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Mortality following stroke during and after acute care according to neighbourhood deprivation: a disease registry study
Conclusions The gradient of higher poststroke mortality with increasing neighbourhood deprivation was noticeable only after acute hospital discharge. Quality of postacute care and social support are potential determinants of these variations.
Source: Journal of Neurology, Neurosurgery and Psychiatry - November 17, 2014 Category: Neurosurgery Authors: Grimaud, O., Leray, E., Lalloue, B., Aghzaf, R., Durier, J., Giroud, M., Bejot, Y. Tags: Stroke, Hypertension, Adult intensive care Cerebrovascular disease Source Type: research

Changes in Functional Outcome Over the First Year After Stroke: An Observational Study From the Swedish Stroke Register Clinical Sciences
Conclusions— Transition from ADL independence to dependence was observed in a high proportion of patients between 3 and 12 months, challenging the common belief that functioning after stroke is stable beyond 3 months. Deterioration occurred more commonly in women, among whom 1/6 converted to dependency.
Source: Stroke - January 26, 2015 Category: Neurology Authors: Ullberg, T., Zia, E., Petersson, J., Norrving, B. Tags: Acute Cerebral Infarction Clinical Sciences Source Type: research

Clinical profile, risk factors, etiology and outcome of stroke in young Filipino adults. (P7.147)
Conclusion - Stroke occurs at a younger age in Filipinos compared to other Asian and European countries. The incidence of stroke in young Filipinos were similar to Asian figures but higher compared to European studies. Hypertension is the most common risk factor in the world followed by diabetes mellitus and dyslipidemia. In Filipinos however, cultural vices such as smoking and alcoholism were the second and third leading risk factors. This paper to the best of our knowledge is the first to report the unique profile of stroke in young Filipino patients.Disclosure: Dr. Talamera has nothing to disclose. Dr. San Jose has noth...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Talamera, T. A., San Jose, M. C., Sanchez, J. A., Pascual IV, J. L. Tags: Cerebrovascular Disease and Interventional Neurology: Race, Ethnicity, and Stroke Source Type: research

Ethnic Differences in Associations Between Blood Pressure and Stroke in South Asian and European Men Epidemiology/Population
We report findings from a UK cohort study of 1375 European and 1074 South Asian men, not receiving antihypertensive medication, aged 40 to 69 years at baseline (1988–1991). Assessment included BP, blood tests, anthropometry, and questionnaires. Incident stroke was established at 20 years from death certification, hospital and primary care records, and participant report. South Asians had higher systolic BP, diastolic BP, and mean arterial pressure than Europeans, and similar pulse pressure. Associations between systolic BP or diastolic BP and stroke were stronger in South Asians than Europeans, after adjustment for a...
Source: Hypertension - August 12, 2015 Category: Cardiology Authors: Eastwood, S. V., Tillin, T., Chaturvedi, N., Hughes, A. D. Tags: Cerebrovascular disease/stroke, Risk Factors, Epidemiology Epidemiology/Population Source Type: research

Association of Hemoglobin A1c and Baseline Ischemic Stroke Severity: A Population-Based Study (P1.187)
Conclusions: We found that elevated HbA1c was associated with decreased stroke severity at presentation. However, this effect is mediated by the history of DM rather than a specific dose-effect of glycemic control. Our results provide evidence that although chronic hyperglycemia increases risk of stroke, it is not associated with increased stroke severity.Disclosure: Dr. Yang has nothing to disclose. Dr. Khoury has nothing to disclose. Dr. Alwell has nothing to disclose. Dr. Moomaw has received research support from the National Institutes of Health. Dr. Yeramaneni has nothing to disclose. Dr. Woo has received research sup...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Yang, Y., Khoury, J., Alwell, K., Moomaw, C., Yeramaneni, S., Woo, D., Flaherty, M., Adeoye, O., Ferioli, S., De Los Rios La Rosa, F., Kissela, B., Kleindorfer, D. Tags: Ischemic Stroke Outcomes Source Type: research

Diabetes Mellitus Impairs Cognitive Function in Middle-Aged Rats and Neurological Recovery in Middle-Aged Rats After Stroke Basic Sciences
Conclusions— Our data suggest that DM exacerbates neurovascular damage and hinders brain repair processes, which likely contribute to the impairment of stroke recovery.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Zhang, L., Chopp, M., Zhang, Y., Xiong, Y., Li, C., Sadry, N., Rhaleb, I., Lu, M., Zhang, Z. G. Tags: Basic Science Research, Cognitive Impairment, Neurogenesis Basic Sciences Source Type: research

Circulating biomarkers and incident ischemic stroke in the Framingham Offspring Study
Conclusions: Higher levels of 4 biomarkers—CRP, tHcy, TNFR2, and VEGF—increased risk of IIS and improved the predictive ability of the Framingham Stroke Risk Profile score. Further research is warranted to explore their role as potential therapeutic targets.
Source: Neurology - September 18, 2016 Category: Neurology Authors: Shoamanesh, A., Preis, S. R., Beiser, A. S., Kase, C. S., Wolf, P. A., Vasan, R. S., Benjamin, E. J., Seshadri, S., Romero, J. R. Tags: Other cerebrovascular disease/ Stroke, All Cerebrovascular disease/Stroke, Cohort studies, Incidence studies, Infarction ARTICLE Source Type: research

