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Condition: Heart Failure

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Total 5960 results found since Jan 2013.

The efficacy and safety of rivaroxaban in coronary artery disease patients with heart failure and sinus rhythm: a systematic review and meta-analysis
ConclusionsIn SR patients with CAD and HF, the rates of MI and stroke associated with rivaroxaban combined with APT were lower than those associated with APT alone, and the two treatments had similar rates of all-cause death and major bleeding.
Source: European Journal of Clinical Pharmacology - September 21, 2021 Category: Drugs & Pharmacology Source Type: research

Comparing the clinical outcomes across different sodium/glucose cotransporter 2 (SGLT2) inhibitors in heart failure patients: a systematic review and network meta-analysis of randomized controlled trials
ConclusionsThere were no demonstrable treatment differences across SGLT2 inhibitors across cardiovascular, renal, and metabolic outcomes, although this needs to be interpreted considering the wide confidence intervals, limited number of included studies, and heterogeneity present. Future research of different SGLT2 inhibitors in head-to-head studies is warranted to determine if there is a drug class effect.
Source: European Journal of Clinical Pharmacology - September 21, 2021 Category: Drugs & Pharmacology Source Type: research

Impact of renin ‐angiotensin system inhibitors on long‐term clinical outcomes of patients with rheumatic heart disease
ConclusionRenin –angiotensin–aldosterone system inhibitor treatment was significantly associated with decreased risks of mortality, HF rehospitalization, and new-onset AF in RHD patients in median 5.9 year follow-up.
Source: ESC Heart Failure - September 21, 2021 Category: Cardiology Authors: Cheng Liu, Yanxian Lai, Deping Wu, Ruibin Fu, Yanfang Li, Hu Li, Tianwang Guan, Yan Shen Tags: Original Research Article Source Type: research

Inhaled Beta2-Agonists Increase In-Hospital Mortality in ICU Patients with Heart Failure
This study aimed to investigate whether inhaled B2As increased in-hospital mortality in ICU patients with HF.The Multiparameter Intelligent Monitoring in Intensive Care III database was initially searched to identify adult patients (≥ 18 years old) with HF in ICU. Then, patients using or not using inhaled B2As were matched using propensity score matching on a 1:1 basis to control for baseline confounders. In-hospital mortality was compared between the two groups, and logistic regression analysis was performed to assess the association between B2As and in-hospital mortality.The initial search retrieved 2345 eligible patie...
Source: International Heart Journal - September 21, 2021 Category: Cardiology Authors: Zexiong Li Yesheng Ling Qian Chen Bingyuan Wu Long Peng Xixiang Tang Jinlai Liu Suhua Li Source Type: research

Left ventricular dimensions and cardiovascular outcomes in systolic heart failure: the WARCEF trial
ConclusionsLeft ventricular enlargement is an independent predictor of CV events in patients with HFrEF and recommended HF treatment. LV dimensions should be considered in the risk assessment.
Source: ESC Heart Failure - September 21, 2021 Category: Cardiology Authors: Kazato Ito, Siyuan Li, Shunichi Homma, John L.P. Thompson, Richard Buchsbaum, Kenji Matsumoto, Stefan D. Anker, Min Qian, Marco R. Di Tullio, for the WARCEF Investigators Tags: Original Research Article Source Type: research

Mutual effects of fine particulate matter, nitrogen dioxide, and fireworks on cause-specific acute cardiovascular mortality: A case-crossover study in communities affected by aircraft noise
This study confirms the association between ambient NO2, as a marker for primary emissions, and acute cardiovascular mortality in a specific setting around a major airport. Future research should clarify the role of additional air pollutants including ultra-fine particles on cardiovascular diseases to inform most efficient control measures.PMID:34536646 | DOI:10.1016/j.envpol.2021.118066
Source: Environmental Pollution - September 18, 2021 Category: Environmental Health Authors: Apolline Saucy Kees de Hoogh Danielle Vienneau Louise Tangermann Beat Sch äffer Jean-Marc Wunderli Nicole Probst-Hensch Martin R öösli Source Type: research

