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Total 5890 results found since Jan 2013.

Blood Pressure-Lowering Treatment With Candesartan in Patients With Acute Hemorrhagic Stroke Brief Reports
Conclusions— There was no evidence that blood pressure–lowering treatment with candesartan is beneficial during the first week of hemorrhagic stroke. Instead, there were signs that such treatment may be harmful, but this needs to be verified in larger studies. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00120003.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Jusufovic, M., Sandset, E. C., Bath, P. M. W., Berge, E., on behalf of the Scandinavian Candesartan Acute Stroke Trial Study Group Tags: Cerebrovascular disease/stroke, Acute Cerebral Hemorrhage, Other Stroke Treatment - Medical Brief Reports Source Type: research

Effects of Stroke Education of Junior High School Students on Stroke Knowledge of Their Parents: Tochigi Project Brief Reports
Conclusions— Improvement of stroke knowledge immediately after the stroke lesson was observed in parents as well as their children, which indicated that our teaching materials using the Manga was effective in delivering the stroke knowledge to parents through their children.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Matsuzono, K., Yokota, C., Takekawa, H., Okamura, T., Miyamatsu, N., Nakayama, H., Nishimura, K., Ohyama, S., Ishigami, A., Okumura, K., Toyoda, K., Miyamoto, Y., Minematsu, K., on behalf of the Tochigi Junior High School Stroke Education Group, Participa Tags: Behavioral Changes and Stroke Brief Reports Source Type: research

Risk Factors, Stroke Prevention Treatments, and Prevalence of Cerebral Microbleeds in the Framingham Heart Study Brief Reports
Conclusions— We observed the expected association of hypertension with deep CMB and low cholesterol and APOE 4 with lobar CMB. In addition, statin use was independently associated with CMB risk. This potential adverse effect of statin use needs to be examined in other cohorts.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Romero, J. R., Preis, S. R., Beiser, A., DeCarli, C., Viswanathan, A., Martinez-Ramirez, S., Kase, C. S., Wolf, P. A., Seshadri, S. Tags: Risk Factors for Stroke, Epidemiology Brief Reports Source Type: research

Sleep Duration and Risk of Stroke Mortality Among Chinese Adults: Singapore Chinese Health Study Clinical Sciences
Conclusions— Both short and long sleep durations are associated with increased risk of stroke mortality in a Chinese population, particularly among those with a history of hypertension.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Pan, A., De Silva, D. A., Yuan, J.-M., Koh, W.-P. Tags: Behavioral/psychosocial - stroke, Cerebrovascular disease/stroke, Risk Factors for Stroke, Epidemiology Clinical Sciences Source Type: research

Combined Effects of Socioeconomic Position, Smoking, and Hypertension on Risk of Ischemic and Hemorrhagic Stroke Clinical Sciences
Conclusions— Reducing smoking in those with low socioeconomic position and in those with hypertension could potentially reduce social inequality stroke incidence.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Nordahl, H., Osler, M., Frederiksen, B. L., Andersen, I., Prescott, E., Overvad, K., Diderichsen, F., Rod, N. H. Tags: Behavioral/psychosocial - stroke, Cerebrovascular disease/stroke, Acute Cerebral Hemorrhage, Cerebral Aneurysm, AVM, & Subarachnoid hemorrhage, Epidemiology Clinical Sciences Source Type: research

High Prevalence of Atrial Fibrillation Among Patients With Ischemic Stroke Clinical Sciences
Conclusions— Access to nationwide register data shows that AF is more common among patients with ischemic stroke than those previously reported. Few patients with stroke and AF had anticoagulant treatment before the event, and few got it after the event. CHA2DS2-VASc could be a useful monitoring tool to intensify efforts to diagnose AF among patients with cryptogenic stroke.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Friberg, L., Rosenqvist, M., Lindgren, A., Terent, A., Norrving, B., Asplund, K. Tags: Coumarins, Arrhythmias, clinical electrophysiology, drugs, Embolic stroke, Epidemiology Clinical Sciences Source Type: research

Sickle Cell Trait and Incident Ischemic Stroke in the Atherosclerosis Risk in Communities Study Clinical Sciences
Conclusions— We observed an increased risk of ischemic stroke in blacks with SCT. Further investigation of the incidence and pathophysiology of stroke in patients with SCT is warranted.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Caughey, M. C., Loehr, L. R., Key, N. S., Derebail, V. K., Gottesman, R. F., Kshirsagar, A. V., Grove, M. L., Heiss, G. Tags: Genetics of Stroke, Risk Factors for Stroke, Epidemiology Clinical Sciences Source Type: research