Post-Glucose Load Measures of Insulin Resistance and Prognosis of Nondiabetic Patients With Ischemic Stroke Stroke
This study aimed to estimate the association between post–glucose load measures of insulin resistance and prognosis of nondiabetic patients with ischemic stroke.Methods and ResultsData were derived from the ACROSS‐China (Abnormal Glucose Regulation in Patients with Acute Stroke across China) registry. Patients with ischemic stroke without a history of diabetes mellitus were included. Two post–glucose load measures of insulin sensitivity, the insulin sensitivity indices ISI(composite) and the ISI0,120, were calculated. Outcomes included stroke recurrence, all‐cause death, and poor functional outcome at 12 months. A...
Source: JAHA:Journal of the American Heart Association - January 20, 2017 Category: Cardiology Authors: Pan, Y., Jing, J., Chen, W., Zheng, H., Jia, Q., Mi, D., Li, H., Zhao, X., Liu, L., Wang, C., Gaisano, H. Y., He, Y., Wang, Y., Tags: Ischemic Stroke Original Research Source Type: research

Serum matrix metalloproteinase-9 levels and prognosis of acute ischemic stroke
Conclusions: Higher serum MMP-9 levels in the acute phase of ischemic stroke were associated with increased risk of mortality and major disability, suggesting that serum MMP-9 could be an important prognostic factor for ischemic stroke.
Source: Neurology - August 21, 2017 Category: Neurology Authors: Zhong, C., Yang, J., Xu, T., Xu, T., Peng, Y., Wang, A., Wang, J., Peng, H., Li, Q., Ju, Z., Geng, D., Zhang, Y., He, J., For the CATIS Investigators Tags: Stroke prevention, Prognosis, All Cerebrovascular disease/Stroke, Clinical trials Observational study (Cohort, Case control), Cohort studies ARTICLE Source Type: research

Disparities among Asians and Native Hawaiians and Pacific Islanders with ischemic stroke
Conclusions: Asians, NHPI, and whites with ischemic stroke have substantially different cardiovascular risk factors. Targeted secondary prevention will be important in reducing disparities among these racial groups.
Source: Neurology - February 25, 2013 Category: Neurology Authors: Nakagawa, K., Koenig, M. A., Asai, S. M., Chang, C. W., Seto, T. B. Tags: All Cerebrovascular disease/Stroke, Risk factors in epidemiology ARTICLE Source Type: research

The Impact Factors on the Cost and Length of Stay among Acute Ischemic Stroke
Conclusions: Age 65 and over, atrial fibrillation, stroke treatment, and subtypes were the significant predictive factors affecting hospital costs and LOS. Compared to other countries, Taiwan spent the least while Canada had the highest expense. The United States had the shortest LOS (6 days) in contrast to Canada with the longest LOS (34-47 days). Regarding mean daily cost of stroke, the United States had the highest cost per day while China spent the least.
Source: Journal of Stroke and Cerebrovascular Diseases - December 17, 2012 Category: Neurology Authors: Ying-Chih Huang, Chaur-Jong Hu, Tsong-Hai Lee, Jen-Tsung Yang, Hsu-Huei Weng, Leng Chieh Lin, Shiao-Lin Lai Tags: Original Articles Source Type: research

Differences in lipid profiles in two Hispanic ischemic stroke populations
ConclusionWe found significant differences in lipid fractions in Hispanic ischemic stroke patients, with lower total cholesterol and low‐density lipoprotein, and higher triglyceride levels in Mexicans. These findings highlight the heterogeneity of dyslipidemia among the Hispanic race‐ethnic group and may lead to different secondary prevention strategies.
Source: International Journal of Stroke - December 20, 2013 Category: Neurology Authors: A. Arauz, J. G. Romano, A. Ruiz‐Franco, T. Shang, C. Dong, T. Rundek, S. Koch, B. Hernández‐Curiel, J. Pacheco, P. Rojas, F. Ruiz‐Navarro, M. Katsnelson, R. L. Sacco Tags: Research Source Type: research

Validation of the Totaled Health Risks In Vascular Events (THRIVE) score for outcome prediction in endovascular stroke treatment
ConclusionsThe THRIVE score reliably predicts outcomes after endovascular stroke treatment and may be useful as a clinical prognostic tool and to perform severity adjustments in stroke clinical research.
Source: International Journal of Stroke - August 29, 2012 Category: Neurology Authors: Alexander C. Flint, Hooman Kamel, Vivek A. Rao, Sean P. Cullen, Bonnie S. Faigeles, Wade S. Smith Tags: Research Source Type: research

Adiponectin and Risk of Stroke: Prospective Study and Meta-analysis Clinical Sciences
Conclusions— Adiponectin is not associated with risk of stroke. If anything, adiponectin relates directly to stroke risk after controlling for risk factors that favorably correlate with adiponectin.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Arregui, M., Buijsse, B., Fritsche, A., di Giuseppe, R., Schulze, M. B., Westphal, S., Isermann, B., Boeing, H., Weikert, C. Tags: Risk Factors, Acute Cerebral Infarction, Epidemiology Clinical Sciences Source Type: research

Venous Thromboembolism in the Get With The Guidelines-Stroke Acute Ischemic Stroke Population: Incidence and Patterns of Prophylaxis
Conclusions: Despite a high overall rate of VTE prophylaxis, VTE was found to occur in approximately 3% of GWTG-S patients. Reported rates of VTE prophylaxis differed among hospitals by region and hospital type, and among patients by age, race, and medical comorbidities.
Source: Journal of Stroke and Cerebrovascular Diseases - December 17, 2012 Category: Neurology Authors: G. Logan Douds, Anne S. Hellkamp, DaiWai M. Olson, Gregg C. Fonarow, Eric E. Smith, Lee H. Schwamm, Kevin M. Cockroft Tags: Original Articles Source Type: research