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Total 153 results found since Jan 2013.

Potential Mechanism of Venous System for Leukoaraiosis: From post-mortem to in vivo Research.
Abstract BACKGROUND: Leukoaraiosis (LA), widely accepted as a feature of cerebral small vessel disease, significantly increases the incidence of stroke, dementia, and death. Cerebral small artery disease has been considered as one of the main causes of LA. However, since the term "venous collagenosis" (VC) was proposed in an atrophy research in 1995, there have been pathological and neuroimaging studies proving the association between the venous system and LA in aging, Alz-heimer's disease (AD), and Parkinson's disease. SUMMARY: Autopsy studies confirmed that thickening of the lumen wall in venules, which res...
Source: Neuro-Degenerative Diseases - February 11, 2020 Category: Neurology Authors: Nan D, Cheng Y, Feng L, Zhao M, Ma D, Feng J Tags: Neurodegener Dis Source Type: research

Association of serum retinoic acid with depression in patients with acute ischemic stroke.
This study was aimed to evaluate the relationship between RA levels in serum and post-stroke depression (PSD). A single-center (Chengdu, China) prospective cohort study was conducted on patients with acute ischemic stroke. The RA serum level was measured at admission. The PSD was assessed in the 3-month follow-up. The RA-PSD relationship was evaluated with conditional logistic regression. In total, 239 ischemic stroke cases and 100 healthy controls were included. The median RA serum level in patients with ischemic stroke was 2.45 ng/ml (interquartile range [IQR], 0.72-4.33), lower(P<0.001) than 3.89 ng/ml of those in co...
Source: Aging - February 10, 2020 Category: Biomedical Science Authors: Yang CD, Cheng ML, Liu W, Zeng DH Tags: Aging (Albany NY) Source Type: research

Comment on: Risk of acute stroke in patients with retinal artery occlusion: a systematic review and meta-analysis
Eye, Published online: 05 February 2020; doi:10.1038/s41433-020-0796-1Comment on: Risk of acute stroke in patients with retinal artery occlusion: a systematic review and meta-analysis
Source: Eye - February 5, 2020 Category: Opthalmology Authors: Arani Nitkunan Anthony C. Pereira Source Type: research

Beneficial actions of prothymosin alpha-mimetic hexapeptide on central post-stroke pain, reduced social activity, learning-deficit and depression following cerebral ischemia in mice
Publication date: Available online 23 January 2020Source: PeptidesAuthor(s): Keita Sasaki, Sebok Kumar Halder, Hayato Matsunaga, Hiroshi UedaAbstractProthymosin alpha (ProTα)-mimetic hexapeptide (amino acid: NEVDQE, P6Q) inhibits cerebral or retinal ischemia-induced behavioral, electrophysiological and histological damage. P6Q also abolishes cerebral hemorrhage induced by ischemia with tissue plasminogen activator (tPA). In the present study we examined the beneficial effects of P6Q on other post-stroke prognostic psychology-related symptoms, which obstruct the motivation toward physical therapy. Intravenous (i.v.) admini...
Source: Peptides - January 24, 2020 Category: Biochemistry Source Type: research

Fetal Bovine Serum-More Data
Primary and Stem Cell CultureThis just came across our radar." SUPPLEMENTARY MATERIAL An eye opener in stroke: Mitochondrial dysfunction and stem cell repair in MCAO induced retinal ischemia "We are always delighted when researchers supplement their cell culture media with ourFetal Bovine Serum (FBS).RPE Cells and MSC Culture Retinal pigmented epithelium (RPE, CRL-4000; ATCC) cells were cultured in Dulbecco ’s Modified Eagle Media/F-12 (DMEM/F-12, 11320033; Gibco) containing 10% fetal bovine serum (FBS; FBS001; Neuromics) and 0.01 mg/ml hygromycin B (10687010; Gibco) in incubator (37 °C humidified, with 5% CO2, 95% air)...
Source: Neuromics - January 17, 2020 Category: Neuroscience Tags: adult stem cells FBS Fetal Bovine Serum Human Mesenchymal Stem Cells MSCs Retinal Pigment Epithelial Cells RPES Source Type: news

