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Source: Behavioural Brain Research
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Total 25 results found since Jan 2013.

Progesterone improves long-term functional and histological outcomes after permanent stroke in older rats.
Abstract Previous studies have shown progesterone to be beneficial in animal models of central nervous system injury, but less is known about its longer-term sustained effects on recovery of function following stroke. We evaluated progesterone's effects on a panel of behavioral tests up to 8 weeks after permanent middle cerebral artery occlusion (pMCAO). Male Sprague-Dawley rats 12m.o. were subjected to pMCAO and, beginning 3h post-pMCAO, given intraperitoneal injections of progesterone (8mg/kg) or vehicle, followed by subcutaneous injections at 8h and then every 24h for 7 days, with tapering of the last 2 treatme...
Source: Behavioural Brain Research - February 24, 2016 Category: Neurology Authors: Wali B, Ishrat T, Stein DG, Sayeed I Tags: Behav Brain Res Source Type: research

Post-stroke protection from maladaptive effects of learning with the non-paretic forelimb by bimanual home cage experience in C57BL/6 mice.
Abstract Behavioral experience, in the form of skilled limb use, has been found to impact the structure and function of the central nervous system, affecting post-stroke behavioral outcome in both adaptive and maladaptive ways. Learning to rely on the less-affected, or non-paretic, body side is common following stroke in both humans and rodent models. In rats, it has been observed that skilled learning with the non-paretic forelimb following ischemic insult leads to impaired or delayed functional recovery of the paretic limb. Here we used a mouse model of focal motor cortical ischemic injury to examine the effects...
Source: Behavioural Brain Research - June 8, 2013 Category: Neurology Authors: Kerr AL, Wolke ML, Bell JA, Jones TA Tags: Behav Brain Res Source Type: research

Compensatory Motor Network Connectivity is Associated with Motor Sequence Learning after Subcortical Stroke.
Abstract Following stroke, functional networks reorganize and the brain demonstrates widespread alterations in cortical activity. Implicit motor learning is preserved after stroke. However the manner in which brain reorganization occurs, and how it supports behaviour within the damaged brain remains unclear. In this functional magnetic resonance imaging (fMRI) study, we evaluated whole brain patterns of functional connectivity during the performance of an implicit tracking task at baseline and retention, following 5 days of practice. Following motor practice, a significant difference in connectivity within a motor...
Source: Behavioural Brain Research - March 7, 2015 Category: Neurology Authors: Wadden KP, Woodward TS, Metzak PD, Lavigne KM, Lakhani B, Auriat AM, Boyd LA Tags: Behav Brain Res Source Type: research

H2S attenuates cognitive deficits through Akt1/JNK3 signaling pathway in ischemic stroke.
In this study, we established four-vessel occlusion model in rats with cerebral ischemia. We found that NaHS (28mmol/kg, intraperitoneally, for 7 days before ischemia), donor of H2S, significantly shortened the distance and time of loading onto the hidden platform in the positioning navigation process, decreased the latency in the space exploration process when cognitive testing with Morris water maze was performed during ischemic stroke in rats. NaHS also significantly shortened latency and reduced the number of errors in the platform diving experiment. The survival rate of neurons in the CA1 area of the hippocampus and t...
Source: Behavioural Brain Research - April 23, 2014 Category: Neurology Authors: Wen X, Qi D, Sun Y, Huang X, Zhang F, Wu J, Fu Y, Du Y, Dong H, Liu Y, Liu H, Song Y Tags: Behav Brain Res Source Type: research

Procedural learning as a measure of functional impairment in a mouse model of ischemic stroke.
Abstract Basal ganglia stroke is often associated with functional deficits in patients, including difficulties to learn and execute new motor skills (procedural learning). To measure procedural learning in a murine model of stroke (30min. right MCAO), we submitted C57Bl/6J mice to various sensorimotor tests, then to an operant procedure (Serial Order Learning) specifically assessing the ability to learn a simple motor sequence. Results showed that MCAO affected the performance in some of the sensorimotor tests (accelerated rotating rod and amphetamine rotation test) and the way animals learned a motor sequence. Th...
Source: Behavioural Brain Research - March 17, 2016 Category: Neurology Authors: Linden J, Beeck LV, Plumier JC, Ferrara A Tags: Behav Brain Res Source Type: research

