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Total 7395 results found since Jan 2013.

Use of Warfarin at Discharge Among Acute Ischemic Stroke Patients With Nonvalvular Atrial Fibrillation in China Clinical Sciences
Conclusions— The rate of warfarin use remains low among patients with ischemic stroke and known nonvalvular atrial fibrillation in China. Hospital size and academic status together with patient age, heart failure, heavy alcohol drinking, international normalized ratio in hospital, and stroke severity on admission were each independently associated with the use of warfarin at discharge. There is much room for improvement for secondary stroke prevention in nonvalvular atrial fibrillation patients in China.
Source: Stroke - January 25, 2016 Category: Neurology Authors: Yang, X., Li, Z., Zhao, X., Wang, C., Liu, L., Wang, C., Pan, Y., Li, H., Wang, D., Hart, R. G., Wang, Y., Wang, Y., on behalf of the China National Stroke Registry II Investigators Tags: Anticoagulants, Treatment, Quality and Outcomes, Ischemic Stroke Clinical Sciences Source Type: research

Adiposity, Adipokines, and Risk of Incident Stroke in Older Men Original Contributions
Conclusions— Conventional adiposity measures were not associated with increased stroke risk in older men. However, leptin (a good marker of percent fat mass), but not adiponectin, predicted stroke, suggesting a link between fat mass and stroke risk.
Source: Stroke - December 24, 2012 Category: Neurology Authors: Wannamethee, S. G., Shaper, A. G., Whincup, P. H., Lennon, L., Sattar, N. Tags: Acute Cerebral Infarction, Risk Factors for Stroke, Epidemiology Original Contributions Source Type: research

Amino Terminal Pro-B-Type Natriuretic Peptide, Secondary Stroke Prevention, and Choice of Antithrombotic Therapy Clinical Sciences
Conclusions— For secondary stroke prevention, elevated NT-proBNP concentrations may identify a subgroup of ischemic stroke patients without known atrial fibrillation, about 5% based on the current study, who may benefit more from anticoagulants than antiplatelet agents. Clinical Trial Registration— This trial was not registered because enrollment began before 2005.
Source: Stroke - February 25, 2013 Category: Neurology Authors: Longstreth, W. T., Kronmal, R. A., Thompson, J. L. P., Christenson, R. H., Levine, S. R., Gross, R., Brey, R. L., Buchsbaum, R., Elkind, M. S. V., Tirschwell, D. L., Seliger, S. L., Mohr, J. P., deFilippi, C. R. Tags: Primary and Secondary Stroke Prevention Clinical Sciences Source Type: research

Protective Effect of Time Spent Walking on Risk of Stroke in Older Men Clinical Sciences
Conclusions— Time spent walking was associated with reduced risk of onset of stroke in dose–response fashion, independent of walking pace. Walking could form an important part of stroke-prevention strategies in older people.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Jefferis, B. J., Whincup, P. H., Papacosta, O., Wannamethee, S. G. Tags: Behavioral Changes and Stroke, Epidemiology, Coagulation and fibronolysis Clinical Sciences Source Type: research

Quality of Care and Outcomes for In-Hospital Ischemic Stroke: Findings From the National Get With The Guidelines-Stroke Clinical Sciences
Conclusions— Compared with community-onset ischemic stroke, patients with in-hospital stroke experienced more severe strokes, received lower adherence to process-based quality measures, and had worse outcomes. These findings suggest there is an important opportunity for targeted quality improvement efforts for patients with in-hospital stroke.
Source: Stroke - December 23, 2013 Category: Neurology Authors: Cumbler, E., Wald, H., Bhatt, D. L., Cox, M., Xian, Y., Reeves, M., Smith, E. E., Schwamm, L., Fonarow, G. C. Tags: Health policy and outcome research, Emergency treatment of Stroke, Risk Factors for Stroke, Thrombolysis Clinical Sciences Source Type: research

Comparison of Clinical Risk Stratification for Predicting Stroke and Thromboembolism in Atrial Fibrillation Clinical Sciences
Conclusions— A direct comparison of 9 risk schemes reveals no profound differences in risk stratification accuracy for high-risk patients. Accurate prediction of low-risk patients is perhaps more valuable in determining those unlikely to benefit from oral anticoagulation therapy. Among our cohort, CHA2DS2-VASc performed best in this purpose.
Source: Stroke - January 27, 2014 Category: Neurology Authors: Aakre, C. A., McLeod, C. J., Cha, S. S., Tsang, T. S. M., Lip, G. Y. H., Gersh, B. J. Tags: Cerebrovascular disease/stroke, Arrhythmias, clinical electrophysiology, drugs, Embolic stroke, Anticoagulants Clinical Sciences Source Type: research