Low incidence of major complications after the first six hours post atrial fibrillation ablation: Is same ‐day discharge safe and feasible in most patients?
ConclusionAfter AF ablation, very few complications occurred between six hours post-procedure and discharge the next day. Therefore, same-day discharge is a safe option for a majority of patients.This article is protected by copyright. All rights reserved.
Source: Journal of Cardiovascular Electrophysiology - September 18, 2021 Category: Cardiology Authors: Astrid Paul Nordin, Nikola Drca, Per Insulander, Hamid Bastani, Tara Bourke, Frieder Braunschweig, G öran Kennebäck, Gesa Olshausen, Bita Sadigh, Ott Saluveer, Jari Tapanainen, Jonas Schwieler, Finn Åkerström, Mats Jensen‐Urstad Tags: ORIGINAL ‐ ELECTROPHYSIOLOGY Source Type: research

Is Medication Adherence Predictive of Cardiovascular Outcomes and Blood Pressure Control? The Systolic Blood Pressure Intervention Trial (SPRINT)
CONCLUSION: In SPRINT, medication adherence as measured using the MMAS-8 was not associated with outcomes or BP control.PMID:34528669 | DOI:10.1093/ajh/hpab145
Source: American Journal of Hypertension - September 16, 2021 Category: Cardiology Authors: Stephen P Glasser Mara Vitolins Michael V Rocco Carolyn Harmon Still Stacey S Cofield William E Haley David Goff SPRINT Research Group Source Type: research

Extended-Duration Low-intensity Apixaban to Prevent Recurrence in Patients with Provoked Venous Thromboembolism: Design of the HI-PRO Trial
Thromb Haemost. 2021 Sep 16. doi: 10.1055/a-1646-2244. Online ahead of print.ABSTRACTPatients with acute venous thromboembolism (VTE) in the setting of transient provoking factors are typically treated with short-term anticoagulation. However, the risk of recurrence may be increased in the presence of enduring risk factors. In such patients, the optimal duration of treatment remains uncertain. HI-PRO is a single-center, double-blind randomized trial. Patients with deep vein thrombosis (DVT) or pulmonary embolism (PE) following a major provoking factor, including major surgery or major trauma, who completed at least 3 month...
Source: Thrombosis and Haemostasis - September 16, 2021 Category: Hematology Authors: Behnood Bikdeli Heather Hogan Ruth Morrison John Fanikos Umberto Campia Briana Barns Mariana Pfeferman Julia Snyder Candrika Khairani Samuel Z Goldhaber Gregory Piazza Source Type: research

Hypothyroidism is associated with clinical outcomes in patients with acute myocardial infarction: subgroup analysis of China PEACE study
ConclusionCompared with euthyroid status, hypothyroid status has an independent predicting value for adverse cardiovascular events in AMI patients. Further investigations are required to illustrate whether treatment of thyroid dysfunction could improve the prognosis of AMI patients.
Source: Endocrine - September 15, 2021 Category: Endocrinology Source Type: research

Heat-related cardiovascular morbidity and mortality in Switzerland: a clinical perspective
CONCLUSIONS: Volume depletion and vasodilation from heat stress plausibly explain the risk reduction of heat-related emergency hospital admissions for hypertension and heart failure. Since primary cause of death mostly refers to the underlying chronic disease, the seemingly paradoxical heat-related mortality increase can plausibly be explained by an exacerbation of heat effects by antihypertensive and diuretic drugs. Clinical guidelines should consider recommending strict therapy monitoring of such medication during heatwaves, particularly in the elderly.PMID:34519460 | DOI:10.4414/SMW.2021.w30013
Source: Swiss Medical Weekly - September 14, 2021 Category: General Medicine Authors: Florian Schulte Martin R öösli Martina S Ragettli Source Type: research

Efficacy and Cardiovascular Safety of Roxadustat in Dialysis-Dependent Chronic Kidney Disease: Pooled Analysis of Four Phase 3 Studies
ConclusionRoxadustat improved hemoglobin similarly to ESA while demonstrating comparable cardiovascular and overall safety profiles in a wide spectrum of dialysis-dependent patients with anemia of CKD. Roxadustat represents an oral alternative to ESAs for achieving a target hemoglobin for anemia of CKD in dialysis-dependent patients.
Source: Advances in Therapy - September 14, 2021 Category: Drugs & Pharmacology Source Type: research