Retinal vessel changes in cerebrovascular disease
Purpose of review The retina is growingly recognized as a window into cerebrovascular and systemic vascular conditions. The utility of noninvasive retinal vessel biomarkers in cerebrovascular risk assessment has expanded due to advances in retinal imaging techniques and machine learning-based digital analysis. The purpose of this review is to underscore the latest evidence linking retinal vascular abnormalities with stroke and vascular-related cognitive disorders; to highlight modern developments in retinal vascular imaging modalities and software-based vasculopathy quantification. Recent findings Longitudinal studies...
Source: Current Opinion in Neurology - January 17, 2020 Category: Neurology Tags: NEURO-OPHTHALMOLOGY: Edited by Heather E. Moss Source Type: research

Spectrum of Eye Disease in Diabetes (SPEED) in India: A prospective facility-based study. Report # 3. Retinal vascular occlusion in patients with type 2 diabetes mellitus
Conclusion: RVO is a frequent finding in people with T2DM. History of stroke carries the highest risk followed by HTN. The management of people with T2DM and RVO must also include comanagement of all associated systemic conditions.
Source: Indian Journal of Ophthalmology - January 17, 2020 Category: Opthalmology Authors: Harsha Bhattacharjee Manabjyoti Barman Divakant Misra Prabhjot K Multani Shriya Dhar Umesh C Behera Taraprasad Das Clare Gilbert G V S Murthy R Rajalakshmi Hira B Pant on behalf of the SPEED study group Source Type: research

Comparison of Prediction Models based on Risk Factors and Retinal Characteristics Associated with Recurrence One Year after Ischemic Stroke
Patients who survive an ischemic stroke have a high risk of stroke recurrence within a year. About 80%-85% of patients who have survived a first ischemic stroke would suffer at least 1 recurrence, and 8%-15% of the recurrences occurred in the first year.1
Source: Journal of Stroke and Cerebrovascular Diseases - January 13, 2020 Category: Neurology Authors: Zhuo Yuanyuan, Wu Jiaman, Qu Yimin, Yu Haibo, Yuan Weiqu, Yang Zhuoxin Source Type: research

Lactate: More Than Merely a Metabolic Waste Product in the Inner Retina
AbstractThe retina is an extension of the central nervous system and has been considered to be a simplified, more tractable and accessible version of the brain for a variety of neuroscience investigations. The optic nerve displays changes in response to underlying neurodegenerative diseases, such as stroke, multiple sclerosis, and Alzheimer ’s disease, as well as inner retinal neurodegenerative disease, e.g., glaucoma. Neurodegeneration has increasingly been linked to dysfunctional energy metabolism or conditions in which the energy supply does not meet the demand. Likewise, increasing lactate levels have been correlated...
Source: Molecular Neurobiology - January 8, 2020 Category: Neurology Source Type: research

Involvement of regulated necrosis in blinding diseases: Focus on necroptosis and ferroptosis.
Abstract Besides apoptosis, necrosis can also occur in a highly regulated and genetically controlled manner, defined as regulated necrosis, which is characterized by a loss of cell membrane integrity and release of cytoplasmic content. Depending on the involvement of its signal pathway, regulated necrosis can be further classified as necroptosis, ferroptosis, pyroptosis and parthanatos. Numerous studies have demonstrated that regulated necrosis is involved in the pathogenesis of many diseases covering almost all organs including the brain, heart, liver, kidney, intestine, blood vessel, eye and skin, particularly m...
Source: Experimental Eye Research - January 7, 2020 Category: Opthalmology Authors: Peng JJ, Song WT, Yao F, Zhang X, Peng J, Luo XJ, Xia XB Tags: Exp Eye Res Source Type: research

Prevalence of Retinal Emboli and Acute Retinal Artery Occlusion in Acute Ischemic Stroke
In population-based studies asymptomatic retinal emboli occur in .32%-2.9% of people. Retinal artery occlusion (RAO) may occur concurrently with cerebral stroke but the frequency is unknown. No study has examined how commonly retinal emboli occur in the acute stroke population. We aimed to assess the prevalence of retinal emboli and RAO at the time of carotid territory ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - December 16, 2019 Category: Neurology Authors: Robert A. Egan, Helmi L. Lutsep Source Type: research

