two single-nucleotide polymorphisms (SNPs) in SELS genes were analyzed for association with the risk of ischemic stroke in the Chinese Han population. No ev...
Source: Blood Coagulation and Fibrinolysis - January 30, 2015 Category: Hematology Tags: Original Articles Source Type: research

Relationship Between Red Cell Distribution Width and Stroke in Patients With Stable Chronic Heart Failure: A Propensity Score Matching Analysis
Conclusion: In conclusion, this study demonstrated that RDW may be important hematological indices for stroke in patients with HF using propensity score analysis.
Source: Clinical and Applied Thrombosis/Hemostasis - February 2, 2015 Category: Hematology Authors: Kaya, A., Isik, T., Kaya, Y., Enginyurt, O., Gunaydin, Z. Y., Iscanli, M. D., Kurt, M., Tanboga, I. H. Tags: Original Articles Source Type: research

Is plasma C3 and C4 levels useful in young cerebral ischemic stroke patients? Associations with prognosis at 3 months
Abstract Plasma complement C3 and C4 act as risk factor for vascular diseases related to atherosclerosis. The association C3 and C4 levels in young ischemic stroke patients with the prognosis were still not unknown. We conducted this study to establish the significance of admission C3 and C4 levels as a possible predictor of 3 months prognosis in young patients with acute ischemic stroke. We conducted this study in 1,451 young Chinese patients as determined by the modified Rankin Scale at 3 months. Bivariate logistic regression analyses were used to determine the risk factors of outcome in male and female patie...
Source: Journal of Thrombosis and Thrombolysis - February 1, 2015 Category: Hematology Source Type: research

Innovative thrombolytic strategy using a heterodimer diabody against TAFI and PAI-1 in mouse models of thrombosis and stroke
In conclusion, administration of a bispecific inhibitor against TAFI and PAI-1 results in a prominent profibrinolytic effect in mice without increased bleeding.
Source: Blood - February 19, 2015 Category: Hematology Authors: Wyseure, T., Rubio, M., Denorme, F., Martinez de Lizarrondo, S., Peeters, M., Gils, A., De Meyer, S. F., Vivien, D., Declerck, P. J. Tags: Thrombosis and Hemostasis Source Type: research

Risk of ischemic stroke associated with non‐steroidal anti‐inflammatory drugs and paracetamol: a population‐based case‐control study
ConclusionsDiclofenac and aceclofenac increase the risk of ischemic stroke while ibuprofen and naproxen do not. Dose, duration and baseline CV risk, but not aspirin use, appear to modulate the risk. Paracetamol does not increase the risk, even in patients with a high background CV risk.
Source: Journal of Thrombosis and Haemostasis - February 24, 2015 Category: Hematology Authors: P. García‐Poza, F. J. Abajo, M. J. Gil, A. Chacón, V. Bryant, L. A. García‐Rodríguez Tags: Original Article Source Type: research

Anticoagulation for stroke prevention in new atrial fibrillation after coronary artery bypass graft surgery
The benefit of early anticoagulation for stroke prophylaxis in atrial fibrillation after coronary artery bypass graft (CABG) surgery is uncertain. We therefore studied what proportion of ischemic strokes in patients with atrial fibrillation early after CABG surgery were potentially preventable by anticoagulation with warfarin.
Source: Thrombosis Research - February 24, 2015 Category: Hematology Authors: S. Schulman, I. Cybulsky, J. Delaney Tags: Regular Article Source Type: research

Red Blood Cell Distribution Width in Patients With Cryptogenic Stroke
Conclusion: The RDW >14% increased the risk of CS by 2.5-fold, irrespectively of anemia, inflammation, and lipidic profile.
Source: Clinical and Applied Thrombosis/Hemostasis - February 27, 2015 Category: Hematology Authors: Vaya, A., Hernandez, V., Rivera, L., Hernandez, J. L., Lago, A., Espana, F., Bautista, D. Tags: Original Articles Source Type: research

Stroke risk in atrial fibrillation: Do we anticoagulate CHADS2 or CHA2DS2-VASc ≥1, or higher?
PMID: 25743201 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - March 6, 2015 Category: Hematology Authors: Olesen JB, Torp-Pedersen C Tags: Thromb Haemost Source Type: research

