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Effects of Neurotrophic Factors in Glial Cells in the Central Nervous System: Expression and Properties in Neurodegeneration and Injury
Conclusion and Future Aspects This review summarizes available NTF expression data, compiles existing evidence on the effects of glial NTF signaling in healthy conditions and in disease models (Figure 1), and highlights the importance of this topic for future studies. The relationship between NTFs and glia is crucial for both the developing and adult brain. While some of these factors, such as NT-3 and CNTF, have highly potent effects on gliogenesis, others like BDNF and GDNF, are important for glia-mediated synapse formation. Neurotrophic factors play significant roles during neurodegenerative disorders. In many cases, ...
Source: Frontiers in Physiology - April 25, 2019 Category: Physiology Source Type: research

Will MRI replace the EEG for the diagnosis of nonconvulsive status epilepticus, especially focal?
Authors: Gelisse P, Genton P, Crespel A, Lefevre PH Abstract Magnetic resonance imaging (MRI) can now be used to diagnose or to provide confirmation of focal nonconvulsive status epilepticus (NCSE). Approximately half of patients with status epilepticus (SE) have signal changes. MRI can also aid in the differential diagnosis with generalized NCSE when there is a clinical or EEG doubt, e.g. with metabolic/toxic encephalopathies or Creutzfeldt-Jakob disease. With the development of stroke centers, MRI is available 24h/24 in most hospitals. MRI has a higher spatial resolution than electroencephalography (EEG). MRI wit...
Source: Revue Neurologique - January 26, 2021 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Documented Goals of Care Conversations with Hospitalized Patients After Severe Stroke (S513)
1. Understand the prevalence, frequency, timing, and content of a goals-of-care conversation (GOCC)2. Learn best practices in GOCC documentation
Source: Journal of Pain and Symptom Management - April 12, 2022 Category: Palliative Care Authors: Amber Comer, Claire Creutzfeldt, Robert Holloway, Stephanie Bartlett, James Slaven, Linda Williams, Alexia Torke Source Type: research

Documented Goals of Care Conversations with Hospitalized Patients After Severe Stroke (GP715)
1. Understand the prevalence, frequency, timing, and content of a goals-of-care conversation2. Learn best practices in goals-of-care conversation documentation
Source: Journal of Pain and Symptom Management - May 17, 2022 Category: Palliative Care Authors: Amber Comer, Claire Creutzfeldt, Lynn D'Cruz, Stephanie Bartlett, Robert Holloway, Alexia Torke, Laura Petras, Linda Williams Source Type: research