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Chronic Kidney Disease and Risk of Stroke. Resolved Chronic Kidney Disease is A Biomarker Rather Than A Risk Factor for Stroke
Over the last approximate 15 years some have suggested that chronic kidney disease (CKD) is a risk factor for stroke in and of itself. The assertion that CKD is a risk factor for stroke requires more scrutiny. It is possible that CKD is a reflection of severity of conditions such as hypertension and diabetes that are themselves among the most treatable risk factors for stroke or it is possible that the effects of CKD change vascular and related physiological functions and therefor directly contribute to increased risk of stroke and it is also possible that treatments for advance CKD such has hemodialysis could contribute t...
Source: Journal of Stroke and Cerebrovascular Diseases - May 29, 2021 Category: Neurology Authors: Judy Dawod, Bruce M Coull Source Type: research

High-Dose Vitamin C Prevents Secondary Brain Damage After Stroke via Epigenetic Reprogramming of Neuroprotective Genes
AbstractVitamin C has recently been identified as an epigenetic regulator by activating ten-eleven translocases (TETs), enzymes involved in generating DNA hydroxymethylcytosine (5hmC). Currently, we investigated whether high-dose vitamin C promotes neuroprotection through epigenetic modulation of 5hmC, if there are sex-specific differences in outcome, and the therapeutic potential of vitamin C in stroke-related comorbidities in adult mice. Post-stroke treatment with ascorbate (reduced form), but not dehydroascorbate (oxidized form), increased TET3 activity and 5hmC levels and reduced infarct following focal ischemia. Hydro...
Source: Translational Stroke Research - March 20, 2022 Category: Neurology Source Type: research

Causes of ischemic stroke in young adults versus non-young adults: A multicenter hospital-based observational study
CONCLUSIONS: Certain embolic sources and uncommon causes may be etiologically important causes of ischemic stroke in young adults. However, the contribution of conventional vascular risk factors and lifestyle-related risk factors is not negligible with advancing age, even in young adults.PMID:35830430 | DOI:10.1371/journal.pone.0268481
Source: Atherosclerosis - July 13, 2022 Category: Cardiology Authors: Yuichiro Ohya Ryu Matsuo Noriko Sato Fumi Irie Kuniyuki Nakamura Yoshinobu Wakisaka Tetsuro Ago Masahiro Kamouchi Takanari Kitazono Investigators for Fukuoka Stroke Registry Source Type: research

Effect of metformin on outcome after acute ischemic stroke in patients with type 2 diabetes mellitus
Diabetes mellitus is a well-known risk factor for ischemic stroke and is associated with unfavorable outcome after stroke. Metformin is recommended as first-line treatment in these patients. Pre-stroke metformin use might have neuroprotective properties resulting in reduced stroke severity. However, results of the effects of pre-stroke metformin use on functional outcome are conflicting and has not been previously described in patients with type 2 diabetes mellitus regardless of stroke severity or revascularization treatment.
Source: Journal of Stroke and Cerebrovascular Diseases - August 1, 2022 Category: Neurology Authors: C.J.B.A. Kersten, I.L.H. Knottnerus, E. Heijmans, M. Haalboom, A.A.M. Zandbergen, H.M. den Hertog Source Type: research

Thrombolysis in Stroke Despite Contraindications or Warnings? Clinical Sciences
Conclusions— This comprehensive retrospective analysis of various contraindications and warnings provides reassurance about benefits and risks of intravenous alteplase treatment in common clinical situations.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Frank, B., Grotta, J. C., Alexandrov, A. V., Bluhmki, E., Lyden, P., Meretoja, A., Mishra, N. K., Shuaib, A., Wahlgren, N. G., Weimar, C., Lees, K. R., for the VISTA Collaborators Tags: Thrombolysis Clinical Sciences Source Type: research

Exclusion Criteria for Intravenous Thrombolysis in Stroke Mimics: An Observational Study
Conclusions: SM patients frequently had exclusion criteria for systemic thrombolysis, the most frequent being presenting beyond the established thrombolytic window.
Source: Journal of Stroke and Cerebrovascular Diseases - December 17, 2012 Category: Neurology Authors: Alejandro M. Brunser, Sergio Illanes, Pablo M. Lavados, Paula Muñoz, Daniel Cárcamo, Arnold Hoppe, Verónica V. Olavarria, Iris Delgado, Violeta Díaz Tags: Original Articles Source Type: research

Does Socioeconomic Status or Acculturation Modify the Association Between Ethnicity and Hypertension Treatment Before Stroke? Brief Reports
Conclusions— We found no evidence that socioeconomic status or acculturation modifies the association between ethnicity and hypertension treatment before stroke.
Source: Stroke - October 21, 2013 Category: Neurology Authors: Levine, D. A., Morgenstern, L. B., Langa, K. M., Skolarus, L. E., Smith, M. A., Lisabeth, L. D. Tags: Health policy and outcome research, Primary prevention, Acute Cerebral Infarction Brief Reports Source Type: research

