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1H NMR-Based Metabolomics Reveals Refined-Huang-Lian-Jie-Du-Decoction (BBG) as a Potential Ischemic Stroke Treatment Drug With Efficacy and a Favorable Therapeutic Window
This study was carried out in accordance with the recommendations of Animal Ethics Committee of China Pharmaceutical University. The protocol was approved by Animal Ethics Committee of China Pharmaceutical University. Author Contributions JW, MY, and LK conceived the experiments and helped to coordinate support and funding. XF performed the research and drafted the manuscript. SL, YL, and DX participated in the experiments. JW analyzed the data and edited the paper. All authors read and approved the final manuscript. Conflict of Interest Statement The authors declare that the research was conducted in the absence of an...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research

Lithium Carbonate in a Poststroke Population: Exploratory Analyses of Neuroanatomical and Cognitive Outcomes
Conclusions Lithium pharmacotherapy may be associated with gray matter volume change and verbal memory improvement in stroke patients, providing a rationale for future trials assessing therapeutic potential of lithium in a poststroke population.
Source: Journal of Clinical Psychopharmacology - December 19, 2018 Category: Psychiatry Tags: Brief Reports Source Type: research

Lithium chloride promotes neural functional recovery after local cerebral ischemia injury in rats through Wnt signaling pathway activation
Folia Morphol (Warsz). 2022 Aug 2. doi: 10.5603/FM.a2022.0068. Online ahead of print.ABSTRACTLithium chloride (LiCl) has a significant neuroprotective effect in cerebral ischemia. However, to date, there is a paucity of evidence on the role of LiCl in neural restoration after brain ischemia and the signaling pathways involved remain unclear. Therefore, to address this gap, the middle cerebral artery occlusion (MCAO) rat model was used to simulate human ischemia stroke. Male SD rats were given MCAO for 90 min followed by reperfusion, and Dickkopf-1(DKK1, 5.0 μg/kg) was administered half an hour before MCAO. Rats were then ...
Source: Folia Morphologica - August 2, 2022 Category: Anatomy Authors: Z Junde L Tingting Z Lu C Shan Y Dan Source Type: research

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