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Clinical and Economic Implications of Apixaban Versus Aspirin in the Low-Risk Nonvalvular Atrial Fibrillation Patients Clinical Sciences
Conclusions— Anticoagulant treatment with apixaban versus aspirin in low-risk patients, as identified using CHADS2 or CHA2DS2–VASc, is projected to increase life expectancy and provide clinical benefits that are cost effective.
Source: Stroke - September 28, 2015 Category: Neurology Authors: Lip, G. Y. H., Lanitis, T., Mardekian, J., Kongnakorn, T., Phatak, H., Dorian, P. Tags: Primary prevention, Cerebrovascular disease/stroke, Anticoagulants, Antiplatelets Clinical Sciences Source Type: research

A call for new attitudes on infection, vaccination, and childhood stroke
Population-based estimates of the incidence of childhood stroke range from 2.6 to 13 cases per 100,000 children per year. Unlike in adults, conventional stroke risk factors such as arterial hypertension, diabetes, and cigarette smoking make little contribution to the etiology of stroke in children. Developmental, genetic, and environmental factors are major contributors to ischemic stroke in children.
Source: Neurology - October 26, 2015 Category: Neurology Authors: Biller, J., Heyer, G. L. Tags: Childhood stroke, All Infections, Pediatric stroke; see Cerebrovascular Disease/ Childhood stroke, Case control studies EDITORIALS Source Type: research

Impact of Comorbidities on Acute Injury and Recovery in Preclinical Stroke Research: Focus on Hypertension and Diabetes
Abstract Human ischemic stroke is very complex, and no single preclinical model can comprise all the variables known to contribute to stroke injury and recovery. Hypertension, diabetes, and hyperlipidemia are leading comorbidities in stroke patients. The use of predominantly young adult and healthy animals in experimental stroke research has created a barrier for translation of findings to patients. As such, more and more disease models are being incorporated into the research design. This review highlights the major strengths and weaknesses of the most commonly used animal models of these conditions in preclinica...
Source: Translational Stroke Research - March 29, 2016 Category: Neurology Source Type: research

Increasing comorbidity and health services utilization in older adults with prior stroke
Conclusions: Our findings demonstrate the importance of community-based patient-centered care strategies for stroke survivors that address their range of health needs and prevent more costly acute care use.
Source: Neurology - November 13, 2016 Category: Neurology Authors: Gruneir, A., Griffith, L. E., Fisher, K., Panjwani, D., Gandhi, S., Sheng, L., Patterson, C., Gafni, A., Ploeg, J., Markle-Reid, M. Tags: All Health Services Research, All Cerebrovascular disease/Stroke ARTICLE Source Type: research

The relationship between chemerin levels and carotid intima-media thickness in patients with ischemic stroke (P1.262)
Conclusions:Consequently, this study showed that serum chemerin levels may play role in atherosclerosis and ischemic stroke.Study Supported by: Fırat University (FÜBAP)Disclosure: Dr. Demir has nothing to disclose. Dr. Atas has nothing to disclose. Dr. Aytaç has nothing to disclose. Dr. Gonen has nothing to disclose. Dr. Erten has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Demir, C., Ataş, I., Aytac, E., Gonen, M., Erten, Z. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Empagliflozin and Cerebrovascular Events in Patients With Type 2 Diabetes Mellitus at High Cardiovascular Risk Clinical Sciences
Conclusions—In patients with type 2 diabetes mellitus and high cardiovascular risk, there was no significant difference in the risk of cerebrovascular events with empagliflozin versus placebo.Clinical Trial Registration—URL: http://www.clinicaltrials.gov. Unique identifier: NCT01131676.
Source: Stroke - April 24, 2017 Category: Neurology Authors: Bernard Zinman, Silvio E. Inzucchi, John M. Lachin, Christoph Wanner, David Fitchett, Sven Kohler, Michaela Mattheus, Hans J. Woerle, Uli C. Broedl, Odd Erik Johansen, Gregory W. Albers, Hans Christoph Diener Tags: Cardiovascular Disease, Diabetes, Type 2, Cerebrovascular Disease/Stroke, Ischemic Stroke, Transient Ischemic Attack (TIA) Original Contributions Source Type: research

Sex Differences in the Association Between Insulin Resistance and Incident Coronary Heart Disease and Stroke Among Blacks Without Diabetes Mellitus: The Jackson Heart Study Epidemiology
ConclusionsBoth HOMA‐IR and the McAuley index demonstrate strong associations with CHD but not stroke risk in blacks. The logHOMA‐IR and CHD association was present in men, but not in women.
Source: JAHA:Journal of the American Heart Association - February 2, 2017 Category: Cardiology Authors: Effoe, V. S., Wagenknecht, L. E., Echouffo Tcheugui, J. B., Chen, H., Joseph, J. J., Kalyani, R. R., Bell, R. A., Wu, W.-C. H., Casanova, R., Bertoni, A. G. Tags: Cardiovascular Disease, Epidemiology, Risk Factors, Cerebrovascular Disease/Stroke Original Research Source Type: research

Serum Potassium Is Positively Associated With Stroke and Mortality in the Large, Population-Based Malmo Preventive Proȷect Cohort Clinical Sciences
Background and Purpose—Low serum potassium is associated with stroke in populations with cardiovascular disease, hypertension, and diabetes mellitus but has not been studied in a mainly healthy population. We aimed to study the relation between serum potassium and incident stroke and mortality in the Malmö Preventive Project, a large cohort with screening in early mid-life and follow-up>25 years.Methods—Serum potassium measurements and covariates were available in 21 353 individuals (79% men, mean age 44 years). Mean follow-up time was 26.9 years for stroke analyses and 29.3 years for mortality analyses. There were ...
Source: Stroke - October 23, 2017 Category: Neurology Authors: Linda S. Johnson, Nick Mattsson, Ahmad Saȷadieh, Per Wollmer, Martin Soderholm Tags: Diet and Nutrition, Epidemiology, Lifestyle, Primary Prevention, Risk Factors Original Contributions Source Type: research

Diabetes and obesity are associated with disability in community-dwelling stroke survivors: A cross-sectional study of 37,955 Behavioral Risk Factor Surveillance System respondents
Conclusion. Stroke survivors with obesity or diabetes experience increased risk for disability compared to survivors without these chronic conditions. Interventions for managing disability, obesity, and diabetes concomitantly may be warranted and deserve further consideration.PMID:33775239 | DOI:10.1080/10749357.2021.1904537
Source: Topics in Stroke Rehabilitation - March 29, 2021 Category: Neurology Authors: Ryan R Bailey Molly Conroy Source Type: research