Potassium Intake and Risk of Stroke in Women With Hypertension and Nonhypertension in the Women's Health Initiative Clinical Sciences
Conclusions— High potassium intake is associated with a lower risk of all stroke and ischemic stroke, as well as all-cause mortality in older women, particularly those who are not hypertensive.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Seth, A., Mossavar-Rahmani, Y., Kamensky, V., Silver, B., Lakshminarayan, K., Prentice, R., Van Horn, L., Wassertheil-Smoller, S. Tags: Cerebrovascular disease/stroke, Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Epidemiology Clinical Sciences Source Type: research

Population-Based Study of Blood Biomarkers in Prediction of Subacute Recurrent Stroke Clinical Sciences
Conclusions— In the largest study to date, we found limited predictive use for early recurrent stroke for a panel of inflammatory, thrombotic, and cell damage biomarkers.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Segal, H. C., Burgess, A. I., Poole, D. L., Mehta, Z., Silver, L. E., Rothwell, P. M. Tags: Other diagnostic testing, Risk Factors for Stroke, Coagulation and fibronolysis Clinical Sciences Source Type: research

Validation of the Montreal Cognitive Assessment Versus Mini-Mental State Examination Against Hypertension and Hypertensive Arteriopathy After Transient Ischemic Attack or Minor Stroke Clinical Sciences
Conclusions— The stronger relationship between impairment on the MoCA with hypertensive arteriopathy, independent of age, indicates a greater sensitivity for vascular-origin cognitive impairment. Use of MoCA should improve sensitivity for cognitive impairment and treatment effects in future studies.
Source: Stroke - October 27, 2014 Category: Neurology Authors: Webb, A. J. S., Pendlebury, S. T., Li, L., Simoni, M., Lovett, N., Mehta, Z., Rothwell, P. M. Tags: Cerebrovascular disease/stroke, Epidemiology Clinical Sciences Source Type: research

Age- and gender-specific prevalence of risk factors in patients with first-ever ischemic stroke in china.
Conclusion. Our study showed that vascular risk factors had a specific age and gender distribution pattern in Chinese IS patients. Secondary prevention strategy should emphasize on the control of different risk factors based on patient's age and gender. PMID: 22762013 [PubMed]
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research

Hospitalization Within the First Year After Stroke: The Dijon Stroke Registry Clinical Sciences
Conclusions— Stroke survivors are at high risk of hospitalization after the episode, and subsequent admission is associated with poor survival, thus highlighting the need for follow-up interventions after discharge to prevent readmission.
Source: Stroke - December 22, 2014 Category: Neurology Authors: Lainay, C., Benzenine, E., Durier, J., Daubail, B., Giroud, M., Quantin, C., Bejot, Y. Tags: Cerebrovascular disease/stroke, Epidemiology Clinical Sciences Source Type: research

Genetic Architecture of White Matter Hyperintensities Differs in Hypertensive and Nonhypertensive Ischemic Stroke Clinical Sciences
Conclusions— A quarter of variance is attributable to common SNPs, but this estimate was greater in hypertensive individuals. These findings suggest that the genetic architecture of WMH in ischemic stroke differs between hypertensives and nonhypertensives. Future WMHV GWAS studies may gain power by accounting for this interaction.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Adib-Samii, P., Devan, W., Traylor, M., Lanfranconi, S., Zhang, C. R., Cloonan, L., Falcone, G. J., Radmanesh, F., Fitzpatrick, K., Kanakis, A., Rothwell, P. M., Sudlow, C., Boncoraglio, G. B., Meschia, J. F., Levi, C., Dichgans, M., Bevan, S., Rosand, J. Tags: Cerebrovascular disease/stroke, Other hypertension, Genetics of Stroke, Risk Factors for Stroke Clinical Sciences Source Type: research

Analysis of Tissue Plasminogen Activator Eligibility by Sex in the Greater Cincinnati/Northern Kentucky Stroke Study Clinical Sciences
Conclusions— Within a large, biracial population, eligibility for r-tPA was similar by sex. Women were more likely to have the modifiable exclusion criterion of severe hypertension but were not more likely to be treated. Women were more likely to have 2 of the 5 ECASS III exclusion criteria. Undertreatment of hypertension in women is a potentially modifiable contributor to reported differences in r-tPA administration.
Source: Stroke - February 23, 2015 Category: Neurology Authors: Madsen, T. E., Khoury, J. C., Alwell, K. A., Moomaw, C. J., Kissela, B. M., De Los Rios La Rosa, F., Woo, D., Adeoye, O., Flaherty, M. L., Khatri, P., Ferioli, S., Kleindorfer, D. Tags: Cerebrovascular disease/stroke, Other hypertension, Acute Cerebral Infarction, Acute Stroke Syndromes, Emergency treatment of Stroke, Thrombolysis Clinical Sciences Source Type: research

