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Condition: Atrial Fibrillation

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Total 17201 results found since Jan 2013.

12/15-Lipoxygenase Inhibition or Knockout Reduces Warfarin-Associated Hemorrhagic Transformation After Experimental Stroke Basic Sciences
Conclusions—In addition to its benefits in infarct size reduction, 12/15-LOX inhibition also may independently reduce HT in warfarin-treated mice. ML351 should be further evaluated as stroke treatment in anticoagulated patients suffering a stroke, either alone or in conjunction with tissue-type plasminogen activator.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Yu Liu, Yi Zheng, Hulya Karatas, Xiaoying Wang, Christian Foerch, Eng H. Lo, Klaus van Leyen Tags: Blood-Brain Barrier, Ischemic Stroke, Neuroprotectants Original Contributions Source Type: research

Stroke as the Initial Manifestation of Atrial Fibrillation Brief Report
Conclusions—We observed that stroke is an uncommon but measureable presenting feature of AF. Our data imply that emphasizing cost-effectiveness of population-wide AF-screening efforts will be important given the relative infrequency with which stroke represents the initial manifestation of AF.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Steven A. Lubitz, Xiaoyan Yin, David D. McManus, Lu-Chen Weng, Hugo J. Aparicio, Allan J. Walkey, Jose Rafael Romero, Carlos S. Kase, Patrick T. Ellinor, Philip A. Wolf, Sudha Seshadri, Emelia J. Benjamin Tags: Atrial Fibrillation, Epidemiology, Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA) Brief Reports Source Type: research

Secondary Versus Primary Stroke Prevention in Atrial Fibrillation: Insights From the Darlington Atrial Fibrillation Registry Clinical Sciences
The objective of this study is to compare clinical outcomes of AF patients with versus without previous stroke in relation to guideline-adherent antithrombotic treatment in a contemporary primary care population.Methods—Community cohort of 105 000 patients from 11 general practices in Darlington, England, was used to assess AF stroke prevention strategies against 2014 National Institute for Health and Care Excellence guidelines.Results—Overall, 2259 (2.15%) patients with AF were identified, of which 18.9% constituted a secondary prevention cohort. For secondary prevention, antithrombotic treatment was guideline adher...
Source: Stroke - July 24, 2017 Category: Neurology Authors: Michał Mazurek, Eduard Shantsila, Deirdre A. Lane, Andreas Wolff, Marco Proietti, Gregory Y.H. Lip Tags: Catheter Ablation and Implantable Cardioverter-Defibrillator, Secondary Prevention, Mortality/Survival, Statements and Guidelines, Ischemic Stroke Original Contributions Source Type: research

Real-World Setting Comparison of Nonvitamin-K Antagonist Oral Anticoagulants Versus Vitamin-K Antagonists for Stroke Prevention in Atrial Fibrillation Clinical Sciences
Conclusions—This meta-analysis confirms the main findings of the randomized controlled trials of dabigatran, rivaroxaban, and apixaban in the real-world setting and, hence, strengthens their validity.
Source: Stroke - August 28, 2017 Category: Neurology Authors: George Ntaios, Vasileios Papavasileiou, Konstantinos Makaritsis, Konstantinos Vemmos, Patrik Michel, Gregory Y.H. Lip Tags: Arrhythmias, Secondary Prevention, Meta Analysis, Mortality/Survival, Ischemic Stroke Original Contributions Source Type: research

Predicting Major Bleeding in Ischemic Stroke Patients With Atrial Fibrillation Brief Report
Conclusions—Performance of prediction models for major bleeding in patients with cerebral ischemia and atrial fibrillation is modest but comparable with performance in patients with only atrial fibrillation. Bleeding risk scores cannot guide treatment decisions for oral anticoagulants but may still be useful to identify modifiable risk factors for bleeding. Clinical usefulness may be best for ORBIT, which is based on a limited number of easily obtainable variables and showed reasonable performance.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Nina A. Hilkens, Ale Algra, Jacoba P. Greving Tags: Atrial Fibrillation, Secondary Prevention, Ischemic Stroke Brief Reports Source Type: research