Retinal artery occlusion does not portend an increased risk of stroke
The aim of this study was to determine the subsequent risk of stroke after a diagnosis of retinal artery occlusion (RAO). We hypothesized that the risk would be low and comparable to that of the general population. RAO is relatively rare and often incorrectly diagnosed. We believe our institution is in a unique position to investigate this relationship with both a high-volume eye center and vascular laboratory.
Source: Journal of Vascular Surgery - December 13, 2019 Category: Surgery Authors: David J. Laczynski, Joshua Gallop, Sean P. Lyden, Jim Bena, Alex Yuan, Christopher J. Smolock, Francis J. Caputo Source Type: research

Intrathecal baclofen as emergency treatment alleviates severe intractable autonomic dysreflexia in cervical spinal cord injury.
Conclusion/Clinical Relevance: The case demonstrated that refractory AD could be managed with ITB in an emergency. PMID: 31815605 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - December 10, 2019 Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research

Demonstration of acute retinal ischemia on diffusion weighted magnetic resonance imaging
In this case, we demonstrate the ability of diffusion weighted magnetic resonance imaging to localize retinal ischemia in a patient with acute vision loss. MRI is widely used for the evaluation of acute stroke, but there has only been one other case report showing the ability of DWI to rapidly localize retinal pathology, including central retinal artery occlusion [1]. Central retinal artery occlusion is an ocular emergency presenting with acute, painless loss of vision as a result of retinal ischemia.
Source: Clinical Imaging - November 27, 2019 Category: Radiology Authors: Bhavana Pottabatula, Garrett Smith, Nandakumar Nagaraja, Mehmet Sait Albayram Tags: Neuroradiology Source Type: research

Risk of acute stroke in patients with retinal artery occlusion
Eye, Published online: 25 November 2019; doi:10.1038/s41433-019-0715-5Risk of acute stroke in patients with retinal artery occlusion
Source: Eye - November 25, 2019 Category: Opthalmology Authors: Sohan Singh Hayreh Source Type: research

Vitrectomy for idiopathic macular hole in patients aged 80 years or older: efficacy and safety.
Conclusions: The results from our study indicate the efficacy and safety of vitrectomy for idiopathic macular hole in patients aged 80 years or older, and idiopathic MH surgery should not be denied on basis of patient age alone. PMID: 31747306 [PubMed - as supplied by publisher]
Source: Current Eye Research - November 20, 2019 Category: Opthalmology Authors: Wang J, Li Q, Jiang J, Che X, Qian Y, Zhou X, Zhang Y, Wang Z Tags: Curr Eye Res Source Type: research

Phenotypic Delineation of the Retinal Arterial Macroaneurysm with Supravalvular Pulmonic Stenosis (RAMSVPS) Syndrome.
This article is protected by copyright. All rights reserved. PMID: 31730227 [PubMed - as supplied by publisher]
Source: Clinical Genetics - November 15, 2019 Category: Genetics & Stem Cells Authors: Alkuraya H, Patel N, Ibrahim N, Al Ghamdi B, Alsulaiman SM, Nowilaty SR, Abboud E, Alturki R, Alkharashi A, Eyaid W, Almasseri Z, Alzaidan H, Alotaibi MD, Abu El-Asrar AM, Alamro B, Helaby R, Elshaer A, Almontashiri NAM, Al-Hussaini AA, Alkuraya FS Tags: Clin Genet Source Type: research

Symptomatic carotid near-occlusion causes a high risk of recurrent ipsilateral ischemic stroke
ConclusionsSymptomatic carotid near-occlusion has a high short-term risk of recurrent ipsilateral ischemic stroke, especially near-occlusion with full collapse.
Source: Journal of Neurology - November 7, 2019 Category: Neurology Source Type: research

275 A Case Study of Retinal Artery Occlusion Following Mechanical Thrombectomy via Direct Carotid Puncture.
ConclusionProximal intracranial occlusion can effectively be treated with mechanical thrombectomy. Carotid puncture is a rarely used but effective alternative method of arterial access (11 out of 498 procedures between August 2016 and August 2018). Retinal artery occlusion is a possible complication from mechanical thrombectomy with carotid puncture.
Source: Age and Ageing - September 16, 2019 Category: Geriatrics Source Type: research

