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Total 595 results found since Jan 2013.

Guidelines for the Prevention of Stroke in Women: A Statement for Healthcare Professionals From the American Heart Association/American Stroke Association AHA/ASA Guideline
Conclusions— To more accurately reflect the risk of stroke in women across the lifespan, as well as the clear gaps in current risk scores, we believe a female-specific stroke risk score is warranted.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Bushnell, C., McCullough, L. D., Awad, I. A., Chireau, M. V., Fedder, W. N., Furie, K. L., Howard, V. J., Lichtman, J. H., Lisabeth, L. D., Pina, I. L., Reeves, M. J., Rexrode, K. M., Saposnik, G., Singh, V., Towfighi, A., Vaccarino, V., Walters, M. R., o Tags: AHA Statements and Guidelines AHA/ASA Guideline Source Type: research

Metabolic Syndrome Associated with Ischemic Stroke among the Mexican Hispanic Population in the El Paso/US–Mexico Border Region
In this report, data were collected in the El Paso/US–Mexico border region, where 82% of the population is Mexican Hispanic, through a retrospective study of ischemic stroke from 2005-2010. Odds ratios (ORs), 95% confidence intervals, logistic regression, and multivariate analysis of the ORs adjusted for other variables, were used to analyze the effects of various risk factors on ischemic stroke. The metabolic syndrome and its components, specifically hypertension, diabetes, and dyslipidemia appeared to be strongly associated with ischemic stroke in the Mexican Hispanic population. Mexican Hispanic ischemic stroke patien...
Source: Journal of Stroke and Cerebrovascular Diseases - February 19, 2014 Category: Neurology Authors: Michael F. Osborn, Charles C. Miller, Ahmed Badr, Jun Zhang Tags: Original Articles Source Type: research

Different Risk Factor Profiles for Ischemic and Hemorrhagic Stroke in Type 1 Diabetes Mellitus Clinical Sciences
Conclusions— The risk factor profile for ischemic stroke seems partly different from that of hemorrhagic stroke in patients with type 1 diabetes mellitus.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Hagg, S., Thorn, L. M., Forsblom, C. M., Gordin, D., Saraheimo, M., Tolonen, N., Waden, J., Liebkind, R., Putaala, J., Tatlisumak, T., Groop, P.-H., on behalf of the FinnDiane Study Group Tags: Risk Factors, Type 1 diabetes, Acute Cerebral Hemorrhage, Acute Cerebral Infarction Clinical Sciences Source Type: research

Strong Improvement of Apolipoprotein E/Low-Density Lipoprotein Receptor Signals by Telmisartan in Poststroke Spontaneously Hypertensive Stroke Resistant
Conclusions: These findings suggest that both low and high doses of telmisartan prevented the activation of ApoE/LDL-R in SHR-SR after tMCAO, and that the antimetabolic effect was regarded as the most important mechanism with few additional benefits by lowering BP in this transient stroke model.
Source: Journal of Stroke and Cerebrovascular Diseases - September 1, 2014 Category: Neurology Authors: Toru Yamashita, Yun Zhai, Tomoko Kurata, Nozomi Hishikawa, Nobutoshi Morimoto, Yasuyuki Ohta, Kentaro Deguchi, Koji Abe Tags: Original Articles Source Type: research

Long-term Amelioration of Telmisartan on Metabolic Syndrome-related Molecules in Stroke-resistant Spontaneously Hypertensive Rat after Transient Middle Cerebral Artery Occlusion
We examined the effects of telmisartan on metabolic syndrome-related molecules such as insulin receptor (IR), peroxisome proliferator-activated receptor gamma (PPAR-γ), and angiotensin 2 type 1 receptor (AT1R) in stroke-resistant spontaneously hypertensive rat (SHR-SR) after transient middle cerebral artery occlusion (tMCAO), by administering telmisartan at either 0 (vehicle), .3 mg/kg/day (low dose), or 3 mg/kg/day (high dose), postoperatively, from 3 months of age and performed immunohistologic analysis at 6, 12, and 18 months of age.
Source: Journal of Stroke and Cerebrovascular Diseases - October 9, 2014 Category: Neurology Authors: Kentaro Deguchi, Tomoko Kurata, Yusuke Fukui, Wentao Liu, Zhai Yun, Yoshio Omote, Kota Sato, Syoichiro Kono, Nozomi Hishikawa, Toru Yamashita, Koji Abe Source Type: research

