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Admission glucose level was associated with increased short-term mortality and length-of-stay irrespective of diagnosis, treating medical specialty or concomitant laboratory values.
CONCLUSIONS: Short-term mortality increased substantially with admission hypo- and hyperglycemia for patients both with and without diabetes, irrespective of treating medical specialty, main discharge diagnosis, or concurrent laboratory values. Patients with diabetes (16%) were older, with higher glucose levels at admission, and with a different pattern of the association of admission glucose and mortality. PMID: 31982283 [PubMed - as supplied by publisher]
Source: European Journal of Internal Medicine - January 22, 2020 Category: Internal Medicine Authors: Björk M, Melin EO, Frisk T, Thunander M Tags: Eur J Intern Med Source Type: research
Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome.
CONCLUSIONS: Our data demonstrate that acute inhibition of a subset of excitatory neurons after ischemic stroke can prevent brain injury and improve functional outcome. This study, together with the previous work in optogenetic neuronal modulation during the chronic phase of stroke, supports the notion that targeting neuronal activity is a promising strategy in stroke therapy. PMID: 31962128 [PubMed - as supplied by publisher]
Source: Experimental Neurology - January 18, 2020 Category: Neurology Authors: Wang YC, Galeffi F, Wang W, Li X, Lu L, Sheng H, Hoffmann U, Turner DA, Yang W Tags: Exp Neurol Source Type: research
Interim effects of salt substitution on urinary electrolytes and blood pressure in the China Salt Substitute and Stroke Study (SSaSS)
Publication date: Available online 7 January 2020Source: American Heart JournalAuthor(s): Liping Huang, Maoyi Tian, Jie Yu, Qiang Li, Yishu Liu, Xuejun Yin, Jason HY Wu, Matti Marklund, Yangfeng Wu, Nicole Li, Paul Elliot, Lijing L. Yan, Darwin R. Labarthe, Zhixin Hao, Jingpu Shi, Xiangxian Feng, Jianxin Zhang, Yuhong Zhang, Ruijuan Zhang, Bo ZhouAbstractThe Salt Substitute and Stroke Study is an ongoing 5-year large-scale cluster randomized trial investigating the effects of potassium-enriched salt substitute compared to usual salt on the risk of stroke. The study involves 600 villages and 20,996 individuals in rural Chin...
Source: American Heart Journal - January 7, 2020 Category: Cardiology Source Type: research
Top 10 Health Questions America Asked Dr. Google In 2019
(CNN) — Google users in the United States had a lot of questions about blood pressure, the keto diet and hiccups in 2019. Those topics were among the 10 most-searched health-related questions on the search engine this year, according to new data from Google. The list was based on search terms collected between January and early December. Last year, the top health-related questions Googled by people in the US included what is amyotrophic lateral sclerosis, or ALS, what is endometriosis and how long does weed stay in your urine. In 2017, what is lupus, how long does the flu last and what causes hiccups were some of the...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - December 12, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Google Source Type: news
Down ‐regulation of miR‐3068‐3p enhances kcnip4‐regulated A‐type potassium current to protect against glutamate‐induced excitotoxicity
AbstractThe main cause of excitotoxic neuronal death in ischemic stroke is the massive release of glutamate. Recently, microRNAs (miRNAs) have been found to play an essential role in stroke pathology, although the molecular mechanisms remain to be investigated. Here, to identify potential candidate miRNAs involved in excitotoxicity, we treated rat primary cortical neurons with glutamate and found that miR ‐3068‐3p, a novel miRNA, was upregulated. We hypothesized that restoring miR‐3068‐3p expression might influence the neuronal injury outcomes. The inhibition of miR‐3068‐3p, using tough decoy lentiviruses, sign...
Source: Journal of Neurochemistry - December 2, 2019 Category: Neuroscience Authors: Zi ‐Jun Su, Xu‐Yi Wang, Chen Zhou, Zhen Chai Tags: ORIGINAL ARTICLE Source Type: research
Potassium binding for conservative and preservative management of chronic kidney disease
In conclusion, there are new well tolerated and effective K+-binding agents for acutely and chronically managing hyperkalemia.
