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Stroke in Patients With Aortic Stenosis: The Simvastatin and Ezetimibe in Aortic Stenosis Study Clinical Sciences
Conclusions— In patients with aortic stenosis not prescribed oral anticoagulation, atrial fibrillation, AVR with concomitant coronary artery bypass grafting, and CHA2DS2-VASc score were the major predictors of stroke. Incident stroke was strongly associated with mortality. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00092677.
Source: Stroke - June 23, 2014 Category: Neurology Authors: Greve, A. M., Dalsgaard, M., Bang, C. N., Egstrup, K., Ray, S., Boman, K., Rossebo, A. B., Gohlke-Baerwolf, C., Devereux, R. B., Kober, L., Wachtell, K. Tags: Thrombosis risk factors, CV surgery: valvular disease, Acute Cerebral Infarction Clinical Sciences Source Type: research
Slope in preload recruitable stroke work relationship predicts survival after left ventriculoplasty and mitral repair in patients with idiopathic cardiomyopathy.
CONCLUSIONS: Mw, the slope in the PRSW relationship, may predict survival after LVP and MVP in patients with idiopathic DCM. PMID: 24954287 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - June 18, 2014 Category: Cardiology Authors: Shingu Y, Kubota S, Wakasa S, Ooka T, Kato H, Tachibana T, Matsui Y Tags: J Cardiol Source Type: research
At 5 years, transcatheter aortic valve replacement had similar rates of mortality and stroke as surgical aortic valve replacement in high-risk patients
Commentary on: Kapadia SR, Leon MB, Makkar RR, et al., PARTNER trial investigators. 5-year outcomes of transcatheter aortic valve replacement compared with standard treatment for patients with inoperable aortic stenosis (PARTNER 1): a randomised controlled trial. Lancet 2015;385:2485–91 and Mack MJ, Leon MB, Smith CR, et al., PARTNER 1 trial investigators. 5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER1): a randomised controlled trial. Lancet 2015;385:2477–84. Context When calcific aortic stenosis is as...
Source: Evidence-Based Medicine - November 24, 2015 Category: Internal Medicine Authors: Reardon, M. J., Kleiman, N. S. Tags: Clinical trials (epidemiology), Epidemiologic studies, Drugs: cardiovascular system, Heart failure, Stroke, Interventional cardiology, Valvar diseases Therapeutics/Prevention Source Type: research
A Meta-Analysis of Early Versus Delayed Surgery for Valvular Infective Endocarditis Complicated by Embolic Ischemic Stroke
Conclusions: In patients with valvular IE complicated by ischemic stroke, early surgery is associated with an increased risk of operative mortality, with no observed benefit in 1-year survival.
Source: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery - May 1, 2016 Category: Cardiovascular & Thoracic Surgery Tags: Original Articles Source Type: research
Intermediate-term rates of stroke following cardiac procedures: the Nationwide Readmissions Database (P4.305)
Conclusions:Using a large, nationally representative database of inpatient admissions from 2013, we found that 90-day stroke rates are higher after cardiac procedures compared to non-cardiac procedures and non-surgical admissions. However, these rates are likely lower than previously reported.Disclosure: Dr. Stein has nothing to disclose. Dr. Thaler has nothing to disclose. Dr. Liang has nothing to disclose. Dr. Tuhrim has nothing to disclose. Dr. Dhamoon has nothing to disclose. Dr. Dhamoon has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Stein, L., Thaler, A., Liang, J., Tuhrim, S., Dhamoon, A., Dhamoon, M. Tags: Neuroepidemiology: Cerebrovascular Disease I Source Type: research
Factors associated with non –vitamin K antagonist oral anticoagulants for stroke prevention in patients with new-onset atrial fibrillation: Results from the Outcomes Registry for Better Informed Treatment of Atrial Fibrillation II (ORBIT-AF II)
Conclusions In contemporary clinical practice, up to three-fourths of patients with new-onset AF are now initially treated with a NOAC for stroke prevention. Those selected for NOAC treatment had lower stroke and bleeding risk profiles, were more likely treated by cardiologists, and had higher socioeconomic status. Trial registration clinicaltrials.gov Identifier: NCT01701817
Source: American Heart Journal - April 25, 2017 Category: Cardiology Source Type: research
FDA warns of high stroke, mortality risk with SynCardia TAH-t C2 controller
The FDA on Friday released a letter warning of a higher mortality risk and stroke rate than expected for patients receiving treatment from SynCardia Systems’ Temporary Total Artificial Heart Companion 2 Driver System. Data indicating the higher mortality and stroke rate came from a post-approval study conducted by the company itself, the FDA said. The study indicated that patients treated with the previous generation driver of the device, the Circulatory Support System Console, experienced a lower rate of stroke and mortality compared with the C2. The TAH-t system is designed to function as a bridge to a heart transplant...
