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Total 46129 results found since Jan 2013.

Impaired Glucose Regulation Predicted 1-Year Mortality of Chinese Patients With Ischemic Stroke: Data From Abnormal Glucose Regulation in Patients With Acute Stroke Across China Brief Reports
Conclusions— IGR was an independent predictor for the mortality of patients with ischemic stroke. IGR should be highlighted and intervened actively in the patients with ischemic stroke.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Jia, Q., Liu, G., Zheng, H., Zhao, X., Wang, C., Wang, Y., Liu, L., Wang, Y., on behalf of the Investigators for the Survey on Abnormal Glucose Regulation in Patients With Acute Stroke Across China Tags: Cerebrovascular disease/stroke, Glucose intolerance, Risk Factors for Stroke Brief Reports Source Type: research

Geomagnetic Storms Can Trigger Stroke: Evidence From 6 Large Population-Based Studies in Europe and Australasia Clinical Sciences
Conclusions— Geomagnetic storms are associated with increased risk of stroke and should be considered along with other established risk factors. Our findings provide a framework to advance stroke prevention through future investigation of the contribution of geomagnetic factors to the risk of stroke occurrence and pathogenesis.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Feigin, V. L., Parmar, P. G., Barker-Collo, S., Bennett, D. A., Anderson, C. S., Thrift, A. G., Stegmayr, B., Rothwell, P. M., Giroud, M., Bejot, Y., Carvil, P., Krishnamurthi, R., Kasabov, N., for the International Stroke Incidence Studies Data Pooling P Tags: Behavioral/psychosocial - stroke Clinical Sciences Source Type: research

Phase II Trial of the Sigma-1 Receptor Agonist Cutamesine (SA4503) for Recovery Enhancement After Acute Ischemic Stroke Clinical Sciences
Conclusions— Cutamesine was safe and well tolerated at both dosage levels. Although no significant effects on functional end points were seen in the population as a whole, greater improvement in National Institutes of Health Stroke Scale scores among patients with greater pretreatment deficits seen in post hoc analysis warrants further investigation. Additional studies should focus on the patient population with moderate-to-severe stroke. Clinical Trial Registration— URL: http://www.clinicaltrials.gov/show/NCT00639249. Unique identifier: NCT00639249. The EudraCT number is 2007-004840-60 (https://www.clinicaltr...
Source: Stroke - October 27, 2014 Category: Neurology Authors: Urfer, R., Moebius, H. J., Skoloudik, D., Santamarina, E., Sato, W., Mita, S., Muir, K. W., for the Cutamesine Stroke Recovery Study Group Tags: Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Blood Pressure-Lowering Treatment With Candesartan in Patients With Acute Hemorrhagic Stroke Brief Reports
Conclusions— There was no evidence that blood pressure–lowering treatment with candesartan is beneficial during the first week of hemorrhagic stroke. Instead, there were signs that such treatment may be harmful, but this needs to be verified in larger studies. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00120003.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Jusufovic, M., Sandset, E. C., Bath, P. M. W., Berge, E., on behalf of the Scandinavian Candesartan Acute Stroke Trial Study Group Tags: Cerebrovascular disease/stroke, Acute Cerebral Hemorrhage, Other Stroke Treatment - Medical Brief Reports Source Type: research

Effects of Stroke Education of Junior High School Students on Stroke Knowledge of Their Parents: Tochigi Project Brief Reports
Conclusions— Improvement of stroke knowledge immediately after the stroke lesson was observed in parents as well as their children, which indicated that our teaching materials using the Manga was effective in delivering the stroke knowledge to parents through their children.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Matsuzono, K., Yokota, C., Takekawa, H., Okamura, T., Miyamatsu, N., Nakayama, H., Nishimura, K., Ohyama, S., Ishigami, A., Okumura, K., Toyoda, K., Miyamoto, Y., Minematsu, K., on behalf of the Tochigi Junior High School Stroke Education Group, Participa Tags: Behavioral Changes and Stroke Brief Reports Source Type: research

