Filtered By:
Condition: Metabolic Syndrome

This page shows you your search results in order of relevance. This is page number 7.

Order by Relevance | Date

Total 926 results found since Jan 2013.

Stroke in the patient with diabetes (part 1) – Epidemiology, etiology, therapy and prognosis
There is a higher incidence of stroke in both the type 2 diabetic and the non-diabetic insulin resistant patient which is accompanied by higher morbidity and mortality. The increase in the frequency of stroke is due to an increase in cerebral infarction, mainly lacunar infarcts, with the incidence of cerebral hemorrhage being less frequent. The major risk factors for stroke in the type 2 diabetic patient are age, hypertension, the number of features of the Metabolic Syndrome, the presence of diabetic nephropathy in both the type 1 and type 2 patient, the presence of peripheral and coronary artery disease and especially the...
Source: Diabetes Research and Clinical Practice - May 18, 2020 Category: Endocrinology Authors: David S.H. Bell, Edison Goncalves Tags: Review Source Type: research

Metabolic syndrome is associated with cognitive impairment after transient ischemic attack/mild stroke, but does not affect cognitive recovery in short term
The metabolic syndrome (MetS) is a cluster of risk factors for cognitive impairment. We aimed to investigate the association between MetS and risk of persistent cognitive impairment in patients with a transient ischemic attack (TIA) or mild ischemic stroke. This is a prospective and observational study in consecutive patients with first-ever TIA or mild stroke (National Institutes of Health Stroke Scale score ≤ 6). Patients underwent Montreal cognitive assessment (MoCA) at hospital admission and day 30 after discharge. We defined cognitive impairment as a MoCA score of ≤26. Persistent cognitive impairment was defin...
Source: NeuroReport - July 30, 2020 Category: Neurology Tags: Clinical Neuroscience Source Type: research

Crocins for Ischemic Stroke: A Review of Current Evidence
Crocins (CRs) and the related active constituents derived from Crocus sativus L. (Saffron) have demonstrated protective effects against cerebral ischemia and ischemic stroke, with various bioactivities including neuroprotection, anti-neuroinflammation, antioxidant, and cardiovascular protection. Among CRs, crocin (CR) has been shown to act on multiple mechanisms and signaling pathways involved in ischemic stroke, including mitochondrial apoptosis, nuclear factor kappa light chain enhancer of B cells pathway, S100 calcium-binding protein B, interleukin-6 and vascular endothelial growth factor-A. CR is generally safe and wel...
Source: Frontiers in Pharmacology - August 5, 2022 Category: Drugs & Pharmacology Source Type: research

Determinants of metabolic syndrome and its prognostic implications among stroke patients in Africa: Findings from the Stroke Investigation Research Network (SIREN) study
This study aimed to investigate the determinants of METS and its prognostic implications among Africans with newly diagnosed stroke in the SIREN study.
Source: Journal of the Neurological Sciences - August 8, 2022 Category: Neurology Authors: Abiodun M. Adeoye, Adeseye A. Akintunde, Joshua Akinyemi, Adekunle G. Fakunle, Fred S. Sarfo, Albert Akpalu, Kolawole Wahab, Reginald Obiako, Morenikeji Komolafe, Lukman Owolabi, Godwin O. Osaigbovo, Onoja Akpa, Oyedunni Arulogun, Akinkunmi P. Okekunle, O Source Type: research