Source: Mass Device - August 20, 2018 Category: Medical Devices Authors: Fink Densford Tags: Cardiovascular Clinical Trials Food & Drug Administration (FDA) SynCardia Source Type: news
Perioperative changes of the slope in the preload recruitable stroke work relationship by a single-beat technique after mitral valve surgery in functional mitral regurgitation with non-ischemic dilated cardiomyopathy
ConclusionsThe change of slope was dependent on surgical procedures. In functional mitral regurgitation, the slope may be a more sensitive parameter in reflecting the left ventricular contractile function than the left ventricular ejection fraction.
Source: General Thoracic and Cardiovascular Surgery - June 21, 2019 Category: Cardiovascular & Thoracic Surgery Source Type: research
Flow, Reflected by Stroke Volume Index, is a Risk Marker in High Gradient Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve Replacement
ConclusionsSVi can further characterise patients with HG-AS and may help to identify those who are at increased risk following TAVR.
Source: Canadian Journal of Cardiology - August 30, 2019 Category: Cardiology Source Type: research
Flow, Reflected by Stroke Volume Index, Is a Risk Marker in High-Gradient Aortic Stenosis Patients Undergoing Transcatheter Aortic Valve Replacement
ConclusionsSVi can further characterize patients with HG-AS and may help to identify those who are at increased risk after TAVR.RésuméContexteDes outils sont nécessaires pour dépister les patients exposés à un risque accru à la suite d’un remplacement valvulaire aortique par cathéter (RVAC). Le volume systolique indexé (VSI) est une mesure échocardiographique utilisée dans les cas de sténose aortique à faible gradient. Nous avons vérifié si un faible VSI était un marqueur de risque accru chez les patients présentant une sténose aortique à gradient élevé et avons évalué comment la relation entre le ...
Source: Canadian Journal of Cardiology - December 24, 2019 Category: Cardiology Source Type: research
Percutaneous Mitral Valve Repair for Mitral Regurgitation in High-Risk Patients Results of the EVEREST II Study
BackgroundThe EVEREST II (Endovascular Valve Edge-to-Edge REpair STudy) High-Risk registry and REALISM Continued Access Study High-Risk Arm are prospective registries of patients who received the MitraClip device (Abbott Vascular, Santa Clara, California) for mitral regurgitation (MR) in the United States.ObjectivesThe purpose of this study was to report 12-month outcomes in high-risk patients treated with the percutaneous mitral valve edge-to-edge repair.MethodsPatients with grades 3 to 4+ MR and a surgical mortality risk of ≥12%, based on the Society of Thoracic Surgeons risk calculator or the estimate of a surgeon c...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - July 7, 2014 Category: Cardiology Source Type: research
Improved Functional Status and Quality of Life in Prohibitive Surgical Risk Patients With Degenerative Mitral Regurgitation After Transcatheter Mitral Valve Repair
This study aimed to evaluate treatment of mitral regurgitation (MR) in patients with severe DMR at prohibitive surgical risk undergoing TMVR.MethodsA prohibitive-risk DMR cohort was identified by a multidisciplinary heart team that retrospectively evaluated high-risk DMR patients enrolled in the EVEREST (Endovascular Valve Edge-to-Edge Repair Study) II studies.ResultsA total of 141 high-risk DMR patients were consecutively enrolled; 127 of these patients were retrospectively identified as meeting the definition of prohibitive risk and had 1-year follow-up (median: 1.47 years) available. Patients were elderly (mean age: 8...