Mechanical Thrombectomy in and Outside the REVASCAT Trial: Insights From a Concurrent Population-Based Stroke Registry Clinical Sciences
Conclusions— REVASCAT enrolled nearly all eligible patients representing one third of all patients treated with EVT. Patients treated with EVT within and outside REVASCAT had similar outcomes, reinforcing the therapeutic value of EVT. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01692379.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Urra, X., Abilleira, S., Dorado, L., Ribo, M., Cardona, P., Millan, M., Chamorro, A., Molina, C., Cobo, E., Davalos, A., Jovin, T. G., Gallofre, M., Catalan Stroke Code and Reperfusion Consortium, Catalan Stroke Code and Reperfusion Consortium Stroke Prog Tags: Cardiopulmonary Resuscitation and Emergency Cardiac Care, Treatment, Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Clinical Sciences Source Type: research

Use of Warfarin at Discharge Among Acute Ischemic Stroke Patients With Nonvalvular Atrial Fibrillation in China Clinical Sciences
Conclusions— The rate of warfarin use remains low among patients with ischemic stroke and known nonvalvular atrial fibrillation in China. Hospital size and academic status together with patient age, heart failure, heavy alcohol drinking, international normalized ratio in hospital, and stroke severity on admission were each independently associated with the use of warfarin at discharge. There is much room for improvement for secondary stroke prevention in nonvalvular atrial fibrillation patients in China.
Source: Stroke - January 25, 2016 Category: Neurology Authors: Yang, X., Li, Z., Zhao, X., Wang, C., Liu, L., Wang, C., Pan, Y., Li, H., Wang, D., Hart, R. G., Wang, Y., Wang, Y., on behalf of the China National Stroke Registry II Investigators Tags: Anticoagulants, Treatment, Quality and Outcomes, Ischemic Stroke Clinical Sciences Source Type: research

Arterial Tortuosity: An Imaging Biomarker of Childhood Stroke Pathogenesis? Clinical Sciences
Conclusions— In children with dissection and transient cerebral arteriopathy, cerebral arteries demonstrate increased tortuosity. Quantified arterial tortuosity may represent a clinically relevant imaging biomarker of vascular biology in pediatric stroke.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Wei, F., Diedrich, K. T., Fullerton, H. J., deVeber, G., Wintermark, M., Hodge, J., Kirton, A., the Vascular Effects of Infection in Pediatric Stroke (VIPS) Investigators, Dowling, Benedict, Bernard, Fox, Friedman, Lo, Ichord, Tan, Mackay, Hernandez, Hump Tags: Risk Factors, Angiography, Magnetic Resonance Imaging (MRI), Ischemic Stroke, Vascular Disease Clinical Sciences Source Type: research

Ischemic Stroke Risk in Patients With Atrial Fibrillation and CHA2DS2-VASc Score of 1: Systematic Review and Meta-Analysis Brief Reports
Conclusions— Our meta-analysis of ischemic stroke risk in atrial fibrillation patients suggests that those with CHA2DS2-VASc score of 1 may be considered for a novel oral anticoagulant, but because of high heterogeneity, the decision should be based on individual patient characteristics.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Joundi, R. A., Cipriano, L. E., Sposato, L. A., Saposnik, G., on behalf of the Stroke Outcomes Research Working Group Tags: Atrial Fibrillation, Meta Analysis, Ischemic Stroke Brief Reports Source Type: research

Smoking-Thrombolysis Relationship Depends on Ischemic Stroke Subtype Clinical Sciences
Conclusions— In patients treated with intravenous thrombolysis, smoking could be related to a better chance of functional independence if their subtype of stroke was noncardioembolic, and a lower risk of symptomatic intracranial hemorrhage and mortality in those with large artery atherosclerosis.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Tong, X., Wang, C., Liao, X., Pan, Y., Yan, H., Cao, Y., Liu, L., Zheng, H., Zhao, X., Wang, C., Li, H., Wang, D., Wang, Y., Wang, Y., on behalf of the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China (TIMS-China) Investigators* Tags: Clinical Studies, Risk Factors, Pharmacology, Treatment, Ischemic Stroke Clinical Sciences Source Type: research

Underutilization of Ambulatory ECG Monitoring After Stroke and Transient Ischemic Attack: Missed Opportunities for Atrial Fibrillation Detection Clinical Sciences
Conclusions— Less than one third of patients in our cohort received guideline-recommended 24-hour Holter monitoring, and <1% received prolonged ambulatory ECG monitoring. These findings highlight a modifiable evidence-practice gap that likely contributes to an overdiagnosis of strokes as cryptogenic, an underdiagnosis of atrial fibrillation, and missed anticoagulant treatment opportunities for secondary stroke prevention.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Edwards, J. D., Kapral, M. K., Fang, J., Saposnik, G., Gladstone, D. J., Investigators of the Registry of the Canadian Stroke Network Tags: Atrial Fibrillation, Secondary Prevention, Electrocardiology (ECG), Ischemic Stroke, Transient Ischemic Attack (TIA) Clinical Sciences Source Type: research