Interplay between polymorphisms in the endothelial nitric oxide synthase (eNOS) gene and metabolic syndrome in determining the risk of ischemic stroke in Koreans
Abstract: Background: Endothelial nitric oxide synthase (eNOS) gene variants are known to play a role in atherosclerotic development. However, whether interplay between eNOS polymorphisms and metabolic syndrome (MetS) affects ischemic stroke (IS) risk has yet to be discovered. We investigated whether the combined effects of eNOS polymorphisms and MetS influence ischemic stroke risk in Koreans.Methods: We genotyped the eNOS −922A>G, −786T>C, 4a4b, and 894G>T polymorphisms in 531 IS cases and 502 controls using polymerase chain reaction-amplified DNA. We then investigated whether the presence of MetS and the number of Me...
Source: Journal of the Neurological Sciences - June 20, 2014 Category: Neurology Authors: Min Kyu Kang, Ok Joon Kim, Young Joo Jeon, Hyun Sook Kim, Seung Hun Oh, Jin Kwon Kim, Eo Jin Kim, Tae Sun Hwang, Nam Keun Kim Tags: Original Articles Source Type: research

Telmisartan Promotes Potential Glucose Homeostasis in Stroke-Resistant Spontaneously Hypertensive Rats via Peroxisome Proliferator-Activated Receptor γ Activation.
Abstract An angiotensin 2 type 1 receptor blocker (ARB) telmisartan possesses not only an anti-hypertensive effect but also an anti-metabolic syndrome effect due to peroxisome proliferator-activated receptor γ (PPAR-γ) activation. In the present study, we examined the effects of telmisartan on the angiotensin 2 type 1 receptor (AT1R), PPAR-γ, and insulin receptor (IR) in stroke-resistant spontaneously hypertensive rats (SHR-SR), comparing them with Wistar rats. Three-months-old SHR-SR rats were divided into three treatment groups, i.e., vehicle (SHR/Ve), low-dose telmisartan (0.3 mg/kg/day, SHR/Low), and high-d...
Source: Current Neurovascular Research - January 4, 2015 Category: Neurology Authors: Omote Y, Deguchi K, Kurata T, Yamashita T, Sato K, Hishikawa N, Abe K Tags: Curr Neurovasc Res Source Type: research

Relationship Between Insulin-like Growth Factor Binding Protein-2 and Left Ventricular Stroke Volume in Patients with Aortic Stenosis
Conclusions In this study, we documented that lower IGFBP-2 levels are independently associated with lower SVi, a powerful predictor of worse outcomes in the mild to moderate AS population. Teaser In aortic stenosis (AS) patients, LV remodeling and function vary extensively from one patient to another. Considering the associations between circulating IGFBP-2 and markers of the metabolic syndrome, the aim of the study was to examine the relationship between circulating IGFBP-2 and left ventricle (LV) pump function as measured by stroke volume index in AS patients with preserved LV ejection fraction.
Source: Canadian Journal of Cardiology - April 30, 2015 Category: Cardiology Source Type: research

Metabolic syndrome correlates poorly with cognitive performance in stroke-free community-dwelling older adults: a population-based, cross-sectional study in rural Ecuador.
CONCLUSIONS: This population-based study showed a poor correlation of metabolic syndrome with cognitive performance after adjusting for relevant confounders. Of the individual components of metabolic syndrome, only hypertriglyceridemia correlated with worse cognitive performance. PMID: 26142624 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - July 5, 2015 Category: Geriatrics Authors: Del Brutto OH, Mera RM, Zambrano M Tags: Aging Clin Exp Res Source Type: research

Impaired Collateral Flow Compensation During Chronic Cerebral Hypoperfusion in the Type 2 Diabetic Mice Basic Sciences
Conclusions—Type 2 diabetes mellitus is an additional risk factor for hemodynamic compromise during cerebral hypoperfusion, which may increase the severity and the risk of stroke or transient ischemic attack.
Source: Stroke - November 27, 2016 Category: Neurology Authors: Yasuo Nishijima, Yosuke Akamatsu, Shih Yen Yang, Chih Cheng Lee, Utku Baran, Shaozhen Song, Ruikang K. Wang, Teiji Tominaga, Jialing Liu Tags: Animal Models of Human Disease, Basic Science Research, Ischemia Original Contributions Source Type: research