Bioinformatic analysis for potential biological processes and key targets of heart failure-related stroke
This study aimed to uncover underlying mechanisms and promising intervention targets of heart failure (HF)-related stroke. HF-related dataset GSE42955 and stroke-related dataset GSE58294 were obtained from the Gene Expression Omnibus (GEO) database. Weighted gene co-expression network analysis (WGCNA) was conducted to identify key modules and hub genes. Gene Ontology (GO) and pathway enrichment analyses were performed on genes in the key modules. Genes in HF- and stroke-related key modules were intersected to obtain common genes for HF-related stroke, which were further intersected with hub genes of stroke-related key modu...
Source: J Zhejiang Univ Sci ... - September 13, 2021 Category: Science Authors: Chiyu Liu Sixu Chen Haifeng Zhang Yangxin Chen Qingyuan Gao Zhiteng Chen Zhaoyu Liu Jingfeng Wang Source Type: research

Left Atrial Dilatation and Reduced Left Ventricular Ejection Fraction Are Associated With Cardioembolic Stroke
Conclusions: LA dilatation along with reduced EF is a reliable predictor of Afib and cardioembolic stroke. Further studies are warranted to determine the benefit of anticoagulation for secondary stroke prevention in such patient population.
Source: Frontiers in Neurology - September 13, 2021 Category: Neurology Source Type: research

Experiences With Intravenous Thrombolysis in Acute Ischemic Stroke by Elderly Patients –A “Real World Scenario”
Conclusion: Although, the outcomes were less favorable in patients over 80 years of age, our results support the feasibility of using intravenous thrombolysis among patients over 80 years of age.
Source: Frontiers in Neurology - September 13, 2021 Category: Neurology Source Type: research

Bone mineral density and risk of cardiovascular disease in men and women: the HUNT study
AbstractThe association between bone mineral density (BMD) and cardiovascular disease (CVD) is not fully understood. We evaluated BMD as a risk factor for cardiovascular disease and specifically atrial fibrillation (AF), acute myocardial infarction (AMI), ischemic (IS) and hemorrhagic stroke (HS) and heart failure (HF) in men and women. This prospective population cohort utilized data on 22 857 adults from the second and third surveys of the HUNT Study in Norway free from CVD at baseline. BMD was measured using single and dual-energy X-ray absorptiometry in the non-dominant distal forearm and T-score was calculated. Hazard...
Source: European Journal of Epidemiology - September 13, 2021 Category: Epidemiology Source Type: research

Peripheral microvascular dysfunction is associated with plaque progression and adverse long ‐term outcomes in heart transplant patients
ConclusionsPeripheral endothelial dysfunction is associated with increased plaque progression and adverse long-term cardiovascular outcomes in transplant patients. PED assessment might be a useful clinical tool for risk stratification after heart transplantation.
Source: ESC Heart Failure - September 12, 2021 Category: Cardiology Authors: Ilke Ozcan, Takumi Toya, Michel T. Corban, Ali Ahmad, Lilach O. Lerman, Sudhir S. Kushwaha, Amir Lerman Tags: Original Research Article Source Type: research

ERLEADA ® (apalutamide) Oral Presentations Demonstrate Importance of Prostate Specific Antigen (PSA) as Key Efficacy Indicator and Show Strong Patient Adherence Rates
September 11, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson today announced new data demonstrating robust prostate-specific antigen (PSA) response and strong adherence rates in patients with non-metastatic castration-resistant prostate cancer (nmCRPC) treated with ERLEADA® (apalutamide) in the real-world clinical setting. The strong PSA response was also seen in a separate post-hoc analysis that showed a correlation between rapid and deep PSA response and prolonged survival in both metastatic castration-sensitive prostate cancer (mCSPC) and nmCRPC. The post-hoc analysis also suppor...
Source: Johnson and Johnson - September 12, 2021 Category: Pharmaceuticals Source Type: news