Effects of thalamic hemorrhagic lesions on explicit and implicit learning during the acquisition and retrieval phases in an animal model of central post-stroke pain.
Abstract Hemorrhagic stroke has many symptoms, including central pain, learning and memory impairments, motor deficits, language problems, emotional disturbances, and social maladjustment. Lesions of the ventral basal complex (VBC) of the thalamus elicit thermal and mechanical hyperalgesia, forming an animal model of central post-stroke pain (CPSP). However, no research has yet examined the involvement of learning and memory in CPSP using an animal model. The present study examined whether VBC lesions affect motor function, conditioned place preference (CPP; implicit memory), and spatial learning (explicit memory)...
Source: Behavioural Brain Research - September 24, 2016 Category: Neurology Authors: Wang CC, Shih HC, Shyu BC, Huang AC Tags: Behav Brain Res Source Type: research

H2S prevents injury after ischemic stroke by diminishing the assembly of CaMKII with ASK1-MKK3-p38 signaling module.
Abstract Cerebral ischemia/reperfusion (I/R) injury is a leading cause of learning and memory dysfunction. Hydrogen sulfide (H2S) has been shown to confer neuroprotection in various neurodegenerative diseases, including cerebral I/R-induced hippocampal CA1 injury. However, the underlying mechanisms have not been completely understood. In the present study, rats were pretreated with SAM/NaHS (SAM, an H2S agonist, and NaHS, an H2S donor) only or SAM/NaHS combined with CaM (an activator of CaMKII) prior to cerebral ischemia. The Morris water maze test demonstrated that SAM/NaHS could alleviate learning and memory imp...
Source: Behavioural Brain Research - January 28, 2020 Category: Neurology Authors: Song YJ, Shi Y, Cui M, Li M, Wen XR, Zhou XY, Lou HQ, Wang YL, Qi DS, Tang M, Zhang XB Tags: Behav Brain Res Source Type: research

Oral Administration of Cyclic Glycyl-Proline Facilitates Task Learning in a Rat Stroke Model
Behav Brain Res. 2021 Sep 9:113561. doi: 10.1016/j.bbr.2021.113561. Online ahead of print.ABSTRACTCyclic glycyl-proline (cGP) exerts neuroprotective effects against ischemic stroke and may promote neural plasticity or network remodeling. We sought to determine to what extent oral administration of cGP could facilitate task learning in rats with ischemic lesions. We trained rats to perform a choice reaction time task using their forepaws. One week after changing the food to pellets containing cGP (no cGP: 0mg/kg; low cGP: 25mg/kg; and high cGP: 75mg/kg), we made a focal ischemic lesion on the left or right forepaw area of t...
Source: Behavioural Brain Research - September 12, 2021 Category: Neurology Authors: Hidekazu Kaneko Masakazu Namihira Shoko Yamamoto Noriaki Numata Koji Hyodo Source Type: research

Ischemic lesions localized to the medial prefrontal cortex produce selective deficits in measures of executive function in rats.
In this study we used bilateral micro-injections (1μl) of the vasoconstricting peptide endothelin-1 (ET-1) into the medial PFC in male Sprague Dawley rats (or vehicle control, N = 17-18 per group) in order to model ischemic lesions in the medial PFC. The effects of these lesions on executive function were assessed using tests of set-shifting and temporal order recognition. ET-1 injections in the medial PFC resulted in replicable and specific lesions within the PFC with an average infarct volume of 16.63 ± 2.71mm(3). The ischemic lesions resulted in specific contextual set-shifting deficits within the maze, including an i...
Source: Behavioural Brain Research - July 9, 2015 Category: Neurology Authors: Deziel RA, Ryan CL, Tasker RA Tags: Behav Brain Res Source Type: research

Training in a cooperative bimanual skilled reaching task, the popcorn retrieval task, improves unimanual function after motor cortical infarcts in rats.
Abstract Disuse of the paretic hand after stroke is encouraged by compensatory reliance on the nonparetic hand, to exacerbate impairment and potentially constrain motor rehabilitation efficacy. Rodent stroke model findings support that learning new unimanual skills with the nonparetic forelimb diminishes functional improvements that can be driven by rehabilitative training of the paretic forelimb. The influence of learning new ways of skillfully using the two hands together on paretic side function is much less clear. To begin to explore this, we developed a new cooperative bimanual skilled reaching task for rats,...
Source: Behavioural Brain Research - September 13, 2020 Category: Neurology Authors: Dutcher AM, Truong KV, Miller DD, Allred RP, Nudi E, Jones TA Tags: Behav Brain Res Source Type: research