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Innovations in major system reconfiguration in England: a study of the effectiveness, acceptability and processes of implementation of two models of stroke care
This study will analyse processes involved in making significant changes to stroke care services over a short time period, and the factors influencing these processes. We will examine whether the changes have delivered improvements in quality of care and patient outcomes; and, in light of this, whether the significant extra financial investment represented good value for money. Methods: This study brings together quantitative data on 'what works and at what cost?' with qualitative data on 'understanding implementation and sustainability' to understand major system change in two large conurbations in England. Data on proces...
Source: BioMed Central - January 5, 2013 Category: Journals (General) Authors: Naomi FulopRuth BoadenRachael HunterChristopher McKevittSteve MorrisNanik PursaniAngus IG RamsayAnthony G RuddPippa J TyrrellCharles Wolfe Source Type: research

How collaborative are quality improvement collaboratives: a qualitative study in stroke care
Conclusions: Collaboration is not the only mode of behavior likely to occur within a QIC. Our study revealed a mixed picture of collaboration, free-riding and competition. QICs should learn from work on the challenges of collective action; set realistic goals; account for context; ensure sufficient time and resources are made available; and carefully manage the collaborative to mitigate the risks of collaborative inertia and unhelpful competitive or anti-cooperative behaviors. Individual organizations should assess the costs and benefits of collaboration as a means of attaining quality improvement.
Source: BioMed Central - March 11, 2014 Category: Journals (General) Authors: Pam CarterPiotr OzieranskiSarah McNicolMaxine PowerMary Dixon-Woods Source Type: research

Human adipose-derived stem cells partially rescue the stroke syndromes by promoting spacial learning and memory in mouse middle cerebral artery occlusion model
IntroductionGrowing evidence has brought stem cell therapy to the forefront as new promising approaches towards stroke treatment. Of all candidate seeding cells, adipose-derived stem cells (ADSCs) are considered as one of the most appropriate for stroke treatment. However, previous experimental data could not reach to an agreement on the efficacy of ADSC transplantation for treating stroke in vivo as well as its mechanism which hinders their further clinical translational application. Methods: To explore their in vivo mechanism of hADSC administration on neurological injury, hADSC were labeled with EGFP expressing FG12 len...
Source: BioMed Central - May 8, 2015 Category: Journals (General) Authors: Fei ZhouShane GaoLin WangChenxi SunLu ChenPing YuanHaiyang ZhaoYi YiYing QinZhiqiang DongLimei CaoHaiyan RenLiang ZhuQiang LiBing LuAibin LiangGuotong XuHongwen ZhuZhengliang GaoJie MaJun XuXu Chen Source Type: research

Perspective of synaptic protection after post-infarction treatment with statins
Stroke is the second most common cause of death in people over 45 years of age in Colombia and is the leading cause of permanent disability worldwide. Cerebral ischemia is a stroke characterized by decreased blood flow due to the occlusion of one or more cerebral arteries, which can cause memory problems and hemiplegia or paralysis, among other impairments. The literature contains hundreds of therapies (invasive and noninvasive) that exhibit a neuroprotective effect when evaluated in animal models. However, in clinical trials, most of these drugs do not reproduce the previously demonstrated neuroprotective property, and s...
Source: BioMed Central - April 13, 2015 Category: Journals (General) Authors: Johanna Gutiérrez-VargasAngel Cespedes-RubioGloria Cardona-Gómez Source Type: research

More to science: working in Business Management
What is your scientific background? I was conferred my PhD in Neuroscience from the Georgetown University Medical Center (GUMC) Interdisciplinary Program in Neuroscience (IPN). I studied central nervous system trauma in rodent models of contusive spinal cord injury. Judy Lytle My thesis centered on a specific type of progenitor cell, and its role in post-injury adult spinal cord tissue. I worked to characterize this cell population’s proliferative capabilities after injury, its ability to become neural cells in the post-injury environment, and tested various growth factors to attempt to recapitulate the cell populationâ€...
Source: BioMed Central Blog - February 27, 2017 Category: Journals (General) Authors: Dana Berry Tags: Biology Health Medicine #moretoscience careers early career researchers PhD Science > Careers Source Type: blogs