Association Between Onset-to-Door Time and Clinical Outcomes After Ischemic Stroke Clinical Sciences
Conclusions—Early hospital arrival within 6 hours after stroke onset is associated with favorable outcomes after ischemic stroke, regardless of reperfusion treatment or stroke severity.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Ryu Matsuo, Yuko Yamaguchi, Tomonaga Matsushita, Jun Hata, Fumi Kiyuna, Kenȷi Fukuda, Yoshinobu Wakisaka, Junya Kuroda, Tetsuro Ago, Takanari Kitazono, Masahiro Kamouchi, on behalf of the Fukuoka Stroke Registry Investigators† Tags: Ischemic Stroke Original Contributions Source Type: research

Cognitive Impairment and Risk of Stroke: A Systematic Review and Meta-Analysis of Prospective Cohort Studies Clinical Sciences
Conclusions— Cognitive impairment is associated with higher risk of stroke. The associations were not significantly different for executive function, memory, and language.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Rostamian, S., Mahinrad, S., Stijnen, T., Sabayan, B., de Craen, A. J. M. Tags: Behavioral Changes and Stroke Clinical Sciences Source Type: research

Insomnia Subtypes and the Subsequent Risks of Stroke: Report From a Nationally Representative Cohort Clinical Sciences
Conclusions— Insomnia predisposes individuals to increased risk of stroke and this association is profound among young adults. Our results underscore the clinical importance of identifying and treating insomnia. A novel behavioral intervention targeting insomnia that may prevent stroke should be explored.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Wu, M.-P., Lin, H.-J., Weng, S.-F., Ho, C.-H., Wang, J.-J., Hsu, Y.-W. Tags: Behavioral/psychosocial - stroke Clinical Sciences Source Type: research

Comparison of Magnetic Resonance Imaging Mismatch Criteria to Select Patients for Endovascular Stroke Therapy Clinical Sciences
Conclusions— The MRA–DWI mismatch is a promising alternative to DEFUSE 2’s PWI–DWI mismatch for patient selection in endovascular stroke trials.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Mishra, N. K., Albers, G. W., Christensen, S., Marks, M., Hamilton, S., Straka, M., Liggins, J. T. P., Kemp, S., Mlynash, M., Bammer, R., Lansberg, M. G., for Diffusion and Perfusion Imaging Evaluation for Understanding Stroke Evolution 2 Investigators Tags: Angiography, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research

Challenges of Decision Making Regarding Futility in a Randomized Trial: The Interventional Management of Stroke III Experience Clinical Sciences
Conclusions— Even in spite of prespecified interim analysis boundaries, interim looks at data pose challenges in interpretation and decision making, underscoring the importance of objective stopping criteria. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00359424.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Yeatts, S. D., Martin, R. H., Coffey, C. S., Lyden, P. D., Foster, L. D., Woolson, R. F., Broderick, J. P., Di Tullio, M. R., Jungreis, C. A., Palesch, Y. Y., for the IMS III Investigators Tags: Emergency treatment of Stroke Clinical Sciences Source Type: research

Incident Stroke Is Associated With Common Carotid Artery Diameter and Not Common Carotid Artery Intima-Media Thickness Clinical Sciences
Conclusions— Although common carotid IMT is not associated with stroke, interadventitial diameter of the common carotid artery is independently associated with first-time incident ischemic stroke even after adjusting for IMT. Our hypothesis that this is in part attributable to the effects of exposure to blood pressure needs confirmation by other studies. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00063440.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Polak, J. F., Sacco, R. L., Post, W. S., Vaidya, D., Arnan, M. K., O'Leary, D. H. Tags: Cerebrovascular disease/stroke, Risk Factors, Risk Factors for Stroke, Epidemiology Clinical Sciences Source Type: research