Noncardiogenic Stroke Patients with Metabolic Syndrome Have More Border-zone Infarction and Intracranial Artery Stenosis
Little is known about the clinical character of stroke patients with metabolic syndrome (MetS) in Chinese population. In this hospital-based cross-sectional study, we elucidated the prevalence of MetS among patients with acute noncardiogenic cerebral infarction from south China, the topographic infarction patterns in magnetic resonance imaging, and vascular angiography findings of stroke patients with MetS.
Source: Journal of Stroke and Cerebrovascular Diseases - January 2, 2015 Category: Neurology Authors: Zheng Zhang, Meijuan Xiao, Zusen Ye, Wanli Zhang, Bin Han, Youcheng Li Source Type: research

Predictors Of Early Mortality And Bad Outcome In Ischemic Stroke (P3.072)
Conclusion: identifying predictors of early mortality or post-stroke disability is mandatory in order to recognize opportunities of improvement and develop strategies for clinical care in this specific subgroup of patients. A multidisciplinary approach is essential to reduce clinical complications and to improve follow up after the hospitalization period.Disclosure: Dr. Luzzi has nothing to disclose. Dr. Zurru has nothing to disclose. Dr. Alonzo has nothing to disclose. Dr. Brescacin has nothing to disclose. Dr. Pigretti has nothing to disclose. Dr. Camera has nothing to disclose. Dr. Colla Machado has nothing to disclose....
Source: Neurology - April 8, 2015 Category: Neurology Authors: Luzzi, A., Zurru, M., Alonzo, C., Brescacin, L., Pigretti, S., Camera, L., Colla Machado, P., Waisman, G., Cristiano, E. Tags: Cerebrovascular Disease and Interventional Neurology: Ischemic Stroke Outcome Source Type: research

Intravenous Thrombolysis with Recombinant Tissue-type Plasminogen Activator for Acute Ischemic Stroke in Patients with Metabolic Syndrome
The metabolic syndrome (MetS) is common in patients with acute ischemic stroke (IS); however, its impact on outcome after intravenous thrombolysis (iv-thrombolysis) remains unclear. Thus, we aimed at evaluating the relationship between MetS and functional long-term outcome, mortality, and the presence of hemorrhagic complications in patients with IS treated with iv-thrombolysis.
Source: Journal of Stroke and Cerebrovascular Diseases - May 7, 2015 Category: Neurology Authors: Piotr Sobolewski, Waldemar Brola, Wiktor Szczuchniak, Małgorzata Fudala, Grzegorz Kozera Source Type: research

Metabolic Syndrome in Polish Ischemic Stroke Patients
Metabolic syndrome (MetS) predisposes individuals to cardiovascular disease or stroke development. We aimed at evaluating the prevalence of MetS in a population of acute ischemic stroke (IS) patients from central Poland and at estimating the relationship between MetS and stroke risk.
Source: Journal of Stroke and Cerebrovascular Diseases - July 7, 2015 Category: Neurology Authors: Waldemar Brola, Piotr Sobolewski, Małgorzata Fudala, Anna Goral, Marta Kasprzyk, Wiktor Szczuchniak, Renata Pejas-Dulewicz, Wojciech Przybylski Source Type: research

Metabolic Syndrome Predicts Refractoriness to Intravenous Thrombolysis in Acute Ischemic Stroke
Background: Metabolic syndrome (MetS) has been associated with higher resistance to clot lysis at 24 hours after tissue plasminogen activator (tPA) administration in patients with acute ischemic stroke. We aimed to test this hypothesis at earlier time points, when neurointerventional rescue procedures may still be indicated to achieve arterial recanalization. Methods: This is a prospective and observational study in consecutive stroke patients with MCA occlusion treated with IV tPA. MetS was diagnosed following the unified criteria of the last Joint Interim Statement 2009 participating several major organizations.
Source: Journal of Stroke and Cerebrovascular Diseases - September 9, 2015 Category: Neurology Authors: Laura Dorado, Juan F Arenillas, Elena López-Cancio, María Hernández-Pérez, Natalia Pérez de la Ossa, Meritxell Gomis, Mònica Millán, María Luisa Granada, Amparo Galán, Ernest Palomeras, Antoni Dávalos Source Type: research

