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Is now the time to reconsider risks, benefits, and limitations of estrogen preparations as a treatment for menstrually related migraine?
Expert Rev Neurother. 2023 Apr;23(4):377-388. doi: 10.1080/14737175.2023.2198705. Epub 2023 Apr 10.ABSTRACTINTRODUCTION: Estrogen fluctuations modulate pain threshold and play a pivotal role in the central and peripheral pathogenesis of menstrually related migraine (MRM). Estrogen-withdrawal during the perimenstrual phase of a spontaneous menstrual cycle or the hormone-free interval (HFI) of hormonal treatments seems to be the culprit.AREA COVERED: The authors report the most relevant data on risks, benefits, and limitations of exogenous estrogens as a treatment for MRM considering gynecological comorbidities associated wi...
Source: Expert Review of Neurotherapeutics - April 11, 2023 Category: Neurology Authors: Lara Tiranini Laura Cucinella Silvia Martella David Bosoni Ellis Martini Rossella E Nappi Source Type: research