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Total 16 results found since Jan 2013.
Hyaluronic acid and Regenerative medicine: New insights into the stroke therapy.
Abstract Stroke is known as one of very important public health problems which are related to a societal burden and tremendous economic. It has been showed, there are few therapeutic approaches in the treatment of this disease. In this regard, present therapeutic platforms aim to obtain neuroprotection, reperfusion, and neurorecovery. Among these therapies, regenerative medicine-based therapies have been appeared as new ways in stroke therapy. Hyaluronic acid (HA) is a new candidate which could be applied as regerenative medicine-based therapy in the treatment of stroke. HA is a glycosaminoglycan which is formed o...
Source: Current Molecular Medicine - March 24, 2020 Category: Molecular Biology Authors: Shahi M, Mohammadnejad D, Karimipour M, Rasta SH, Rahbarghazi R, Elahi AA Tags: Curr Mol Med Source Type: research
Different types of stroke linked to different foods
Fibre linked to lower ischaemic stroke risk Related items fromOnMedica Obesity associated with worse mortality and higher CVD risk Heart disease and stroke deaths plummet in Scotland Vegetarians and pescatarians have lower risk of CHD Glucosamine supplements may reduce stroke risk Young adults with hypertension or hypercholesterolaemia have greater risk of heart disease in later life
Source: OnMedica Latest News - February 23, 2020 Category: UK Health Source Type: news
Women get half as many heart attack treatments as men
Diagnoses increase but gender gap in treatment persist Related items fromOnMedica Coronary heart disease remains UK ’s biggest killer Glucosamine supplements may reduce stroke risk The new GP contract: transforming primary care, transforming CVD prevention Statins halve heart attack and stroke risk in healthy adults More Scottish GPs needed to fight heart disease
Source: OnMedica Latest News - October 14, 2019 Category: UK Health Source Type: news
Daytime napping may lower cardiovascular events
Only once or twice weekly nap beneficial Related items fromOnMedica Glucosamine supplements may reduce stroke risk The new GP contract: transforming primary care, transforming CVD prevention New ‘treadmill test’ can predict mortality Heart attack protocol eliminates gender gap in outcome No increased risk of cardiac arrest at the weekend
Source: OnMedica Latest News - September 9, 2019 Category: UK Health Source Type: news
Over-75s stopping statins face increased heart attack risk
Stopping statins raises heart attack risk by almost half for over 75s, researchers find Related items fromOnMedica Glucosamine supplements may reduce stroke risk Vitamin D supplements do not confer cardiovascular protection Gestational diabetes raises long-term CVD risk Coronary heart disease remains UK ’s biggest killer Heart disease and stroke deaths plummet in Scotland
Source: OnMedica Latest News - July 30, 2019 Category: UK Health Source Type: news
Glucosamine supplements may reduce stroke risk
Study finds lower risk of CVD events in users Related items fromOnMedica The new GP contract: transforming primary care, transforming CVD prevention New ‘treadmill test’ can predict mortality Heart disease and stroke deaths plummet in Scotland Public urged to check their ‘heart age’ to prevent premature death Mexican fish offer clues on heart repair
Source: OnMedica Latest News - May 14, 2019 Category: UK Health Source Type: news
Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer ’s Disease Through Activation of BDNF-TrkB Signaling Pathway
Conclusion The data in this manuscript demonstrates that apelin-13 upregulates BDNF against STZ-induced congnitive impairment by suppressing glial cell activity and inflammatory factors release. This suggests apelin signaling may be a new target in the treatment of AD. Ethics Statement All experimental protocols were carried out according to the National Institutes of Health Guide for the Care and Use of Laboratory Animals approved by the Central South University at XiangYa Animal Care and Use Committee. Author Contributions XqQ and LH conceived the study and contributed to its experimental design. HqL carried out the...
Source: Frontiers in Pharmacology - April 15, 2019 Category: Drugs & Pharmacology Source Type: research
miR-9 Upregulation Integrates Post-ischemic Neuronal Survival and Regeneration In Vitro.
Abstract The irrefutable change in the expression of brain-enriched microRNAs (miRNAs) following ischemic stroke has promoted the development of radical miRNA-based therapeutics encompassing neuroprotection and neuronal restoration. Our previous report on the systems-level prediction of miR-9 in post-stroke-induced neurogenesis served as a premise to experimentally uncover the functional role of miR-9 in post-ischemic neuronal survival and regeneration. The oxygen-glucose deprivation (OGD) in SH-SY5Y cells significantly reduced miR-9 expression, while miR-9 mimic transfection enhanced post-ischemic neuronal cell v...