Source: Current Opinion in Nephrology and Hypertension - November 29, 2019 Category: Urology & Nephrology Tags: NOVEL THERAPEUTIC APPROACHES IN NEPHROLOGY AND HYPERTENSION: Edited by Kamyar Kalantar-Zadeh and Ekamol Tantisattamo Source Type: research
The Potassium SK Channel Activator NS309 Protects Against Experimental Traumatic Brain Injury Through Anti-Inflammatory and Immunomodulatory Mechanisms
Neuroinflammation plays important roles in neuronal cell death and functional deficits after TBI. Small conductance Ca2+-activated K+ channels (SK) have been shown to be potential therapeutic targets for treatment of neurological disorders, such as stroke and Parkinson’s disease (PD). The aim of the present study was to investigate the role of SK channels in an animal model of TBI induced by controlled cortical impact (CCI). The SK channels activator NS309 at a concentration of 2 mg/kg was administered by intraperitoneal injection, and no obviously organ-related toxicity of NS309 was found in Sprague-Dawley (SD) rats. Tr...
Source: Frontiers in Pharmacology - November 29, 2019 Category: Drugs & Pharmacology Source Type: research
A Simple Assay to Evaluate the Function of Human Connexin Hemichannels Expressed in Escherichia coli that Can Be Used for Drug Discovery and Mutant Analysis.
Authors: Fiori MC, Cuello LG, Altenberg GA Abstract Abnormally increased activity of connexin hemichannels contributes to cell damage in many disorders, including deafness, stroke, and cardiac infarct, and therefore hemichannels constitute a potentially important therapeutic target. Unfortunately, the available hemichannel inhibitors are not specific and most are toxic. The absence of a simple and cost-effective screening assay has made the discovery of hemichannel inhibitors difficult. Here, we present an optimized assay where human connexins are expressed in genetically modified Escherichia coli cells deficient i...
Source: Current Protocols in Pharmacology - November 24, 2019 Category: Drugs & Pharmacology Tags: Curr Protoc Pharmacol Source Type: research
Changes in electrolyte concentrations alter the impedance during ischemia-reperfusion injury in rat
In this study, changes in the bio-impedance spectroscopy using a two-electrode method with varying frequencies from 100 to 35 kHz have been assessed in a model of global cerebral ischemia in anesthetized rats during normal, occlusion and reperfusion conditions. Global cerebral ischemia was induced by bilateral common carotid artery occlusion for 40 min following 40 min of reperfusion. The concentration of sodium, potassium, calcium and chloride ions in the whole rat brain was determined by electrolyte analyzer. For the interpretation of in vivo results, changes in electrical impedance with varying concentrati...
Source: Physiological Measurement - October 30, 2019 Category: Physiology Authors: Gaurav Kumar, Uvanesh Kasiviswanathan, Sumedha Mukherjee, Sanjeev Kumar Mahto, Neeraj Sharma and Ranjana Patnaik Source Type: research
Hyperkalemia in heart failure patients in Spain and its impact on guidelines and recommendations: ESC-EORP-HFA Heart Failure Long-Term Registry
ConclusionsThis study highlights the magnitude of the problem of hyperkalemia in patients with heart failure in everyday clinical practice and the need to improve monitoring of this factor in these patients due to its interference with the possibility of receiving optimal treatment.ResumenIntroducción y objetivosLa hiperpotasemia es una preocupación creciente en el tratamiento de los pacientes con insuficiencia cardiaca y fracción de eyección reducida, pues limita el uso de fármacos eficaces. Este trabajo ofrece estimaciones de la magnitud de este problema en la práctica clínica habitual en España, los cambios en l...
Source: Revista Espanola de Cardiologia - October 29, 2019 Category: Cardiology Source Type: research
Registration of amiloride in South Africa: Cutting the Gordian knot.
Authors: Rayner BL, Spence JD, Bryer A, Mpe MT Abstract Amiloride is an antagonist of the renal tubular epithelial sodium channel (ENaC). As such, it is a diuretic that is both potassium and magnesium sparing. It is used for the treatment of potassium depletion and hypertension, and is the specific therapy for hypertension due to overactivity of the ENaC (Liddle syndrome and several additional genetic causes of the Liddle phenotype - low renin and low aldosterone). It is listed as a World Health Organization essential drug, but has never been registered in South Africa (SA) and can therefore only be prescribed unde...
Source: South African Medical Journal - October 24, 2019 Category: African Health Tags: S Afr Med J Source Type: research
KCa3.1 deficiency attenuates neuroinflammation by regulating an astrocyte phenotype switch involving the PI3K/AKT/GSK3 β pathway.
