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Total 123 results found since Jan 2013.

Functional Brain Correlates of Upper Limb Spasticity and Its Mitigation following Rehabilitation in Chronic Stroke Survivors.
Conclusions. Contralesional motor regions may contribute to restoring control of muscle tone in chronic stroke. PMID: 25101190 [PubMed]
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Predicting Future Brain Tissue Loss From White Matter Connectivity Disruption in Ischemic Stroke Clinical Sciences
Conclusions— ChaCo scores varied, but the most affected regions included those with sensorimotor, perception, learning, and memory functions. Correlations between baseline ChaCo and subsequent tissue loss suggest that the Network Modification Tool could be used to identify regions most susceptible to remote degeneration from acute infarcts.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Kuceyeski, A., Kamel, H., Navi, B. B., Raj, A., Iadecola, C. Tags: Computerized tomography and Magnetic Resonance Imaging, Pathology of Stroke Clinical Sciences Source Type: research

Boosted Tree Model Reforms Multimodal Magnetic Resonance Imaging Infarct Prediction in Acute Stroke Clinical Sciences
Background and Purpose—Stroke imaging is pivotal for diagnosis and stratification of patients with acute ischemic stroke to treatment. The potential of combining multimodal information into reliable estimates of outcome learning calls for robust machine learning techniques with high flexibility and accuracy. We applied the novel extreme gradient boosting algorithm for multimodal magnetic resonance imaging–based infarct prediction.Methods—In a retrospective analysis of 195 patients with acute ischemic stroke, fluid-attenuated inversion recovery, diffusion-weighted imaging, and 10 perfusion parameters were derived from...
Source: Stroke - March 26, 2018 Category: Neurology Authors: Michelle Livne, Jens K. Boldsen, Irene K. Mikkelsen, Jochen B. Fiebach, Jan Sobesky, Kim Mouridsen Tags: Magnetic Resonance Imaging (MRI), Ischemic Stroke Original Contributions Source Type: research

Prediction of Tissue Outcome and Assessment of Treatment Effect in Acute Ischemic Stroke Using Deep Learning Clinical Sciences
Background and Purpose—Treatment options for patients with acute ischemic stroke depend on the volume of salvageable tissue. This volume assessment is currently based on fixed thresholds and single imagine modalities, limiting accuracy. We wish to develop and validate a predictive model capable of automatically identifying and combining acute imaging features to accurately predict final lesion volume.Methods—Using acute magnetic resonance imaging, we developed and trained a deep convolutional neural network (CNNdeep) to predict final imaging outcome. A total of 222 patients were included, of which 187 were treated with...
Source: Stroke - May 25, 2018 Category: Neurology Authors: Anne Nielsen, Mikkel Bo Hansen, Anna Tietze, Kim Mouridsen Tags: Magnetic Resonance Imaging (MRI), Treatment, Quality and Outcomes, Statements and Guidelines, Ischemic Stroke Original Contributions Source Type: research

Striking a balance: Charlie ’s recovery from neonatal stroke
“Hey, Charlie,” says Dr. Michael Rivkin as he gently dangles a small rubber ducky in front of the little boy. “Would you like this?” A wide smile breaks out across the toddler’s face. Why yes, he certainly would like that duck. He reaches and grasps at it, closing his tiny fingers around the toy. For Charlie Strzempek, it’s nothing more than a playful act. But for his parents, Kathleen and Tom, it’s a major accomplishment. Dr. Rivkin isn’t simply offering his patient a toy. He’s testing his ability to grab and hold an object in his right hand — the side of his body affected by a neonatal stroke. A shin...
Source: Thrive, Children's Hospital Boston - December 27, 2017 Category: Pediatrics Authors: Jessica Cerretani Tags: Diseases & Conditions Our Patients’ Stories Dr. Michael Rivkin Julie Croteau occupational therapy stroke Stroke and Cerebrovascular Center Source Type: news

Bouncing back: Nolan ’s life after stroke
Although he’s only a little over a year old, Nolan Morel is a bona fide charmer. Clad in a red shirt and navy blue suspenders, he flashes a happy grin at his mother, Rosalia; his physician, Dr. Laura Lehman; and the others in the room. “Look at those dimples!” someone coos, and he giggles in response. “I can’t believe how social he’s being,” laughs Rosalia. “He wasn’t always like this.” In fact, Nolan’s first several days of life were anything but lighthearted. Just a few hours after his birth at a hospital north of Boston, he stopped breathing and had to be manually resuscitated and given oxygen. Whe...
Source: Thrive, Children's Hospital Boston - December 7, 2017 Category: Pediatrics Authors: Jessica Cerretani Tags: Diseases & Conditions Our Patients’ Stories child life Dr. Laura Lehman feeding therapy occupational therapy physical therapy stroke Stroke and Cerebrovascular Center Source Type: news

Uric Acid and Gluconic Acid as Predictors of Hyperglycemia and Cytotoxic Injury after Stroke
AbstractHyperglycemia is a feature of worse brain injury after acute ischemic stroke, but the underlying metabolic changes and the link to cytotoxic brain injury are not fully understood. In this observational study, we applied regression and machine learning classification analyses to identify metabolites associated with hyperglycemia and a neuroimaging proxy for cytotoxic brain injury. Metabolomics and lipidomics were carried out using liquid chromatography-tandem mass spectrometry in admission plasma samples from 381 patients presenting with an acute stroke. Glucose was measured by a central clinical laboratory, and a s...
Source: Translational Stroke Research - October 17, 2020 Category: Neurology Source Type: research