The risks of risk scores for stroke risk assessment in atrial fibrillation.
PMID: 25759209 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - March 11, 2015 Category: Hematology Authors: Nielsen PB, Chao TF Tags: Thromb Haemost Source Type: research

Intravenous thrombolysis for stroke in patients taking non-VKA oral anticoagulants: a 2014 update.
PMID: 25809649 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - March 26, 2015 Category: Hematology Authors: Cappellari M, Bovi P Tags: Thromb Haemost Source Type: research

Oral Contraceptive Use and Incident Stroke in Women with Sickle Cell Disease
Oral contraceptives increase the risk of ischemic stroke among women. However, the effect is not studied in the stroke prone sickle cell disease population. We want to determine the rate of incident stroke among women with sickle cell disease (SCD) enrolled in a large cohort with longitudinal follow-up.
Source: Thrombosis Research - April 13, 2015 Category: Hematology Authors: Adnan I. Qureshi, Ahmed A. Malik, Malik M. Adil, M. Fareed K. Suri Tags: Regular article Source Type: research

Endothelial progenitor cells in ischemic stroke: an exploration from hypothesis to therapy
As the population ages and lifestyles change in concordance, the number of patients suffering from ischemic stroke and its associated disabilities is increasing. Studies on determining the relationship between endothelial progenitor cells (EPCs) and ischemic stroke have become a new hot spot and have reported that EPCs may protect the brain against ischemic injury, promote neurovascular repair, and improve long-term neurobehavioral outcomes. More importantly, they introduce a new perspective for prognosis assessment and therapy of ischemic stroke. However, EPCs’ origin, function, influence factors, injury repair mechanis...
Source: Journal of Hematology and Oncology - April 11, 2015 Category: Hematology Authors: Ya-Feng LiLi-Na RenGeng GuoLee CannellaValeria ChernayaSonia SamuelSu-Xuan LiuHong WangXiao-Feng Yang Source Type: research

Current use of oral contraceptives and the risk of first-ever ischemic stroke: A meta-analysis of observational studies
: To evaluate the risk of first-ever ischemic stroke associated with current use of oral contraceptive pills (OCPs), and to describe how the risk was influenced by estrogen dose, progestin type, and study characteristics.
Source: Thrombosis Research - April 24, 2015 Category: Hematology Authors: Zhenlin Xu, Ying Li, Shaowen Tang, Xiaoping Huang, Tong Chen Tags: Regular Article Source Type: research

Polymorphisms in prothrombotic genes in young stroke patients in Greece: a case-controlled study
Mechanisms of ischemic stroke in young adults are poorly understood. The aim of the study was to investigate and compare the frequency of common variations in prothrombotic genes between young patients with ischemic stroke and controls. Fifty-one cases of first-ever ischemic stroke and 70 community-based controls aged below 50 years were studied. In both groups, the insertion/deletion 4G/5G variation (−675 4G/5G PAI-1) as well as the single-nucleotide polymorphism-844 G/A of the PAI-1 (−844 G/A PAI-1) gene promoter, factor V Leiden (FVL) G1691Α, the prothrombin variant (allele 20210A, FIIG20210A), factor XIII-A Val34L...
Source: Blood Coagulation and Fibrinolysis - May 1, 2015 Category: Hematology Tags: Original Articles Source Type: research

Neutrophil to Lymphocyte Ratio (NLR) and Risk of First Episode Stroke in Patients with Atrial Fibrillation: A Cohort Study
ConclusionsNLR is directly associated with the risk of stroke in patients with atrial fibrillation. Future studies are needed to replicate these findings.This article is protected by copyright. All rights reserved.
Source: Journal of Thrombosis and Haemostasis - May 18, 2015 Category: Hematology Authors: Walid Saliba, Ofra Barnett‐Griness, Mazen Elias, Gad Rennert Tags: Original Article ‐ Cardiovascular Medicine Source Type: research

Neutrophil to Lymphocyte Ratio (NLR) and Risk of First Episode Stroke in Patients with Atrial Fibrillation: A Cohort Study.
CONCLUSIONS: NLR is directly associated with the risk of stroke in patients with atrial fibrillation. Future studies are needed to replicate these findings. This article is protected by copyright. All rights reserved. PMID: 25988740 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - May 18, 2015 Category: Hematology Authors: Saliba W, Barnett-Griness O, Elias M, Rennert G Tags: J Thromb Haemost Source Type: research