KCa3.1 deficiency attenuates neuroinflammation by regulating an astrocyte phenotype switch involving the PI3K/AKT/GSK3β pathway. Neurobiol Dis. 2019 Aug 27;:104588 Authors: Wei T, Wang Y, Xu W, Yan L, Chen H, Yu Z Abstract Neuroinflammation may induce a phenotype switch to reactive astrogliosis in neurodegenerative disorders. The calcium-activated potassium channel (KCa3.1) is active in the phenotypic switch that occurs during astrogliosis in Alzheimer's disease and ischemic stroke. Here, transcriptome sequencing (RNA-Seq), immunohistochemistry, western blotting, pharmacological blockade, and calcium...
Source: Neurobiology of Disease - August 27, 2019 Category: Neurology Authors: Wei T, Wang Y, Xu W, Yan L, Chen H, Yu Z Tags: Neurobiol Dis Source Type: research
Sodium-activated potassium channels moderate excitability in vascular smooth muscle.
This article is protected by copyright. All rights reserved. PMID: 31444905 [PubMed - as supplied by publisher]
Source: The Journal of Physiology - August 24, 2019 Category: Physiology Authors: Li P, Halabi CM, Stewart R, Butler A, Brown B, Xia X, Santi C, England S, Ferreira J, Mecham RP, Salkoff L Tags: J Physiol Source Type: research
Descriptive Analysis of Cerebral Arterial Vascular Architecture in Dromedary Camel (Camelus dromedarius)
This study employed the new casting method to illustrate a new arterial source to RERM and the various anastomoses among arterial sources supplying the brain in the dromedary. These anastomoses play an important role in maintaining an uninterrupted cerebral blood supply, decreasing the vulnerability of the fragile brain against ischaemia and stroke, as well as, play an important role in maintaining blood pressure and flow in long-necked dromedaries when they raise or lower their heads.
Source: Frontiers in Neuroanatomy - July 5, 2019 Category: Neurology Source Type: research
Cardiovascular risk in primary aldosteronism: A systematic review and meta-analysis
This study aimed to evaluate whether the increased cardiovascular risk and the incidence of cerebrovascular (CCV) events in hypertensive patients were related to primary aldosteronism (PA). Methods: The PubMed, EmBase, and the Cochrane Central Register of Controlled Trials were searched to evaluate the risk of CCV in PA patients and compared to essential hypertension (EH) patients. The mean differences (MD) and the risk ratios (RR) were calculated to assess the risk of main outcomes, such as stroke, coronary artery disease, left ventricular hypertrophy (LVH), levels of systolic blood pressure (SBP), diastolic blood pres...
Source: Medicine - June 1, 2019 Category: Internal Medicine Tags: Research Article: Systematic Review and Meta-Analysis Source Type: research
Serum Glucose and Potassium Ratio as Risk Factors for Cerebral Vasospasm after Aneurysmal Subarachnoid Hemorrhage
Objective: Cerebral vasospasm is associated with poor prognosis in patients with aneurysmal subarachnoid hemorrhage (SAH), and biomarkers for predicting poor prognosis have not yet been established. We attempted to clarify the relationship between serum glucose/potassium ratio and cerebral vasospasm in patients with aneurysmal SAH. Methods: We studied 333 of 535 aneurysmal SAH patients treated between 2006 and 2016 (123 males, 210 females; mean age 59.7 years; range 24-93). We retrospectively analyzed the relationship between cerebral vasospasm grade and clinical risk factors, including serum glucose/potassium ratio.
Source: Journal of Stroke and Cerebrovascular Diseases - May 3, 2019 Category: Neurology Authors: Fumihiro Matano, Yu Fujiki, Takayuki Mizunari, Kenta Koketsu, Tomonori Tamaki, Yasuo Murai, Hiroyuki Yokota, Akio Morita Source Type: research
Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats
Conclusion Principal findings of this work are that abnormal Ca2+ transient amplitude, contractile dysfunction; and impaired relaxation of MetS cardiomyocytes underlies intrinsic dysfunctional RyR2 and SERCA pump. Abnormal activity of RyRs was evidenced by its decreased ability to bind [3H]-ryanodine. Although the MetS condition does not modify RyR2 protein expression, its phosphorylation at Ser2814 is decreased, which impairs its capacity for activation during ECC. The dysfunctional RyRs, together with a decreased activity of SERCA pump due to decreased Thr17-PLN phosphorylation suggest a downregulation of CaMKII in MetS...