Short-Term Blood Pressure Variability in Acute Stroke: Post Hoc Analysis of the Controlling Hypertension and Hypotension Immediately Post Stroke and Continue or Stop Post-Stroke Antihypertensives Collaborative Study Trials Clinical Sciences
Conclusions— When derived from casual cuff BP measures, short-term BPV is not a useful predictor of early (2 weeks) outcome after acute stroke. Differing methodology may account for the discordance with previous studies indicating long-term (casual BPV) and short-term (beat-to-beat BPV) prognostic value. Clinical Trial Registration— COSSACS was registered on the International Standard Randomised Controlled Trial Register; URL: http://www.isrctn.com. Unique identifier: ISRCTN89712435. CHHIPS was registered on the National Research Register; URL: http://public.ukcrn.org.uk. Unique identifier: N0484128008.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Manning, L. S., Mistri, A. K., Potter, J., Rothwell, P. M., Robinson, T. G. Tags: Cerebrovascular disease/stroke, Clinical Studies, Acute Stroke Syndromes Clinical Sciences Source Type: research

Obesity Increases Risk of Ischemic Stroke in Young Adults Brief Reports
Conclusions— These results indicate that obesity is a risk factor for young onset ischemic stroke and suggest that this association may be partially mediated through hypertension, diabetes mellitus, or other variables associated with these conditions.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Mitchell, A. B., Cole, J. W., McArdle, P. F., Cheng, Y.-C., Ryan, K. A., Sparks, M. J., Mitchell, B. D., Kittner, S. J. Tags: Risk Factors for Stroke Brief Reports Source Type: research

Meta-Analysis of Genome-Wide Association Studies Identifies Genetic Risk Factors for Stroke in African Americans Clinical Sciences
Conclusions— We identified a novel genetic variant associated with total stroke in African Americans and found that ischemic stroke loci identified in European-ancestry populations may also be relevant for African Americans. Our findings support investigation of diverse populations to identify and characterize genetic risk factors, and the importance of shared genetic risk across populations.
Source: Stroke - July 27, 2015 Category: Neurology Authors: Carty, C. L., Keene, K. L., Cheng, Y.-C., Meschia, J. F., Chen, W.-M., Nalls, M., Bis, J. C., Kittner, S. J., Rich, S. S., Tajuddin, S., Zonderman, A. B., Evans, M. K., Langefeld, C. D., Gottesman, R., Mosley, T. H., Shahar, E., Woo, D., Yaffe, K., Liu, Y Tags: Genetics of Stroke Clinical Sciences Source Type: research

Patients With Ischemic Stroke and Incident Atrial Fibrillation: A Nationwide Cohort Study Clinical Sciences
Conclusions— Ischemic stroke was associated with a substantially increased risk of incident AF, particularly among individuals with higher CHADS2 or CHA2DS2-VASc scores. These risk scores seem to be simple tools for identifying patients at higher risk of incident AF after ischemic stroke.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Fauchier, L., Clementy, N., Pelade, C., Collignon, C., Nicolle, E., Lip, G. Y. H. Tags: Arrhythmias, clinical electrophysiology, drugs, Embolic stroke Clinical Sciences Source Type: research

Prevalence of Stroke and Its Risk Factors in Urban Sri Lanka: Population-Based Study Brief Reports
Conclusions— Age-adjusted stroke prevalence in urban Sri Lanka lies between high-income and low-/middle-income countries. The prevalence of stroke and its risk factors were higher among men.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Chang, T., Gajasinghe, S., Arambepola, C. Tags: Cerebrovascular disease/stroke, Acute Cerebral Hemorrhage, Acute Cerebral Infarction Brief Reports Source Type: research

Intravenous Thrombolysis for Stroke Recurring Within 3 Months From the Previous Event Clinical Sciences
Conclusions— Patients currently treated with alteplase, despite a history of previous stroke ≤3 months, do not seem to achieve worse outcome than those with first-ever stroke. Although careful patient selection was probably of major importance, our findings provide reassurance that this group of patients may safely benefit from thrombolysis and should not be arbitrarily excluded as a whole. Further studies are needed to identify the shortest safe time lapse from the previous event to treatment with alteplase.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Karlinski, M., Kobayashi, A., Czlonkowska, A., Mikulik, R., Vaclavik, D., Brozman, M., Gdovinova, Z., Švigelj, V., Csiba, L., Fekete, K., Korv, J., Demarin, V., Bašic-Kes, V., Vilionskis, A., Jatuzis, D., Krespi, Y., Shamalov, N., Andonova, Tags: Emergency treatment of Stroke, Thrombolysis Clinical Sciences Source Type: research