Recognition Memory Impairments After Subcortical White Matter Stroke in Mice Basic Sciences
Conclusions— Taken together, these data show the usefulness of microinjections of endothelin-1 into periventricular white matter to study focal infarcts and cognitive deficit in WT mice. In short-term studies, stroke outcome was worse in NOTCH3 null mice, consistent with the notion that the lack of the NOTCH3 receptor affects white matter stroke susceptibility.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Blasi, F., Wei, Y., Balkaya, M., Tikka, S., Mandeville, J. B., Waeber, C., Ayata, C., Moskowitz, M. A. Tags: Animal models of human disease, Behavioral Changes and Stroke, Genetics of Stroke Basic Sciences Source Type: research

Risk Factors, Stroke Prevention Treatments, and Prevalence of Cerebral Microbleeds in the Framingham Heart Study Brief Reports
Conclusions— We observed the expected association of hypertension with deep CMB and low cholesterol and APOE 4 with lobar CMB. In addition, statin use was independently associated with CMB risk. This potential adverse effect of statin use needs to be examined in other cohorts.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Romero, J. R., Preis, S. R., Beiser, A., DeCarli, C., Viswanathan, A., Martinez-Ramirez, S., Kase, C. S., Wolf, P. A., Seshadri, S. Tags: Risk Factors for Stroke, Epidemiology Brief Reports Source Type: research

Smartphone-Assisted Prehospital Medical Information System for Analyzing Data on Prehospital Stroke Care Brief Reports
Conclusions— SPMIS enabled us to analyze the prehospital information of patients with stroke in a short time with little effort. More large-scale studies on prehospital stroke care will become feasible using SPMIS, which may lead to advances in stroke treatment.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Nakae, T., Kataoka, H., Kuwata, S., Iihara, K. Tags: Emergency treatment of Stroke Brief Reports Source Type: research

Fruits and Vegetables Consumption and Risk of Stroke: A Meta-Analysis of Prospective Cohort Studies Clinical Sciences
Conclusions— Fruits and vegetables consumption are inversely associated with the risk of stroke.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Hu, D., Huang, J., Wang, Y., Zhang, D., Qu, Y. Tags: Primary prevention, Cerebrovascular disease/stroke, Risk Factors for Stroke, Epidemiology Clinical Sciences Source Type: research

Sleep Duration and Risk of Stroke Mortality Among Chinese Adults: Singapore Chinese Health Study Clinical Sciences
Conclusions— Both short and long sleep durations are associated with increased risk of stroke mortality in a Chinese population, particularly among those with a history of hypertension.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Pan, A., De Silva, D. A., Yuan, J.-M., Koh, W.-P. Tags: Behavioral/psychosocial - stroke, Cerebrovascular disease/stroke, Risk Factors for Stroke, Epidemiology Clinical Sciences Source Type: research

Sex-Related Differences of Acute Stroke Unit Care: Results From the Austrian Stroke Unit Registry Clinical Sciences
Conclusions— We identified no disproportions in quality of care in the acute SU setting between men and women, but the outcome was significantly different. Further studies on the poststroke period including socioeconomic aspects are needed to clarify this finding.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Gattringer, T., Ferrari, J., Knoflach, M., Seyfang, L., Horner, S., Niederkorn, K., Culea, V., Beitzke, M., Lang, W., Enzinger, C., Fazekas, F. Tags: Acute Cerebral Infarction, Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Assessing the Performance of the Framingham Stroke Risk Score in the Reasons for Geographic and Racial Differences in Stroke Cohort Clinical Sciences
Conclusions— Although higher FSRS was associated with higher stroke risk, the FSRS overestimated the observed stroke rates in this study, particularly in certain subgroups. This may be because of temporal declines in stroke rates, secular trends in prevention treatments, or differences in populations studied. More accurate estimates of event rates are critical for planning research, including clinical trials, and targeting health-care efforts.
Source: Stroke - May 27, 2014 Category: Neurology Authors: McClure, L. A., Kleindorfer, D. O., Kissela, B. M., Cushman, M., Soliman, E. Z., Howard, G. Tags: Risk Factors for Stroke Clinical Sciences Source Type: research

Blocking of {alpha}4 Integrin Does Not Protect From Acute Ischemic Stroke in Mice Basic Sciences
Conclusions— Pharmacological inhibition of the VLA-4/vascular adhesion molecule-1 axis in experimental stroke was ineffective in our hands. Our results cast doubt on the effectiveness of anti-CD49d as a stroke treatment. Further translational studies should be performed before testing anti–VLA-4 antibodies in patients with stroke.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Langhauser, F., Kraft, P., Gob, E., Leinweber, J., Schuhmann, M. K., Lorenz, K., Gelderblom, M., Bittner, S., Meuth, S. G., Wiendl, H., Magnus, T., Kleinschnitz, C. Tags: Cerebrovascular disease/stroke, Animal models of human disease, Acute Cerebral Infarction Basic Sciences Source Type: research