N-Terminal Pro-B-type Natriuretic Peptide and Stroke Risk: The Reasons for Geographic and Racial Differences in Stroke Cohort Clinical Sciences
Conclusions— NT-proBNP was a major independent risk marker for stroke. Considering this and other data for stroke, coronary disease, and atrial fibrillation, the clinical use of NT-proBNP measurement in primary prevention settings should be considered.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Cushman, M., Judd, S. E., Howard, V. J., Kissela, B., Gutierrez, O. M., Jenny, N. S., Ahmed, A., Thacker, E. L., Zakai, N. A. Tags: Acute Cerebral Infarction, Embolic stroke, Epidemiology Clinical Sciences Source Type: research

Rivaroxaban for Stroke Prevention in East Asian Patients From the ROCKET AF Trial Clinical Sciences
Conclusions— Observed relative efficacy and safety of rivaroxaban versus warfarin were similar among patients within and outside East Asia. Rivaroxaban, 20 mg once daily, is an alternative to warfarin for stroke prevention in East Asians with nonvalvular atrial fibrillation. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00123456.
Source: Stroke - May 27, 2014 Category: Neurology Authors: Wong, K. S. L., Hu, D. Y., Oomman, A., Tan, R.-S., Patel, M. R., Singer, D. E., Breithardt, G., Mahaffey, K. W., Becker, R. C., Califf, R., Fox, K. A. A., Berkowitz, S. D., Hacke, W., Hankey, G. J., on behalf of The Executive Steering Committee and the RO Tags: Other anticoagulants, Embolic stroke, Anticoagulants Clinical Sciences Source Type: research

High Prevalence of Atrial Fibrillation Among Patients With Ischemic Stroke Clinical Sciences
Conclusions— Access to nationwide register data shows that AF is more common among patients with ischemic stroke than those previously reported. Few patients with stroke and AF had anticoagulant treatment before the event, and few got it after the event. CHA2DS2-VASc could be a useful monitoring tool to intensify efforts to diagnose AF among patients with cryptogenic stroke.
Source: Stroke - August 25, 2014 Category: Neurology Authors: Friberg, L., Rosenqvist, M., Lindgren, A., Terent, A., Norrving, B., Asplund, K. Tags: Coumarins, Arrhythmias, clinical electrophysiology, drugs, Embolic stroke, Epidemiology Clinical Sciences Source Type: research

Predictors of Finding Occult Atrial Fibrillation After Cryptogenic Stroke Clinical Sciences
Conclusions— Mobile cardiac outpatient telemetry detects AF in a substantial proportion of cryptogenic stroke patients. Age >60 years and radiographic evidence of prior cortical or cerebellar infarction are robust indicators of occult AF. Patients with neither had a low prevalence of AF.
Source: Stroke - April 27, 2015 Category: Neurology Authors: Favilla, C. G., Ingala, E., Jara, J., Fessler, E., Cucchiara, B., Messe, S. R., Mullen, M. T., Prasad, A., Siegler, J., Hutchinson, M. D., Kasner, S. E. Tags: Acute Cerebral Infarction, Arrhythmias, clinical electrophysiology, drugs, Embolic stroke, Pathology of Stroke, Risk Factors for Stroke Clinical Sciences Source Type: research

Left Atrial Enlargement and Stroke Recurrence: The Northern Manhattan Stroke Study Clinical Sciences
Conclusion— Moderate to severe LAE was an independent marker of recurrent cardioembolic or cryptogenic stroke in a multiethnic cohort of ischemic stroke patients. Further research is needed to determine whether anticoagulant use may reduce risk of recurrence in ischemic stroke patients with moderate to severe LAE.
Source: Stroke - May 22, 2015 Category: Neurology Authors: Yaghi, S., Moon, Y. P., Mora-McLaughlin, C., Willey, J. Z., Cheung, K., Di Tullio, M. R., Homma, S., Kamel, H., Sacco, R. L., Elkind, M. S. V. Tags: Embolic stroke Clinical Sciences Source Type: research

Patients With Ischemic Stroke and Incident Atrial Fibrillation: A Nationwide Cohort Study Clinical Sciences
Conclusions— Ischemic stroke was associated with a substantially increased risk of incident AF, particularly among individuals with higher CHADS2 or CHA2DS2-VASc scores. These risk scores seem to be simple tools for identifying patients at higher risk of incident AF after ischemic stroke.
Source: Stroke - August 24, 2015 Category: Neurology Authors: Fauchier, L., Clementy, N., Pelade, C., Collignon, C., Nicolle, E., Lip, G. Y. H. Tags: Arrhythmias, clinical electrophysiology, drugs, Embolic stroke Clinical Sciences Source Type: research

Electrocardiographic Left Atrial Abnormality and Risk of Stroke: Northern Manhattan Study Clinical Sciences
Conclusions— ECG-defined left atrial abnormality was associated with incident cryptogenic or cardioembolic stroke independently of the presence of AF, suggesting atrial thromboembolism may occur without recognized AF.
Source: Stroke - October 26, 2015 Category: Neurology Authors: Kamel, H., Hunter, M., Moon, Y. P., Yaghi, S., Cheung, K., Di Tullio, M. R., Okin, P. M., Sacco, R. L., Soliman, E. Z., Elkind, M. S. V. Tags: Electrocardiology, Echocardiography, Arrhythmias, clinical electrophysiology, drugs, Embolic stroke, Risk Factors for Stroke Clinical Sciences Source Type: research