Recurrent vascular events in lacunar stroke patients with metabolic syndrome and/or diabetes
Conclusion: METS and DM were significant comorbid conditions in lacunar stroke patients and they were associated with stroke recurrence. In patients with lacunar infarcts, a vigilant approach to prevent development of DM in those with METS may be a potential strategy to reduce recurrent strokes.
Source: Neurology - September 14, 2015 Category: Neurology Authors: Zhu, S., McClure, L. A., Lau, H., Romero, J. R., White, C. L., Babikian, V., Nguyen, T., Benavente, O. R., Kase, C. S., Pikula, A. Tags: All Cerebrovascular disease/Stroke ARTICLE Source Type: research

Metabolic Syndrome, Its Components, and Diabetes on 5-Year Risk of Recurrent Stroke among Mild-to-Moderate Ischemic Stroke Survivors: A Multiclinic Registry Study
This study aimed to examine these associations.
Source: Journal of Stroke and Cerebrovascular Diseases - December 24, 2015 Category: Neurology Authors: Xianghua Fang, Hongjun Liu, Xinqing Zhang, Hongmei Zhang, Xiaoming Qin, Xunming Ji Source Type: research

Women Had Worse Stroke Outcome (P1.217)
Conclusion: in our cohort women have worst post-stroke outcome, even though they have higher burden of vascular risk factors they have lower prevalence of vascular disease in other vascular beds previous to stroke. This difference persists after adjusting by age, raising the possibility of specific gender risk factors influencing on ischemic stroke outcomes.Disclosure: Dr. Zurru has nothing to disclose. Dr. Colla Machado has nothing to disclose. Dr. Alonzo has nothing to disclose. Dr. Brescacin has nothing to disclose. Dr. Luzzi has nothing to disclose. Dr. Pigretti has nothing to disclose. Dr. Balian has nothing to disclo...
Source: Neurology - April 3, 2016 Category: Neurology Authors: Zurru, M., Colla Machado, P., Alonzo, C., Brescacin, L., Luzzi, A., Pigretti, S., Balian, N., Waisman, G., Cristiano, E. Tags: Re-admission and Stroke Outcomes Source Type: research

Metabolic Syndrome and the Risk of Ischemic Stroke: Methodological Issues
We were interested to read the paper entitled “Metabolic Syndrome and the Risk of Ischemic Stroke” that was published by Sarrafzadegan et al in Journal of Stroke and Cerebrovascular Diseases in 2016.1 They assessed the predictive value of metabolic syndrome (MetS) and its components for stoke among the Iranian population. They concluded tha t MetS and its main components can be potent predictors for long-term ischemic stroke.1
Source: Journal of Stroke and Cerebrovascular Diseases - December 18, 2016 Category: Neurology Authors: Erfan Ayubi, Saeid Safiri Tags: Letter to the Editor Source Type: research

Is Metabolic Syndrome Associated with the Risk of Recurrent Stroke: A Meta-Analysis of Cohort Studies
The association between metabolic syndrome (MetS) and recurrence of stroke remains unknown. We summarized the evidence by a meta-analysis of prospective cohort studies.
Source: Journal of Stroke and Cerebrovascular Diseases - October 16, 2017 Category: Neurology Authors: Xuelong Li, Xianliang Li, Fang Fang, Xian Fu, Hualiang Lin, Qingchun Gao Tags: Review Article Source Type: research

Diet Beverages Linked To Increased Stroke Risk & Heart Attacks
This study, as well as other research on the connection between diet beverages and vascular disease, is observational and cannot show cause and effect. That’s a major limitation, researchers say, as it’s impossible to determine whether the association is due to a specific artificial sweetener, a type of beverage or another hidden health issue. “Postmenopausal women tend to have higher risk for vascular disease because they are lacking the protective effects of natural hormones,” North Carolina cardiologist Dr. Kevin Campbell said, which could contribute to increased risk for heart disease and stroke...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - February 14, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Heart Attack Stroke Source Type: news

Diet Drinks Linked To Increased Stroke Risk & Heart Attacks
This study, as well as other research on the connection between diet beverages and vascular disease, is observational and cannot show cause and effect. That’s a major limitation, researchers say, as it’s impossible to determine whether the association is due to a specific artificial sweetener, a type of beverage or another hidden health issue. “Postmenopausal women tend to have higher risk for vascular disease because they are lacking the protective effects of natural hormones,” North Carolina cardiologist Dr. Kevin Campbell said, which could contribute to increased risk for heart disease and stroke...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - February 14, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Heart Attack Stroke Source Type: news

