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Total 1870 results found since Jan 2013.

More Evidence Salt Substitutes Lower Risk of CVD and Death More Evidence Salt Substitutes Lower Risk of CVD and Death
The blood pressure –lowering effects of dietary salt substitutes have a clear protective effect on hard clinical outcomes, leading to a reduction in heart attack, stroke, and death, a meta-analysis shows.Medscape Medical News
Source: Medscape Cardiology Headlines - August 10, 2022 Category: Cardiology Tags: Cardiology News Source Type: news

Molecules, Vol. 27, Pages 5100: Tetrahydrocurcumin-Related Vascular Protection: An Overview of the Findings from Animal Disease Models
nov Feng Wang Tetrahydrocurcumin (THC), one of the major metabolites of CUR, possesses several CUR-like pharmacological effects; however, its mechanisms of action are largely unknown. This manuscript aims to summarize the literature on the preventive role of THC on vascular dysfunction and the development of hypertension by exploring the effects of THC on hemodynamic status, aortic elasticity, and oxidative stress in vasculature in different animal models. We review the protective effects of THC against hypertension induced by heavy metals (cadmium and iron), as well as its impact on arterial stiffness and vascular r...
Source: Molecules - August 10, 2022 Category: Chemistry Authors: Li Zhang Changhu Li Sicheng Wang Dimiter Avtanski Nikola Hadzi-Petrushev Vadim Mitrokhin Mitko Mladenov Feng Wang Tags: Review Source Type: research

Replacing salt with low-sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women
CONCLUSIONS: When compared to regular salt, LSSS probably reduce blood pressure, non-fatal cardiovascular events and cardiovascular mortality slightly in adults. However, LSSS also probably increase blood potassium slightly in adults. These small effects may be important when LSSS interventions are implemented at the population level. Evidence is limited for adults without elevated blood pressure, and there is a lack of evidence in pregnant women and people in whom an increased potassium intake is known to be potentially harmful, limiting conclusions on the safety of LSSS in the general population. We also cannot draw firm...
Source: Cochrane Database of Systematic Reviews - August 9, 2022 Category: General Medicine Authors: Amanda Brand Marianne E Visser Anel Schoonees Celeste E Naude Source Type: research

Association of an evolutionary-concordance lifestyle pattern score with cardiovascular disease incidence among Black and White men and women
Br J Nutr. 2022 Aug 9:1-28. doi: 10.1017/S0007114522002549. Online ahead of print.ABSTRACTDietary and lifestyle evolutionary discordance is hypothesized to play a role in the etiology of cardiovascular disease (CVD), including coronary heart disease (CHD), and stroke. We aimed to investigate associations of a previously-reported, total (dietary plus lifestyle) evolutionary-concordance (EC) pattern score with incident CVD, CHD, and stroke. We used multivariable Cox proportional hazards regression to investigate associations of the EC score with CVD, CHD, and stroke incidence among United States Black and White men and women...
Source: The British Journal of Nutrition - August 9, 2022 Category: Nutrition Authors: Ziling Mao Alyssa N Troeschel Suzanne Judd James M Shikany Emily B Levitan Monika M Safford Roberd M Bostick Source Type: research

Replacing salt with low-sodium salt substitutes (LSSS) for cardiovascular health in adults, children and pregnant women
CONCLUSIONS: When compared to regular salt, LSSS probably reduce blood pressure, non-fatal cardiovascular events and cardiovascular mortality slightly in adults. However, LSSS also probably increase blood potassium slightly in adults. These small effects may be important when LSSS interventions are implemented at the population level. Evidence is limited for adults without elevated blood pressure, and there is a lack of evidence in pregnant women and people in whom an increased potassium intake is known to be potentially harmful, limiting conclusions on the safety of LSSS in the general population. We also cannot draw firm...
Source: Cochrane Database of Systematic Reviews - August 9, 2022 Category: General Medicine Authors: Amanda Brand Marianne E Visser Anel Schoonees Celeste E Naude Source Type: research