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - July 7, 2014 Category: Cardiology Source Type: research
Preoperative Tissue Doppler Imaging-Derived Atrial Conduction Time Can Predict Postoperative Atrial Fibrillation in Patients Undergoing Aortic Valve Replacement for Aortic Valve Stenosis.
Conclusions:The PA-TDI duration was an independent predictor of POAF after AVR for AS. Patients with PA-TDI duration >147 ms should be considered high risk and treated appropriately to improve outcomes. PMID: 25030299 [PubMed - as supplied by publisher]
Source: Circulation Journal - July 15, 2014 Category: Cardiology Authors: Takahashi S, Fujiwara M, Watadani K, Taguchi T, Katayama K, Takasaki T, Kurosaki T, Imai K, Sueda T Tags: Circ J Source Type: research
Perioperative risk of major non-cardiac surgery in patients with severe aortic stenosis: a reappraisal in contemporary practice
Conclusion Severe aortic stenosis is associated with increased risk of MACE. In contemporary practice, perioperative mortality of patients with SAS is lower than previously reported and the difference from controls did not reach statistical significance. Emergency surgery is the strongest predictor of post-operative death. These results have implications for perioperative risk assessment and management strategies in patients with SAS.
Source: European Heart Journal - September 14, 2014 Category: Cardiology Authors: Tashiro, T., Pislaru, S. V., Blustin, J. M., Nkomo, V. T., Abel, M. D., Scott, C. G., Pellikka, P. A. Tags: Valvular heart disease Source Type: research
Influence of percutaneous mitral valve repair using the MitraClip® system on renal function in patients with severe mitral regurgitation
Conclusion: Successful PMVR was associated with an improvement in renal function. The improvement in renal function was associated with the extent of MR reduction and pre‐existing kidney dysfunction. Our data emphasize the relevance of PVMR to stabilize the cardiorenal axis in patients with severe mitral regurgitation. © 2014 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - October 17, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Tienush Rassaf, Jan Balzer, Christos Rammos, Tobias Zeus, Katharina Hellhammer, Silke van Hall, Rabea Wagstaff, Malte Kelm Tags: Original Studies Source Type: research
P113 * Clinical outcomes following double and triple valve surgery in Hong Kong
Conclusion: Patient requiring double and triple valve surgeries represent a heterogeneous and complex group of patients. They are a significant portion of patients undergoing valve surgery in our Institution. Outcomes in comparison to pre-operative risk scores and International Databases are satisfactory.
Source: European Journal of Heart Failure Supplements - February 23, 2012 Category: Cardiology Authors: Wong, H. L., Ng, S. H., Kwok, W. T., Yeung, C. L., Yu, S. Y., Wan, Y. P., Wan, S., Underwood, M. J., Bai, W. J., Li, H., Tang, H., Wang, H., Rao, L., Li, H., Bai, W. J., Chen, Y., Tang, H., Peng, Y., Rao, L., Park, Y. H., Han, D. C., Sohn, C. B., Kim, J. Tags: Valvular Heart Disease Source Type: research
Short-Term Results of Transapical Transcatheter Mitral Valve Implantation for Mitral Regurgitation
ConclusionsTransapical transcatheter mitral valve implantation is technically feasible and can be performed safely. Early hemodynamic performance of the prosthesis was excellent. Transcatheter mitral valve implantation may become an important treatment option for patients with severe MR who are at high operative risk.
Source: Journal of the American College of Cardiology: Cardiovascular Interventions - October 20, 2014 Category: Cardiology Source Type: research
Importance of Exercise Capacity in Predicting Outcomes and Determining Optimal Timing of Surgery in Significant Primary Mitral Regurgitation Valvular Heart Disease
Conclusion In patients with primary MR that underwent exercise echocardiography followed by MV surgery, lower achieved metabolic equivalents were associated with worse long-term outcomes. In those with preserved exercise capacity, delaying MV surgery by ≥1 year did not adversely affect outcomes.
Source: JAHA:Journal of the American Heart Association - September 11, 2014 Category: Cardiology Authors: Naji, P., Griffin, B. P., Barr, T., Asfahan, F., Gillinov, A. M., Grimm, R. A., Rodriguez, L. L., Mihaljevic, T., Stewart, W. J., Desai, M. Y. Tags: Valvular Heart Disease Source Type: research
089 * innominate artery cannulation for proximal aortic surgery: outcomes and neurologic events in 263 patients
Conclusion: Innominate artery cannulation can be performed safely and poses a low risk of neurologic events in procedures requiring hypothermic circulatory arrest. This artery may be considered the optimal perfusion site for delivering ACP.