Shengui Sansheng San Ameliorates Cerebral Energy Deficiency via Citrate Cycle After Ischemic Stroke
Conclusion In summary, SSS extraction significantly ameliorates cerebral energy metabolism via boosting citrate cycle, which mainly embodies the enhancements of blood glucose concentration, glucose and lactate transportation and glucose utilization, as well as the regulations of relative enzymes activities in citrate cycle. These ameliorations ultimately resulted in numerous ATP yield after stroke, which improved neurological function and infarcted volume. Collectively, it suggests that SSS extraction has exerted advantageous effect in the treatment of cerebral ischemia. Ethics Statement All animal operations were accor...
Source: Frontiers in Pharmacology - April 22, 2019 Category: Drugs & Pharmacology Source Type: research

What Are the Classifications of Perinatal Stroke?
Discussion Perinatal stroke occurs in about 1:1000 live births and is a “focal vascular injury from the fetal period to 28 days postnatal age.” Perinatal stroke is the most common cause of hemiparetic cerebral palsy and causes other significant morbidity including cognitive deficits, learning disabilities, motor problems, sensory problems including visual and hearing disorders, epilepsy, and behavioral and psychological problems. Family members are also affected because of the potential anxiety and guilt feelings that having a child with a stroke presents, along with the care that may be needed over the child&#...
Source: PediatricEducation.org - May 1, 2023 Category: Pediatrics Authors: Pediatric Education Tags: Uncategorized Source Type: news

Machine learning identifies stroke features between species
Conclusion: Our findings reveal that the segmentation produced by our proposed framework using 24 h MRI rat data strongly correlated with the final stroke volume, denoting a predictive effect. In addition, we show for the first time that the stroke imaging features can be directly translated between species, allowing identification of acute stroke in humans using the model trained on animal data. This discovery reduces the gap between the clinical and preclinical fields, unveiling a novel approach to directly co-analyze clinical and preclinical data. Such methods can provide further biological insights into human stroke an...
Source: Theranostics - January 15, 2021 Category: Molecular Biology Authors: Salvador Castaneda-Vega, Prateek Katiyar, Francesca Russo, Kristin Patzwaldt, Luisa Schnabel, Sarah Mathes, Johann-Martin Hempel, Ursula Kohlhofer, Irene Gonzalez-Menendez, Leticia Quintanilla-Martinez, Ulf Ziemann, Christian la Fougere, Ulrike Ernemann, Tags: Research Paper Source Type: research

Ischemic and haemorrhagic stroke risk estimation using a machine-learning-based retinal image analysis
ConclusionA fast and fully automatic method can be used for stroke subtype risk assessment and classification based on fundus photographs alone.
Source: Frontiers in Neurology - August 22, 2022 Category: Neurology Source Type: research

Pregnancy-Related Stroke: A Review
Conclusions and Relevance Early recognition and management are integral in decreasing the morbidity and mortality associated with a stroke in pregnancy. Relevance Statement This study was an evidence-based review of stroke in pregnancy and how to diagnose and mange a pregnancy complicated by a stroke. Target Audience Obstetricians and gynecologist, family physicians Learning Objectives After completing this learning activity, the participant should be better able to identify the pregnancy-related risk factors for a stroke; explain the presenting signs and symptoms of a stroke in pregnancy; describe...
Source: Obstetrical and Gynecological Survey - June 1, 2022 Category: OBGYN Tags: CME ARTICLES Source Type: research

Impaired implicit learning and feedback processing after stroke
Publication date: 9 February 2016 Source:Neuroscience, Volume 314 Author(s): J.M. Lam, C. Globas, J.A. Hosp, H.-O. Karnath, T. Wächter, A.R. Luft The ability to learn is assumed to support successful recovery and rehabilitation therapy after stroke. Hence, learning impairments may reduce the recovery potential. Here, the hypothesis is tested that stroke survivors have deficits in feedback-driven implicit learning. Stroke survivors (n =30) and healthy age-matched control subjects (n =21) learned a probabilistic classification task with brain activation measured using functional magnetic resonance imaging in a subse...
Source: Neuroscience - December 18, 2015 Category: Neuroscience Source Type: research

Reduced striatal activation in response to rewarding motor performance feedback after stroke
ConclusionStriatal hypoactivation in stroke survivors may cause impaired consolidation of motor skills. Stronger rewarding stimuli or drug-mediated enhancement may be needed to normalize reward processing after stroke with positive effects on recovery.
Source: NeuroImage: Clinical - October 24, 2019 Category: Radiology Source Type: research

Compensatory Motor Network Connectivity is Associated with Motor Sequence Learning after Subcortical Stroke.
Abstract Following stroke, functional networks reorganize and the brain demonstrates widespread alterations in cortical activity. Implicit motor learning is preserved after stroke. However the manner in which brain reorganization occurs, and how it supports behaviour within the damaged brain remains unclear. In this functional magnetic resonance imaging (fMRI) study, we evaluated whole brain patterns of functional connectivity during the performance of an implicit tracking task at baseline and retention, following 5 days of practice. Following motor practice, a significant difference in connectivity within a motor...
Source: Behavioural Brain Research - March 7, 2015 Category: Neurology Authors: Wadden KP, Woodward TS, Metzak PD, Lavigne KM, Lakhani B, Auriat AM, Boyd LA Tags: Behav Brain Res Source Type: research