Electrocardiographic Left Atrial Abnormality and Risk of Stroke: Northern Manhattan Study Clinical Sciences
Conclusions— ECG-defined left atrial abnormality was associated with incident cryptogenic or cardioembolic stroke independently of the presence of AF, suggesting atrial thromboembolism may occur without recognized AF.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Kamel, H., Hunter, M., Moon, Y. P., Yaghi, S., Cheung, K., Di Tullio, M. R., Okin, P. M., Sacco, R. L., Soliman, E. Z., Elkind, M. S. V. Tags: Electrocardiology, Echocardiography, Arrhythmias, clinical electrophysiology, drugs, Embolic stroke, Risk Factors for Stroke Clinical Sciences Source Type: research

Effects of Blood Pressure and Blood Pressure-Lowering Treatment During the First 24 Hours Among Patients in the Third International Stroke Trial of Thrombolytic Treatment for Acute Ischemic Stroke Clinical Sciences
Conclusions— Among patients with ischemic stroke who are candidates for thrombolytic treatment, high baseline blood pressure and a large pressure variability during the first 24 hours may be associated with a poor prognosis, whereas a large reduction in blood pressure and the use of blood pressure–lowering treatment during the first 24 hours may be associated with a favorable prognosis. These data support the rationale for further trials of agents that lower blood pressure or reduce blood pressure variability in the acute phase of ischemic stroke. Clinical Trial Registration— URL: http://www.clinicaltria...
Source: Stroke - November 23, 2015 Category: Neurology Authors: Berge, E., Cohen, G., Lindley, R. I., Sandercock, P., Wardlaw, J. M., Sandset, E. C., Whiteley, W. Tags: Treatment, Cerebrovascular Disease/Stroke, Ischemic Stroke Clinical Sciences Source Type: research

Rates and Determinants of 5-Year Outcomes After Atrial Fibrillation-Related Stroke: A Population Study Clinical Sciences
Conclusions— AF-stroke is associated with considerable long-term morbidity, fatality, stroke recurrence, and nursing home requirement. Adequately resourced national AF strategies to improve AF detection and prevention are needed.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Hayden, D. T., Hannon, N., Callaly, E., Ni Chroinin, D., Horgan, G., Kyne, L., Duggan, J., Dolan, E., O'Rourke, K., Williams, D., Murphy, S., Kelly, P. J. Tags: Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research

Role of Prestroke Vascular Pathology in Long-Term Prognosis After Stroke: The Rotterdam Study Clinical Sciences
Conclusions— One quarter of deaths after stroke could theoretically be prevented with rigorous cardiovascular prevention and treatment, but this should preferably start before stroke occurrence. In addition, research into factors explaining the remaining deaths needs to be encouraged.
Source: Stroke - December 28, 2015 Category: Neurology Authors: Portegies, M. L. P., Bos, M. J., Hofman, A., Heeringa, J., Franco, O. H., Koudstaal, P. J., Ikram, M. A. Tags: Epidemiology, Risk Factors, Mortality/Survival, Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research

Association of MTHFR C677T Genotype With Ischemic Stroke Is Confined to Cerebral Small Vessel Disease Subtype Clinical Sciences
Conclusions— MTHFR C677T was associated with magnetic resonance imaging–confirmed lacunar stroke, but not large artery or cardioembolic stroke. The association may act through increased susceptibility to, or interaction with, high blood pressure. This heterogeneity of association might explain the lack of effect of lowering homocysteine in secondary prevention trials which included all strokes.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Rutten-Jacobs, L. C. A., Traylor, M., Adib-Samii, P., Thijs, V., Sudlow, C., Rothwell, P. M., Boncoraglio, G., Dichgans, M., Meschia, J., Maguire, J., Levi, C., Rost, N. S., Rosand, J., Hassan, A., Bevan, S., Markus, H. S. Tags: Genetic, Association Studies, Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research

Short Leukocyte Telomere Length Is Associated With Cardioembolic Stroke Risk in Patients With Atrial Fibrillation Brief Reports
Conclusions— Telomere shortening is associated with cardioembolic stroke risk in patients with AF. Prospective studies are encouraged to establish the value of LTL to improve prediction tools to categorize cardioembolic stroke risk in AF.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Allende, M., Molina, E., Gonzalez-Porras, J. R., Toledo, E., Lecumberri, R., Hermida, J. Tags: Atrial Fibrillation, Risk Factors, Genetics, Cerebrovascular Disease/Stroke, Ischemic Stroke Brief Reports Source Type: research