Rates and Determinants of 5-Year Outcomes After Atrial Fibrillation-Related Stroke: A Population Study Clinical Sciences
Conclusions— AF-stroke is associated with considerable long-term morbidity, fatality, stroke recurrence, and nursing home requirement. Adequately resourced national AF strategies to improve AF detection and prevention are needed.
Source: Stroke - November 23, 2015 Category: Neurology Authors: Hayden, D. T., Hannon, N., Callaly, E., Ni Chroinin, D., Horgan, G., Kyne, L., Duggan, J., Dolan, E., O'Rourke, K., Williams, D., Murphy, S., Kelly, P. J. Tags: Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research

Stroke and Heart Failure: Clinical Features, Access to Care, and Outcomes
Limited information is known regarding acute ischemic stroke (AIS) and heart failure (HF). The aim of the study was to evaluate clinical characteristics, predisposing factors, and outcomes in AIS with HF.
Source: Journal of Stroke and Cerebrovascular Diseases - February 4, 2016 Category: Neurology Authors: Jitphapa Pongmoragot, Douglas S. Lee, Tai Hwan Park, Jiming Fang, Peter C. Austin, Gustavo Saposnik, Investigators of the Registry of the Canadian Stroke Network, University of Toronto Stroke Program for the Stroke Outcomes Research Canada (SORCan—www.s Source Type: research

Short Leukocyte Telomere Length Is Associated With Cardioembolic Stroke Risk in Patients With Atrial Fibrillation Brief Reports
Conclusions— Telomere shortening is associated with cardioembolic stroke risk in patients with AF. Prospective studies are encouraged to establish the value of LTL to improve prediction tools to categorize cardioembolic stroke risk in AF.
Source: Stroke - February 22, 2016 Category: Neurology Authors: Allende, M., Molina, E., Gonzalez-Porras, J. R., Toledo, E., Lecumberri, R., Hermida, J. Tags: Atrial Fibrillation, Risk Factors, Genetics, Cerebrovascular Disease/Stroke, Ischemic Stroke Brief Reports Source Type: research

Cost-Effectiveness of Oral Anticoagulants for Ischemic Stroke Prophylaxis Among Nonvalvular Atrial Fibrillation Patients Clinical Sciences
Conclusions— All the newer oral anticoagulants compared were more effective than adjusted dosed warfarin. Our model showed that apixaban was the most effective anticoagulant in a general atrial fibrillation population and has an incremental cost-effectiveness ratio <$50 000/QALY. For those with higher stroke risk (CHADS2≥3), dabigatran was the most cost-effective treatment option.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Shah, A., Shewale, A., Hayes, C. J., Martin, B. C. Tags: Anticoagulants, Cost-Effectiveness, Ischemic Stroke Clinical Sciences Source Type: research

Reducing Readmissions After Stroke With a Structured Nurse Practitioner/Registered Nurse Transitional Stroke Program Clinical Sciences
Conclusions— Evaluation in a nurse practitioner–led structured clinic is a model that may reduce readmissions at 30 days for stroke patients discharged home.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Condon, C., Lycan, S., Duncan, P., Bushnell, C. Tags: Cost-Effectiveness, Health Services, Quality and Outcomes, Cerebrovascular Disease/Stroke Clinical Sciences Source Type: research

Carotid Atherosclerosis and Stroke in Atrial Fibrillation: The Atherosclerosis Risk in Communities Study Brief Reports
Conclusions— Increased cIMT and presence of carotid plaque are associated with increased risk of ischemic stroke in individuals with AF. Furthermore, they may improve risk prediction of stroke, over and above the CHA2DS2-VASc score.
Source: Stroke - May 22, 2016 Category: Neurology Authors: Bekwelem, W., Jensen, P. N., Norby, F. L., Soliman, E. Z., Agarwal, S. K., Lip, G. Y. H., Pan, W., Folsom, A. R., Longstreth, W. T., Alonso, A., Heckbert, S. R., Chen, L. Y. Tags: Atrial Fibrillation, Risk Factors, Ischemic Stroke, Atherosclerosis Brief Reports Source Type: research

Left Ventricular Ejection Fraction and Risk of Stroke and Cardiac Events in Heart Failure: Data From the Warfarin Versus Aspirin in Reduced Ejection Fraction Trial Clinical Sciences
Conclusions— In patients with systolic HF and sinus rhythm, LVEF is inversely associated with death and its components, whereas an association with stroke exists for very low LVEF values. An interaction with warfarin treatment on stroke risk may exist. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00041938.
Source: Stroke - July 24, 2016 Category: Neurology Authors: Di Tullio, M. R., Qian, M., Thompson, J. L. P., Labovitz, A. J., Mann, D. L., Sacco, R. L., Pullicino, P. M., Freudenberger, R. S., Teerlink, J. R., Graham, S., Lip, G. Y. H., Levin, B., Mohr, J. P., Buchsbaum, R., Estol, C. J., Lok, D. J., Ponikowski, P. Tags: Heart Failure, Echocardiography, Anticoagulants, Ischemic Stroke Clinical Sciences Source Type: research