Source: Frontiers in Physiology - April 30, 2019 Category: Physiology Source Type: research
Using Dental Pulp Stem Cells for Stroke Therapy
Conclusion and Future Perspectives Stem cell-based therapy is a promising alternative for stroke treatment. While stem cells from different sources, including induced PSC, ESC, MSC, and NSC, have been investigated, using NSC and enhancing the natural mechanisms is most appropriate for brain repair. In preclinical models of stroke, stem cell transplantation has led to positive outcomes through a variety of cellular and molecular mechanisms, many being mediated by the array of beneficial factors produced by the cells. Recent advances in cellular reprogramming have provided alternative sources of NSC to be investigated, allo...
Source: Frontiers in Neurology - April 29, 2019 Category: Neurology Source Type: research
A Novel Variant in Non-coding Region of GJB1 Is Associated With X-Linked Charcot-Marie-Tooth Disease Type 1 and Transient CNS Symptoms
Conclusion A novel GJB1 variant of c.-170T>G in non-coding region was found in this big Chinese CMTX1 pedigree. This is the first report of variant in non-coding DNA sequence associated with transient CNS symptoms. Thyroid malfunction may contribute to the CNS symptoms in this case. Ethics Statement This study has been reviewed and approved by the Ethics Committee of the China-Japan Union Hospital of Jilin University. Each member of the family provided written informed consent to the participation in the study, the genetic test, and authorized to publish the study including the photos in accordance with the Decl...
Source: Frontiers in Neurology - April 24, 2019 Category: Neurology Source Type: research
Multifractal Desynchronization of the Cardiac Excitable Cell Network During Atrial Fibrillation. II. Modeling
In this study, we elaborate on a tentative interpretation of the observed intermittent dynamics during AF as the signature of synaptic plasticity. Typical individual GJC transition times between open and closed states were shown to be much longer than those of membrane polarization but compare well with membrane recovery time (≳ 100ms) (Spray et al., 1984; Neyton and Trautmann, 1986; Wang et al., 1992; Bukauskas and Verselis, 2004; Desplantez et al., 2007). Moreover, slow gating modulations have been evidenced due to cytoplasmic protons (low pH) and free calcium (Spray et al., 1984; Burt and Sray, 1988; Kumar and G...
Source: Frontiers in Physiology - April 24, 2019 Category: Physiology Source Type: research
Atrial Transcriptional Profiles of Molecular Targets Mediating Electrophysiological Function in Aging and Pgc-1 β Deficient Murine Hearts
Conclusion: These findings limit the possible roles of gene transcriptional changes in previously reported age-dependent pro-arrhythmic electrophysiologial changes observed in Pgc-1β-/- atria to an altered Ca2+-ATPase (Atp2a2) expression. This directly parallels previously reported arrhythmic mechanism associated with p21-activated kinase type 1 deficiency. This could add to contributions from the direct physiological outcomes of mitochondrial dysfunction, whether through reactive oxygen species (ROS) production or altered Ca2+ homeostasis. Introduction Atrial arrhythmias constitute a major public health pro...
Source: Frontiers in Physiology - April 24, 2019 Category: Physiology Source Type: research
Nrf2 as a Potential Mediator of Cardiovascular Risk in Metabolic Diseases
Conclusion Activation of the Nrf2-dependent antioxidant system plays an important role in cell defense against oxidative stress damage, whereas the insufficiency of the Nrf2 system is associated with multiple aspects of the genesis and progression of metabolic diseases, posing a great risk to the cardiovascular system (Figure 1). The systemic increase of Nrf2 activity by several activators may be beneficial in the treatment of metabolic diseases. In addition, selective upregulation of Nrf2 genes may represent a potential therapy in obesity, diabetes and atherosclerosis. Looking to the future, experimental research that el...
Source: Frontiers in Pharmacology - April 12, 2019 Category: Drugs & Pharmacology Source Type: research
Role of TREK-1 in Health and Disease, Focus on the Central Nervous System
Conclusion and Perspectives Since their cloning 20 years ago, the physiological importance of TREK-1 channels has continued to grow (Figure 3). Today, TREK-1 channels have been shown to be important and their presence is essential in a number of physiopathological processes. Their involvement in these different processes demonstrate the necessity to design pharmacological modulators, activators or inhibitors, of these channels to correct any TREK-1-related dysfunctions. Despites a number of studies and many molecule screenings, only few putative new drugs were identified. The activators belonging to the ML and BL series ...