Cocaine Use and Risk of Ischemic Stroke in Young Adults Clinical Sciences
Conclusions— Our data are consistent with a causal association between acute cocaine use and risk of early-onset IS.
Source: Stroke - March 27, 2016 Category: Neurology Authors: Cheng, Y.-C., Ryan, K. A., Qadwai, S. A., Shah, J., Sparks, M. J., Wozniak, M. A., Stern, B. J., Phipps, M. S., Cronin, C. A., Magder, L. S., Cole, J. W., Kittner, S. J. Tags: Risk Factors, Ischemic Stroke Clinical Sciences Source Type: research

Trends in Age of First-Ever Stroke Following Increased Incidence and Life Expectancy in a Low-Income Chinese Population Clinical Sciences
Conclusions— The age of stroke onset tends to be younger among low-income population in China after the dramatic increased incidence of stroke during the gradual extension of life expectancy of population in China. These findings suggested that stroke burden will continue to increase in the long time, unless the risk factors in low-income populations are effectively controlled.
Source: Stroke - March 27, 2016 Category: Neurology Authors: Wang, J., Bai, L., Shi, M., Yang, L., An, Z., Li, B., Zhao, W., Gu, H., Zhan, C., Tu, J., Ning, X. Tags: Epidemiology, Lifestyle, Primary Prevention, Risk Factors, Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research

Dietary Approaches to Stop Hypertension Diet and Incidence of Stroke: Results From 2 Prospective Cohorts Clinical Sciences
Conclusions— These findings indicate that high adherence to the DASH diet is associated with a reduced risk of ischemic stroke. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifiers: NCT01127698 and NCT01127711 for the Swedish Mammography Cohort and the Cohort of Swedish Men, respectively.
Source: Stroke - March 27, 2016 Category: Neurology Authors: Larsson, S. C., Wallin, A., Wolk, A. Tags: Diet and Nutrition, Epidemiology, Hypertension, Ischemic Stroke Clinical Sciences Source Type: research

Antihypertensive Drug Use, Blood Pressure Variability, and Incident Stroke Risk in Older Adults: Three-City Cohort Study Clinical Sciences
Conclusions— The angiotensin receptor blocker and β-blocker drug classes were associated with incident stroke and ischemic stroke in older adults. BPV was generally not associated with incident stroke.
Source: Stroke - April 24, 2016 Category: Neurology Authors: Tully, P. J., Debette, S., Dartigues, J.-F., Helmer, C., Artero, S., Tzourio, C. Tags: High Blood Pressure, Hypertension, Cerebrovascular Disease/Stroke, Ischemic Stroke Clinical Sciences Source Type: research

Cost-Effectiveness of Oral Anticoagulants for Ischemic Stroke Prophylaxis Among Nonvalvular Atrial Fibrillation Patients Clinical Sciences
Conclusions— All the newer oral anticoagulants compared were more effective than adjusted dosed warfarin. Our model showed that apixaban was the most effective anticoagulant in a general atrial fibrillation population and has an incremental cost-effectiveness ratio <$50 000/QALY. For those with higher stroke risk (CHADS2≥3), dabigatran was the most cost-effective treatment option.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Shah, A., Shewale, A., Hayes, C. J., Martin, B. C. Tags: Anticoagulants, Cost-Effectiveness, Ischemic Stroke Clinical Sciences Source Type: research

Recanalization Modulates Association Between Blood Pressure and Functional Outcome in Acute Ischemic Stroke Clinical Sciences
Conclusions— Systemic BP in the first 24 hours after ischemic stroke influences 3-month clinical outcome. This association is dependent on the revascularization status.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Martins, A. I., Sargento-Freitas, J., Silva, F., Jesus-Ribeiro, J., Correia, I., Gomes, J. P., Aguiar-Goncalves, M., Cardoso, L., Machado, C., Rodrigues, B., Santo, G. C., Cunha, L. Tags: High Blood Pressure, Hypertension, Cerebrovascular Procedures, Ischemic Stroke Clinical Sciences Source Type: research

Carotid Atherosclerosis and Stroke in Atrial Fibrillation: The Atherosclerosis Risk in Communities Study Brief Reports
Conclusions— Increased cIMT and presence of carotid plaque are associated with increased risk of ischemic stroke in individuals with AF. Furthermore, they may improve risk prediction of stroke, over and above the CHA2DS2-VASc score.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Bekwelem, W., Jensen, P. N., Norby, F. L., Soliman, E. Z., Agarwal, S. K., Lip, G. Y. H., Pan, W., Folsom, A. R., Longstreth, W. T., Alonso, A., Heckbert, S. R., Chen, L. Y. Tags: Atrial Fibrillation, Risk Factors, Ischemic Stroke, Atherosclerosis Brief Reports Source Type: research