Source: Interactive CardioVascular and Thoracic Surgery - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Preventza, O., Garcia, A., Tuluca, A., Henry, M., Bakaeen, F., Omer, S., Cornwell, L., Coselli, J. S. Tags: Part II: Cannulation issues in aortic surgery: Doing things right or doing the right things Source Type: research
224 * what is the best surgical strategy for aortic disease in redo scenarios? a comparison between traditional aortic valve replacement and transapical transcatheter aortic valve implantation from two real-world multicentre surgical registries
Conclusion: Outcome differences between RAVR and TaTAVI in redo scenarios reflect methodological differences and different baseline risk-profiles. Propensity-matched patients show comparable outcome data, which slightly favour TaTAVI.
Source: Interactive CardioVascular and Thoracic Surgery - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Onorati, F. E., D'Onofrio, A., Gerosa, G., Faggian, G. Tags: Transcatheter aortic valve implantation: The treatment of choice Source Type: research
335 * transaortic transcatheter aortic valve implantation: experience from the first multicentre, multinational prospective registry (route)
Conclusion: The preliminary results of this landmark registry provide important information on the procedural success rates and early mortality in patients undergoing Tao-TAVI in a large cohort.
Source: Interactive CardioVascular and Thoracic Surgery - September 23, 2014 Category: Cardiovascular & Thoracic Surgery Authors: Romano, M., Bramlage, P., Bonaros, N., Jagielak, D., Cocchieri, R., Heinz, A., Bapat, V. N. Tags: Late Breakers I Source Type: research
This year's top 10 advances in cardiovascular disease
Progress in the fight against heart disease and stroke came on many fronts during 2014, from novel drugs and procedures to improvements and newfound benefits from existing treatments. In the December 2014 Harvard Heart Letter, Editor in Chief Dr. Deepak L. Bhatt selected 10 of the most important advances. New drugs cut cholesterol levels by half. A new class of drugs, given by injection just once or twice a month, can slash harmful LDL cholesterol levels by about 50%. Studies are under way to see if any of these experimental agents, called PCSK9 inhibitors, prevent heart attacks or improve heart disease survival. Replacing...
Source: New Harvard Health Information - November 24, 2014 Category: Consumer Health News Source Type: news
Postoperative Atrial Fibrillation After Thoracic Aortic Surgery
Conclusions Several risk factors contribute to the incidence of POAF after thoracic aortic surgery. We found that POAF significantly increased 30-day operative mortality (p < 0.0001). Our findings can be used to develop a risk stratification system for the prediction of POAF.
Source: The Annals of Thoracic Surgery - December 30, 2014 Category: Cardiovascular & Thoracic Surgery Source Type: research
Mid-term results of aortic valve surgery in redo scenarios in the current practice: results from the multicentre European RECORD (REdo Cardiac Operation Research Database) initiative ADULT CARDIAC
CONCLUSIONS RAVR achieves overall satisfactory results. Baseline risk factors and perioperative complications strongly affect outcomes and mandate improvements in perioperative management. New emerging strategies might be considered in selected high-risk cases.
Source: European Journal of Cardio-Thoracic Surgery - January 7, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Onorati, F., Biancari, F., De Feo, M., Mariscalco, G., Messina, A., Santarpino, G., Santini, F., Beghi, C., Nappi, G., Troise, G., Fischlein, T., Passerone, G., Heikkinen, J., Faggian, G. Tags: Basic research vascular ADULT CARDIAC Source Type: research
Aortic infective endocarditis: Value of surgery. About 48 cases.