Source: Frontiers in Pharmacology - April 11, 2019 Category: Drugs & Pharmacology Source Type: research
Factors Influencing Quality of Life in Stroke Patients: Focus on Eating Habits
This study aimed to identify lifestyle factors about eating habits that may affect the quality of life (QOL) in elderly stroke patients. Methods: Fifty elderly patients with a first-ever stroke were enrolled. QOL was assessed by the Stroke and Aphasia QOL Scale-39-J. Lifestyle factors about eating habits were collected using questionnaires (Questions 1-17) for the intake of salt, calcium, magnesium, potassium, taurine, fiber, and protein, and the frequency of breakfast.
Source: Journal of Stroke and Cerebrovascular Diseases - March 19, 2019 Category: Neurology Authors: Reina Chiba, Saya Tominaga, Kasumi Mikami, Maiko Kitajima, Mayumi Urushizaka, Toshiko Tomisawa, Junko Chiba, Joji Hagii, Minoru Yasujima, Tomohiro Osanai Source Type: research
Increased burden of rare deleterious variants of the KCNQ1 gene in patients with large ‑vessel ischemic stroke.
Increased burden of rare deleterious variants of the KCNQ1 gene in patients with large‑vessel ischemic stroke. Mol Med Rep. 2019 Feb 25;: Authors: Janicki PK, Eyileten C, Ruiz-Velasco V, Pordzik J, Czlonkowska A, Kurkowska-Jastrzebska I, Sugino S, Imamura Kawasawa Y, Mirowska-Guzel D, Postula M Abstract The impact of rare and damaging variants in genes associated with platelet function in large‑vessel ischemic stroke (LVIS) remains unknown. The aim of this study was to investigate the contribution of some of these variants to the genetic susceptibility to LVIS in Polish patients using a deep re‑...
Source: Molecular Medicine Reports - March 4, 2019 Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Prevent heart attack and stroke with potassium; it keeps your arteries flexible
(Natural News) Take care of your heart by eating at least one potassium-rich food such as a banana or an avocado a day to prevent heart attacks and stroke. A boost in potassium intake helps regulate blood pressure and give strength to muscles. Foods with high levels of potassium such as bananas and avocados are often called “brain...
Source: NaturalNews.com - February 13, 2019 Category: Consumer Health News Source Type: news
A Novel Model for Studying Voltage-Gated Ion Channel Gene Expression during Reversible Ischemic Stroke.
In conclusion, to our knowledge, this is the first report of the successful evaluation of voltage-gated ion channel gene expression in TIA and RIND animal models. This model will aid future studies in investigating pathophysiological mechanisms, and in developing new therapeutic compounds for the treatment of TIA and RIND. PMID: 30662329 [PubMed - in process]
Source: International Journal of Medical Sciences - January 22, 2019 Category: Biomedical Science Tags: Int J Med Sci Source Type: research
Dietary Sodium, Sodium-to-Potassium Ratio, and Risk of Stroke: A Systematic Review and Nonlinear Dose-Response Meta-Analysis
This study aimed to test the dose-response association of dietary sodium and sodium-to-potassium ratio with risk of stroke in adults aged 18 years or older.
Source: Clinical Nutrition - June 1, 2018 Category: Nutrition Authors: Ahmad Jayedi, Farnoosh Ghomashi, Mahdieh Sadat Zargar, Sakineh Shab-Bidar Source Type: research
The role of KATP channels in cerebral ischemic stroke and diabetes.
Abstract ATP-sensitive potassium (KATP) channels are ubiquitously expressed on the plasma membrane of cells in multiple organs, including the heart, pancreas and brain. KATP channels play important roles in controlling and regulating cellular functions in response to metabolic state, which are inhibited by ATP and activated by Mg-ADP, allowing the cell to couple cellular metabolic state (ATP/ADP ratio) to electrical activity of the cell membrane. KATP channels mediate insulin secretion in pancreatic islet beta cells, and controlling vascular tone. Under pathophysiological conditions, KATP channels play cytoprotect...