A mini-review on the impact of COVID 19 on vital organs
Biomed Pharmacother. 2021 Sep 4;143:112158. doi: 10.1016/j.biopha.2021.112158. Online ahead of print.ABSTRACTCOVID-19 (Corona Virus Disease-2019) is an infectious disease caused by a novel coronavirus, known as the acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This is a highly contagious disease that has already affected more than 220 countries globally, infecting more than 212 million people and resulting in the death of over 4.4 million people. This review aims to highlight the pertinent documentary evidence upon the adverse effects of the SARS-CoV-2 infection on several vital human organs. SARS-CoV-2 primarily ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 10, 2021 Category: Drugs & Pharmacology Authors: Muhammad Dawood Shah Aini Simon Sumeh Muhammad Sheraz Muthu Subash Kavitha Balu Alagar Venmathi Maran Kenneth Francis Rodrigues Source Type: research

Stroke in Patients with Left Ventricular Assist Devices
Background: Left ventricular assist devices (LVADs) are artificial pumps used in end-stage heart failure to support the circulatory system. These cardiac assist devices work in parallel to the heart, diverting blood from the left ventricle through an outflow graft and into the ascending aorta. LVADs have allowed patients with end-stage heart failure to live longer and with improved quality of life compared to best medical therapy alone. However, they are associated with significant risks related to both thrombosis and bleeding in this medically complex patient population. As LVADs continue to be used more widely, stroke ne...
Source: Cerebrovascular Diseases - September 10, 2021 Category: Neurology Source Type: research

Adherence to oral anticoagulation in ischemic stroke patients with atrial fibrillation
CONCLUSIONS: Adherence was poor in half of AF patients who survived an ischaemic stroke. Independent patient-related factors, rather than composite scores, were associated with poor adherence in these patients.KEY MESSAGESAdherence was poor in half of the atrial fibrillation patients who survived an ischaemic stroke.Independent patient-related factors rather than composite scores were associated with poor adherence.The findings support the importance of recognising adherence support as a crucial part of holistic patient care recommended by recent AF guideline.PMID:34498537 | DOI:10.1080/07853890.2021.1968031
Source: Annals of Medicine - September 9, 2021 Category: Internal Medicine Authors: Paula Tiili Ioannis Leventis Janne Kinnunen Ida Svedjeb äck Mika Lehto Efstathia Karagkiozi Dimitrios Sagris George Ntaios Jukka Putaala Source Type: research

Anticoagulation in cardiomyopathy: unravelling the hidden threat and challenging the threat individually
AbstractCardiomyopathy comprises a heterogeneous group of myocardial abnormalities, structural or functional in nature, in the absence of coronary artery disease and other abnormal loading conditions. These myocardial pathologies can result in premature death or disability from progressive heart failure, arrhythmia, stroke, or other embolic events. The European Cardiomyopathy Registry reports a high stroke risk in cardiomyopathy patients ranging from 2.1% to 4.5%, as well as high prevalence of atrial fibrillation ranging from 14.0% to 48.5%. There is a growing interest in evaluating the risk of thromboembolism depending on...
Source: ESC Heart Failure - September 9, 2021 Category: Cardiology Authors: Xiaogang Zhu, Zhenhua Wang, Markus W. Ferrari, Katharina Ferrari ‐Kuehne, Javed Bulter, Xiuying Xu, Quanzhong Zhou, Yuhui Zhang, Jian Zhang Tags: Review Source Type: research

Janssen Demonstrates Commitment to Advancing Science and Innovation in the Treatment of Solid Tumors at ESMO Annual Congress
September 8, 2021 (RARITAN, N.J.) – The Janssen Pharmaceutical Companies of Johnson & Johnson announced today that more than ten data presentations from its lung cancer, bladder cancer and prostate cancer portfolio and pipeline will be featured during the European Society for Medical Oncology (ESMO) Annual Congress 2021 virtual meeting, September 16–21. Further details about these data and the science Janssen is advancing will be made available throughout ESMO via the Janssen Oncology Virtual Newsroom.“With a diverse oncology portfolio and pipeline spanning bladder cancer, lung cancer and prostate cancer, Janssen...
Source: Johnson and Johnson - September 8, 2021 Category: Pharmaceuticals Tags: Innovation Source Type: news