Increased Stroke Risk in Metabolically Abnormal Normal Weight: a 10-Year Follow-up of 102,037 Participants in China
AbstractThe purpose of this study was to investigate the risks of stroke in subjects with metabolically abnormal normal weight (MANW) in China. We recruited 102,037 participants from the Zhejiang Metabolic Syndrome Cohort and the Kailuan cohort. The mean years of follow-up were 9.9  years. General obesity was defined by body mass index (BMI) ≥ 28, overweight by BMI <  28 and ≥ 24, and normal weight by BMI <  24 and ≥ 18.5. Metabolic abnormality was defined as two or more abnormal components (elevated triglycerides, low high-density lipoprotein cholesterol, elevated systolic blood pressure or di...
Source: Translational Stroke Research - September 6, 2021 Category: Neurology Source Type: research

Interplay between polymorphisms in the endothelial nitric oxide synthase (eNOS) gene and metabolic syndrome in determining the risk of ischemic stroke in Koreans
Abstract: Background: Endothelial nitric oxide synthase (eNOS) gene variants are known to play a role in atherosclerotic development. However, whether interplay between eNOS polymorphisms and metabolic syndrome (MetS) affects ischemic stroke (IS) risk has yet to be discovered. We investigated whether the combined effects of eNOS polymorphisms and MetS influence ischemic stroke risk in Koreans.Methods: We genotyped the eNOS −922A>G, −786T>C, 4a4b, and 894G>T polymorphisms in 531 IS cases and 502 controls using polymerase chain reaction-amplified DNA. We then investigated whether the presence of MetS and the number of Me...
Source: Journal of the Neurological Sciences - June 20, 2014 Category: Neurology Authors: Min Kyu Kang, Ok Joon Kim, Young Joo Jeon, Hyun Sook Kim, Seung Hun Oh, Jin Kwon Kim, Eo Jin Kim, Tae Sun Hwang, Nam Keun Kim Tags: Original Articles Source Type: research

Metabolic Syndrome Associated with Ischemic Stroke among the Mexican Hispanic Population in the El Paso/US–Mexico Border Region
Source: Journal of Stroke and Cerebrovascular Diseases - February 19, 2014 Category: Neurology Authors: Michael F. Osborn, Charles C. Miller, Ahmed Badr, Jun Zhang Tags: Original Articles Source Type: research

Aging, the metabolic syndrome, and ischemic stroke: redefining the approach for studying the blood-brain barrier in a complex neurological disease.
Abstract The blood-brain barrier (BBB) has many important functions in maintaining the brain's immune-privileged status. Endothelial cells, astrocytes, and pericytes have important roles in preserving vasculature integrity. As we age, cell senescence can contribute to BBB compromise. The compromised BBB allows an influx of inflammatory cytokines to enter the brain. These cytokines lead to neuronal and glial damage. Ultimately, the functional changes within the brain can cause age-related disease. One of the most prominent age-related diseases is ischemic stroke. Stroke is the largest cause of disability and is thi...
Source: Advances in Pharmacology - October 15, 2014 Category: Drugs & Pharmacology Authors: Lucke-Wold BP, Logsdon AF, Turner RC, Rosen CL, Huber JD Tags: Adv Pharmacol Source Type: research

Age and the metabolic syndrome as risk factors for ischemic stroke: improving preclinical models of ischemic stroke.
Authors: Lucke-Wold BP, Turner RC, Lucke-Wold AN, Rosen CL, Huber JD Abstract Ischemic stroke represents a leading cause of morbidity and mortality in the developed world. This disabling and sometimes fatal event puts an ever increasing burden on the family members and medical professionals who care for stroke victims. Preclinical ischemic stroke research has predominantly utilized young adult, healthy animals, a clear discrepancy when considering the clinical population affected by stroke. A broad spectrum of risk factors such as age, obesity, diabetes, and hypertension has been associated with an increased stroke...
Source: The Yale Journal of Biology and Medicine - November 26, 2014 Category: Universities & Medical Training Tags: Yale J Biol Med Source Type: research