Risk Stratification for Recurrence and Mortality in Embolic Stroke of Undetermined Source Clinical Sciences
Conclusions— The risk of recurrent ischemic stroke/TIA and death in ESUS is reliably stratified by CHADS2 and CHA2DS2-VASc scores. Compared with the low-risk group, patients in the high-risk CHA2DS2-VASc group have much higher risk of ischemic stroke recurrence/TIA and death, approximately 3-fold and 13-fold, respectively.
Source: Stroke - August 21, 2016 Category: Neurology Authors: Ntaios, G., Vemmos, K., Lip, G. Y. H., Koroboki, E., Manios, E., Vemmou, A., Rodriguez-Campello, A., Cuadrado-Godia, E., Giralt-Steinhauer, E., Arnao, V., Caso, V., Paciaroni, M., Diez-Tejedor, E., Fuentes, B., Perez Lucas, J., Arauz, A., Ameriso, S. F., Tags: Ischemic Stroke Clinical Sciences Source Type: research

Stroke Risk and Mortality in Patients With Ventricular Assist Devices Clinical Sciences
Conclusions—The incidence of stroke after VAD implantation was 8.7% per year, and incident stroke was strongly associated with subsequent in-hospital mortality. Notably, ischemic stroke occurred at nearly twice the rate of hemorrhagic stroke. Women seemed to face a higher risk for hemorrhagic stroke than men.
Source: Stroke - October 23, 2016 Category: Neurology Authors: Parikh, N. S., Cool, J., Karas, M. G., Boehme, A. K., Kamel, H. Tags: Heart Failure, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

Pioglitazone for Secondary Stroke Prevention Clinical Sciences
Conclusions—Pioglitazone reduces recurrent stroke and major vascular events in ischemic stroke patients with insulin resistance, prediabetes, and diabetes mellitus.
Source: Stroke - January 22, 2017 Category: Neurology Authors: Meng Lee, Jeffrey L. Saver, Hung-Wei Liao, Chun-Hsien Lin, Bruce Ovbiagele Tags: Cardiovascular Disease, Diabetes, Type 2, Secondary Prevention, Meta Analysis, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Risk of Stroke in Patients With Heart Failure Clinical Sciences
Conclusions—Heart failure was associated with increased short-term and long-term risk of all stroke subtypes, suggesting that heart failure is a potent and persistent risk factor for ischemic stroke, ICH, and SAH.
Source: Stroke - April 24, 2017 Category: Neurology Authors: Kasper Adelborg, Szimonetta Szepligeti, Jens Sundboll, Erzsebet Horvath–Puho, Victor W. Henderson, Anne Ording, Lars Pedersen, Henrik Toft Sorensen Tags: Heart Failure, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research

CHA2DS2-VASc Score (Congestive Heart Failure, Hypertension, Age >=75 Doubled, Diabetes Mellitus, Prior Stroke or Transient Ischemic Attack Doubled, Vascular Disease, Age 65-74, Female) for Stroke in Asian Patients With Atrial Fibrillation Clinical Sciences
Background and Purpose—The CHA2DS2-VASc stroke score (congestive heart failure, hypertension, age ≥75 (doubled), diabetes mellitus, prior stroke or transient ischemic attack (doubled), vascular disease, age 65–74, female) is used in most guidelines for risk stratification in atrial fibrillation (AF), but most data for this score have been derived in Western populations. Ethnic differences in stroke risk may be present. Our objective was to investigate risk factors for stroke in AF and application of the CHA2DS2-VASc score in an Asian AF population from Korea.Methods—A total of 5855 oral anticoagulant–naive nonval...
Source: Stroke - May 22, 2017 Category: Neurology Authors: Tae-Hoon Kim, Pil-Sung Yang, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y.H. Lip Tags: Arrhythmias, Risk Factors, Ischemic Stroke Original Contributions Source Type: research

CHA2DS2-VASc Score for Identifying Truly Low-Risk Atrial Fibrillation for Stroke Clinical Sciences
Conclusions—The CHA2DS2-VASc score shows good performance in defining truly low-risk Asian patients with atrial fibrillation for stroke compared with CHADS2 and ATRIA scores.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Tae-Hoon Kim, Pil-Sung Yang, Daehoon Kim, Hee Tae Yu, Jae-Sun Uhm, Jong-Youn Kim, Hui-Nam Pak, Moon-Hyoung Lee, Boyoung Joung, Gregory Y.H. Lip Tags: Atrial Fibrillation, Quality and Outcomes, Ischemic Stroke Original Contributions Source Type: research