Long-Term Risk and Predictors of Recurrent Stroke Beyond the Acute Phase Brief Reports
Conclusions— Despite declining recurrence rates in this relatively young stroke population, almost one third are either dead or have experienced a second stroke in 5 years.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Pennlert, J., Eriksson, M., Carlberg, B., Wiklund, P.-G. Tags: Risk Factors for Stroke, Epidemiology Brief Reports Source Type: research

Safety of Thrombolysis in Patients With Acute Ischemic Stroke and Cerebral Cavernous Malformations Brief Reports
Conclusions— Given the limitations of our study (mainly low number of patients with CCM), the risk of thrombolysis-associated hemorrhage in patients with CCM remains uncertain. Although our data do not suggest an increased hazard from thrombolysis in patients with CCM, larger studies are necessary to determine definitively the influence of CCMs on parenchymal hemorrhage and symptomatic intracerebral hemorrhage.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Erdur, H., Scheitz, J. F., Tutuncu, S., Fiebach, J. B., Endres, M., Werring, D. J., Nolte, C. H. Tags: Acute Cerebral Infarction, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Emergency treatment of Stroke, Intracerebral Hemorrhage, Thrombolysis Brief Reports Source Type: research

Statins Improve Survival in Patients With Cardioembolic Stroke Brief Reports
Conclusions— Statin therapy could be associated with reduced mortality in patients with cardioembolic stroke.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Choi, J.-Y., Seo, W.-K., Kang, S. H., Jung, J.-M., Cho, K.-H., Yu, S., Oh, K. Tags: Cerebrovascular disease/stroke, Embolic stroke, Other Stroke Treatment - Medical Brief Reports Source Type: research

Virtual Reality Exercise Improves Mobility After Stroke: An Inpatient Randomized Controlled Trial Brief Reports
Conclusions— This VR exercise intervention for inpatient stroke rehabilitation improved mobility-related outcomes. Future studies could include nonambulatory participants as well as the implementation strategies for the clinical use of VR. Clinical Trial Registration— URL: http://www.ANZCTR.org.au/. Unique identifier: ACTRN12613000710729.
Source: Stroke - May 27, 2014 Category: Neurology Authors: McEwen, D., Taillon-Hobson, A., Bilodeau, M., Sveistrup, H., Finestone, H. Tags: Other Stroke Treatment - Medical Brief Reports Source Type: research

Prevalence of physical activity and sedentary behavior among stroke survivors in the United States.
Conclusion: Findings from this study provide a basis for future work seeking to measure the impact of physical activity on the secondary prevention of stroke by characterizing the prevalence of physical activity and sedentary behavior among stroke survivors in the United States. PMID: 24985392 [PubMed - in process]
Source: Topics in Stroke Rehabilitation - May 1, 2014 Category: Neurology Authors: Butler EN, Evenson KR Tags: Top Stroke Rehabil Source Type: research

Inpatient rehabilitation outcomes of patients with apraxia after stroke.
Conclusions: This study of acute patients found those with apraxia to be significantly less independent upon admission to inpatient rehabilitation compared to patients without apraxia. Although both groups improved a similar amount during rehabilitation, patients with apraxia discharged at a level of independence comparable to patients without apraxia upon admission. Such disparity in independence is of concern, and apraxia as a factor in stroke rehabilitation and recovery deserves further attention. PMID: 24985388 [PubMed - in process]
Source: Topics in Stroke Rehabilitation - May 1, 2014 Category: Neurology Authors: Wu AJ, Burgard E, Radel J Tags: Top Stroke Rehabil Source Type: research

Clinimetric properties of the timed up and go test for patients with stroke: a systematic review.
Conclusion: The TUG can be recommended for measuring basic mobility skills after stroke in patients who are able to walk. However, the procedures and instructions should be described more clearly. PMID: 24985387 [PubMed - in process]
Source: Topics in Stroke Rehabilitation - May 1, 2014 Category: Neurology Authors: HafsteinsdĂłttir TB, Rensink M, Schuurmans M Tags: Top Stroke Rehabil Source Type: research