Source: Acta Pharmacologica Sinica - April 19, 2018 Category: Drugs & Pharmacology Authors: Szeto V, Chen NH, Sun HS, Feng ZP Tags: Acta Pharmacol Sin Source Type: research
Frequency and predictors of post-stroke delirium in PRospective Observational POLIsh Study (PROPOLIS)
AbstractDelirium is the most common and serious neurobehavioral complication in acute hospital admissions. Some patients develop signs of delirium but do not meet all diagnostic criteria. Stroke is a major risk factor for delirium. The aim of this prospective study was to build a predictive model for delirium and subsyndromal post-stroke delirium. Patients with stroke were screened for delirium during the first 7 days after admission. Delirium was diagnosed according to DSM-V criteria. Baseline demographic, biochemical, stroke-related data, medications used, neurological deficit, and premorbid cognitive and functional im...
Source: Journal of Neurology - February 8, 2018 Category: Neurology Source Type: research
Letter by Spence Regarding Article, “Serum Potassium Is Positively Associated With Stroke and Mortality in the Large, Population-Based Malmo Preventive Proȷect Cohort” Letter to the Editor
Source: Stroke - December 22, 2017 Category: Neurology Authors: J. David Spence Tags: Risk Factors, Cerebrovascular Disease/Stroke Letters to the Editor Source Type: research
Response by Johnson and Soderholm to Letter Regarding Article, “Serum Potassium Is Positively Associated With Stroke and Mortality in the Large, Population-Based Malmo Preventive Proȷect Cohort” Letter to the Editor
Source: Stroke - December 22, 2017 Category: Neurology Authors: Linda S. Johnson, Martin Soderholm Tags: Cardiovascular Disease, Epidemiology Letters to the Editor Source Type: research
Intake of potassium- and magnesium-enriched salt improves functional outcome after stroke: a randomized, multicenter, double-blind controlled trial Vitamins, minerals, and phytochemicals
Conclusions: This study suggests that providing the DRI amount of magnesium and potassium together long term is beneficial for stroke patient recovery from neurologic deficits. This trial was registered at clinicaltrials.gov as NCT02910427.
Source: American Journal of Clinical Nutrition - November 1, 2017 Category: Nutrition Authors: Pan, W.-H., Lai, Y.-H., Yeh, W.-T., Chen, J.-R., Jeng, J.-S., Bai, C.-H., Lin, R.-T., Lee, T.-H., Chang, K.-C., Lin, H.-J., Hsiao, C.-F., Chern, C.-M., Lien, L.-M., Liu, C.-H., Chen, W.-H., Chang, A. Tags: Research Need: Role of Nutrition in Medical Management Vitamins, minerals, and phytochemicals Source Type: research
Serum Potassium Is Positively Associated With Stroke and Mortality in the Large, Population-Based Malmo Preventive Proȷect Cohort Clinical Sciences
Background and Purpose—Low serum potassium is associated with stroke in populations with cardiovascular disease, hypertension, and diabetes mellitus but has not been studied in a mainly healthy population. We aimed to study the relation between serum potassium and incident stroke and mortality in the Malmö Preventive Project, a large cohort with screening in early mid-life and follow-up>25 years.Methods—Serum potassium measurements and covariates were available in 21 353 individuals (79% men, mean age 44 years). Mean follow-up time was 26.9 years for stroke analyses and 29.3 years for mortality analyses. There were ...
Source: Stroke - October 23, 2017 Category: Neurology Authors: Linda S. Johnson, Nick Mattsson, Ahmad Saȷadieh, Per Wollmer, Martin Soderholm Tags: Diet and Nutrition, Epidemiology, Lifestyle, Primary Prevention, Risk Factors Original Contributions Source Type: research
Dietary Sodium to Potassium Ratio and Risk of Stroke in a Multiethnic Urban Population Clinical Sciences
Conclusions—Na:K intake is an independent predictor of stroke risk. Further studies are required to understand the joint effect of Na and K intake on risk of cardiovascular disease.
Source: Stroke - October 23, 2017 Category: Neurology Authors: Joshua Willey, Hannah Gardener, Sandino Cespedes, Ying K. Cheung, Ralph L. Sacco, Mitchell S.V. Elkind Tags: Diet and Nutrition, Epidemiology, Risk Factors, Ischemic Stroke Original Contributions Source Type: research
The potassium channel KCa3.1 constitutes a pharmacological target for astrogliosis associated with ischemia stroke
Reactive astrogliosis is one of the significantly pathological features in ischemic stroke accompanied with changes in gene expression, morphology, and proliferation. KCa3.1 was involved in TGF- β-induced astro...