CONCLUSION: The prognosis of infective endocarditis of the aortic valve is severe due to the fast progression to heart failure. Early medical and surgical approach provides good results on morbidity and mortality in the short- and mid-terms. PMID: 25813653 [PubMed - as supplied by publisher]
Source: Annales de Cardiologie et d'Angeiologie - March 23, 2015 Category: Cardiology Authors: Tribak M, Konaté M, Elhassani A, Mahfoudi L, Jaabari I, Elkenassi F, Boutayeb A, Lachhab F, Filal J, Maghraoui A, Bensouda A, Marmade L, Moughil S Tags: Ann Cardiol Angeiol (Paris) Source Type: research
Patients’ Time in Therapeutic Range on Warfarin Among U.S. Atrial Fibrillation Patients: Results from ORBIT-AF Registry
Conclusions Among AF patients in US clinical practices, TTR on warfarin is suboptimal and those at highest predicted risks for stroke and bleeding were least likely to be in therapeutic range.
Source: American Heart Journal - April 3, 2015 Category: Cardiology Source Type: research
CHADS2 and CHA2DS2-VASc Scoring Systems for Predicting Atrial Fibrillation following Cardiac Valve Surgery
by Liang Yin, Xinyu Ling, Yufeng Zhang, Hua Shen, Jie Min, Wang Xi, Jing Wang, Zhinong Wang Objective Clinical use of CHADS2 and CHA2DS2-VASc scoring systems for predicting AF following cardiac surgery have been reported in previous studies and demonstrated well-validated predictive value. We sought to investigate whether the two scoring systems are effective for predicting new-onset of AF following cardiac valve surgery and to demonstrate its potential utility of clinical assessment. Methods Medical records of all patients underwent cardiac valve surgeries during the period of January 2003 and December 2013 without preope...
Source: PLoS One - April 7, 2015 Category: Biomedical Science Authors: Liang Yin et al. Source Type: research
Patients’ time in therapeutic range on warfarin among US patients with atrial fibrillation: Results from ORBIT-AF registry
Conclusions Among patients with AF in US clinical practices, TTR on warfarin is suboptimal, and those at highest predicted risks for stroke and bleeding were least likely to be in therapeutic range.
Source: American Heart Journal - April 23, 2015 Category: Cardiology Source Type: research
Characteristics, complications, and gaps in evidence-based interventions in rheumatic heart disease: the Global Rheumatic Heart Disease Registry (the REMEDY study)
Conclusion Rheumatic heart disease patients were young, predominantly female, and had high prevalence of major cardiovascular complications. There is suboptimal utilization of secondary antibiotic prophylaxis, oral anti-coagulation, and contraception, and variations in the use of percutaneous and surgical interventions by country income level.
Source: European Heart Journal - May 7, 2015 Category: Cardiology Authors: Zuhlke, L., Engel, M. E., Karthikeyan, G., Rangarajan, S., Mackie, P., Cupido, B., Mauff, K., Islam, S., Joachim, A., Daniels, R., Francis, V., Ogendo, S., Gitura, B., Mondo, C., Okello, E., Lwabi, P., Al-Kebsi, M. M., Hugo-Hamman, C., Sheta, S. S., Haile Tags: Valvular heart disease Source Type: research
What is the best approach in a patient with a failed aortic bioprosthetic valve: transcatheter aortic valve replacement or redo aortic valve replacement?
A best evidence topic in cardiac surgery was written according to a structured protocol. The question addressed was whether transcatheter aortic valve-in-valve replacement (viv-TAVR) or redo aortic valve replacement (rAVR) is the best strategy in a patient with a degenerative bioprosthetic aortic valve. Altogether, 162 papers were found using the reported search, of which 12 represented the best evidence to answer the question. The authors, journal, date, country of publication, patient group, study type, outcomes and results of papers are tabulated. The results of the studies provided interesting results. All the studies ...
Source: Interactive CardioVascular and Thoracic Surgery - May 28, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Tourmousoglou, C., Rao, V., Lalos, S., Dougenis, D. Tags: Lung - cancer, Trachea and bronchi, Congestive Heart Failure, Transplantation - heart, Valve disease, Vascular malformations Adult Cardiac Source Type: research
Hemiarch and Total Arch Surgery in Patients With Previous Repair of Acute Type I Aortic Dissection
Conclusions In patients with previous acute type I aortic dissection repair, hemiarch and total arch operations have respectable morbidity and survival rates. Congestive heart failure predicts operative death, long-term mortality, and our adverse event endpoint. Cardiopulmonary bypass time predicts operative mortality, and female sex and circulatory arrest time predict long-term mortality.