Efficacy and task structure of bimanual training post stroke: a systematic review.
Conclusion: There were not enough data to draw any conclusions about the effects of bimanual task symmetry or commonality of goal. PMID: 24985386 [PubMed - in process]
Source: Topics in Stroke Rehabilitation - May 1, 2014 Category: Neurology Authors: Wolf A, Scheiderer R, Napolitan N, Belden C, Shaub L, Whitford M Tags: Top Stroke Rehabil Source Type: research

Effect of Genetic Variants Associated With Plasma Homocysteine Levels on Stroke Risk Clinical Sciences
Conclusions— This study found several potential associations with IS and its subtypes: an association of an MUT variant with small-vessel disease, an MTHFR variant with large-vessel disease, and associations of RASIP1 and SLC17A3 variants with overall IS.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Cotlarciuc, I., Malik, R., Holliday, E. G., Ahmadi, K. R., Pare, G., Psaty, B. M., Fornage, M., Hasan, N., Rinne, P. E., Ikram, M. A., Markus, H. S., Rosand, J., Mitchell, B. D., Kittner, S. J., Meschia, J. F., van Meurs, J. B. J., Uitterlinden, A. G., Wo Tags: Genetics of Stroke Clinical Sciences Source Type: research

Impact of Diffusion-Weighted Imaging Alberta Stroke Program Early Computed Tomography Score on the Success of Endovascular Reperfusion Therapy Clinical Sciences
Conclusions— DWI-ASPECTS ≥5 seems to be the optimal threshold to predict favorable outcomes among patients undergoing endovascular reperfusion within 6 hours. Selected patients with a DWI-ASPECTS of <5 may still benefit when a complete reperfusion is achieved.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Inoue, M., Olivot, J.-M., Labreuche, J., Mlynash, M., Tai, W., Albucher, J.-F., Meseguer, E., Amarenco, P., Mazighi, M. Tags: Acute Stroke Syndromes, Thrombolysis Clinical Sciences Source Type: research

Capillary Index Score in the Interventional Management of Stroke Trials I and II Clinical Sciences
Conclusions— A f CIS was found in 50% of subjects and was a virtual prerequisite for good outcome in this study subgroup of IMS I and II. We call this the 50% barrier.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Al-Ali, F., Tomsick, T. A., Connors, J. J., Gebel, J. M., Elias, J. J., Markarian, G. Z., Al-Ali, Z., Broderick, J. P. Tags: Acute Cerebral Infarction, Emergency treatment of Stroke Clinical Sciences Source Type: research

Optimal Workflow and Process-Based Performance Measures for Endovascular Therapy in Acute Ischemic Stroke: Analysis of the Solitaire FR Thrombectomy for Acute Revascularization Study Clinical Sciences
Conclusions— Interval times in the STAR study reflect current intra-arterial therapy for patients with acute ischemic stroke. Improving workflow metrics can further improve clinical outcome. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT01327989.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Menon, B. K., Almekhlafi, M. A., Pereira, V. M., Gralla, J., Bonafe, A., Davalos, A., Chapot, R., Goyal, M., on behalf of the STAR Study Investigators Tags: Acute Stroke Syndromes, Emergency treatment of Stroke, Thrombolysis Clinical Sciences Source Type: research

Methodology for a Community-Based Stroke Preparedness Intervention: The Acute Stroke Program of Interventions Addressing Racial and Ethnic Disparities Study Clinical Sciences
Conclusions— We report the methods, feasibility, and preintervention data collection efforts of the ASPIRE intervention. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00724555.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Boden-Albala, B., Edwards, D. F., St. Clair, S., Wing, J. J., Fernandez, S., Gibbons, M. C., Hsia, A. W., Morgenstern, L. B., Kidwell, C. S. Tags: Behavioral/psychosocial - stroke Clinical Sciences Source Type: research

Point-of-Care Cluster Randomized Trial in Stroke Secondary Prevention Using Electronic Health Records Clinical Sciences
Conclusions— Large pragmatic intervention studies may be implemented at low cost by using electronic health records. The intervention used in this trial was not found to be effective, and further research is needed to develop more effective intervention strategies. Clinical Trial Registration— URL: http://www.controlled-trials.com. Current Controlled Trials identifier: ISRCTN35701810.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Dregan, A., van Staa, T. P., McDermott, L., McCann, G., Ashworth, M., Charlton, J., Wolfe, C. D. A., Rudd, A., Yardley, L., Gulliford, M. C., Meredith, Kerry, Murray, Mant, Robson, Haywood, Pursani Tags: Other Stroke Treatment - Medical Clinical Sciences Source Type: research