Source: Journal of Neuroinflammation - October 16, 2017 Category: Neurology Authors: Mengni Yi, Tianjiao Wei, Yanxia Wang, Qin Lu, Gaoxian Chen, Xiaoling Gao, Herbert M. Geller, Hongzhuan Chen and Zhihua Yu Tags: Research Source Type: research
IJERPH, Vol. 14, Pages 1211: Validation and Assessment of Three Methods to Estimate 24-h Urinary Sodium Excretion from Spot Urine Samples in High-Risk Elder Patients of Stroke from the Rural Areas of Shaanxi Province
Conclusion: The Kawasaki, INTERSALT and Tanaka methods for estimation of 24-h urinary sodium excretion from spot urine specimens were inadequate for the assessment of sodium intake at the population level in high-risk elder patients of stroke from the rural areas of Shaanxi province, although the Kawasaki method was the least biased compared with the other two methods.
Source: International Journal of Environmental Research and Public Health - October 11, 2017 Category: Environmental Health Authors: Wenxia Ma Xuejun Yin Ruijuan Zhang Furong Liu Danrong Yang Yameng Fan Jie Rong Maoyi Tian Yan Yu Tags: Article Source Type: research
Prognostic Impact of Mild Hypokalemia in Terms of Death and Stroke in the General Population —A Prospective Population Study
Potassium supplementation reduces the risk of cardiovascular mortality and stroke in population studies; however, the prognostic impact of mild hypokalemia in the general population has not been thoroughly investigated. We aimed to investigate associations between mild hypokalemia and endpoints in the general population.
Source: The American Journal of Medicine - October 9, 2017 Category: General Medicine Authors: Nick Mattsson, Olav Wendelboe Nielsen, Linda Johnson, Eva Prescott, Peter Schnohr, Gorm Boje Jensen, Lars K øber, Ahmad Sajadieh Tags: Clinical Research Study Source Type: research
Intake of potassium- and magnesium-enriched salt improves functional outcome after stroke: a randomized, multicenter, double-blind controlled trial.
Conclusions: This study suggests that providing the DRI amount of magnesium and potassium together long term is beneficial for stroke patient recovery from neurologic deficits. This trial was registered at clinicaltrials.gov as NCT02910427. PMID: 28877896 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - September 6, 2017 Category: Nutrition Authors: Pan WH, Lai YH, Yeh WT, Chen JR, Jeng JS, Bai CH, Lin RT, Lee TH, Chang KC, Lin HJ, Hsiao CF, Chern CM, Lien LM, Liu CH, Chen WH, Chang A Tags: Am J Clin Nutr Source Type: research
Meta-Analysis of Potassium Intake and the Risk of Stroke Genetics
Conclusions Overall, this dose–response meta-analysis confirms the inverse association between potassium intake and stroke risk, with potassium intake of 90 mmol (3500 mg)/day associated with the lowest risk of stroke.
Source: JAHA:Journal of the American Heart Association - October 6, 2016 Category: Cardiology Authors: Vinceti, M., Filippini, T., Crippa, A., de Sesmaisons, A., Wise, L. A., Orsini, N. Tags: Diet and Nutrition, Epidemiology, Primary Prevention, Risk Factors Genetics Source Type: research
Intakes of magnesium, potassium, and calcium and the risk of stroke among men
ConclusionsA diet rich in magnesium, potassium, and calcium may contribute to reduced risk of stroke among men. Because of significant collinearity, the independent contribution of each cation is difficult to define.
Source: International Journal of Stroke - June 4, 2015 Category: Neurology Authors: Sally N. Adebamowo, Donna Spiegelman, Alan J. Flint, Walter C. Willett, Kathryn M. Rexrode Tags: Research Source Type: research
Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses Nutritional epidemiology and public health
Conclusions: A combined mineral diet score was inversely associated with risk of stroke. High intakes of magnesium and potassium but not calcium were also significantly associated with reduced risk of stroke in women.
Source: American Journal of Clinical Nutrition - June 1, 2015 Category: Nutrition Authors: Adebamowo, S. N., Spiegelman, D., Willett, W. C., Rexrode, K. M. Tags: Nutritional Epidemiology Research Articles Nutritional epidemiology and public health Source Type: research
Association between intakes of magnesium, potassium, and calcium and risk of stroke: 2 cohorts of US women and updated meta-analyses.