Source: The Annals of Thoracic Surgery - June 23, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research
Hemiarch and Total Arch Surgery in Patients With Previous Repair of Acute Type I Aortic Dissection.
CONCLUSIONS: In patients with previous acute type I aortic dissection repair, hemiarch and total arch operations have respectable morbidity and survival rates. Congestive heart failure predicts operative death, long-term mortality, and our adverse event endpoint. Cardiopulmonary bypass time predicts operative mortality, and female sex and circulatory arrest time predict long-term mortality. PMID: 26116478 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - June 23, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Preventza O, Price MD, Simpson KH, Cooley DA, Pocock E, de la Cruz KI, Green SY, LeMaire SA, Rosengart TK, Coselli JS Tags: Ann Thorac Surg Source Type: research
Clinical Presentation of Native Mitral Valve Infective Endocarditis Determines Long‐Term Outcome after Surgery
ConclusionsLong‐term survival after surgery for native mitral valve IE was independently influenced by the presence of preoperative embolic stroke, congestive heart failure or uncontrolled bacteremia alone, or in combination.
Source: Journal of Cardiac Surgery - June 1, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Sigurdur Ragnarsson, Johan Sjögren, Martin Stagmo, Per Wierup, Shahab Nozohoor Tags: Original Article Source Type: research
Transapical and Transaortic Transcatheter Aortic Valve Replacement in the United States
Conclusions Patients undergoing TAo TAVR are older, more likely female, and have significantly higher STS predicted risk of mortality scores than patients operated on by TA access. There were no risk-adjusted differences between TA and TAo access in mortality, stroke, or readmission rates as long as 1 year after TAVR.
Source: The Annals of Thoracic Surgery - July 30, 2015 Category: Cardiovascular & Thoracic Surgery Source Type: research
Transapical and Transaortic Transcatheter Aortic Valve Replacement in the United States.
CONCLUSIONS: Patients undergoing TAo TAVR are older, more likely female, and have significantly higher STS predicted risk of mortality scores than patients operated on by TA access. There were no risk-adjusted differences between TA and TAo access in mortality, stroke, or readmission rates as long as 1 year after TAVR. PMID: 26233276 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - July 29, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Thourani VH, Jensen HA, Babaliaros V, Suri R, Vemulapalli S, Dai D, Brennan JM, Rumsfeld J, Edwards F, Tuzcu EM, Svensson L, Szeto WY, Herrmann H, Kirtane AJ, Kodali S, Cohen DJ, Lerakis S, Devireddy C, Sarin E, Carroll J, Holmes D, Grover FL, Williams M, Tags: Ann Thorac Surg Source Type: research
Aortic Stenosis Valve Replacement or Valve Implantation? ∗
In this issue of the Journal, Tamburino et al. (1) have published a study that compares the clinical outcomes of aortic valve replacement (AVR) with transcatheter aortic valve replacement (TAVR) at 1 year from the OBSERVANT (Observational Study of Effectiveness of SAVR–TAVR Procedures for Severe Aortic Stenosis Treatment) registry, which investigates the management of aortic stenosis (AS) in 93 institutions in Italy. The registry had 7,618 patients with AS (5,707 treated with AVR and 1,991 with TAVR). The investigators excluded 2,150 patients because of combined procedures, porcelain aortas, “hostile thorax,” nonfem...
Source: Journal of the American College of Cardiology - August 10, 2015 Category: Cardiology Source Type: research
Study: Edwards’ Sapien and Medtronic’s CoreValve outcomes are similar
A new study published in the Journal of the American College of Cardiology found that patients treated with Edwards Lifesciences‘s (NYSE:EW) and Medtronic‘s (NYSE:MDT) CoreValve showed similar results after 1 year. The 241-patient trial examined high-risk patients with symptomatic severe aortic stenosis 1 year after being treated with either Edwards’s Sapien balloon expanding or Medtronic’ self-expanding transcatheter heart valve. The rates of all-cause death and cardiovascular death were not statistically different between the groups, with a 3-5% difference between the 2 devices, according to the ...