Risk of Stroke in Patients With Short-Run Atrial Tachyarrhythmia Clinical Sciences
This study aimed to investigate the relationship between short-run AT and the stroke and the use of the CHA2DS2-VASc score for the risk stratification.Methods—From the registry of 24-hour Holter monitoring, 5342 subjects without known atrial fibrillation or stroke were enrolled. Short-run AT was defined as episodes of supraventricular ectopic beats 25 beats/d) independently predicted the risk of stroke. In subgroup analyses, short-run AT patients were divided into 3 groups based on their CHA2DS2-VASc scores: low score (score of 0 [men] or 1 [women]; n=324), intermediate score (score of 1 [men] or 2 [women]; n=275), and h...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Shinya Yamada, Chin-Yu Lin, Shih-Lin Chang, Tze-Fan Chao, Yenn-Jiang Lin, Li-Wei Lo, Fa-Po Chung, Yu-Feng Hu, Ta-Chuan Tuan, Jo-Nan Liao, Abigail Louise D. Te, Yao-Ting Chang, Ting-Yung Chang, Cheng-I Wu, Satoshi Higa, Shih-Ann Chen Tags: Arrhythmias, Ischemic Stroke Original Contributions Source Type: research

Trends in Risk Factor Prevalence and Management Before First Stroke: Data From the South London Stroke Register 1995-2011 Clinical Sciences
Conclusions— Antiplatelet and cholesterol-lowering treatment prescribing have improved significantly over time; however, only a minority with AF received anticoagulants, and this did not improve significantly. Overall, 30% of strokes occurred in patients with previously diagnosed but untreated risk factors.
Source: Stroke - June 24, 2013 Category: Neurology Authors: Marshall, I. J., Wang, Y., McKevitt, C., Rudd, A. G., Wolfe, C. D. A. Tags: Primary prevention, Anticoagulants, Antiplatelets, Other Stroke Treatment - Medical, Epidemiology Clinical Sciences Source Type: research

Outcomes of a Contemporary Cohort of 536 Consecutive Patients With Acute Ischemic Stroke Treated With Endovascular Therapy Clinical Sciences
Conclusions— This study reinforces the role of revascularization and time to treatment to achieve enhanced functional outcomes and identifies other clinical features that independently predict good/fatal outcome after endovascular treatment/therapy.
Source: Stroke - March 24, 2014 Category: Neurology Authors: Abilleira, S., Cardona, P., Ribo, M., Millan, M., Obach, V., Roquer, J., Canovas, D., Marti-Fabregas, J., Rubio, F., Alvarez-Sabin, J., Davalos, A., Chamorro, A., de Miquel, M. A., Tomasello, A., Castano, C., Macho, J. M., Ribera, A., Gallofre, M., on beh Tags: Acute Cerebral Infarction, Emergency treatment of Stroke, Thrombolysis, Other Stroke Treatment - Surgical Clinical Sciences Source Type: research

Functional Gain After Inpatient Stroke Rehabilitation: Correlates and Impact on Long-Term Survival Brief Reports
Conclusions— Several factors are independently associated with functional gain after SR. Our findings strongly suggest that the magnitude of functional improvement is a powerful predictor of long-term mortality in patients admitted for SR.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Scrutinio, D., Monitillo, V., Guida, P., Nardulli, R., Multari, V., Monitillo, F., Calabrese, G., Fiore, P. Tags: Other Stroke Treatment - Medical Brief Reports Source Type: research

Cost-Effectiveness of Oral Anticoagulants for Ischemic Stroke Prophylaxis Among Nonvalvular Atrial Fibrillation Patients Clinical Sciences
Conclusions— All the newer oral anticoagulants compared were more effective than adjusted dosed warfarin. Our model showed that apixaban was the most effective anticoagulant in a general atrial fibrillation population and has an incremental cost-effectiveness ratio <$50 000/QALY. For those with higher stroke risk (CHADS2≥3), dabigatran was the most cost-effective treatment option.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Shah, A., Shewale, A., Hayes, C. J., Martin, B. C. Tags: Anticoagulants, Cost-Effectiveness, Ischemic Stroke Clinical Sciences Source Type: research