CONCLUSIONS: A combined mineral diet score was inversely associated with risk of stroke. High intakes of magnesium and potassium but not calcium were also significantly associated with reduced risk of stroke in women. PMID: 25948665 [PubMed - as supplied by publisher]
Source: The American Journal of Clinical Nutrition - May 6, 2015 Category: Nutrition Authors: Adebamowo SN, Spiegelman D, Willett WC, Rexrode KM Tags: Am J Clin Nutr Source Type: research
Trends in 24-hours sodium and potassium intake, and association with all-cause mortality among US Stroke Survivors (S30.008)
CONCLUSIONS: Less than one in five stroke survivors in the US meet recommendations for sodium consumption. High sodium intake is associated with higher mortality after stroke among the elderly. The combination of high potassium and low sodium intake trended toward a better survival after stroke, highlighting the need for targeted dietary interventions.Disclosure: Dr. Lin has nothing to disclose. Dr. Markovic has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Towfighi, A., Lin, M., Markovic, D., Ovbiagele, B. Tags: Cerebrovascular Disease and Interventional Neurology: Diagnostics, Biomarkers, and Genetics Platform Blitz Source Type: research
Calcium and potassium channels in experimental subarachnoid hemorrhage and transient global ischemia.
Authors: Kamp MA, Dibué M, Schneider T, Steiger HJ, Hänggi D Abstract Healthy cerebrovascular myocytes express members of several different ion channel families which regulate resting membrane potential, vascular diameter, and vascular tone and are involved in cerebral autoregulation. In animal models, in response to subarachnoid blood, a dynamic transition of ion channel expression and function is initiated, with acute and long-term effects differing from each other. Initial hypoperfusion after exposure of cerebral vessels to oxyhemoglobin correlates with a suppression of voltage-gated potassium channel activity...
Source: Stroke Research and Treatment - December 2, 2014 Category: Neurology Tags: Stroke Res Treat Source Type: research
Potassium Intake and Risk of Stroke in Women With Hypertension and Nonhypertension in the Women's Health Initiative Clinical Sciences
Conclusions— High potassium intake is associated with a lower risk of all stroke and ischemic stroke, as well as all-cause mortality in older women, particularly those who are not hypertensive.
Source: Stroke - September 22, 2014 Category: Neurology Authors: Seth, A., Mossavar-Rahmani, Y., Kamensky, V., Silver, B., Lakshminarayan, K., Prentice, R., Van Horn, L., Wassertheil-Smoller, S. Tags: Cerebrovascular disease/stroke, Acute Cerebral Hemorrhage, Acute Cerebral Infarction, Epidemiology Clinical Sciences Source Type: research
Higher Potassium Intake Linked to Reduced Stroke Higher Potassium Intake Linked to Reduced Stroke
Higher dietary potassium is associated with a lower risk for stroke and all-cause mortality, new data from the Women's Health Initiative show, particularly in women without hypertension. Medscape Medical News
Source: Medscape Neurology and Neurosurgery Headlines - September 5, 2014 Category: Neurology Tags: Neurology & Neurosurgery News Source Type: news
Potassium-rich foods cut stroke, death risks among older women
Older women who eat foods with higher amounts of potassium may be at lower risk of stroke and death than women who consume less potassium-rich foods. The health benefits from potassium-rich foods are greater among older women who do not have high blood pressure. Most older American women do not eat the recommended amounts of potassium from foods.
Source: ScienceDaily Headlines - September 5, 2014 Category: Science Source Type: news
Potassium-rich diet and risk of stroke: Updated meta-analysis
Abstract: Recently a few prospective population studies provided additional and heterogeneous information concerning the reported statistical associations between potassium (K) intake and stroke risk. Therefore, we updated our previous meta-analysis of K intake and risk of cerebrovascular events.Three studies were added to the previous analysis, and the results of the comparison between the event rate in the two extreme categories of K intake were used. Pooled analysis of 14 cohorts (overall 333,250 participants and 10,659 events) showed an inverse and significant association between K intake and risk of stroke (Relative ...
Source: Nutrition, Metabolism, and Cardiovascular Diseases : NMCD - April 28, 2014 Category: Nutrition Authors: L. D'Elia, C. Iannotta, P. Sabino, R. Ippolito Tags: Systematic reviews and meta-analyses Source Type: research