Source: Cellular and Molecular Neurobiology - December 11, 2018 Category: Cytology Authors: Nampoothiri SS, Rajanikant GK Tags: Cell Mol Neurobiol Source Type: research
Godly gift for arthritis pain
Big Pharma is at it again… Creating and selling a drug that causes thousands of heart attacks and strokes each year. In 2015, the FDA asked drug makers to strengthen their warning labels. Since then, most have listed their dangerous side effects on the bottle. But one manufacturer thought they didn’t have to warn people about their dangerous drug. They marketed their product as a “unique” breakthrough. They even published studies promising it was “safe for long-term use.” 1 The drug is a 7-year-old arthritis drug called Actemra. It’s made by the Swiss pharmaceutical company Roche. ...
Source: Al Sears, MD Natural Remedies - October 5, 2017 Category: Complementary Medicine Authors: Al Sears Tags: Anti-Aging Source Type: news
Significance of Mitochondrial Protein Post-translational Modifications in Pathophysiology of Brain Injury
AbstractMitochondria are complex organelles that undergo constant fusion and fission in order to adapt to the ever-changing cellular environment. The fusion/fission proteins, localized in the inner and outer mitochondrial membrane, play critical roles under pathological conditions such as acute brain injury and neurodegenerative diseases. Post-translational modifications of these proteins tightly regulate their function and activity, ultimately impacting mitochondrial dynamics and their efficiency to generate ATP. The individual post-translational modifications that are known to affect mitochondrial dynamics include SUMOyl...
Source: Translational Stroke Research - September 21, 2017 Category: Neurology Source Type: research
French Intensive Care Society, International congress - Réanimation 2016.
C, Sauneuf B, Verrier P, Pottier V, Orabona M, Samba D, Viquesnel G, Lermuzeaux M, Hazera P, Hanouz JL, Parienti JJ, Du Cheyron D, Demoule A, Clavel M, Rolland-Debord C, Perbet S, Terzi N, Kouatchet A, Wallet F, Roze H, Vargas F, Guérin C, Dellamonica J, Jaber S, Similowski T, Quenot JP, Binquet C, Vinsonneau C, Barbar SD, Vinault S, Deckert V, Lemaire S, Hssain AA, Bruyère R, Souweine B, Lagrost L, Adrie C, Jung B, Daurat A, De Jong A, Chanques G, Mahul M, Monnin M, Molinari N, Lheureux O, Trepo E, Hites M, Cotton F, Wolff F, Surin R, Créteur J, Vincent JL, Gustot T, Jacobs F, Taccone FS, Neuville M, Timsit JF, El-Hel...
Source: Australian Family Physician - May 31, 2016 Category: Primary Care Authors: Jaillette E, Girault C, Brunin G, Zerimech F, Chiche A, Broucqsault-Dedrie C, Fayolle C, Minacori F, Alves I, Barrailler S, Robriquet L, Delaporte E, Thellier D, Delcourte C, Duhamel A, Nseir S, Valette X, Desmeulles I, Savary B, Masson R, Seguin A, Daubi Tags: Ann Intensive Care Source Type: research
Hypophosphorylation of Ribosomal Protein S6 is a Molecular Mechanism Underlying Ischemic Tolerance Induced by either Hibernation or Preconditioning
This article is protected by copyright. All rights reserved.
Source: Journal of Neurochemistry - September 16, 2015 Category: Neuroscience Authors: Shin‐ichi Miyake, Hideaki Wakita, Joshua D. Bernstock, Paola Castri, Christl Ruetzler, Junko Miyake, Yang‐ja Lee, John M. Hallenbeck Tags: Original Article Source Type: research
Sweet nanoparticles target stroke
Materials resulting from chemical bonding of glucosamine, a type of sugar, with fullerenes, kind of nanoparticles known as buckyballs, might help to reduce cell damage and inflammation occurring after stroke. A team has tested this on mice, opening the door to potential new drugs for the cerebrovascular accident.
Source: ScienceDaily Headlines - March 12, 2015 Category: Science Source Type: news
Fullerenols and glucosamine fullerenes reduce infarct volume and cerebral inflammation after ischemic stroke in normotensive and hypertensive rats.
In conclusion, OH-F and GlcN-F lead to a reduction of cellular damage and inflammation after stroke, rendering these compounds attractive therapeutics for stroke. PMID: 25625851 [PubMed - as supplied by publisher]
Source: Experimental Neurology - January 24, 2015 Category: Neurology Authors: Fluri F, Grünstein D, Cam E, Ungethuem U, Hatz F, Schäfer J, Samnick S, Israel I, Kleinschnitz C, Orts-Gil G, Moch H, Zeis T, Schaeren-Wiemers N, Seeberger P Tags: Exp Neurol Source Type: research
Protective effect of telmisartan on neurovascular unit and inflammasome in stroke-resistant spontaneously hypertensive rats.
Discussion: These results suggest that telmisartan comprehensively protected the NVU components by reducing inflammatory reactions relative to AD in hypertensive rats, which could also preclude the risk of AD under hypertension. PMID: 25591419 [PubMed - as supplied by publisher]
Source: Neurological Research - January 18, 2015 Category: Neurology Tags: Neurol Res Source Type: research