Serum Galectin-3 and Poor Outcomes Among Patients With Acute Ischemic Stroke Brief Report
Background and Purpose—Elevated galectin-3 has been associated with atherosclerosis and poor outcomes in patients with heart failure. However, it remains unclear whether galectin-3 has any effect on the poor outcomes of ischemic stroke. The aim of the present study was to examine the association between galectin-3 with poor outcomes among patients with acute ischemic stroke.Methods—Serum galectin-3 was measured in 3082 patients with acute ischemic stroke. The primary outcome was a combination of death or major disability (modified Rankin Scale score, ≥3) at 3 months after stroke.Results—Compared with the lowest qua...
Source: Stroke - December 22, 2017 Category: Neurology Authors: Aili Wang, Chongke Zhong, Zhengbao Zhu, Tian Xu, Yanbo Peng, Tan Xu, Hao Peng, Chung-Shiuan Chen, Jinchao Wang, Zhong Ju, Qunwei Li, Deqin Geng, Yingxian Sun, Jianhui Zhang, Xiaodong Yuan, Jing Chen, Yonghong Zhang, Jiang He Tags: Biomarkers, Clinical Studies, Cerebrovascular Disease/Stroke Brief Reports Source Type: research

Serum Hepatocyte Growth Factor Is Probably Associated With 3-Month Prognosis of Acute Ischemic Stroke Clinical Sciences
Background and Purpose—Serum hepatocyte growth factor (HGF) is positively associated with poor prognosis of heart failure and myocardial infarction, and it can also predict the risk of ischemic stroke in population. The goal of this study was to investigate the association between serum HGF and prognosis of ischemic stroke.Methods—A total of 3027 acute ischemic stroke patients were included in this post hoc analysis of the CATIS (China Antihypertensive Trial in Acute Ischemic Stroke). The primary outcome was composite outcome of death or major disability (modified Rankin Scale score ≥3) within 3 months.Results—Afte...
Source: Stroke - January 22, 2018 Category: Neurology Authors: Zhengbao Zhu, Tan Xu, Daoxia Guo, Xinfeng Huangfu, Chongke Zhong, Jingyuan Yang, Aili Wang, Chung-Shiuan Chen, Yanbo Peng, Tian Xu, Jinchao Wang, Yingxian Sun, Hao Peng, Qunwei Li, Zhong Ju, Deqin Geng, Jing Chen, Yonghong Zhang, Jiang He Tags: Biomarkers, Clinical Studies, Epidemiology, Prognosis, Ischemic Stroke Original Contributions Source Type: research

Elevated Plasma D-Dimer Level Is Associated With Short-Term Risk of Ischemic Stroke in Patients With Acute Heart Failure Brief Report
We examined 721 consecutive hospitalized AHF patients with plasma D-dimer level on admission from our prospective registry between January 2013 and May 2016. The study end points were incidence of ischemic stroke during hospitalization and at 30 days after admission.Results—Of the total participants (mean age, 76 years; male, 60%; atrial fibrillation, 54%; mean left ventricular ejection fraction, 38%), in-hospital ischemic stroke occurred in 18 patients (2.5%) during a median hospitalization period of 21 days, and 30-day ischemic stroke occurred in 16 patients (2.2%). Higher D-dimer level on admission was an independent ...
Source: Stroke - June 25, 2018 Category: Neurology Authors: Yasuhiro Hamatani, Toshiyuki Nagai, Michikazu Nakai, Kunihiro Nishimura, Yasuyuki Honda, Hiroki Nakano, Satoshi Honda, Naotsugu Iwakami, Yasuo Sugano, Yasuhide Asaumi, Takeshi Aiba, Teruo Noguchi, Kengo Kusano, Kazunori Toyoda, Satoshi Yasuda, Hiroyuki Yo Tags: Heart Failure, Ischemic Stroke Brief Reports Source Type: research

Outcomes of Thrombolytic Treatment for Acute Ischemic Stroke in Dialysis Dependant Patients in the United States (S02.003)
CONCLUSIONS: The three fold higher odds of in-hospital mortality associated with administration of IV thrombolytics in dialysis dependant patients who present with acute ischemic stroke warrants a careful assessment of risk benefit ratio in this population.Disclosure: Dr. Adil has nothing to disclose. Dr. Adil has nothing to disclose. Dr. Irfan has nothing to disclose. Dr. Chaudhry has nothing to disclose. Dr. ATACH Investigators has nothing to disclose.
Source: Neurology - February 14, 2013 Category: Neurology Authors: Tariq, N., Adil, M., Irfan, M., Chaudhry, S., Qureshi, A. Tags: S02 Acute Stroke Therapy Source Type: research

Anemia is Associated with Poor Outcomes in Patients with Less Severe Ischemic Stroke
Anemia is a known predictor of in-hospital mortality among patients with such vascular conditions as acute myocardial infarction, congestive heart failure, and chronic kidney disease. The role of anemia in patients with acute ischemic stroke is less well understood. We sought to examine the association between anemia at hospital admission and the combined outcome of in-hospital mortality and discharge to hospice in patients with acute ischemic stroke. We evaluated data from a retrospective cohort of consecutive ischemic stroke patients presenting within 48 hours of symptom onset at 5 hospitals between 1998 and 2003. Anemi...
Source: Journal of Stroke and Cerebrovascular Diseases - November 21, 2011 Category: Neurology Authors: Jason J. Sico, John Concato, Carolyn K. Wells, Albert C. Lo, Steven E. Nadeau, Linda S. Williams, Aldo J. Peixoto, Mark Gorman, John L. Boice, Dawn M. Bravata Tags: Original Articles Source Type: research