Race/Ethnic Differences in the Risk of Hemorrhagic Complications Among Patients With Ischemic Stroke Receiving Thrombolytic Therapy Clinical Sciences
Conclusions— In patients with stroke receiving tPA, hemorrhagic complications were slightly higher in blacks and Asians, but not in Hispanics compared with whites. Asians also faced significantly higher risk for sICH relative to other race/ethnic groups. Future studies are needed to evaluate whether reduction in tPA dose similar to that used in many Asian countries could improve the safety of tPA therapy in Asians in the United States with acute ischemic strokes while maintaining efficacy.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Mehta, R. H., Cox, M., Smith, E. E., Xian, Y., Bhatt, D. L., Fonarow, G. C., Peterson, E. D., for the Get With The Guidelines-Stroke Program Tags: Thrombolysis Clinical Sciences Source Type: research

Cryptogenic Subtype Predicts Reduced Survival Among Cancer Patients With Ischemic Stroke Clinical Sciences
Conclusions— Cryptogenic stroke is independently associated with reduced survival in patients with active cancer and ischemic stroke.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Navi, B. B., Singer, S., Merkler, A. E., Cheng, N. T., Stone, J. B., Kamel, H., Iadecola, C., Elkind, M. S. V., DeAngelis, L. M. Tags: Arterial thrombosis, Thrombophilia, Acute Cerebral Infarction, Embolic stroke, Pathology of Stroke Clinical Sciences Source Type: research

Pittsburgh Outcomes After Stroke Thrombectomy Score Predicts Outcomes After Endovascular Therapy for Anterior Circulation Large Vessel Occlusions Clinical Sciences
Conclusions— POST score is a validated predictor of outcome in patients with anterior circulation large vessel occlusions after endovascular therapy.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Rangaraju, S., Liggins, J. T. P., Aghaebrahim, A., Streib, C., Sun, C.-H., Gupta, R., Nogueira, R., Frankel, M., Mlynash, M., Lansberg, M., Albers, G., Jadhav, A., Jovin, T. G. Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Other Stroke Treatment - Surgical Clinical Sciences Source Type: research

Chronic Stress, Depressive Symptoms, Anger, Hostility, and Risk of Stroke and Transient Ischemic Attack in the Multi-Ethnic Study of Atherosclerosis Clinical Sciences
Conclusions— Higher levels of stress, hostility, and depressive symptoms are associated with significantly increased risk of incident stroke or transient ischemic attacks in middle-aged and older adults. Associations are not explained by known stroke risk factors.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Everson-Rose, S. A., Roetker, N. S., Lutsey, P. L., Kershaw, K. N., Longstreth, W. T., Sacco, R. L., Diez Roux, A. V., Alonso, A. Tags: Behavioral/psychosocial - stroke Clinical Sciences Source Type: research

Diagnostic Yield of Pelvic Magnetic Resonance Venography in Patients With Cryptogenic Stroke and Patent Foramen Ovale Clinical Sciences
Conclusions— Among patients with ischemic stroke/transient ischemic attack and patent foramen ovale, the majority of detected DVTs were in LE veins rather than the pelvic veins and did not differ by stroke subtype. The routine inclusion of pelvic magnetic resonance venography in the diagnostic evaluation of CS warrants further prospective investigation.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Liberman, A. L., Daruwalla, V. J., Collins, J. D., Maas, M. B., Botelho, M. P. F., Ayache, J. B., Carr, J., Ruff, I., Bernstein, R. A., Alberts, M. J., Prabhakaran, S. Tags: Deep vein thrombosis, Other diagnostic testing, Acute Cerebral Infarction, Embolic stroke Clinical Sciences Source Type: research