Sympathetic activation in heart failure with reduced and mildly reduced ejection fraction: the role of aetiology
ConclusionsMuscle sympathetic nerve activity parameters indicated significant sympathetic activation in both HFmrEF and HFrEF patients as compared with healthy controls with no difference in relation to ischaemic versus non-ischaemic aetiology.
Source: ESC Heart Failure - September 7, 2021 Category: Cardiology Authors: R éka Urbancsek, Zoltán Csanádi, Ildikó Noémi Forgács, Tímea Bianka Papp, Judit Boczán, Judit Barta, Csaba Jenei, László Nagy, László Rudas Tags: Original Research Article Source Type: research

Acute kidney injury and risk of cardiovascular outcomes: A nationwide cohort study
CONCLUSION: Non-selected patients aged 50 years or above with AKI during admission had significantly higher one-year risk of cardiovascular event or death, especially, but not only due to heart failure, independent of age and eGFR.PMID:34489123 | DOI:10.1016/j.nefro.2021.06.007
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - September 7, 2021 Category: Urology & Nephrology Authors: Philip Andreas Schytz Paul Blanche Anders Bonde Nissen Christian Torp-Pedersen Gunnar H Gislason Karl Emil Nelveg-Kristensen Kristine Hommel Nicholas Carlson Source Type: research

Is your heart skipping beats? If it’s happening a lot, it could be AFib.
An erratic heart rhythm needs to be checked out by a doctor because atrial fibrillation can lead to such complications as stroke and heart failure.
Source: Washington Post: To Your Health - September 6, 2021 Category: Consumer Health News Authors: Laura Entis Source Type: news

Association Between a Body Shape Index and Subclinical Carotid Atherosclerosis in Population Free of Cardiovascular and Cerebrovascular Diseases
CONCLUSIONS: ABSI, as a novel anthropometric indicator compared with traditional indices, was found to have a closer relationship with subclinical carotid atherosclerosis, even in populations free of hypertension, diabetes, and hyperlipidemia.PMID:34483222 | DOI:10.5551/jat.62988
Source: Journal of Atherosclerosis and Thrombosis - September 6, 2021 Category: Cardiology Authors: Xiaotian Ma Lihong Chen Wenchao Hu Lanjie He Source Type: research

The impact of plasma vitamin C levels on the risk of cardiovascular diseases and Alzheimer's disease: a Mendelian randomization study
Previous observational studies have reported associations between plasma vitamin C levels, and cardiovascular diseases (CVDs) and Alzheimer's disease (AD); however, no conclusive results have been obtained. We conducted a Mendelian randomization (MR) study to investigate the causality of vitamin C on the risk of nine CVDs [including coronary artery disease (CAD), myocardial infarction (MI), atrial fibrillation (AF), heart failure (HF), stroke, ischemic stroke (IS), and IS subtypes] and Alzheimer's disease.
Source: Clinical Nutrition - September 4, 2021 Category: Nutrition Authors: Lu Chen, Xingang Sun, Zhen Wang, Yunlong Lu, Miao Chen, Yuxian He, Hongfei Xu, Liangrong Zheng Tags: Original article Source Type: research

Right ventricular and cyclic guanosine monophosphate signalling abnormalities in stages B and C of heart failure with preserved ejection fraction
ConclusionExercise CMR identifies impaired RV-arterial coupling at an early stage of HFpEF. Circulating cGMP levels phenocopy the haemodynamic spectrum in HFpEF but fail to increase after phosphodiesterase type 5 inhibition, endorsing the need for alternative interventions to increase cGMP signalling in HFpEF.
Source: ESC Heart Failure - September 3, 2021 Category: Cardiology Authors: Thibault Petit, Guido Claessen, Mathias Claeys, Andre La Gerche, Piet Claus, Stefan Ghysels, Marion Delcroix, Agnieszka Ciarka, Walter Droogne, Johan Van Cleemput, Rik Willems, Jens ‐Uwe Voigt, Jan Bogaert, Stefan Janssens Tags: Original Research Article Source Type: research