Source: Mass Device - August 11, 2015 Category: Medical Equipment Authors: Fink Densford Tags: Cardiac Implants Cardiovascular Clinical Trials Edwards Lifesciences medtronic Source Type: news
Causes of death and predictors of survival after aortic valve replacement in low flow vs. normal flow severe aortic stenosis with preserved ejection fraction
Conclusion Reduced SVI is associated with higher cardiac mortality after AVR. CHF is the predominant cause of cardiac mortality after AVR in patients with LF, suggesting the presence of persistent myocardial impairment in this population.
Source: European Journal of Echocardiography - October 17, 2015 Category: Cardiology Authors: Eleid, M. F., Michelena, H. I., Nkomo, V. T., Nishimura, R. A., Malouf, J. F., Scott, C. G., Pellikka, P. A. Tags: ORIGINAL ARTICLES Source Type: research
Raised red cell distribution width as a prognostic marker in aortic valve replacement surgery.
CONCLUSIONS: Elevated RDW is associated with a worse outcome following AVR, independent of RBC. PMID: 26502945 [PubMed - as supplied by publisher]
Source: Polish Heart Journal - October 27, 2015 Category: Cardiology Authors: Duchnowski P, Szymański P, Orłowska-Baranowska E, Kuśmierczyk M, Hryniewiecki T Tags: Kardiol Pol Source Type: research
Aortic regurgitation following transcatheter aortic valve replacement: Impact of preprocedural left ventricular diastolic filling patterns on late clinical outcomes
ConclusionsPreprocedural impairment of LV filling, reflected by short DT, portends an adverse prognosis in TAVR patients who develop ARpost independently of other clinical and echocardiocardigraphic measures including AS severity and systolic LV function. © 2015 Wiley Periodicals, Inc.
Source: Catheterization and Cardiovascular Interventions - November 3, 2015 Category: Cardiovascular & Thoracic Surgery Authors: Amir Halkin, Arie Steinvil, Galit Aviram, Simon Biner, Shmuel Banai, Gad Keren, Ariel Finkelstein, Yan Topilsky Tags: Valvular and Structural Heart Diseases Source Type: research
Preoperative Tissue Doppler Imaging-Derived Atrial Conduction Time Predicts Postoperative Atrial Fibrillation in Patients Undergoing Mitral Valve Surgery for Mitral Valve Regurgitation.
CONCLUSIONS: PA-TDI duration was an independent predictor of POAF after MVS. Patients with PA-TDI duration >159.4 ms should be considered high risk and treated appropriately to improve outcome. PMID: 26538374 [PubMed - as supplied by publisher]
Source: Circulation Journal - November 4, 2015 Category: Cardiology Authors: Takahashi S, Katayama K, Watanabe M, Kodama H, Taguchi T, Kurosaki T, Imai K, Sueda T Tags: Circ J Source Type: research
Giant Thrombus Formation Immediately After Mitral Valvuloplasty.
We report the case of a 65-year-old woman with severe mitral regurgitation (MR) and AF in whom a giant thrombus formed almost immediately after mitral and tricuspid valvuloplasty and concurrent LAA resection. No atrial thrombus or spontaneous echo contrast (SEC) was detected by TEE before the surgery. However, a giant intramural thrombus was detected in the left atrium 7 days after surgery. It was thought that the atrial dysfunction as well as the change in morphology of the left atrium resulting from the severe MR complicated by AF and congestive heart failure produced a thrombotic substrate. This case suggests that caref...
Source: International Heart Journal - November 10, 2015 Category: Cardiology Tags: Int Heart J Source Type: research
The Adult with Repaired Coarctation: Need for Lifelong Surveillance
Discussion of these long-term complications is the focus of this article.
Source: Canadian Journal of Cardiology - January 21, 2016 Category: Cardiology Source Type: research
Dabigatran Versus Warfarin After Bioprosthesis Valve Replacement for the Management of Atrial Fibrillation Postoperatively: DAWA Pilot Study
Conclusions The use of dabigatran appears to be similar to warfarin in preventing the formation of intracardiac thrombus. Trial Registration Clinicaltrials.gov NCT01868243.