Atrial Fibrillation in Transient Ischemic Attack Versus Ischemic Stroke: A Swedish Stroke Register (Riksstroke) Study Clinical Sciences
Conclusions— AF is highly prevalent not only in IS but also in TIA patients, with proportions steeply increasing with age. In both TIA and IS, a substantial proportion of patients with AF were discharged without anticoagulant therapy.
Source: Stroke - September 25, 2016 Category: Neurology Authors: Buchwald, F., Norrving, B., Petersson, J. Tags: Atrial Fibrillation, Secondary Prevention, Ischemic Stroke, Transient Ischemic Attack (TIA) Clinical Sciences Source Type: research

Mild Hypokalemia and Supraventricular Ectopy Increases the Risk of Stroke in Community-Dwelling Subjects Clinical Sciences
Background and Purpose—Stroke is independently associated with the common conditions of hypokalemia and supraventricular ectopy, and we hypothesize that the combination of excessive supraventricular ectopic activity and hypokalemia has a synergistic impact on the prognosis in terms of stroke in the general population.Methods—Subjects (55–75 years old) from the Copenhagen Holter Study cohort (N=671) with no history of atrial fibrillation or stroke were studied—including baseline values of potassium and ambulatory 48-hour Holter monitoring. Excessive supraventricular ectopic activity is defined as ≥30 premature atr...
Source: Stroke - February 26, 2017 Category: Neurology Authors: Nick Mattsson, Preman Kumarathurai, Bȷorn Stroier Larsen, Olav Wendelboe Nielsen, Ahmad Saȷadieh Tags: Arrhythmias, ACE/Angiotensin Receptors/Renin Angiotensin System, Epidemiology, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Automated Software System to Promote Anticoagulation and Reduce Stroke Risk Brief Report
Conclusions—No significant change in OAC prescribing occurred. A greater rate of diagnosis of transient ischemic attack (possibly because of improved detection or overdiagnosis) was associated with a reduction (of borderline significance) in stroke and hemorrhage over 12 months.Clinical Trial Registration—URL: http://www.isrctn.com. Unique Identifier: ISRCTN55722437.
Source: Stroke - February 26, 2017 Category: Neurology Authors: Tim A. Holt, Andrew Dalton, Tom Marshall, Matthew Fay, Nadeem Qureshi, Susan Kirkpatrick, Jenny Hislop, Daniel Lasserson, Karen Kearley, Jill Mollison, Ly-Mee Yu, F.D. Richard Hobbs, David Fitzmaurice Tags: Atrial Fibrillation, Anticoagulants, Health Services, Ischemic Stroke Brief Reports Source Type: research

P-Wave Indices and Risk of Ischemic Stroke Clinical Sciences
Background and Purpose—Atrial cardiomyopathy is associated with an increased risk of ischemic stroke. P-wave terminal force in lead V1, P-wave duration, and maximum P-wave area are electrocardiographic parameters that have been used to assess left atrial abnormalities related to developing atrial fibrillation. The aim of this systematic review and meta-analysis was to examine their values for predicting ischemic stroke risk.Methods—PubMed and EMBASE databases were searched until December 2016 for studies that evaluated the association between P-wave indices and stroke risk. Both fixed- and random-effects models were us...
Source: Stroke - July 24, 2017 Category: Neurology Authors: Jinli He, Gary Tse, Panagiotis Korantzopoulos, Konstantinos P. Letsas, Sadeq Ali-Hasan-Al-Saegh, Hooman Kamel, Guangping Li, Gregory Y.H. Lip, Tong Liu Tags: Risk Factors, Electrocardiology (ECG), Complications, Meta Analysis, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Echocardiographic Risk Factors for Stroke and Outcomes in Patients With Atrial Fibrillation Anticoagulated With Apixaban or Warfarin Clinical Sciences
Conclusions—In anticoagulated patients with atrial fibrillation and risk factors for stroke, echocardiographic findings do not seem to add to the risk of thromboembolic events.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00412984.
Source: Stroke - November 27, 2017 Category: Neurology Authors: Dragos Vinereanu, Renato D. Lopes, Hillary Mulder, Bernard J. Gersh, Michael Hanna, Pedro G.M. de Barros e Silva, Dan Atar, Lars Wallentin, Christopher B. Granger, John H. Alexander Tags: Arrhythmias, Echocardiography, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research