Surgical Treatment of Pulmonary Embolism and Chronic Thromboembolic Pulmonary Hypertension
Curr Pharm Des. 2021 Sep 2. doi: 10.2174/1381612827666210902152539. Online ahead of print.ABSTRACTVenous thromboembolism clinically presents as deep venous thrombosis or acute pulmonary embolism and is globally recognized as the third most frequent acute cardiovascular syndrome after myocardial infarction and stroke. Although pulmonary embolism does not typically cause severe pulmonary hypertension in the acute setting, thrombus organization and fibrosis can lead to stenosis or obliteration of pulmonary arteries in a minority of patients, which in turn result in severe pulmonary hypertension and right heart failure. This d...
Source: Current Pharmaceutical Design - September 3, 2021 Category: Drugs & Pharmacology Authors: Nikolaos Papakonstantinou Polydoros Kampaktsis Filippos-Paschalis Rorris Ilias Doulamis Aspasia Tzani Sotirios Katsaridis Dimitrios Avgerinos Source Type: research

Clinical significance of new ‐onset atrial fibrillation in patients with hypertrophic cardiomyopathy
ConclusionsIn our HCM registry in an aged Japanese community, a significant proportion developed AF. The presence of AF, particularly new-onset AF, was associated with increased incidence of HCM-related events. AF may not be just a marker of disease stage but an important trigger of adverse events.
Source: ESC Heart Failure - September 2, 2021 Category: Cardiology Authors: Toru Kubo, Yuichi Baba, Yuri Ochi, Takayoshi Hirota, Naohito Yamasaki, Kazuya Kawai, Katsuhito Yamamoto, Fumiaki Kondo, Kanji Bando, Eisuke Yamada, Takashi Furuno, Toshikazu Yabe, Yoshinori L. Doi, Hiroaki Kitaoka Tags: Original Research Article Source Type: research

Newly Developed Highly Bioavailable Curcumin Formulation, curcuRouge < sup > TM < /sup > , Reduces Neutrophil/Lymphocyte Ratio in the Elderly: A Double-Blind, Placebo-Controlled Clinical Trial
J Nutr Sci Vitaminol (Tokyo). 2021;67(4):249-252. doi: 10.3177/jnsv.67.249.ABSTRACTElevated neutrophil/lymphocyte ratio (NLR) has been reported as a sensitive marker for predicting poor prognosis in chronic inflammation-based diseases such as stroke, heart failure, cancers, and diabetes, as well as acute inflammatory diseases such as bacterial and viral infections, including COVID-19. NLR is also known to increase with age and is considered to be an aging marker. We conducted a double-blind, placebo-controlled trial in elderly volunteers to examine the effect of a newly developed, highly bioavailable curcumin formulation (...
Source: Journal of Nutritional Science and Vitaminology - September 2, 2021 Category: Nutrition Authors: Atsuhiro Kishimoto Atsushi Imaizumi Hiromichi Wada Hajime Yamakage Noriko Satoh-Asahara Tadashi Hashimoto Koji Hasegawa Source Type: research

Assessment of patients with a suspected cardioembolic ischemic stroke. A national consensus statement
Conclusions: A primary neurological and neuroradiological assessment is mandatory and neurovascular specialists should manage the initiation of secondary prophylactic treatment. If a cardioembolic stroke is suspected, a dedicated cardiologist experienced in the management of cardioembolism should provide a tailored clinical and echocardiographic assessment.PMID:34470566 | DOI:10.1080/14017431.2021.1973085
Source: Scandinavian Cardiovascular Journal - September 2, 2021 Category: Cardiology Authors: Mark Aplin Asger Andersen Axel Brandes Helena Dominguez Jordi S Dahl Dorte Damgaard Helle K Iversen Kasper K Iversen Edith Nielsen Niels Risum Michael R Schmidt Niels H Andersen Source Type: research