Source: Drugs in R&D - February 18, 2016 Category: Drugs & Pharmacology Source Type: research
Transcatheter treatment of severe tricuspid regurgitation with the MitraClip system
Conclusions Transcatheter tricuspid valve repair by use of interventional edge-to-edge repair with the MitraClip system was feasible, and safe in three consecutive patients. Reduction of tricuspid insufficiency associates with relief of clinical symptoms for right heart failure. This strategy seems a promising treatment option for patients at prohibitive surgical risk.
Source: European Heart Journal - March 7, 2016 Category: Cardiology Authors: Hammerstingl, C., Schueler, R., Malasa, M., Werner, N., Nickenig, G. Tags: EHJ BRIEF COMMUNICATION Source Type: research
Repeated Aortic Balloon Valvuloplasty in Elderly Patients With Aortic Stenosis Who Are Not Candidates for Definitive Treatment.
CONCLUSION: BAV is associated with poor long-term clinical outcome. However, when no other therapeutic options are feasible, a strategy of repeated palliative BAV appears to be safe and is potentially associated with improved clinical outcomes. PMID: 26378413 [PubMed - in process]
Source: The Journal of Invasive Cardiology - March 11, 2016 Category: Cardiology Tags: J Invasive Cardiol Source Type: research
Surgical ventricular restoration plus mitral valve repair in patients with ischaemic heart failure: risk factors for early and mid-term outcomes ADULT CARDIAC
CONCLUSIONS MV repair combined with SVR is a complex and challenging procedure that can be performed with acceptable early and mid-term results. Interestingly, angina features predict both early and late outcome, with unstable angina at the time of surgery being a predictor of poor early outcome and the absence of angina at surgery, a predictor of favourable outcome at mid-term follow-up.
Source: European Journal of Cardio-Thoracic Surgery - March 16, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Castelvecchio, S., Parolari, A., Garatti, A., Gagliardotto, P., Mossuto, E., Canziani, A., Menicanti, L. Tags: Electrophysiology - arrhythmias, Molecular biology, Basic research vascular ADULT CARDIAC Source Type: research
Mitral valve repair using robotic technology: Safe, effective, and durable
The most recent American College of Cardiology/American Heart Association heart valve guidelines recommend that prompt surgical correction of severe degenerative mitral valve regurgitation, ideally mitral valve repair, should be performed to decrease the risks of long-term mortality and heart failure risks associated with this condition. Mitral valve repair performed using a minimally invasive robotic approach can now be successfully carried out in nearly all cases of degenerative disease with very low risks of stroke or death.
Source: The Journal of Thoracic and Cardiovascular Surgery - February 22, 2016 Category: Cardiovascular & Thoracic Surgery Authors: Rakesh M. Suri, Joseph A. Dearani, Tomislav Mihaljevic, W. Randolph Chitwood, Douglas A. Murphy, Alfredo Trento, Hoda Javadikasgari, Harold M. Burkhart, Wiley L. Nifong, Richard C. Daly, A. Marc Gillinov Tags: Expert opinion Source Type: research
Validated Risk Score for Predicting 6-Month Mortality in Infective Endocarditis Valvular Heart Disease
Conclusions Six-month mortality after IE is 25% and is predicted by host factors, IE characteristics, and IE complications. Surgery during the index hospitalization is associated with lower mortality but is performed less frequently in the highest risk patients. A simplified risk model may be used to identify specific risk subgroups in IE.
Source: JAHA:Journal of the American Heart Association - April 17, 2016 Category: Cardiology Authors: Park, L. P., Chu, V. H., Peterson, G., Skoutelis, A., Lejko-Zupa, T., Bouza, E., Tattevin, P., Habib, G., Tan, R., Gonzalez, J., Altclas, J., Edathodu, J., Fortes, C. Q., Siciliano, R. F., Pachirat, O., Kanj, S., Wang, A., for the International Collaborat Tags: Clinical Studies, Infectious Endocarditis, Valvular Heart Disease, Mortality/Survival Source Type: research
Prediction of Postoperative Cardiac Surgery Outcomes With a Novel Score: R2CHADS2
Conclusion The R2CHADS2 score estimates postoperative events with acceptable accuracy and if validated can be used as a simple preoperative drisk tool calculator.
Source: American Heart Journal - April 29, 2016 Category: Cardiology Source Type: research