Modulation of blood pressure regulatory genes in the Agtrap ‐Plod1 locus associated with a deletion in Clcn6
In this study, we tested whether loss ofClcn6 would be protective against high salt-induced mortality. While we observed no significant differences in longevity or neuronal cell death between the SS-Clcn6 knock-out and SS-WT groups, we found that a mutation inClcn6 could be associated with changes to mRNA expression of nearbyMthfr,Nppa, andNppb genes, thereby complicating the genetic phenotype of our knockout animal. AbstractThe AGTRAP-PLOD1 locus is a conserved gene cluster containing several blood pressure regulatory genes, includingCLCN6,MTHFR,NPPA, andNPPB. Previous work revealed that knockout ofClcn6 on the Dahl Salt-...
Source: Physiological Reports - August 5, 2022 Category: Physiology Authors: Christine A. Klemens, Lashodya V. Dissanayake, Vladislav Levchenko, Adrian Zietara, Oleg Palygin, Alexander Staruschenko Tags: ORIGINAL ARTICLE Source Type: research

Is dietary choline intake related to dementia and Alzheimer's disease risk: results from the Framingham Heart Study
CONCLUSION: Low choline intake was associated with increased risk of incident dementia or AD.PMID:35918258 | DOI:10.1093/ajcn/nqac193
Source: Am J Clin Nutr - August 2, 2022 Category: Nutrition Authors: Jing Yuan Xue Liu Chunyu Liu Alvin F A Ang Joseph Massaro Sherral A Devine Sanford H Auerbach Jan Krzysztof Blusztajn Rhoda Au Paul F Jacques Source Type: research

Low dietary sodium potentially mediates COVID-19 prevention associated with whole food plant-based diets
This article presents evidence that low dietary sodium potentially mediates the association of plant-based diets with COVID-19 prevention. Processed meats and poultry injected with sodium chloride contribute considerable amounts of dietary sodium in the Western diet, and the avoidance or reduction of these and other processed foods in whole food plant-based diets could help lower overall dietary sodium intake. Moreover, high amounts of potassium in plant-based diets increase urinary sodium excretion, and preagricultural diets high in plant-based foods were estimated to contain much lower ratios of dietary sodium to potassi...
Source: The British Journal of Nutrition - August 1, 2022 Category: Nutrition Authors: Ronald B Brown Source Type: research

Dietary Meat, Trimethylamine N-Oxide-Related Metabolites, and Incident Cardiovascular Disease Among Older Adults: The Cardiovascular Health Study
CONCLUSIONS: In this large, community-based cohort, higher meat intake associated with incident ASCVD, partly mediated by microbiota-derived metabolites of L-carnitine, abundant in red meat. These novel findings support biochemical links between dietary meat, gut microbiome pathways, and ASCVD.PMID:35912635 | DOI:10.1161/ATVBAHA.121.316533
Source: Arteriosclerosis, Thrombosis and Vascular Biology - August 1, 2022 Category: Cardiology Authors: Meng Wang Zeneng Wang Yujin Lee Heidi T M Lai Marcia C de Oliveira Otto Rozenn N Lemaitre Amanda Fretts Nona Sotoodehnia Matthew Budoff Joseph A DiDonato Barbara McKnight W H Wilson Tang Bruce M Psaty David S Siscovick Stanley L Hazen Dariush Mozaffarian Source Type: research

Preclinical Evaluation of Fingolimod in Rodent Models of Stroke With Age or Atherosclerosis as Comorbidities
This study used a rigorous study design in normal male C57BL/6JOlaHsd mice and in mice with common stroke comorbidities to further evaluate the translational potential of fingolimod. Stroke was induced via middle cerebral artery electrocoagulation in 8-9-week old mice (young mice), 18 month old mice (aged mice), and in high-fat diet-fed 22-week old ApoE-/- mice (hyperlipidaemic mice). Recovery was evaluated using motor behavioural tests 3 and 7 days after stroke. Tissue damage was evaluated at 7 days. A lower dose of fingolimod, 0.5 mg/kg, but not 1 mg/kg, increased lesion size but decreased ipsilateral brain atrophy in yo...
Source: Atherosclerosis - August 1, 2022 Category: Cardiology Authors: Andrea C Diaz Diaz Kyle Malone Jennifer A Shearer Anne C Moore Christian Waeber Source Type: research