Telmisartan Promotes Potential Glucose Homeostasis in Stroke-Resistant Spontaneously Hypertensive Rats via Peroxisome Proliferator-Activated Receptor γ Activation.
Abstract An angiotensin 2 type 1 receptor blocker (ARB) telmisartan possesses not only an anti-hypertensive effect but also an anti-metabolic syndrome effect due to peroxisome proliferator-activated receptor γ (PPAR-γ) activation. In the present study, we examined the effects of telmisartan on the angiotensin 2 type 1 receptor (AT1R), PPAR-γ, and insulin receptor (IR) in stroke-resistant spontaneously hypertensive rats (SHR-SR), comparing them with Wistar rats. Three-months-old SHR-SR rats were divided into three treatment groups, i.e., vehicle (SHR/Ve), low-dose telmisartan (0.3 mg/kg/day, SHR/Low), and high-d...
Source: Current Neurovascular Research - January 4, 2015 Category: Neurology Authors: Omote Y, Deguchi K, Kurata T, Yamashita T, Sato K, Hishikawa N, Abe K Tags: Curr Neurovasc Res Source Type: research

Metabolic syndrome, platelet activation and the development of transient ischemic attack or thromboembolic stroke
Stroke is the second most common cause of mortality in the world today, where transient ischemic attack (TIA) is a period of focal ischemia, the symptoms of which resemble a thromboembolic stroke. Contrary to stroke, TIA symptoms typically last less than one hour and necrosis is absent. Stroke is often preceded by TIA, making it an important predictor of future ischemic events. The causal role of atherosclerosis in the development of TIA is well established, however, research indicates that the atherosclerotic process begins years earlier with the development of metabolic syndrome, which affects approximately 45% of the ad...
Source: Thrombosis Research - January 16, 2015 Category: Hematology Authors: Mia-Jeanne van Rooy, Etheresia Pretorius Tags: Review Article Source Type: research

Protective effect of telmisartan on neurovascular unit and inflammasome in stroke-resistant spontaneously hypertensive rats.
Discussion: These results suggest that telmisartan comprehensively protected the NVU components by reducing inflammatory reactions relative to AD in hypertensive rats, which could also preclude the risk of AD under hypertension. PMID: 25591419 [PubMed - as supplied by publisher]
Source: Neurological Research - January 18, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Evaluation of low-dose aspirin for primary prevention of ischemic stroke among patients with diabetes: a retrospective cohort study
Conclusions: In this study of patients with diabetes, the use of low-dose aspirin showed an increased risk of hospitalization for ischemic stroke. These results suggest that low-dose aspirin use for the primary prevention of ischemic stroke should be reconsidered in patients with diabetes.
Source: Diabetology and Metabolic Syndrome - February 15, 2015 Category: Endocrinology Authors: Ye-Jee KimNam-Kyong ChoiMi-Sook KimJoongyub LeeYoosoo ChangJong-Mi SeongSun-Young JungJu-Young ShinJi-Eun ParkByung-Joo Park Source Type: research

Habitual snoring and risk of stroke: A meta-analysis of prospective studies
Habitual snoring (HS), which is defined as snoring more than three nights per week, occurs among approximately 33% of the general population [1]. Emerging evidence suggests this increase in HS problems may be due to hypertension [2], diabetes mellitus [3], metabolic syndrome [4], and intima-media thickness (IMT) [5]. In addition, there was mounting evidence for an association between HS and cardiovascular and all-cause mortality [6–8]. However, the role of HS in stroke is still uncertain.
Source: International Journal of Cardiology - March 11, 2015 Category: Cardiology Authors: Min Li, Kun Li, Xiao-Wei Zhang, Wen-Shang Hou, Zhen-Yu Tang Tags: Letter to the Editor Source Type: research

Metabolic Syndrome and Ischemic Stroke Risk by Sex: Meta-analysis (I12-2B)
CONCLUSIONS: The metabolic syndrome is prevalent, and a significant risk factor for ischemic stroke with differential effects by sex. Women with metabolic syndrome had a near 2 folds higher stroke risk than men with metabolic syndrome. Future studies are needed to elucidate the mechanism by which the metabolic syndrome exerts higher stroke burden on women.Disclosure: Dr. Lin has nothing to disclose. Dr. Saposnik has nothing to disclose. Dr. Shi has nothing to disclose. Dr. Towfighi has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Lin, M., Saposnik, G., Shi, Q., Towfighi, A. Tags: Obesity and Neurological Disorders Data Blitz Presentations Source Type: research

Metabolic Syndrome and Ischemic Stroke Risk by Sex: Meta-analysis (P1.004)
CONCLUSIONS: The metabolic syndrome is prevalent, and a significant risk factor for ischemic stroke with differential effects by sex. Women with metabolic syndrome had a near 2 folds higher stroke risk than men with metabolic syndrome. Future studies are needed to elucidate the mechanism by which the metabolic syndrome exerts higher stroke burden on women.Disclosure: Dr. Lin has nothing to disclose. Dr. Saposnik has nothing to disclose. Dr. Shi has nothing to disclose. Dr. Towfighi has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Lin, M., Saposnik, G., Shi, Q., Towfighi, A. Tags: Cerebrovascular Disease and Interventional Neurology Poster Discussion Session Source Type: research