Association Between Midlife Cardiorespiratory Fitness and Risk of Stroke: The Cooper Center Longitudinal Study Clinical Sciences
Conclusions— There is a strong, inverse association between midlife CRF and stroke risk in later life independent of baseline and antecedent burden of risk factors, such as hypertension, diabetes mellitus, and atrial fibrillation.
Source: Stroke - June 26, 2016 Category: Neurology Authors: Pandey, A., Patel, M. R., Willis, B., Gao, A., Leonard, D., Das, S. R., Defina, L., Berry, J. D. Tags: Epidemiology, Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research

Homozygous ALDH2*2 Is an Independent Risk Factor for Ischemic Stroke in Taiwanese Men Clinical Sciences
Conclusions— The study demonstrated that ALDH2*2/*2 may be an independent risk factor for ischemic stroke in Taiwanese men, but not in Taiwanese women.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Sung, Y.-F., Lu, C.-C., Lee, J.-T., Hung, Y.-J., Hu, C.-J., Jeng, J.-S., Chiou, H.-Y., Peng, G.-S. Tags: Risk Factors, Genetic, Association Studies, Ischemic Stroke Clinical Sciences Source Type: research

Blood Pressure, Carotid Flow Pulsatility, and the Risk of Stroke: A Community-Based Study Clinical Sciences
Conclusions— CSBP and common carotid PI jointly and independently predicted future stroke. Carotid flow pulsatility may play an important role in the development of stroke.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Chuang, S.-Y., Cheng, H.-M., Bai, C.-H., Yeh, W.-T., Chen, J.-R., Pan, W.-H. Tags: Risk Factors, High Blood Pressure, Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research

Atrial Fibrillation in Transient Ischemic Attack Versus Ischemic Stroke: A Swedish Stroke Register (Riksstroke) Study Clinical Sciences
Conclusions— AF is highly prevalent not only in IS but also in TIA patients, with proportions steeply increasing with age. In both TIA and IS, a substantial proportion of patients with AF were discharged without anticoagulant therapy.
Source: Stroke - September 25, 2016 Category: Neurology Authors: Buchwald, F., Norrving, B., Petersson, J. Tags: Atrial Fibrillation, Secondary Prevention, Ischemic Stroke, Transient Ischemic Attack (TIA) Clinical Sciences Source Type: research

Association Between Carotid Bulb Diaphragm and Ischemic Stroke in Young Afro-Caribbean Patients: A Population-Based Case-Control Study Brief Reports
Conclusions— CBD is associated with an increased risk of ipsilateral CIS in young Afro-Caribbean population.
Source: Stroke - September 25, 2016 Category: Neurology Authors: Joux, J., Boulanger, M., Jeannin, S., Chausson, N., Hennequin, J.-L., Molinie, V., Smadja, D., Touze, E., Olindo, S. Tags: Epidemiology, Cerebrovascular Disease/Stroke Brief Reports Source Type: research

Folic Acid Therapy Reduces the First Stroke Risk Associated With Hypercholesterolemia Among Hypertensive Patients Clinical Sciences
Background and Purpose—We sought to determine whether folic acid supplementation can independently reduce the risk of first stroke associated with elevated total cholesterol levels in a subanalysis using data from the CSPPT (China Stroke Primary Prevention Trial), a double-blind, randomized controlled trial.Methods—A total of 20 702 hypertensive adults without a history of major cardiovascular disease were randomly assigned to a double-blind daily treatment of an enalapril 10-mg and a folic acid 0.8-mg tablet or an enalapril 10-mg tablet alone. The primary outcome was first stroke.Results—The median treatment durat...
Source: Stroke - October 23, 2016 Category: Neurology Authors: Qin, X., Li, J., Spence, J. D., Zhang, Y., Li, Y., Wang, X., Wang, B., Sun, N., Chen, F., Guo, J., Yin, D., Sun, L., Tang, G., He, M., Fu, J., Cai, Y., Shi, X., Ye, P., Chen, H., Zhao, S., Chen, M., Gao, C., Kong, X., Hou, F. F., Huang, Y., Huo, Y. Tags: Clinical Studies, Diet and Nutrition, Primary Prevention, Hypertension, Ischemic Stroke Original Contributions Source Type: research