Age, sex, and race/ethnic temporal trends in metabolic syndrome prevalence among individuals with myocardial infarction or stroke in the United States
Metabolic syndrome (MetS), an independent risk factor for myocardial infarction (MI) and stroke, affects 1 in 3 adults in the United States. Recent trends in MetS prevalence among MI and stroke survivors are unknown.
Source: Journal of the Neurological Sciences - January 31, 2017 Category: Neurology Authors: Alain Lekoubou, Bruce Ovbiagele, Daniela Markovic, Nerses Sanossian, Amytis Towfighi Source Type: research

The effect of metabolic syndrome and obesity on outcomes of acute ischemic stroke patients treated with systemic thrombolysis
Metabolic syndrome (MetS) is associated with increased risk of ischemic stroke; while central obesity has controversial effects on ischemic stroke. We investigated effects of MetS and obesity on clinical courses and outcomes of patients treated with intravenous recombinant tissue-type plasminogen activator (iv rt-PA). 319 patients treated with intravenous thrombolysis were included to our study. Metabolic syndrome was determined if ≥3 of following criteria are present: elevated waist circumference; elevated triglycerides; reduced high density-lipoprotein cholesterol (HDL-C); elevated blood pressure; elevated fasting glucose.
Source: Journal of the Neurological Sciences - October 10, 2017 Category: Neurology Authors: Demet Funda Bas, Atilla Ozcan Ozdemir Source Type: research

Common comorbidities and survival in MS: Risk for stroke, type 1 diabetes and infections
Conclusions Given the high risk for stroke in this MS population and the observed complexity among the coincident common risk factors for circulatory diseases, the high risk for type 1 diabetes and common infections raise a need to recognize patients at risk with these conditions and with the other known risk factors such as metabolic syndrome and smoking. The survival disadvantage related to circulatory diseases observed in general population is true also in MS and should be recognized to reduce the burden of disease and premature mortality in MS. Graphical abstract
Source: Multiple Sclerosis and Related Disorders - November 13, 2017 Category: Neurology Source Type: research

Polymorphism of IL6 receptor gene is associated with ischaemic stroke in patients with metabolic syndrome.
Abstract The interleukin 6 receptor (IL6R) gene has been shown to locate in the chromosome 1q21 associated with metabolic syndrome (MetS), a condition related to the augmented risk of ischaemic stroke (IS), cardiovascular diseases and all-cause mortality. The aim of this study was to assess the relationship between IL6R gene polymorphisms and IS in patients with MetS in the Chinese Han population. We designed a case-control study enrolling 447 patients with MetS plus IS and 438 patients with MetS alone. Tag single nucleotide polymorphisms (SNPs) of the IL6R gene were determined by a fine-mapping strategy and genot...
Source: Brain Research - December 9, 2019 Category: Neurology Authors: Huang X, Ye Q, Zhu Z, Chen W, Chen Y, Li J, Chen S, Xia N, Huang X, Ye Z Tags: Brain Res Source Type: research

TG/HDL-C ratio as a predictor of stroke in the population with healthy BMI: The Jichi Medical School Cohort Study
This study examined whether TG/HDL-C helps in predicting stroke onset; this was compared between the whole population and healthy body mass index (BMI) population.
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - May 15, 2022 Category: Nutrition Authors: Fumitaka Sato, Yosikazu Nakamura, Kazunori Kayaba, Shizukiyo Ishikawa Source Type: research

Use of Total Cerebral Blood Flow as an Imaging Biomarker of Known Cardiovascular Risks Clinical Sciences
Conclusions— Reduced cerebral blood flow seems to be a correlate of vascular disease risk factors associated with cardiometabolic dysregulation. Cerebral blood flow may provide a valid imaging biomarker for cardiovascular risk.
Source: Stroke - August 26, 2013 Category: Neurology Authors: Jennings, J. R., Heim, A. F., Kuan, D. C.-H., Gianaros, P. J., Muldoon, M. F., Manuck, S. B. Tags: Cerebrovascular disease/stroke, Computerized tomography and Magnetic Resonance Imaging Clinical Sciences Source Type: research