Left Ventricular Systolic Dysfunction, Heart Failure, and the Risk of Stroke and Systemic Embolism in Patients With Atrial Fibrillation: Insights From the ARISTOTLE Trial Original Articles
Conclusions— Patients with LVSD (with/without HF) had a higher risk of SSE or death (but similar rate of SSE) compared with patients with HF but preserved LV systolic function; both had a greater risk than patients without either HF or LVSD. Apixaban reduced the risk of both outcomes more than warfarin in all 3 patient groups. Clinical Trial Registration— URL: http://www.clinicaltrials.gov. Unique identifier: NCT00412984.
Source: Circulation: Heart Failure - May 21, 2013 Category: Cardiology Authors: McMurray, J. J. V., Ezekowitz, J. A., Lewis, B. S., Gersh, B. J., van Diepen, S., Amerena, J., Bartunek, J., Commerford, P., Oh, B.-H., Harjola, V.-P., Al-Khatib, S. M., Hanna, M., Alexander, J. H., Lopes, R. D., Wojdyla, D. M., Wallentin, L., Granger, C. Tags: Congestive, Cerebrovascular disease/stroke, Arrhythmias, clinical electrophysiology, drugs, Embolic stroke Original Articles Source Type: research

Identifying a High Stroke Risk Subgroup in Individuals with Heart Failure
Conclusions: The combination of previous stroke/TIA and DM increases the incidence of stroke in participants with HF without AF. No analyzed subgroup had a stroke rate high enough to make it likely that the benefits of warfarin would outweigh the risks.
Source: Journal of Stroke and Cerebrovascular Diseases - December 6, 2011 Category: Neurology Authors: Patrick M. Pullicino, Leslie A. McClure, Virginia J. Howard, Virginia G. Wadley, Monika M. Safford, James F. Meschia, Aaron Anderson, George Howard, Elsayed Z. Soliman Tags: Original Articles Source Type: research

Forecasting the Future of Stroke in the United States: A Policy Statement From the American Heart Association and American Stroke Association AHA/ASA Policy Statement
Conclusions— These projections suggest that the annual costs of stroke will increase substantially over the next 2 decades. Greater emphasis on implementing effective preventive, acute care, and rehabilitative services will have both medical and societal benefits. (Stroke. 2013;44:2361-2375.)
Source: Stroke - July 22, 2013 Category: Neurology Authors: Ovbiagele, B., Goldstein, L. B., Higashida, R. T., Howard, V. J., Johnston, S. C., Khavjou, O. A., Lackland, D. T., Lichtman, J. H., Mohl, S., Sacco, R. L., Saver, J. L., Trogdon, J. G., on behalf of the American Heart Association Advocacy Coordinating Co Tags: AHA/ASA Policy Statement Source Type: research

Incidence and Clinical Impact of Stroke Complicating Percutaneous Coronary Intervention: Results of the Euro Heart Survey Percutaneous Coronary Interventions Registry Cardiac Catheterization
Conclusions— Stroke as complication of PCI occurs rarely (0.4%) in clinical practice in Europe today. However, peri-interventional stroke is still associated with an exceedingly high in-hospital mortality rate. Most predictors for periprocedural stroke are not modifiable and cannot be diminished before PCI. Therefore, treatment of patients with stroke after PCI needs further research.
Source: Circulation: Cardiovascular Interventions - August 20, 2013 Category: Cardiology Authors: Werner, N., Bauer, T., Hochadel, M., Zahn, R., Weidinger, F., Marco, J., Hamm, C., Gitt, A. K., Zeymer, U. Tags: Acute Stroke Syndromes Cardiac Catheterization Source Type: research

Systolic Blood Pressure During Acute Stroke Is Associated With Functional Status and Long-term Mortality in the Elderly Clinical Sciences
Conclusions— High systolic BP recorded by 24H BPM on the first day of stroke was found to be associated with unfavorable short-term functional status and long-term mortality in elderly patients.
Source: Stroke - August 26, 2013 Category: Neurology Authors: Weiss, A., Beloosesky, Y., Kenett, R. S., Grossman, E. Tags: Acute Cerebral Infarction Clinical Sciences Source Type: research

Gender Difference in Stroke Case Fatality: An Integrated Study of Hospitalization and Mortality
Conclusions: Among persons hospitalized with a stroke in Nebraska between 2005 and 2009, the crude case fatality rate was 50% higher in women. However, after accounting for age and other variables, adjusted mortality rates were essentially the same for men and women.
Source: Journal of Stroke and Cerebrovascular Diseases - December 6, 2011 Category: Neurology Authors: David DeVries, Ying Zhang, Ming Qu, Jihyun Ma, Ge Lin Tags: Original Articles Source Type: research

