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Total 2719 results found since Jan 2013.

A Double-Blind, Randomized, Placebo-Controlled Clinical Trial to Evaluate the Efficacy of Individualized Homeopathic Medicines in Pre-diabetes
CONCLUSION: IHMs produced significantly better results than placebos in FBS and in DSC-R scores but not in OGTT. Independent replications with larger sample sizes are warranted to substantiate the findings.TRIAL REGISTRATION: CTRI/2019/10/021711.PMID:37364594 | DOI:10.1055/s-0043-1769506
Source: Homeopathy - June 26, 2023 Category: Complementary Medicine Authors: Nilanjana Guha Shubhamoy Ghosh Sanjukta Mandal Aakash Deep Das Chithra Palanisamy Shukdeb Maiti Priyanka Ghosh Navin Kumar Singh Munmun Koley Subhranil Saha Source Type: research

Changing profiles of cardiovascular disease and risk factors in China: A secondary analysis for the Global Burden of Disease Study 2019
CONCLUSIONS: The significant increases in the number of CVD incident cases, deaths, and DALYs suggest that the CVD burden is still a concern. Intensified strategies and policies are needed to maintain promising progress in stroke and to reduce the escalating burden of ischemic heart disease. The CVD burden attributable to risk factors has not yet made adequate achievements; even worse, high BMI has contributed to the increasing CVD burden.PMID:37341657 | DOI:10.1097/CM9.0000000000002741
Source: Chinese Medical Journal - June 21, 2023 Category: General Medicine Authors: Huan Wang Hao Zhang Zhiyong Zou Source Type: research

7 Myths About Cholesterol, Debunked
You may not recall every lab value from your last physical, but you probably remember one: Your cholesterol level. If it’s higher than ideal, you’re not alone. According to the U.S. Centers for Disease Control and Prevention, between 2015 and 2018, almost 12% of U.S. adults ages 20 and up had high total cholesterol, defined as above 240 mg/dL. The type that physicians mostly worry about is LDL (or “bad”) cholesterol, which is one component of that total. Why do doctors care so much about cholesterol? First, “it predicts risk,” says Dr. Jeffrey Berger, a cardiologist and director of the C...
Source: TIME: Health - June 19, 2023 Category: Consumer Health News Authors: Katherine Hobson Tags: Uncategorized freelance healthscienceclimate heart health Source Type: news

A cyclic azapeptide ligand of the scavenger receptor CD36/SR-B2 reduces the atherosclerotic lesion progression and enhances plaque stability in apolipoprotein E-deficient mice
Front Pharmacol. 2023 May 30;14:1204905. doi: 10.3389/fphar.2023.1204905. eCollection 2023.ABSTRACTAtherosclerosis is a chronic inflammatory disease of the arterial walls that develops at predisposed sites. As a major risk factor for adverse cardiovascular pathology, atherosclerosis can progress to myocardial infarction and stroke, due to the rupture of unstable atherosclerotic lesions. Macrophage uptake of modified lipoproteins and metabolic dysfunction contributes significantly to the initiation and development of atherosclerotic lesions. The cluster of differentiation 36 receptor [CD36 (SR-B2)] plays a key role in ather...
Source: Atherosclerosis - June 19, 2023 Category: Cardiology Authors: Jade Gauvin Genevi ève Frégeau Hanan Elimam Liliane M énard David Huynh Catherine L ê Ahsanullah Ahsanullah William D Lubell Huy Ong Sylvie Marleau Source Type: research

Prospective associations between diet quality, dietary components, and risk of cardiometabolic multimorbidity in older British men
ConclusionsOur study did not find a significant association of baseline EDI with CMM but showed that consuming more fish/seafood per week was associated with a lower risk of transition from FCMD to CMM in older British men.
Source: European Journal of Nutrition - June 19, 2023 Category: Nutrition Source Type: research

Modulation of the autophagy ‐lysosomal pathway and endoplasmic reticulum stress by ketone bodies in experimental models of stroke
We report for the first time that the protective effect of β-hydroxybutyrate (BHB) against stroke and glucose deprivation is enantiomer selective. We discovered that D-BHB treatment prevented the cleavage of the lysosomal membrane protein LAMP2, maintained lysosome integrity and stimulated the autophagic flux. Also, D-BHB notably reduced the activation of the PERK and IRE1α branches of the unfolded protein response (UPR), attenuating protein synthesis inhibition and preventing endoplasmic reticulum stress. Together our results support the therapeutic use of D-BHB treatment post-ischemia, by preventing the loss of proteos...
Source: Journal of Neurochemistry - June 17, 2023 Category: Neuroscience Authors: Teresa Montiel, Juan Carlos G ómora‐García, Cristian Gerónimo‐Olvera, Yessica Heras‐Romero, Berenice N. Bernal‐Vicente, Xochitl Pérez‐Martínez, Luis B. Tovar‐y‐Romo, Lourdes Massieu Tags: ORIGINAL ARTICLE Source Type: research

The intestinal γδ T cells: functions in the gut and in the distant organs
Located in the frontline against the largest population of microbiota, the intestinal mucosa of mammals has evolved to become an effective immune system. γδ T cells, a unique T cell subpopulation, are rare in circulation blood and lymphoid tissues, but rich in the intestinal mucosa, particularly in the epithelium. Via rapid production of cytokines and growth factors, intestinal γδ T cells are key contributors to epithelial homeostasis and immune surveillance of infection. Intriguingly, recent studies have revealed that the intestinal γδ T cells may play novel exciting functions ranging from epithelial plasticity and ...
Source: Frontiers in Immunology - June 16, 2023 Category: Allergy & Immunology Source Type: research

Inappropriate activation of the renin-angiotensin system improves cardiac tolerance to ischemia/reperfusion injury in rats with late angiotensin II-dependent hypertension
In conclusion, we confirmed improved cardiac tolerance to I/R injury in hypertensive hypertrophied rats and showed that, in the late phase of hypertension, the myocardium is in a compensated phase.
Source: Frontiers in Physiology - June 14, 2023 Category: Physiology Source Type: research