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Nutrition: Ginkgo
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Total 93 results found since Jan 2013.
Ginkgo biloba extract (EGb-761) confers neuroprotection against ischemic stroke by augmenting autophagic/lysosomal signaling pathway
Ginkgo biloba extract (EGb-761) is well-recognized to have neuroprotective properties. Meanwhile, autophagy machinery is extensively involved in the pathophysiological processes of ischemic stroke. The EGb-761 is widely used in the clinical treatment of stroke patients. However, its neuroprotective mechanisms against ischemic stroke are still not fully understood. The present study was conducted to uncover whether the pharmacological effects of EGb-761 can be executed by modulation of the autophagic/lysosomal signaling axis.
Source: Journal of Neuroimmunology - May 4, 2023 Category: Allergy & Immunology Authors: Rui Zang, Fayang Ling, Zhiyuan Wu, Jun Sun, Licong Yang, Zuyin Lv, Nengbo Ji Source Type: research
Ginkgo biloba extract EGb 761 ® improves cognition and overall condition after ischemic stroke: Results from a pilot randomized trial
Conclusion: Over the 24-week period, EGb 761® treatment improved overall cognitive performance among patients with mild to moderate ischemic stroke. Our findings provide valuable recommendations for the design of future trials, including the criteria for patient selection.Clinical Trial Registration:www.isrctn.com, identifier ISRCTN11815543.
Source: Frontiers in Pharmacology - March 29, 2023 Category: Drugs & Pharmacology Source Type: research
Platelet-activating factor receptor antagonists of natural origin for acute ischemic stroke: a systematic review of current evidence
Conclusions: This systematic review not only makes an important contribution to the existing body of current evidence but also lays a well-conducted basis for providing opinions and recommendation on the evaluation of PAFRA-based medicine, which could also highlight the need for well-designed clinical trials of PAFRA for AIS to increase the quality of available evidence. Further research is required, using standardized functional outcome measures for AIS, adequate blinding and suitable comparator groups reflecting current best practice.
Source: Frontiers in Pharmacology - August 31, 2022 Category: Drugs & Pharmacology Source Type: research
Multiple Mechanistic Models Reveal the Neuroprotective Effects of Diterpene Ginkgolides against Astrocyte-Mediated Demyelination via the PAF-PAFR Pathway
Am J Chin Med. 2022 Jul 29:1-33. doi: 10.1142/S0192415X22500665. Online ahead of print.ABSTRACTCurrently, therapies for ischemic stroke are limited. Ginkgolides, unique Folium Ginkgo components, have potential benefits for ischemic stroke patients, but there is little evidence that ginkgolides improve neurological function in these patients. Clinical studies have confirmed the neurological improvement efficacy of diterpene ginkgolides meglumine injection (DGMI), an extract of Ginkgo biloba containing ginkgolides A (GA), B (GB), and K (GK), in ischemic stroke patients. In the present study, we performed transcriptome analys...
Source: The American Journal of Chinese Medicine - July 28, 2022 Category: Complementary Medicine Authors: Tuan-Jie Wang Zi-Yin Wu Chun-Hua Yang Liang Cao Zhen-Zhong Wang Ze-Yu Cao Ming-Yang Yu Meng-Ru Zhao Chen-Feng Zhang Wen-Jun Liu Bin-Jiang Zhao Xue-Qi Shang Yu Feng Hui Wang Li-Li Deng Bao-Guo Xiao Hong-Yan Guo Wei Xiao Source Type: research
Ginkgolide B Protects Against Ischemic Stroke via Targeting AMPK/PINK1
Conclusions: Our observations suggest that GB enhanced AMPK activation in neural cells, reducing neuronal apoptosis, thus eventually preventing ischemic stroke.
Source: Frontiers in Pharmacology - June 28, 2022 Category: Drugs & Pharmacology Source Type: research
What the Science Says About the Health Benefits of Vitamins and Supplements
From multivitamins and melatonin to fiber and fish oil, Americans who are trying to boost their health and immunity have a plethora of supplements to choose from. An estimated 58% of U.S. adults ages 20 and over take dietary supplements, according to the U.S. Centers for Disease Control and Prevention, and the supplement industry is valued at more than $30 billion a year. Supplement use has been growing rapidly over the past few decades along with the wellness industry.
“The popular belief is that a supplement is going to be helpful for promoting health,” says Fang Fang Zhang, a professor at Tufts University&rs...
Source: TIME: Health - April 28, 2022 Category: Consumer Health News Authors: Sandeep Ravindran Tags: Uncategorized Diet & Nutrition healthscienceclimate Source Type: news
The Efficacy and Safety of Ginkgo Terpene Lactone Preparations in the Treatment of Ischemic Stroke: A Systematic Review and Meta-Analysis of Randomized Clinical Trials
Conclusion: Ginkgo terpene lactone preparations have good therapeutic effects on patients with IS. For acute IS, ginkgo diterpene lactone meglumine injection can be used as a complementary therapy to improve the clinical efficacy of rt-PA.
Source: Frontiers in Pharmacology - March 18, 2022 Category: Drugs & Pharmacology Source Type: research
Traditional medicine in China for ischemic stroke: bioactive components, pharmacology, and mechanisms
J Integr Neurosci. 2022 Jan 28;21(1):26. doi: 10.31083/j.jin2101026.ABSTRACTIschemic stroke is an acute cerebrovascular disease and the third most common cause of death after ischemic heart disease. Increasing attention is being paid to finding effective treatments through traditional medicine. Thus, studying the traditional medicine for the treatment of ischemic stroke is of great importance. Traditional medicine in China includes traditional Chinese medicine (TCM) and other ethnic medicines, which is rich in variety and resources. This review first introduces the treatment mechanisms associated with ischemic stroke, such...
Source: Journal of Integrative Neuroscience - February 15, 2022 Category: Neuroscience Authors: Min Xu Rui-Xia Wu Xiao-Li Li Yi-Shen Zeng Jia-Yang Liang Ke Fu Yuan Liang Zhang Wang Source Type: research