Contribution of Established Stroke Risk Factors to the Burden of Stroke in Young Adults Clinical Sciences
Conclusions—Modifiable risk factors previously established in older populations also account for a large part of stroke in younger adults, with 4 risk factors explaining almost 80% of stroke risk.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT00414583.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Annette Aigner, Ulrike Grittner, Arndt Rolfs, Bo Norrving, Bob Siegerink, Markus A. Busch Tags: Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Risk Factors for Pregnancy-Associated Stroke in Women With Preeclampsia Clinical Sciences
Conclusions—Infections, chronic hypertension, coagulopathies, and underlying prothrombotic conditions increase PAS risk in women with preeclampsia. These women may warrant closer monitoring.
Source: Stroke - June 26, 2017 Category: Neurology Authors: Eliza C. Miller, Hajere J. Gatollari, Gloria Too, Amelia K. Boehme, Lisa Leffert, Randolph S. Marshall, Mitchell S.V. Elkind, Joshua Z. Willey Tags: Preeclampsia, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Dolichoectasia and Small Vessel Disease in Young Patients With Transient Ischemic Attack and Stroke Clinical Sciences
Background and Purpose—We evaluated whether basilar dolichoectasia is associated with markers of cerebral small vessel disease in younger transient ischemic attack and ischemic stroke patients.Methods—We used data from the SIFAP1 study (Stroke in Young Fabry Patients), a large prospective, hospital-based, screening study for Fabry disease in young (
Source: Stroke - August 28, 2017 Category: Neurology Authors: Vincent Thijs, Ulrike Grittner, Franz Fazekas, Dominick J.H. McCabe, Anne-Katrin Giese, Christof Kessler, Peter Martus, Bo Norrving, Erich Bernd Ringelstein, Reinhold Schmidt, Christian Tanislav, Jukka Putaala, Turgut Tatlisumak, Bettina von Sarnowski, Ar Tags: Hypertension, Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA), Vascular Disease Original Contributions Source Type: research

Vascular Risk Factor Profiles Differ Between Magnetic Resonance Imaging-Defined Subtypes of Younger-Onset Lacunar Stroke Clinical Sciences
Conclusions—In this magnetic resonance imaging–verified lacunar stroke population, we identified a distinct risk factor profile in the group as a whole. However, there were differing risk factor profiles according to the presence of multiple lacunar infarcts and confluent WMH. The association of hypertension, smoking, and renal impairment with the presence of multiple lacunar infarcts and confluent WMH might reflect a diffuse small vessel arteriopathy.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Loes C.A. Rutten-Jacobs, Hugh S. Markus Tags: Risk Factors, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Blood Biomarkers for the Early Diagnosis of Stroke Clinical Sciences
Conclusions—The studied biomarkers were not sufficient for an accurate differential diagnosis of stroke in the hyperacute setting. Additional discovery of new biomarkers and improvement on laboratory techniques seem necessary for achieving a molecular diagnosis of stroke.
Source: Stroke - August 28, 2017 Category: Neurology Authors: Aleȷandro Bustamante, Elena Lopez–Cancio, Sara Pich, Anna Penalba, Dolors Giralt, Teresa Garcia–Berrocoso, Carles Ferrer–Costa, Teresa Gasull, Maria Hernandez–Perez, Monica Millan, Marta Rubiera, Pedro Cardona, Luis Cano, He Tags: Biomarkers, Clinical Studies, Diagnostic Testing, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Influence of Renal Impairment on Outcome for Thrombolysis-Treated Acute Ischemic Stroke Brief Report
Background and Purpose—Renal dysfunction (RD) is associated with poor prognosis after stroke. We assessed the effects of RD on outcomes and interaction with low- versus standard-dose alteplase in a post hoc subgroup analysis of the ENCHANTED (Enhanced Control of Hypertension and Thrombolysis Stroke Study).Methods—A total of 3220 thrombolysis-eligible patients with acute ischemic stroke (mean age, 66.5 years; 37.8% women) were randomly assigned to low-dose (0.6 mg/kg) or standard-dose (0.9 mg/kg) intravenous alteplase within 4.5 hours of symptom onset. Six hundred and fifty-nine (19.8%) patients had moderate-to-severe R...
Source: Stroke - August 28, 2017 Category: Neurology Authors: Susan J. Carr, Xia Wang, Veronica V. Olavarria, Pablo M. Lavados, Jorge A. Rodriguez, Jong S. Kim, Tsong-Hai Lee, Richard I. Lindley, Octavio M. Pontes-Neto, Stefano Ricci, Shoichiro Sato, Vijay K. Sharma, Mark Woodward, John Chalmers, Craig S. Anderson, Tags: Clinical Studies, Intracranial Hemorrhage, Ischemic Stroke Brief Reports Source Type: research

