• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Stroke Induces a BDNF-Dependent Improvement in Cognitive Flexibility in Aged Mice.
Abstract Stroke remains a leading cause of disability worldwide. Recently, we have established an animal model of stroke that results in delayed impairment in spatial memory, allowing us to better investigate cognitive deficits. Young and aged brains show different recovery profiles after stroke; therefore, we assessed aged-related differences in poststroke cognition. As neurotrophic support diminishes with age, we also investigated the involvement of brain-derived neurotrophic factor (BDNF) in these differences. Young (3-6 months old) and aged (16-21 months old) mice were trained in operant touchscreen chambers t...
Source: Neural Plasticity - June 15, 2019 Category: Neurology Authors: Houlton J, Zhou LYY, Barwick D, Gowing EK, Clarkson AN Tags: Neural Plast Source Type: research

Longitudinal Analysis of Stroke Patients' Brain Rhythms during an Intervention with a Brain-Computer Interface.
Abstract Stroke is a leading cause of motor disability worldwide. Upper limb rehabilitation is particularly challenging since approximately 35% of patients recover significant hand function after 6 months of the stroke's onset. Therefore, new therapies, especially those based on brain-computer interfaces (BCI) and robotic assistive devices, are currently under research. Electroencephalography (EEG) acquired brain rhythms in alpha and beta bands, during motor tasks, such as motor imagery/intention (MI), could provide insight of motor-related neural plasticity occurring during a BCI intervention. Hence, a longitudin...
Source: Neural Plasticity - May 22, 2019 Category: Neurology Authors: Carino-Escobar RI, Carrillo-Mora P, Valdés-Cristerna R, Rodriguez-Barragan MA, Hernandez-Arenas C, Quinzaños-Fresnedo J, Galicia-Alvarado MA, Cantillo-Negrete J Tags: Neural Plast Source Type: research

Finding the Intersection of Neuroplasticity, Stroke Recovery, and Learning: Scope and Contributions to Stroke Rehabilitation.
Conclusions: Our novel approach developed for this review allowed the identification of the common themes/topics that intersect the concepts of neuroplasticity, stroke recovery, and learning. These may be synthesised to advance a neuroscience-informed approach to stroke rehabilitation. We also identified gaps in available literature using this approach. These may help guide future targeted research. PMID: 31191637 [PubMed - in process]
Source: Neural Plasticity - June 15, 2019 Category: Neurology Authors: Carey L, Walsh A, Adikari A, Goodin P, Alahakoon D, De Silva D, Ong KL, Nilsson M, Boyd L Tags: Neural Plast Source Type: research

Targeted Neuromodulation of Abnormal Interhemispheric Connectivity to Promote Neural Plasticity and Recovery of Arm Function after Stroke: A Randomized Crossover Clinical Trial Study Protocol.
Conclusion: The findings from this single-site early stage clinical trial will provide foundational results to inform the design of larger-scale, multisite clinical trials to evaluate the therapeutic potential of ihPAS-based neuromodulation for upper limb recovery after stroke. This trial is registered with NCT02465034. PMID: 29721010 [PubMed - in process]
Source: Neural Plasticity - May 4, 2018 Category: Neurology Authors: Borich MR, Wolf SL, Tan AQ, Palmer JA Tags: Neural Plast Source Type: research

White Matter Biomarkers Associated with Motor Change in Individuals with Stroke: A Continuous Theta Burst Stimulation Study.
Abstract Continuous theta burst stimulation (cTBS) is a form of noninvasive repetitive brain stimulation that, when delivered over the contralesional hemisphere, can influence the excitability of the ipsilesional hemisphere in individuals with stroke. cTBS applied prior to skilled motor practice interventions may augment motor learning; however, there is a high degree of variability in individual response to this intervention. The main objective of the present study was to assess white matter biomarkers of response to cTBS paired with skilled motor practice in individuals with chronic stroke. We tested the effects...
Source: Neural Plasticity - March 15, 2019 Category: Neurology Authors: Wadden KP, Peters S, Borich MR, Neva JL, Hayward KS, Mang CS, Snow NJ, Brown KE, Woodward TS, Meehan SK, Boyd LA Tags: Neural Plast Source Type: research