The risk of fatal stroke in Finnish postmenopausal hormone therapy users before and after the Women's Health Initiative: A cohort study
Stroke is the third most common cause of death and the most common cause of prolonged disability in women worldwide[1]. Therefore, the American Heart and Stroke Association recently published strict new guidelines for the prevention of stroke in women [2]. These guidelines acknowledge a number of female gender-related risk factors for stroke, such as migraine, pregnancy, pre-eclampsia, atrial fibrillation, obesity, metabolic syndrome, living alone -status and consequent delay in thrombolysis, and longevity.
Source: Maturitas - April 13, 2015 Category: Primary Care Authors: Pauliina Tuomikoski, Heli Lyytinen, Pasi Korhonen, Fabian Hoti, Pia Vattulainen, Mika Gissler, Olavi Ylikorkala, Tomi S. Mikkola Source Type: research

Relationship Between Insulin-like Growth Factor Binding Protein-2 and Left Ventricular Stroke Volume in Patients with Aortic Stenosis
Conclusions In this study, we documented that lower IGFBP-2 levels are independently associated with lower SVi, a powerful predictor of worse outcomes in the mild to moderate AS population. Teaser In aortic stenosis (AS) patients, LV remodeling and function vary extensively from one patient to another. Considering the associations between circulating IGFBP-2 and markers of the metabolic syndrome, the aim of the study was to examine the relationship between circulating IGFBP-2 and left ventricle (LV) pump function as measured by stroke volume index in AS patients with preserved LV ejection fraction.
Source: Canadian Journal of Cardiology - April 30, 2015 Category: Cardiology Source Type: research

The Metabolic Syndrome, Atrial Fibrillation and Stroke: Tackling An Emerging Epidemic
The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of metabolic syndrome. Metabolic syndrome describes an association between diabetes, hypertension, obesity, dyslipidaemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle.
Source: Heart Rhythm - June 30, 2015 Category: Cardiology Authors: Reza Hajhosseiny, Gareth K. Matthews, Gregory YH Lip Tags: CRV Source Type: research

Metabolic syndrome correlates poorly with cognitive performance in stroke-free community-dwelling older adults: a population-based, cross-sectional study in rural Ecuador.
CONCLUSIONS: This population-based study showed a poor correlation of metabolic syndrome with cognitive performance after adjusting for relevant confounders. Of the individual components of metabolic syndrome, only hypertriglyceridemia correlated with worse cognitive performance. PMID: 26142624 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - July 5, 2015 Category: Geriatrics Authors: Del Brutto OH, Mera RM, Zambrano M Tags: Aging Clin Exp Res Source Type: research

The metabolic syndrome, atrial fibrillation, and stroke: Tackling an emerging epidemic
The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of the metabolic syndrome. The metabolic syndrome describes an association between diabetes, hypertension, obesity, and dyslipidemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle.
Source: Heart Rhythm - June 30, 2015 Category: Cardiology Authors: Reza Hajhosseiny, Gareth K. Matthews, Gregory Y.H. Lip Tags: Contemporary Review Source Type: research

Metabolic syndrome and the short-term prognosis of acute ischemic stroke: a hospital-based retrospective study
This study aims to evaluate the effects of MetS and its components on the short-term prognosis of patients with acute ischemic stroke. Methods: Subjects with ischemic stroke of
Source: Lipids in Health and Disease - July 22, 2015 Category: Lipidology Authors: Liu LiuLixuan ZhanYisheng WangChengping BaiJianjun GuoQingyuan LinDonghai LiangEn Xu Source Type: research

Metabolic syndrome, atrial fibrillation, and stroke: Tackling an emerging epidemic
The prevalence of atrial fibrillation (AF) and AF-related stroke is set to increase dramatically in coming decades, with developing regions such as Latin America experiencing the greatest impact. These trends are primarily driven by aging populations and by the increasing prevalence of the metabolic syndrome. The metabolic syndrome describes an association between diabetes, hypertension, obesity, and dyslipidemia and an increased risk of cardiovascular disease. It is in large part the result of unbalanced diet and sedentary lifestyle.
Source: Heart Rhythm - June 30, 2015 Category: Cardiology Authors: Reza Hajhosseiny, Gareth K. Matthews, Gregory Y.H. Lip Tags: Contemporary Review Source Type: research

