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MassDevice Q & A: Claret Medical ’ s Azin Parhizgar on trying to make TAVR safer
Cerebral protection developer Claret Medical recently won FDA de novo clearance for its Sentinel device designed to trap blood clots and prevent stroke during heart valve replacement procedures. The Sentinel uses a pair of filters, 1 in the brachiocephalic artery another in the left common carotid artery, to trap debris released during transcatheter aortic valve replacement that could cause a cerebral embolism. The device has seen a rough road to approval, however, after missing the primary efficacy endpoint in its pivotal trial. Despite that, the device saw nearly unanimous support from an FDA advisory panel and was c...
Source: Mass Device - June 12, 2017 Category: Medical Devices Authors: Fink Densford Tags: Neurological Surgical Vascular Claret Medical Inc. Source Type: news

Effects of the dimeric PSD-95 inhibitor UCCB01-144 on functional recovery after fimbria-fornix transection in rats
Publication date: Available online 21 September 2017 Source:Pharmacology Biochemistry and Behavior Author(s): Jens Bak Sommer, Anders Bach, Hana Malá, Kristian Strømgaard, Jesper Mogensen, Darryl S. Pickering Pharmacological inhibition of PSD-95 is a promising therapeutic strategy in the treatment of stroke, and positive effects of monomeric and dimeric PSD-95 inhibitors have been reported in numerous studies. However, whether therapeutic effects will generalize to other types of acute brain injury such as traumatic brain injury (TBI), which has pathophysiological mechanisms in common with stroke, is currently uncertain...
Source: Pharmacology Biochemistry and Behavior - September 22, 2017 Category: Biochemistry Source Type: research

BCI-FES With Multimodal Feedback for Motor Recovery Poststroke
In this report, we describe device parameters and intervention protocols of our BCI-FES system which, combined with standard physical rehabilitation approaches, has proven efficacious in treating UE motor impairment in stroke survivors, regardless of level of impairment and chronicity.
Source: Frontiers in Human Neuroscience - July 6, 2022 Category: Neuroscience Source Type: research

How a Small Tribe Turned Tragedy into Opportunity
An Irula couple fishes in the creeks of the Pichavaram Mangrove Forest in Tamil Nadu. Credit: Malini Shankar/IPSBy Malini ShankarPICHAVARAM, India, Nov 13 2014 (IPS)When the Asian tsunami washed over several Indian Ocean Rim countries on Boxing Day 2004, it left a trail of destruction in its wake, including a death toll that touched 230,000.Millions lost their jobs, food security and traditional livelihoods and many have spent the last decade trying to pick up the pieces of their lives. But for a small tribe in southern India, the tsunami didn’t bring devastation; instead, it brought hope.Numbering some 25,000 people, th...
Source: IPS Inter Press Service - Health - November 13, 2014 Category: Global & Universal Authors: Malini Shankar Tags: Aid Asia-Pacific Biodiversity Civil Society Development & Aid Economy & Trade Editors' Choice Education Environment Featured Food & Agriculture Global Governance Headlines Health Human Rights Indigenous Rights Labour Natu Source Type: news

What ’s the Big Deal about Data in Medtech?
Discussion, “Top 5 Things You Need to Know about the Implantable Internet of Things." Brian Chapman, partner and leader of ZS’s medtech practice of ZS, attributes today’s focus on data to the intersection of two important things: "A general recognition that understanding more and connecting actions with outcomes will provide feedback and understanding that will drive standards of care. This is not new, but as capabilities rise in data collection, aggregation, and synthesize rise, and coupled with machine learning, the promise of data in healthcare is becoming even more ...
Source: MDDI - December 20, 2019 Category: Medical Devices Authors: Daphne Allen Tags: Digital Health Source Type: news

Language and Aphasias
This article reveals how it is possible for a brain composed of 100 billion highly interconnected, lipid-encased, reticular electrochemical devices to support complex functions such as language and how language disorders can be understood as a reflection of degradation of one or more domains of knowledge. RECENT FINDINGS Ongoing research, building on landmark work regarding parallel distributed processing (PDP), provides the basis for understanding cognitive functions as a manifestation of the activity of populations of millions or billions of neurons in various highly interconnected networks. Population encoding ne...
Source: CONTINUUM: Lifelong Learning in Neurology - December 1, 2021 Category: Neurology Tags: REVIEW ARTICLES Source Type: research

Brain PET and Cerebrovascular Disease
Cerebrovascular disease encompasses a broad spectrum of diseases such as stroke, hemorrhage, and cognitive decline associated with vascular narrowing, obstruction, rupture, and inflammation, among other issues. Recent advances in hardware and software have led to improvements in brain PET. Although still in its infancy, machine learning using convolutional neural networks is gaining traction in this area, often with a focus on providing high-quality images with reduced noise using a shorter acquisition time or less radiation exposure for the patient.
Source: PET Clinics - October 27, 2022 Category: Radiology Authors: Katarina Chiam, Louis Lee, Phillip H. Kuo, Vincent C. Gaudet, Sandra E. Black, Katherine A. Zukotynski Source Type: research

Rapid MRI protocol leads to reduced image acquisition times
A rapid lumbar MRI protocol that uses 3D imaging and deep learning reconstructio...Read more on AuntMinnie.comRelated Reading: Reducing use of sedation for pediatric MRI cuts healthcare costs Ultrafast MRI shows promise in predicting DCIS upstaging Ultrafast DCE-MRI helps predict breast cancer treatment response Is abbreviated MRI useful for women at average breast cancer risk? Rapid MRI for ED stroke evaluation cuts costs, hospital length of stay
Source: AuntMinnie.com Headlines - January 6, 2023 Category: Radiology Source Type: news