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Total 5 results found since Jan 2013.
Vagus Nerve Stimulation Delivered During Motor Rehabilitation Improves Recovery in a Rat Model of Stroke
Neural plasticity is widely believed to support functional recovery following brain damage. Vagus nerve stimulation paired with different forelimb movements causes long-lasting map plasticity in rat primary motor cortex that is specific to the paired movement. We tested the hypothesis that repeatedly pairing vagus nerve stimulation with upper forelimb movements would improve recovery of motor function in a rat model of stroke. Rats were separated into 3 groups: vagus nerve stimulation during rehabilitation (rehab), vagus nerve stimulation after rehab, and rehab alone. Animals underwent 4 training stages: shaping (motor ski...
Source: Neurorehabilitation and Neural Repair - August 13, 2014 Category: Neurology Authors: Khodaparast, N., Hays, S. A., Sloan, A. M., Fayyaz, T., Hulsey, D. R., Rennaker, R. L., Kilgard, M. P. Tags: Basic Research Articles Source Type: research
Development of Closed-loop Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) as a Neurorehabilitation Tool
Background: Motor rehabilitation training is considered the optimal method in reducing motor impairments in patients with brain injury. Noninvasive brain stimulation has recently demonstrated promise as a potential adjunct to enhance the outcomes of conventional post-stroke motor rehabilitation. Specifically, transcutaneous auricular vagus nerve stimulation (taVNS) paired with oromotor therapy to learn feeding behavior (Badran Jenkins, 2018) has emerged as a novel therapeutic avenue. Synchronization of taVNS with the specific motor behavior is believed to be critical to patient outcomes.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - January 22, 2019 Category: Neurology Authors: B. Badran, D. Jenkins, W. DeVries, M. Dancy, D. Cook, G. Mappin, M. George Source Type: research
Transcutaneous Auricular Vagus Nerve Stimulation-Paired Rehabilitation for Oromotor Feeding Problems in Newborns: An Open-Label Pilot Study
Neonates born premature or who suffer brain injury at birth often have oral feeding dysfunction and do not meet oral intake requirements needed for discharge. Low oral intake volumes result in extended stays in the hospital (>2 months) and can lead to surgical implant and explant of a gastrostomy tube (G-tube). Prior work suggests pairing vagus nerve stimulation (VNS) with motor activity accelerates functional improvements after stroke, and transcutaneous auricular VNS (taVNS) has emerged as promising noninvasive form of VNS. Pairing taVNS with bottle-feeding rehabilitation may improve oromotor coordination and lead to ...
Source: Frontiers in Human Neuroscience - March 17, 2020 Category: Neuroscience Source Type: research
Vagus nerve stimulation enhances fear extinction as an inverted-U function of stimulation intensity
Exp Neurol. 2021 Apr 9:113718. doi: 10.1016/j.expneurol.2021.113718. Online ahead of print.ABSTRACTStudies in rodents indicate that pairing vagus nerve stimulation (VNS) with extinction training enhances fear extinction. However, the role of stimulation parameters on the effects of VNS remains largely unknown. Identifying the optimal stimulation intensity is a critical step in clinical translation of neuromodulation-based therapies. Here, we sought to investigate the role of stimulation intensity in rats receiving VNS paired with extinction training in a rat model for Posttraumatic Stress Disorder (PTSD). Male Sprague-Dawl...
Source: Experimental Neurology - April 12, 2021 Category: Neurology Authors: Rimenez R Souza Nicole M Robertson Christa K McIntyre Robert L Rennaker Seth A Hays Michael P Kilgard Source Type: research