Influence of racial differences on outcomes after thrombolytic therapy in acute ischemic stroke
ConclusionsThese results do not suggest a differential response to tissue plasminogen activator based on race ethnicity. Among Asians, data were particularly sparse, and results should be interpreted with caution.
Source: International Journal of Stroke - October 22, 2013 Category: Neurology Authors: Nishant K. Mishra, Pitchaiah Mandava, Christopher Chen, James Grotta, Kennedy R. Lees, Thomas A. Kent, Tags: Research Source Type: research

The burden of stroke in México
Regrettably, stroke has been scarcely studied in México, and the available data suffer from great variability in diagnostic testing, risk factor definitions, and poor generalizability. The current cumulative incidence of stroke in Mexico is 232·2 per 100 000, whereas prevalence among people aged 60 years or older is 18·2 per 1000. Hypertension and diabetes are the main risk factors. Ischemic stroke is the most frequent sub‐type. Stroke mortality has been increasing during last years, and 30‐day case fatality rate doubles at one‐year follow‐up. A remarkable finding of a hospital‐based registry was that most o...
Source: International Journal of Stroke - November 10, 2013 Category: Neurology Authors: Juan M Marquez‐Romero, Antonio Arauz, Fernando Góngora‐Rivera, Fernando Barinagarrementeria, Carlos Cantú Tags: Panorama Source Type: research

C-reactive Protein and Homocysteine Predict Long-term Mortality in Young Ischemic Stroke Patients
Conclusions: There is an independent association between CRP and homocysteine levels obtained several years after ischemic stroke in young adults and subsequent mortality, even when adjusting for traditional risk factors. This association seems to continue for at least 12 years after the measurements.
Source: Journal of Stroke and Cerebrovascular Diseases - June 3, 2013 Category: Neurology Authors: Halvor Naess, Harald Nyland, Titto Idicula, Ulrike Waje-Andreassen Tags: Original Articles Source Type: research

Prediction of Major Vascular Events after Stroke: The Stroke Prevention by Aggressive Reduction in Cholesterol Levels Trial
Conclusions: Both a baseline FCRS of 20% or more and a novel predictive model were associated with future MVEs in SPARCL trial subjects. The novel model needs to be validated, and the benefits of using either the FCRS or the novel model in clinical practice needs to be assessed.
Source: Journal of Stroke and Cerebrovascular Diseases - February 26, 2014 Category: Neurology Authors: Bruce Ovbiagele, Larry B. Goldstein, Pierre Amarenco, Michael Messig, Henrik Sillesen, Alfred Callahan, Michael G. Hennerici, Justin Zivin, K.Michael A. Welch, SPARCL Investigators Tags: Original Articles Source Type: research

The Impact of a Stroke Prevention Clinic after Discharge for TIA/ Stroke: University Hospitals Case Medical Center Comprehensive Stroke Center Experience (P3.121)
Conclusions: The burden of risk factors in our patients was very high. Although patients reported uniform adherence to treatment, risk factor control to target was good for hypertension and atrial fibrillation and poor for smoking, diabetes and dyslipidemia. Despite high rates of insurance and established primary care, multiple interventions were performed during this visit, particularly in the more disabled. The post-discharge SPC visit augments primary care and offers an important opportunity to review and revise the care plan, assess patient adherence and control of risk factors to target.*Chart and Graph imaging to be ...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Shams, T., Vickers, K., Jung, R., Sila, C. Tags: Cerebrovascular Disease and Interventional Neurology: Primary and Comprehensive Stroke Centers Source Type: research

Combined Elevation of FVIII and von Willebrand Factor Predicts Risk for Worse Outcomes in Patients with Acute Ischemic Stroke (AIS) (P7.152)
CONCLUSIONS:Concurrent elevation in FVIII and vWF predicts higher odds of worse outcomes for AIS patients. Our findings suggest that FVIII and vWF levels may serve as clinically useful stroke biomarkers by providing risk profiles for stroke patients on admission with a hypercoagulable state.Disclosure: Dr. Samai has nothing to disclose. Dr. Monlezun, Jr has nothing to disclose. Dr. George has received research support from Tulane University School of Medicine. Dr. Dowell has nothing to disclose. Dr. Schluter has nothing to disclose. Dr. El Khoury has nothing to disclose. Dr. Martin-Schild has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Samai, A., Monlezun, D., George, A., Dowell, L., Schluter, L., El Khoury, R., Martin-Schild, S. Tags: Cerebrovascular Disease and Interventional Neurology: Predictors of Outcome After Ischemic Stroke Source Type: research

Stroke in Very Old Patients (I2-1.004)
Conclusion: very elderly patients have a different risk factor profile, have more anterior circulation infarcts and have a worse prognosis with i creased mortality and increased length of stay in hospitalStudy Supported by:Disclosure: Dr. Dobi has nothing to disclose. Dr. Kapisyzi has nothing to disclose. Dr. Kruja has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Dobi, D., Kapisyzi, M., Kruja, J. Tags: New Antithrombotic Agents for Stroke Prevention Poster Presentations Source Type: research