Newly Developed Highly Bioavailable Curcumin Formulation, curcuRouge < sup > TM < /sup > , Reduces Neutrophil/Lymphocyte Ratio in the Elderly: A Double-Blind, Placebo-Controlled Clinical Trial
J Nutr Sci Vitaminol (Tokyo). 2021;67(4):249-252. doi: 10.3177/jnsv.67.249.ABSTRACTElevated neutrophil/lymphocyte ratio (NLR) has been reported as a sensitive marker for predicting poor prognosis in chronic inflammation-based diseases such as stroke, heart failure, cancers, and diabetes, as well as acute inflammatory diseases such as bacterial and viral infections, including COVID-19. NLR is also known to increase with age and is considered to be an aging marker. We conducted a double-blind, placebo-controlled trial in elderly volunteers to examine the effect of a newly developed, highly bioavailable curcumin formulation (...
Source: Journal of Nutritional Science and Vitaminology - September 2, 2021 Category: Nutrition Authors: Atsuhiro Kishimoto Atsushi Imaizumi Hiromichi Wada Hajime Yamakage Noriko Satoh-Asahara Tadashi Hashimoto Koji Hasegawa Source Type: research

Bioinformatic analysis for potential biological processes and key targets of heart failure-related stroke
This study aimed to uncover underlying mechanisms and promising intervention targets of heart failure (HF)-related stroke. HF-related dataset GSE42955 and stroke-related dataset GSE58294 were obtained from the Gene Expression Omnibus (GEO) database. Weighted gene co-expression network analysis (WGCNA) was conducted to identify key modules and hub genes. Gene Ontology (GO) and pathway enrichment analyses were performed on genes in the key modules. Genes in HF- and stroke-related key modules were intersected to obtain common genes for HF-related stroke, which were further intersected with hub genes of stroke-related key modu...
Source: Journal of Zhejiang University. Science. B. - September 1, 2021 Category: Universities & Medical Training Source Type: research

Cerebral-Cardiac Syndrome and Diabetes: Cardiac Damage After Ischemic Stroke in Diabetic State
Cerebral-cardiac syndrome (CCS) refers to cardiac dysfunction following varying brain injuries. Ischemic stroke is strongly evidenced to induce CCS characterizing as arrhythmia, myocardial damage, and heart failure. CCS is attributed to be the second leading cause of death in the post-stroke stage; however, the responsible mechanisms are obscure. Studies indicated the possible mechanisms including insular cortex injury, autonomic imbalance, catecholamine surge, immune response, and systemic inflammation. Of note, the characteristics of the stroke population reveal a common comorbidity with diabetes. The close and causative...
Source: Frontiers in Immunology - August 27, 2021 Category: Allergy & Immunology Source Type: research

Anticoagulants for stroke prevention in heart failure with reduced ejection fraction
AbstractImpaired left-ventricular ejection-fraction (LV-EF) is a known risk factor for ischemic stroke and systemic embolism in patients with heart failure (HF) even in the absence of atrial fibrillation. While stroke risk is inversely correlated with LV-EF in HF patients with sinus rhythm, strategies using anticoagulation with Vitamin-K antagonists (VKA) were futile as the increase in major bleedings outweighed the potential benefit in stroke reduction. Non-Vitamin K oral anticoagulants (NOACs) proved to be an effective and in general safer approach for stroke prevention in patients with atrial fibrillation and may also h...
Source: Clinical Research in Cardiology - August 27, 2021 Category: Cardiology Source Type: research

Trends, risk factors, and outcomes of post ‐operative stroke after heart transplantation: an analysis of the UNOS database
ConclusionsPost-operative stroke after HTx is infrequent but associated with higher mortality. Redo sternotomy, LVAD, and ECMO support at HTx are among the risk factors identified.
Source: ESC Heart Failure - August 25, 2021 Category: Cardiology Authors: Paulino Alvarez, Takeshi Kitai, Toshihiro Okamoto, Hiromichi Niikawa, Kenneth R. McCurry, Adamantia Papamichail, Ilias Doulamis, Alexandros Briasoulis Tags: Original Research Article Source Type: research