Risk of acute stroke in patients with retinal artery occlusion: a systematic review and meta-analysis
Eye, Published online: 16 September 2019; doi:10.1038/s41433-019-0576-yRisk of acute stroke in patients with retinal artery occlusion: a systematic review and meta-analysis
Source: Eye - September 16, 2019 Category: Opthalmology Authors: Matteo Fallico Andrew J. Lotery Antonio Longo Teresio Avitabile Vincenza Bonfiglio Andrea Russo Paolo Murabito Stefano Palmucci Alfredo Pulvirenti Michele Reibaldi Source Type: research

Preventive Effects of Dexmedetomidine on Renal Dysfunction and Hemodynamic Stability in Malignant Obstructive Jaundice Patients During Peri-Operative Period.
CONCLUSIONS Dexmedetomidine plays preventive effects on renal dysfunction and hemodynamic stability in malignant obstructive jaundice patients during peri-operative period. PMID: 31498783 [PubMed - in process]
Source: Medical Science Monitor - September 11, 2019 Category: Research Tags: Med Sci Monit Source Type: research

Serum Retinoic Acid Level and The Risk of Poststroke Cognitive Impairment in Ischemic Stroke Patients
This study aimed to detect the association between RA level and PSCI among patients with first-ever acute ischemic stroke. Methods: Two hundred and 61 consecutive patients were prospectively recruited during March 2018 and March 2019.
Source: Journal of Stroke and Cerebrovascular Diseases - September 6, 2019 Category: Neurology Authors: Le Hou, Caixia Ding, Zhao Chen, Yuanyue Liu, Haishan Shi, Cong Zou, Hui Zhang, Zhiwei Lu, Dong Zheng Source Type: research

Role of Bariatric Surgery in Managing Macrovascular Complications of Obesity-Related Type 2 Diabetes
Reducing the risk of macrovascular events, including myocardial infarction and stroke, is a major goal when treating diabetes. Despite this focus, of the major randomized trials used to support current diabetes guidelines (ACCORD, ADVANCE, UKPDS 33, UKPDS 34, VADT), none showed reductions in macrovascular events when the trial results were first reported. For example, UKPDS is still frequently cited in support of aggressive glucose lowering, yet when the primary outcome data were presented in 1998, the results showed no difference between groups in terms of reducing the risk of all-cause mortality (relative risk [RR], 0.94...
Source: JAMA - Journal of the American Medical Association - September 2, 2019 Category: General Medicine Source Type: research

Obstructive Sleep Apnea in Neuro-Ophthalmology
Conclusions: OSA is associated with many diseases seen in neuro-ophthalmology clinics. More studies are required to assess the real ability of CPAP to reverse pathological changes. Ophthalmologists can screen for undiagnosed OSA in patients presenting with certain eye diseases.
Source: Journal of Neuro-Ophthalmology - August 30, 2019 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research

ASSOCIATION OF RETINAL VEIN OCCLUSION WITH CARDIOVASCULAR EVENTS AND MORTALITY: A Systematic Review and Meta-analysis
Conclusion: This review suggests patients with RVO have an increased risk of cardiovascular events and all-cause mortality. More studies are needed to determine the highest risk periods for cardiovascular events and mortality after RVO and whether immediate cardiovascular evaluation and intervention will improve outcomes.
Source: RETINA - August 24, 2019 Category: Opthalmology Tags: Review Source Type: research

Retinal Artery Occlusion Does Not Portend an Increased Risk of Stroke
The aim of this study was to determine the subsequent risk of stroke after a diagnosis of retinal artery occlusion (RAO). We hypothesized that the risk would be low and comparable to that of the general population. RAO is relatively rare and often incorrectly diagnosed. We believe our institution is in a unique position to investigate this relationship with both a high-volume eye center and vascular laboratory.
Source: Journal of Vascular Surgery - August 21, 2019 Category: Surgery Authors: David J. Laczynski, Sean P. Lyden, Joshua Gallop, James Bena, Francis J. Caputo Tags: Abstract from the 2019 Midwestern Vascular Surgical Society Annual Meeting Source Type: research