Warfarin versus Aspirin for Prevention of Stroke in Heart Failure: A Meta-analysis of Randomized Controlled Clinical Trials
Conclusions: Compared with aspirin, warfarin reduced the risk of stroke while conferring an increased risk of major hemorrhage. Warfarin does not increase mortality or confer an increased risk of ICH compared with aspirin.
Source: Journal of Stroke and Cerebrovascular Diseases - November 21, 2012 Category: Neurology Authors: Gyanendra Kumar, Munish Kumar Goyal Tags: Original Articles Source Type: research

Risk Factors for Poor Outcome and Mortality at 3 Months after the Ischemic Stroke in Patients with Atrial Fibrillation
Conclusions: Age, gender, and NIHSS score were independently associated with poor outcome for IS or TIA patients with nonvalvular atrial fibrillation in the early recovery stage.
Source: Journal of Stroke and Cerebrovascular Diseases - May 30, 2013 Category: Neurology Authors: Shuya Li, Xingquan Zhao, Chunxue Wang, Liping Liu, Gaifen Liu, Yilong Wang, Chunjuan Wang, Jing Jing, Yong-Jun Wang Tags: Original Articles Source Type: research

Incidence and Cost of Stroke and Hemorrhage in Patients Diagnosed with Atrial Fibrillation in France
Conclusions: The incidence and cost of hospitalization for hemorrhage should be considered in the global burden of AF. These data should be useful for pharmacoeconomic evaluation of new oral anticoagulant medications. Such real-world studies may be relevant for monitoring mid- to long-term morbidity and mortality in the AF population.
Source: Journal of Stroke and Cerebrovascular Diseases - October 10, 2013 Category: Neurology Authors: François-Emery Cotté, Gwendoline Chaize, Isabelle Kachaner, Anne-Françoise Gaudin, Alexandre Vainchtock, Isabelle Durand-Zaleski Tags: Original Articles Source Type: research

Usefulness of N-Terminal Pro-B-Type Natriuretic Peptide Levels for Stroke Risk Prediction in Anticoagulated Patients With Atrial Fibrillation Clinical Sciences
Conclusions— In real-world cohort of anticoagulated patients with AF, NT-proBNP provided complementary prognostic information to an established clinical risk score (CHA2DS2–VASc) for the prediction of stroke/systemic embolism. NT-proBNP was also predictive of all-cause mortality, suggesting that this biomarker may potentially be used to refine clinical risk stratification in anticoagulated patients with AF.
Source: Stroke - February 24, 2014 Category: Neurology Authors: Roldan, V., Vilchez, J. A., Manzano-Fernandez, S., Jover, E., Galvez, J., Puche, C. M., Valdes, M., Vicente, V., Lip, G. Y. H., Marin, F. Tags: Arterial thrombosis, Coumarins, Anticoagulants Clinical Sciences Source Type: research

Cryptogenic Stroke with More Than One Cause versus No Cause by TOAST Classification Lacks Adequate Predictive Power for Stroke Risk Factors and Outcomes (P1.116)
Conclusion: Differentiating between cryptogenic more than one cause and cryptogenic no cause demonstrates significant difference in the rates of cardiac-related, vasculature-related, and outcome variables. However, cryptogenic more than one cause does not have significant predictive power in demographic, baseline, or outcome prediction models.Disclosure: Dr. Scullen has nothing to disclose. Dr. Monlezun, Jr has nothing to disclose. Dr. George has received research support from Tulane University School of Medicine. Dr. Siegler has nothing to disclose. Dr. Schwickrath has nothing to disclose. Dr. El Khoury has nothing to dis...
Source: Neurology - April 9, 2014 Category: Neurology Authors: Scullen, T., Monlezun, D., George, A., Siegler, J., Schwickrath, M., El Khoury, R., Martin-Schild, S. Tags: Cerebrovascular Disease and Interventional Neurology: Ischemic Stroke Subtype Source Type: research

"No Turn Back Approach" to Reduce Treatment Time for Endovascular Treatment of Acute Ischemic Stroke (P4.214)
Conclusions: The "no turn back approach" appeared to be feasible and reduced the time interval between ED arrival and microcatheter placement in acute ischemic stroke patients undergoing endovascular treatment.Disclosure: Dr. Egila has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Siddiqi has nothing to disclose. Dr. Mian has nothing to disclose. Dr. Hassan has nothing to disclose. Dr. Miley has nothing to disclose. Dr. Rodriguez has nothing to disclose. Dr. Suri has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Egila, H., Adil, M., Siddiqi, H., Mian, N., Hassan, A., Miley, J., Rodriguez, G., Suri, M., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Endovascular Source Type: research

Thrombolytic Treatment for Acute Ischemic Stroke Patients with History of Migraine Headaches (P4.223)
Conclusion: Patients with migraine headaches receiving IV rt-PA treatment for acute ischemic stroke appear to have a lower rates of death and disability most likely related to their decreased rates of intracerebral hemorrhage.Disclosure: Dr. Malik has nothing to disclose. Dr. Malik has nothing to disclose. Dr. Nickles has nothing to disclose. Dr. Qureshi has nothing to disclose.
Source: Neurology - April 9, 2014 Category: Neurology Authors: Malik, A., Adil, M., Chaudhry, S., Qureshi, A. Tags: Cerebrovascular Disease and Interventional Neurology: Acute Stroke Thrombolysis Source Type: research