Vessel Wall Magnetic Resonance Imaging in Acute Ischemic Stroke: Effects of Embolism and Mechanical Thrombectomy on the Arterial Wall Clinical Sciences
Conclusions— Mechanical thrombectomy results in intracranial arterial wall thickening and enhancement, potentially mimicking the VW-MRI appearance of primary arteritis. This arterial wall abnormality is less common in patients with arterial occlusion who have been treated with medical therapy alone.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Power, S., Matouk, C., Casaubon, L. K., Silver, F. L., Krings, T., Mikulis, D. J., Mandell, D. M. Tags: Embolic stroke, Computerized tomography and Magnetic Resonance Imaging, Pathology of Stroke, Primary and Secondary Stroke Prevention Clinical Sciences Source Type: research

Standard-Dose Intravenous Tissue-Type Plasminogen Activator for Stroke Is Better Than Low Doses Clinical Sciences
Conclusions— Our study suggests that standard-dose intravenous tPA for stroke had more favorable outcome without increasing the risk of symptomatic intracranial hemorrhage than low-dose tPA. For Asian people, 0.9 mg/kg should be the optimal dose of tPA to treat acute ischemic stroke.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Liao, X., Wang, Y., Pan, Y., Wang, C., Zhao, X., Wang, D. Z., Wang, C., Liu, L., Wang, Y., on behalf of the Thrombolysis Implementation and Monitor of Acute Ischemic Stroke in China Investigators Tags: Acute Cerebral Infarction, Thrombolysis Clinical Sciences Source Type: research

Different Doses of Recombinant Tissue-Type Plasminogen Activator for Acute Stroke in Chinese Patients Clinical Sciences
Conclusions— These results did not support the dose of 0.9 mg/kg of r-tPA being optimal for all patients in the East Asian population. In elderly patients (71–80 years), a lower dose of 0.6 mg/kg is associated with a better outcome. Confirmation of the results through randomized trial is required.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Chao, A.-C., Liu, C.-K., Chen, C.-H., Lin, H.-J., Liu, C.-H., Jeng, J.-S., Hu, C.-J., Chung, C.-P., Hsu, H.-Y., Sheng, W.-Y., Hu, H.-H., on behalf of the Taiwan Thrombolytic Therapy for Acute Ischemic Stroke (TTT-AIS) Study Group Tags: Thrombolysis Clinical Sciences Source Type: research

Predictors and Biomarkers of Treatment Gains in a Clinical Stroke Trial Targeting the Lower Extremity Clinical Sciences
Conclusions— A multimodal model incorporating behavioral and fMRI measures best predicted treatment-induced changes in gait velocity in a clinical trial setting. Results also suggest potential use of fMRI measures as biomarkers of treatment gains.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Burke, E., Dobkin, B. H., Noser, E. A., Enney, L. A., Cramer, S. C. Tags: Exercise/exercise testing/rehabilitation, Other Treatment, Behavioral Changes and Stroke, Computerized tomography and Magnetic Resonance Imaging, Rehabilitation, Stroke Clinical Sciences Source Type: research

Socioeconomic Inequalities in Stroke Incidence Among Migrant Groups: Analysis of Nationwide Data Clinical Sciences
Conclusions— Our findings reveal socioeconomic inequalities in stroke incidence among all ethnic groups. Reduction of socioeconomic inequalities in stroke incidence among all ethnic groups may lead to a major public health improvement for all. Policy measures tackling socioeconomic inequalities should take into account the increased risk of stroke among ethnic minority populations.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Agyemang, C., van Oeffelen, A. A., Norredam, M., Kappelle, L. J., Klijn, C. J. M., Bots, M. L., Stronks, K., Vaartjes, I. Tags: Cerebrovascular disease/stroke, Epidemiology Clinical Sciences Source Type: research

Physical Activity and Exercise Recommendations for Stroke Survivors: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association AHA/ASA Scientific Statement
Conclusions— The recommendation from this writing group is that physical activity and exercise prescription should be incorporated into the management of stroke survivors. The promotion of physical activity in stroke survivors should emphasize low- to moderate-intensity aerobic activity, muscle-strengthening activity, reduction of sedentary behavior, and risk management for secondary prevention of stroke.
Source: Stroke - July 28, 2014 Category: Neurology Authors: Billinger, S. A., Arena, R., Bernhardt, J., Eng, J. J., Franklin, B. A., Johnson, C. M., MacKay-Lyons, M., Macko, R. F., Mead, G. E., Roth, E. J., Shaughnessy, M., Tang, A., on behalf of the American Heart Association Stroke Council, Council on Cardiovasc Tags: AHA Statements and Guidelines AHA/ASA Scientific Statement Source Type: research