Stroke Incidence by Major Pathological Type and Ischemic Subtypes in the Auckland Regional Community Stroke Studies Clinical Sciences
Conclusions—A lack of change in IS and ICH incidence may reflect a trend toward increased incidence of younger strokes. Increased rates of large-artery atherosclerosis and small-vessel occlusion are associated with increased smoking and high blood pressure. Ethnic differences in the proportional distribution of pathological stroke subtypes suggest differential exposure and susceptibility to risk factors.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Rita V. Krishnamurthi, Suzanne Barker-Collo, Varsha Parag, Priyakumari Parmar, Emma Witt, Amy Jones, Susan Mahon, Craig S. Anderson, P. Alan Barber, Valery L. Feigin Tags: Epidemiology, Cerebrovascular Disease/Stroke, Ischemic Stroke Original Contributions Source Type: research

Predictive Value of Pulse Pressure in Acute Ischemic Stroke for Future Major Vascular Events Clinical Sciences
This study aimed to investigate whether pulse pressure (PP) obtained during the acute stage of ischemic stroke can be used as a predictor for future major vascular events.Methods—Using a multicenter prospective stroke registry database, patients who were hospitalized for ischemic stroke within 48 hours of onset were enrolled in this study. We analyzed blood pressure (BP) data measured during the first 3 days from onset. Primary and secondary outcomes were time to a composite of stroke recurrence, myocardial infarction, all-cause death, and time to stroke recurrence, respectively.Results—Of 9840 patients, 4.3% experienc...
Source: Stroke - December 22, 2017 Category: Neurology Authors: Keon-Joo Lee, Beom Joon Kim, Moon-Ku Han, Joon-Tae Kim, Ki-Hyun Cho, Dong-Ick Shin, Min-Ju Yeo, Jae-Kwan Cha, Dae-Hyun Kim, Hyun-Wook Nah, Dong-Eog Kim, Wi-Sun Ryu, Jong-Moo Park, Kyusik Kang, Soo Joo Lee, Mi-Sun Oh, Kyung-Ho Yu, Byung-Chul Lee, Keun-Sik Tags: High Blood Pressure, Hypertension, Mortality/Survival, Quality and Outcomes, Ischemic Stroke Original Contributions Source Type: research

Prognostic Significance of Blood Pressure Variability on Beat-to-Beat Monitoring After Transient Ischemic Attack and Stroke Clinical Sciences
Conclusions—Beat-to-beat BPV predicted recurrent stroke and cardiovascular events, independently of mean systolic BP and risk factors but short-term BPV on ambulatory BP monitoring did not. Beat-to-beat BPV may be a useful additional marker of cardiovascular risk.
Source: Stroke - December 22, 2017 Category: Neurology Authors: Alastair J.S. Webb, Sara Mazzucco, Linxin Li, Peter M. Rothwell Tags: Hypertension, Prognosis, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

PINGS (Phone-Based Intervention Under Nurse Guidance After Stroke) Brief Report
Background and Purpose—Stroke exacts an immense toll in sub-Saharan Africa where there are few resources, and stroke prevention research is limited. The aim of this study is to test the feasibility and preliminary efficacy of an m-Health technology–enabled, nurse-guided intervention in improving blood pressure (BP) control among Ghanaian stroke patients within 1 month of symptom onset.Methods—We conducted a 2-arm cluster pilot randomized controlled trial involving 60 recent stroke survivors encountered within a single tertiary medical system in Ghana. Subjects in the intervention arm (n=30) received a Blue-toothed UA...
Source: Stroke - December 22, 2017 Category: Neurology Authors: Fred Sarfo, Frank Treiber, Mulugeta Gebregziabher, Sheila Adamu, Sachin Patel, Michelle Nichols, Dominic Awuah, Asumadu Sakyi, Nyantakyi Adu-Darko, Arti Singh, Raelle Tagge, Jenkins Carolyn, Bruce Ovbiagele Tags: Epidemiology, Hypertension, Nursing, Treatment, Cerebrovascular Disease/Stroke Brief Reports Source Type: research

Predictors of Thrombolysis Administration in Mild Stroke Clinical Sciences
Conclusions—Mild acutely presenting stroke patients are more likely to receive thrombolysis if they are young, white, or Hispanic and arrive early to the hospital with more severe neurological presentation. Identification of predictors of thrombolysis is important in design of future studies to assess the use of thrombolysis for mild stroke.
Source: Stroke - February 26, 2018 Category: Neurology Authors: Negar Asdaghi, Kefeng Wang, Maria A. Ciliberti-Vargas, Carolina Marinovic Gutierrez, Sebastian Koch, Hannah Gardener, Chuanhui Dong, David Z. Rose, Enid J. Garcia, W. Scott Burgin, Juan Carlos Zevallos, Tatjana Rundek, Ralph L. Sacco, Jose G. Romano Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research