Association between metabolic syndrome and multiple lesions of intracranial atherothrombotic stroke: a hospital-based study
Conclusion: MetS may be pathophysiologically associated with intracranial atherothrombotic stroke multiplicity in women in particular. Future studies are warranted to confirm the findings.
Source: Cardiovascular Diabetology - August 14, 2015 Category: Cardiology Authors: Kazuhiko KotaniNoriko Satoh-AsaharaTakuya NakakukiHajime YamakageAkira ShimatsuTetsuya Tsukahara Source Type: research

Metabolic syndrome increases oxidative stress but does not influence disability and short-time outcome in acute ischemic stroke patients
In conclusion, an increase in oxidative stress markers was shown in acute ischemic stroke patients with MetS and this elevation seems to be involved mainly with changes in lipid profile, but the presence of MetS did not influence short-time disability and survival of the acute ischemic stroke patients.
Source: Metabolic Brain Disease - November 11, 2015 Category: Neurology Source Type: research

Only the overworked die young
Follow me at @JohnRossMD Billy Joel was on to something. As the singer-songwriter suggested in “Movin’ Out,” working too hard really can give you a “heart attack-ack-ack…” And, as a recent study has also shown, stroke may be an even bigger problem than heart attack in people who are overworked. For the study, researchers from University College London compiled data on the relationship between working hours and heart attack risk in over 600,000 workers, as well as similar data on stroke risk in over 500,000 workers. They adjusted their data to compensate for individual workers’ differences due to healt...
Source: New Harvard Health Information - December 14, 2015 Category: Consumer Health News Authors: John Ross, MD, FIDSA Tags: Behavioral Health Heart Health Hypertension and Stroke Prevention Stress overworked Source Type: news

Plasma L5 levels are elevated in ischemic stroke patients and enhance platelet aggregation
L5, the most electronegative and atherogenic subfraction of low-density lipoprotein (LDL), induces platelet activation. We hypothesized that plasma L5 levels are increased in acute ischemic stroke patients and examined whether lectin-like oxidized LDL receptor-1 (LOX-1), the receptor for L5 on endothelial cells and platelets, plays a critical role in stroke. Because amyloid β (Aβ) stimulates platelet aggregation, we studied whether L5 and Aβ function synergistically to induce prothrombotic pathways leading to stroke. Levels of plasma L5, serum Aβ, and platelet LOX-1 expression were significantly higher ...
Source: Blood - March 10, 2016 Category: Hematology Authors: Shen, M.-Y., Chen, F.-Y., Hsu, J.-F., Fu, R.-H., Chang, C.-M., Chang, C.-T., Liu, C.-H., Wu, J.-R., Lee, A.-S., Chan, H.-C., Sheu, J.-R., Lin, S.-Z., Shyu, W.-C., Sawamura, T., Chang, K.-C., Hsu, C. Y., Chen, C.-H. Tags: Free Research Articles, Platelets and Thrombopoiesis, Thrombosis and Hemostasis Source Type: research

Omentin-1 and risk of myocardial infarction and stroke: Results from the EPIC-Potsdam cohort study
The recently identified adipokine omentin-1 is inversely associated with body fatness, metabolic syndrome and cardiovascular disease (CVD) in cross-sectional analyses. However, prospective data on the association between plasma omentin-1 levels and future risk of CVD are lacking. The aim of the study was to investigate the relationship between omentin-1 and incident myocardial infarction (MI) and stroke.
Source: Atherosclerosis - June 1, 2016 Category: Cardiology Authors: Juliane Menzel, Romina di Giuseppe, Ronald Biemann, Clemens Wittenbecher, Krasimira Aleksandrova, Tobias Pischon, Andreas Fritsche, Matthias B. Schulze, Heiner Boeing, Berend Isermann, Cornelia Weikert Source Type: research

Metabolic health is more closely associated with prevalence of cardiovascular diseases or stroke than obesity: A cross-sectional study in Korean populations
Abstract: Mounting evidence suggests that not all obese subjects are at increased cardiovascular risk. However, the relationship between the metabolically healthy obese (MHO) phenotype and cardiovascular diseases (CVDs) or stroke remains unclear. Therefore, we retrospectively investigated the prevalence of CVDs or stroke according to metabolic health with obese. We studied 3695 subjects (40–85 years) from the Fifth Korean National Health and Nutrition Examination Survey. Participants were divided into 2 groups and 6 subgroups based on the body mass index (BMI) and metabolic syndrome (MetS) components: healthy (exhibitin...
Source: Medicine - June 1, 2016 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