Contemporary prevalence of carotid stenosis in patients presenting with ischaemic stroke.
CONCLUSION: Carotid stenosis is common, affecting one in five patients presenting with stroke or TIA. Careful MDT discussion may avoid unnecessary intervention and should be the standard of care. PMID: 30938840 [PubMed - as supplied by publisher]
Source: The British Journal of Surgery - April 2, 2019 Category: Surgery Authors: Cheng SF, Brown MM, Simister RJ, Richards T Tags: Br J Surg Source Type: research

Atrial Fibrillation: An Underestimated Cause of Ischemic Monocular Visual Loss?
Introduction: Atrial fibrillation (AF) is a major cause of ischemic stroke and Transient Ischemic Attack (TIA) and investigation for paroxysmal AF is recommended following an embolic brain event. In contrast, retinal ischemic monocular blindness is traditionally considered most linked to carotid artery disease (CAS) and investigating for AF is less vigilant. We aimed to determine the prevalence of AF in patients with ischemic monocular blindness. Methods: Consecutive records of all patients presenting to a daily TIA clinic with transient or permanent ischemic monocular blindness were reviewed, January 2014-October 2016.
Source: Journal of Stroke and Cerebrovascular Diseases - March 29, 2019 Category: Neurology Authors: Angeliki Zarkali, Suk Fun Cheng, Agnes Dados, Robert Simister, Arvind Chandratheva Source Type: research

Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion
We thank Dr Brown for her interest in our article and for the opportunity to respond and re-emphasize important aspects of preventing stroke in patients with central retinal artery occlusion (CRAO).
Source: American Journal of Ophthalmology - March 1, 2019 Category: Opthalmology Authors: Patrick Lavin, Morgan Patrylo, Matthew Hollar, Kiersten B. Espaillat, Howard Kirshner, Matthew Schrag Tags: Correspondence Source Type: research

Stroke Risk Before and After Central Retinal Artery Occlusion in a US Cohort
To determine the risk of ischemic stroke, transient ischemic attack (TIA), and amaurosis fugax around the time of central retinal artery occlusion (CRAO).
Source: Mayo Clinic Proceedings - January 31, 2019 Category: Internal Medicine Authors: Kevin D. Chodnicki, Jose S. Pulido, David O. Hodge, James P. Klaas, John J. Chen Tags: Original article Source Type: research

Plasma retinol and the risk of first stroke in hypertensive adults: a nested case-control study.
Conclusions: Our data showed a significant inverse association between plasma retinol and the risk of first stroke among Chinese hypertensive adults. This study was registered at clinicaltrials.gov as NCT00794885. PMID: 30624586 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - January 9, 2019 Category: Nutrition Authors: Yu Y, Zhang H, Song Y, Lin T, Zhou Z, Guo H, Liu L, Wang B, Liu C, Li J, Zhang Y, Huo Y, Wang C, Wang X, Hou FF, Qin X, Xu X Tags: Am J Clin Nutr Source Type: research

Stroke Risk and Risk Factors in Patients With Central Retinal Artery Occlusion
We read with interest the recently published article1 and commentaries2,3 on the stroke risk and acute management of patients with central retinal artery occlusion (CRAO). As emphasized by Lavin and associates,1 CRAO patients have a high risk of stroke and cardiovascular events. In Lavin and associates' series of 103 patients with acute CRAO seen within 7  days of onset of visual loss, 37.3% of the 67 patients with brain magnetic resonance imaging had coincident acute strokes, 36.7% of patients had severe carotid disease (greater than 70% stenosis, dissection, or intra-arterial thrombus), 33% presented with hypertensive...
Source: American Journal of Ophthalmology - December 19, 2018 Category: Opthalmology Authors: Valerie Biousse, Nancy J. Newman Tags: Correspondence Source Type: research

Evaluation of retinal injury in a rat model of transient ischemic stroke.
This study was designed to evaluate in vivo retinal injury induced by transient global cerebral ischemia/reperfusion (I/R). A stroke-induced retinal injury model in Wistar rats was established by electrocoagulation of bilateral vertebral arteries, combined with transient ligation of the bilateral common carotid arteries. Rats were randomly divided into groups based on the time post cerebral perfusion (3 h, 24 h, 48 h, 72 h, and 7 days). Retinal injury was evaluated by histological analysis, examination of eye fundus, and TUNEL staining. The expression of protein kinase C-alpha (PKCα) and fibrillary acidic protein (GFAP) w...
Source: Histology and Histopathology - November 11, 2018 Category: Cytology Tags: Histol Histopathol Source Type: research