Defining Optimal Aerobic Exercise Parameters to Affect Complex Motor and Cognitive Outcomes after Stroke: A Systematic Review and Synthesis.
Abstract Although poststroke aerobic exercise (AE) increases markers of neuroplasticity and protects perilesional tissue, the degree to which it enhances complex motor or cognitive outcomes is unknown. Previous research suggests that timing and dosage of exercise may be important. We synthesized data from clinical and animal studies in order to determine optimal AE training parameters and recovery outcomes for future research. Using predefined criteria, we included clinical trials of stroke of any type or duration and animal studies employing any established models of stroke. Of the 5,259 titles returned, 52 artic...
Source: Neural Plasticity - February 18, 2016 Category: Neurology Authors: Hasan SM, Rancourt SN, Austin MW, Ploughman M Tags: Neural Plast Source Type: research

Electroacupuncture Regulates Hippocampal Synaptic Plasticity via miR-134-Mediated LIMK1 Function in Rats with Ischemic Stroke.
Abstract MircoRNAs (miRs) have been implicated in learning and memory, by regulating LIM domain kinase (LIMK1) to induce synaptic-dendritic plasticity. The study aimed to investigate whether miRNAs/LIMK1 signaling was involved in electroacupuncture- (EA-) mediated synaptic-dendritic plasticity in a rat model of middle cerebral artery occlusion induced cognitive deficit (MICD). Compared to untreatment or non-acupoint-EA treatment, EA at DU20 and DU24 acupoints could shorten escape latency and increase the frequency of crossing platform in Morris water maze test. T2-weighted imaging showed that the MICD rat brain le...
Source: Neural Plasticity - January 25, 2017 Category: Neurology Authors: Liu W, Wu J, Huang J, Zhuo P, Lin Y, Wang L, Lin R, Chen L, Tao J Tags: Neural Plast Source Type: research

Functional Connectivity Changes in Multiple-Frequency Bands in Acute Basal Ganglia Ischemic Stroke Patients: A Machine Learning Approach
CONCLUSION: Acute BGIS patients had frequency-specific alterations in FC; SVM is a promising method for exploring these frequency-dependent FC alterations. The abnormal brain regions might be potential targets for future researchers in the rehabilitation and treatment of stroke patients.PMID:35356364 | PMC:PMC8958111 | DOI:10.1155/2022/1560748
Source: Neural Plasticity - March 31, 2022 Category: Neurology Authors: Jie Li Lulu Cheng Shijian Chen Jian Zhang Dongqiang Liu Zhijian Liang Huayun Li Source Type: research

Increased Alpha-Rhythm Dynamic Range Promotes Recovery from Visuospatial Neglect: A Neurofeedback Study.
Abstract Despite recent attempts to use electroencephalogram (EEG) neurofeedback (NFB) as a tool for rehabilitation of motor stroke, its potential for improving neurological impairments of attention-such as visuospatial neglect-remains underexplored. It is also unclear to what extent changes in cortical oscillations contribute to the pathophysiology of neglect, or its recovery. Utilizing EEG-NFB, we sought to causally manipulate alpha oscillations in 5 right-hemisphere stroke patients in order to explore their role in visuospatial neglect. Patients trained to reduce alpha oscillations from their right posterior pa...
Source: Neural Plasticity - May 24, 2017 Category: Neurology Authors: Ros T, Michela A, Bellman A, Vuadens P, Saj A, Vuilleumier P Tags: Neural Plast Source Type: research

Mirror Visual Feedback Training Improves Intermanual Transfer in a Sport-Specific Task: A Comparison between Different Skill Levels.
This study evaluated whether these augmented performance improvements by mirror visual feedback (MVF) could be used for learning a sport-specific skill and if the effects are modulated by skill level. A sample of 39 young, healthy, and experienced basketball and handball players and 41 novices performed a stationary basketball dribble task at a mirror box in a standing position and received either MVF or direct feedback. After four training days using only the right hand, performance of both hands improved from pre- to posttest measurements. Only the left hand (untrained) performance of the experienced participants receivi...
Source: Neural Plasticity - September 21, 2016 Category: Neurology Authors: Steinberg F, Pixa NH, Doppelmayr M Tags: Neural Plast Source Type: research

The White Matter Functional Abnormalities in Patients with Transient Ischemic Attack: A Reinforcement Learning Approach
CONCLUSION: The present study revealed abnormal WM functional alterations in the low-frequency range in patients with TIA. These results support the role of WM functional neural activity as a potential neuromarker in classifying patients with TIA and offer novel insights into the underlying mechanisms in patients with TIA from the perspective of WM function.PMID:36300173 | PMC:PMC9592236 | DOI:10.1155/2022/1478048
Source: Neural Plasticity - October 27, 2022 Category: Neurology Authors: Huibin Ma Zhou Xie Lina Huang Yanyan Gao Linlin Zhan Su Hu Jiaxi Zhang Qingguo Ding Source Type: research