The Relationship between Metabolically Obese Non-Obese Weight and Stroke: The Korea National Health and Nutrition Examination Survey
This study aimed to compare the prevalence of stroke in MONW and MHO individuals. MethodsA total of 25,744 subjects aged ≥40 years were selected from the 2007–2014 Korean National Health and Nutrition Examination Survey. MetS was defined using 2001 National Cholesterol Education Program/Adult Treatment Panel III and 2005 American Heart Association/National Heart, Lung, and Blood Institute criteria. Non-obese weigh t and obesity were defined as a body mass index (BMI)
Source: PLoS One - August 4, 2016 Category: Biomedical Science Authors: Young-Gyun Seo Source Type: research

Peripheral biomarkers of stroke: Focus on circulatory microRNAs
This article also reviews research investigating circulatory miRNAs as peripheral biomarkers of stroke.
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - August 9, 2016 Category: Molecular Biology Source Type: research

Sex differences in neuroinflammation and neuroprotection in ischemic stroke
Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke‐related disability. Stroke has dropped to the fifth leading cause of death in men, but remains the third in women. This review discusses sex differences in common stroke risk factors, the efficacy of stroke prevention therapies, acute treatment responses, and post‐stroke recovery in clinical populations. Women have an increased lifetime risk of stroke compared to men, largely due to a s...
Source: Journal of Neuroscience Research - November 6, 2016 Category: Neuroscience Authors: Monica S. Spychala, Pedram Honarpisheh, Louise D. McCullough Tags: Review Source Type: research

Fermented rice bran supplementation mitigates metabolic syndrome in stroke-prone spontaneously hypertensive rats
Previous study shown that enzyme treated-rice bran effectively improved hypertension and glucose intolerance in stroke-prone spontaneously hypertensive rat (SHRSP). However, dual fermentation of rice bran ’s ef...
Source: BMC Complementary and Alternative Medicine - November 8, 2016 Category: Complementary Medicine Authors: Md Alauddin, Hitoshi Shirakawa, Takuya Koseki, Naoko Kijima, Ardiansyah, Slamet Budijanto, Jahidul Islam, Tomoko Goto and Michio Komai Source Type: research

Sex differences in neuroinflammation and neuroprotection in ischemic stroke.
Abstract Stroke is not only a leading cause of mortality and morbidity worldwide it also disproportionally affects women. There are currently over 500,000 more women stroke survivors in the US than men, and elderly women bear the brunt of stroke-related disability. Stroke has dropped to the fifth leading cause of death in men, but remains the third in women. This review discusses sex differences in common stroke risk factors, the efficacy of stroke prevention therapies, acute treatment responses, and post-stroke recovery in clinical populations. Women have an increased lifetime risk of stroke compared to men, larg...
Source: Cell Research - November 23, 2016 Category: Cytology Authors: Spychala MS, Honarpisheh P, McCullough LD Tags: J Neurosci Res Source Type: research

Impaired Collateral Flow Compensation During Chronic Cerebral Hypoperfusion in the Type 2 Diabetic Mice Basic Sciences
Conclusions—Type 2 diabetes mellitus is an additional risk factor for hemodynamic compromise during cerebral hypoperfusion, which may increase the severity and the risk of stroke or transient ischemic attack.
Source: Stroke - November 27, 2016 Category: Neurology Authors: Yasuo Nishijima, Yosuke Akamatsu, Shih Yen Yang, Chih Cheng Lee, Utku Baran, Shaozhen Song, Ruikang K. Wang, Teiji Tominaga, Jialing Liu Tags: Animal Models of Human Disease, Basic Science Research, Ischemia Original Contributions Source Type: research

Gender Differences in Risks of Coronary Heart Disease and Stroke in Patients with Type 2 Diabetes Mellitus and Their Association with Metabolic Syndrome in China.
In conclusion, our findings indicated that Chinese women with T2DM are less susceptible to CHD and stroke than men. Further, MS increases the risk of both these events, highlighting the need for comprehensive metabolic control in T2DM. PMID: 28042294 [PubMed]
Source: International Journal of Endocrinology - January 4, 2017 Category: Endocrinology Tags: Int J Endocrinol Source Type: research