Intracranial Hemorrhage Among Patients With Atrial Fibrillation Anticoagulated With Warfarin or Rivaroxaban: The Rivaroxaban Once Daily, Oral, Direct Factor Xa Inhibition Compared With Vitamin K Antagonism for Prevention of Stroke and Embolism Trial in Atrial Fibrillation Clinical Sciences
Conclusions— Among patients with atrial fibrillation treated with anticoagulation, the risk of ICH was higher among Asians, blacks, the elderly, and in those with previous stroke or transient ischemic attack, increased diastolic blood pressure, and reduced platelet count or serum albumin at baseline. The risk of ICH was significantly lower in patients with heart failure and in those who were randomized to rivaroxaban instead of warfarin. The external validity of these findings requires testing in other atrial fibrillation populations.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Hankey, G. J., Stevens, S. R., Piccini, J. P., Lokhnygina, Y., Mahaffey, K. W., Halperin, J. L., Patel, M. R., Breithardt, G., Singer, D. E., Becker, R. C., Berkowitz, S. D., Paolini, J. F., Nessel, C. C., Hacke, W., Fox, K. A. A., Califf, R. M., on behal Tags: Acute Cerebral Hemorrhage, Anticoagulants Clinical Sciences Source Type: research

Incidence, Trends, and Predictors of Ischemic Stroke 30 Days After an Acute Myocardial Infarction Clinical Sciences
Conclusions— The incidence of ischemic stroke within 30 days of an AMI has decreased during the period 1998 to 2008. This decrease is associated with increased use of acetylsalicylic acid, P2Y12 inhibitors, statins, and percutaneous coronary intervention.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Kajermo, U., Ulvenstam, A., Modica, A., Jernberg, T., Mooe, T. Tags: Risk Factors, Acute myocardial infarction, Acute Cerebral Infarction, Epidemiology Clinical Sciences Source Type: research

Age Dependence of Risk Factors for Stroke and Death in Young Patients With Atrial Fibrillation: A Nationwide Study Clinical Sciences
Conclusions— The CHA2DS2-VASc score is an applicable tool for all age groups and in nonvalvular atrial fibrillation patients <65 years old, the same risk factors apply.
Source: Stroke - April 28, 2014 Category: Neurology Authors: Melgaard, L., Rasmussen, L. H., Skjoth, F., Lip, G. Y. H., Larsen, T. B. Tags: Acute Cerebral Infarction, Anticoagulants Clinical Sciences Source Type: research

Factors Associated with Proximal Carotid Axis Occlusion in Patients with Acute Stroke and Atrial Fibrillation
Conclusions: Female sex, advanced age, history of systemic embolism, and higher BNP level were independently associated with more proximal carotid axis occlusion. Patients with AF having these factors may be prone to have relatively large thrombi in the heart.
Source: Journal of Stroke and Cerebrovascular Diseases - October 7, 2013 Category: Neurology Authors: Yuki Sakamoto, Shoichiro Sato, Yuka Kuronuma, Kazuyuki Nagatsuka, Kazuo Minematsu, Kazunori Toyoda Tags: Original Articles Source Type: research

Hyponatremia in the Prognosis of Acute Ischemic Stroke
Background: Hyponatremia is a risk factor for stroke and cardiovascular disease. Even mild hyponatremia is associated with increased 30-day mortality after myocardial infarction, and it has recently shown to increase the 3-year mortality after a stroke. In this work, we investigated both acute and chronic clinical outcomes after a stroke in hyponatremic patients.Methods: We reviewed all patients admitted between 2004 and 2011 with the diagnosis of acute ischemic stroke. Hyponatremia was defined as serum sodium level less than 135 mmol/L and recorded on admission. All hemorrhagic strokes were excluded. Data were analyzed us...
Source: Journal of Stroke and Cerebrovascular Diseases - August 19, 2013 Category: Neurology Authors: Bernardo Rodrigues, Ilene Staff, Gilbert Fortunato, Louise D. McCullough Tags: Original Articles Source Type: research

“No Turn Back Approach” to Reduce Treatment Time for Endovascular Treatment of Acute Ischemic Stroke
Conclusions: The no turn back approach appeared to be feasible and reduced the time interval between ED arrival and microcatheter placement in acute ischemic stroke patients undergoing endovascular treatment.
Source: Journal of Stroke and Cerebrovascular Diseases - February 21, 2014 Category: Neurology Authors: Adnan I. Qureshi, Hossam Egila, Malik M. Adil, Harris Siddiqi, Nidaullah Mian, Ameer E. Hassan, Jefferson T. Miley, Gustavo J. Rodriguez, M. Fareed K. Suri Tags: Original Articles Source Type: research