Retinal Vasculature Reactivity During Flicker Light Provocation, Cardiac Stress and Stroke Risk in Africans: The SABPA Study
AbstractStructural and functional similarities exist between the retinal, cerebral and, as previously suggested, the coronary microvasculature. Retinal microvascular structure and functionality (in response to flicker-light-induced-provocation (FLIP)) may relate to coronary artery disease risk and possible stroke risk. We investigated associations between retinal vessel structure, functionality and cardiac stress markers (cardiac troponin T [cTnT], amino-terminal B-type natriuretic peptide [NT-proBNP]) to translate these retina –heart relationships to stroke risk. We included 317 African and Caucasian teachers’ (aged 2...
Source: Translational Stroke Research - November 9, 2018 Category: Neurology Source Type: research

Risk of Ischemic Stroke, Hemorrhagic Stroke, and All-Cause Mortality in Retinal Vein Occlusion: A Nationwide Population-Based Cohort Study.
Conclusions: People with RVO are at a significantly greater risk of developing stroke, ischemic stroke, and hemorrhagic stroke. However, RVO does not significantly increase the risk of all-cause mortality. PMID: 30271630 [PubMed]
Source: Journal of Ophthalmology - October 3, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research

Bilateral central retinal vein occlusions in a young patient with a history of eosinophilic pneumonia and thalamic stroke
Conclusion: Central retinal vein occlusion in young patients is a rare condition often presenting as a manifestation of an underlying inflammatory or hematological disorder. Combined anti–vascular endothelial growth factor treatment and pan-retinal photocoagulation may have resolved the associated cystoid macular edema in this case, although continued observation is necessary.
Source: Retinal Cases and Brief Reports - October 1, 2018 Category: Opthalmology Tags: Case Report Source Type: research

The mediating role of the venules between smoking and ischemic stroke
This study was part of a population-based study including 9109 stroke-free persons participated in the study in 1990, 2004, or 2006 (mean age: 63.7  years; 58% women). Smoking behavior (smoking versus non-smoking) was identified by interview. Retinal venular calibers were measured semi-automatically on retinal photographs. Incident strokes were assessed until January 2016. A regression-based approach was used with venular calibers as mediator to decompose the total effect of smoking compared to non-smoking into four components: controlled direct effect (neither mediation nor interaction), pure indirect effect (mediation o...
Source: European Journal of Epidemiology - September 4, 2018 Category: Epidemiology Source Type: research

Stroke risk and risk factors in patients with central retinal artery occlusion
This study evaluates the yield of this evaluation in patients with CRAO and frequency of stroke in this population.
Source: American Journal of Ophthalmology - August 25, 2018 Category: Opthalmology Authors: Patrick Lavin, Morgan Patrylo, Matthew Hollar, Kiersten B. Espaillat, Howard Kirshner, Matthew Schrag Tags: Original Articles Source Type: research

Risk of Acute Ischemic Stroke in Patients With Monocular Vision Loss of Vascular Etiology
Conclusions: Patients with MVL of vascular etiology such as TMVL, CRAO, or BRAO may have up to 19.5% risk of concurrent ischemic stroke, even when there are no other neurologic deficits. These strokes were detected acutely with brain MRI using DWI but were missed on CT.
Source: Journal of Neuro-Ophthalmology - August 18, 2018 Category: Opthalmology Tags: Original Contribution Source Type: research

The Role of Retinal Vascular Density as a Screening Tool for Ageing and Stroke
Conclusion: Age and stroke are significant risk factors for decreased RVD. Diabetes and arterial hypertension are additional significant risk factors in patients with stroke with respect to RVD.Ophthalmic Res
Source: Ophthalmic Research - June 6, 2018 Category: Opthalmology Source Type: research

Retinal detachment and microangiopathy in mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome.
PMID: 29217043 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - December 1, 2017 Category: Opthalmology Authors: Sultan H, Kellogg C, El-Annan J Tags: Can J Ophthalmol Source Type: research

Neurosurgical Modeling of Retinal Ischemia –Reperfusion Injury
We present a novel reproducible pterygopalatine–ophthalmic artery ligation model of ischemia–reperfusion injury in the retina.
Source: Journal of Stroke and Cerebrovascular Diseases - November 29, 2017 Category: Neurology Authors: Alireza P. Shabanzadeh, Philippe M. D'Onofrio, Philippe P. Monnier, Paulo D. Koeberle Source Type: research

Circulating Endothelial Markers in Retinal Vasculopathy With Cerebral Leukoencephalopathy and Systemic Manifestations Clinical Sciences
Background and Purpose—Retinal vasculopathy with cerebral leukoencephalopathy and systemic manifestations (RVCL-S) is a monogenic small vessel disease, caused by C-terminal truncating TREX1 mutations, that can be considered a model for stroke and vascular dementia. The pathophysiology of RVCL-S is largely unknown, but systemic endothelial involvement has been suggested, leading to pathology in the brain and other highly vascularized organs. Here, we investigated circulating endothelial markers to confirm endothelial involvement and identify biomarkers for disease activity.Methods—We measured circulating levels of von W...
Source: Stroke - November 27, 2017 Category: Neurology Authors: Nadine Pelzer, Roel Bijkerk, Marlies E.J. Reinders, Anton Jan van Zonneveld, Michel D. Ferrari, Arn M.J.M. van den Maagdenberg, Jeroen Eikenboom, Gisela M. Terwindt Tags: Biomarkers, Endothelium/Vascular Type/Nitric Oxide, Genetics, Cerebrovascular Disease/Stroke Original Contributions Source Type: research

Association of Retinal Emboli in Asians With Ethnicity, Stroke, and Renal Disease
This population-based study examines the prevalence of and risk factors for retinal emboli and associations with ethnicity, stroke, and renal disease in a large, contemporary, multiethnic Asian population.
Source: JAMA Ophthalmology - October 1, 2017 Category: Opthalmology Source Type: research

Plasma Retinol-Binding Protein 4 Levels and the Risk of Ischemic Stroke among Women
Plasma retinol-binding protein 4 (RBP4) levels have been associated with cardiovascular risk factors and risk of coronary heart disease, but little is known about the association between RBP4 and the risk of ischemic stroke. We hypothesized that elevated RBP4 levels would be associated with an increased risk of ischemic stroke among women.
Source: Journal of Stroke and Cerebrovascular Diseases - September 6, 2017 Category: Neurology Authors: Pamela M. Rist, Monik C. Jim énez, Shelley S. Tworoger, Frank B. Hu, JoAnn E. Manson, Qi Sun, Kathryn M. Rexrode Source Type: research

New Standards of Care in Ischemic Stroke
Conclusions: Endovascular therapy is now standard of care for eligible patients with anterior large vessel occlusions. Prolonged cardiac monitoring is recommended for patients with cryptogenic stroke. The novel anticoagulants are an alternative to warfarin in patients with AF.
Source: Journal of Neuro-Ophthalmology - August 17, 2017 Category: Opthalmology Tags: State-of-the-Art Review Source Type: research

Response by Golsari and Thomalla to Letter Regarding Article, “Silent Brain Infarctions and Leukoaraiosis in Patients With Retinal Ischemia: A Prospective Single-Center Observational Study” Letter to the Editor
Source: Stroke - July 24, 2017 Category: Neurology Authors: Amir Golsari, Gotz Thomalla Tags: Cerebrovascular Disease/Stroke, Ischemic Stroke Letters to the Editor Source Type: research

Curcumin protects against hypertension aggravated retinal ischemia/reperfusion in a rat stroke model.
The objective of this study was to explore retinal damage in stroke spontaneously hypertensive rats (SHR) and evaluate the role of curcumin in the retinal injury after stroke. Mature male SHR were used as the animal model for hypertension and age-matched male Wistar-Kyoto (WKY) rats as the normotensive controls. The rat model of stroke was made by bilateral vertebral artery electrocoagulation combined with transient bilateral common carotid artery ligation. The animals were randomly divided into sham group, ischemia/reperfusion group, solvent control group, and curcumin treatment group. Each group was subdivided into 2 h, ...
Source: Clinical and Experimental Hypertension - July 5, 2017 Category: Cardiology Authors: Wang S, Ye Q, Tu J, Zhang M, Ji B Tags: Clin Exp Hypertens Source Type: research