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Total 149 results found since Jan 2013.

Use of a bioengineered antioxidant in mouse models of metabolic syndrome.
Conclusions: PEG-HCC can improve some parameters of disease in these models and this may be due to a resulting increase in peripheral insulin sensitivity. However, additional studies are needed to elucidate how PEG-HCCs are producing these effects. PMID: 31937152 [PubMed - as supplied by publisher]
Source: Expert Opinion on Investigational Drugs - January 17, 2020 Category: Drugs & Pharmacology Tags: Expert Opin Investig Drugs Source Type: research

Dulaglutide: A Review in Type 2 Diabetes
AbstractSubcutaneous dulaglutide (Trulicity®) is a once-weekly glucagon-like peptide-1 receptor agonist that is approved in numerous countries as an adjunct to diet and exercise for the treatment of adults with type 2 diabetes (T2D). In the clinical trial and real-world settings, once-weekly subcutaneous dulaglutide, as monotherapy or add-on therapy to other antihyperglycaemic agents (including oral antihyperglycaemic drugs and insulin), was an effective and generally well tolerated treatment in adults with inadequately controlled T2D, including in high-risk patients [e.g. obese and elderly patients, those with stage 3 or...
Source: Drugs - January 29, 2020 Category: Drugs & Pharmacology Source Type: research

Effects of Laser Acupuncture and Dietary Intervention on Key Obesity Parameters.
Conclusions: Combining laser acupuncture and a dietary intervention has good effects on waist:hip ratio, QoL scores, BMI, and appetite scores in obese patients. PMID: 32351664 [PubMed]
Source: Acupuncture in Medicine - March 31, 2020 Category: Complementary Medicine Authors: Sebayang RG, Aditya C, Abdurrohim K, Lauwrence B, Mihardja H, Kresnawan T, Helianthi DR Tags: Med Acupunct Source Type: research

Akebia saponin D ameliorates metabolic syndrome (MetS) via remodeling gut microbiota and attenuating intestinal barrier injury
Biomed Pharmacother. 2021 Feb 27;138:111441. doi: 10.1016/j.biopha.2021.111441. Online ahead of print.ABSTRACTMetabolic syndrome (MetS) is a complex, multifactorial disease which lead to an increased risk of cardiovascular disease, type 2 diabetes, and stroke. However, selective, and potent drugs for the treatment of MetS are still lacking. Previous studies have found that Akebia saponin D (ASD) has beneficial effects on metabolic diseases such as obesity, atherosclerosis, and non-alcoholic fatty liver disease (NAFLD). Therefore, our study was designed to determine the effect and mechanism of action of ASD against MetS in ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - March 2, 2021 Category: Drugs & Pharmacology Authors: Song Yang Ting Hu He Liu Ya-Li Lv Wen Zhang Han Li Lingling Xuan Li-Li Gong Li-Hong Liu Source Type: research

Pro-Neurotensin/Neuromedin N and Risk of Incident Metabolic Syndrome and Diabetes Mellitus in the REGARDS Cohort
CONCLUSIONS: Pro-NT/NMN was associated with MetS and two components, dysglycemia and low HDL, likely explained by insulin resistance.PMID:34013344 | DOI:10.1210/clinem/dgab355
Source: The Journal of Clinical Endocrinology and Metabolism - May 20, 2021 Category: Endocrinology Authors: Charles D Nicoli April P Carson Timothy B Plante D Leann Long Leslie A McClure Janin Schulte Mary Cushman Source Type: research

Diabetes Equates the Rich and the Poor
Diabetes test, Mauritius. Credit: Nasseem Ackbarally/IPSBy Bruno KappaNAIROBI, Nov 12 2021 (IPS) Although for different reasons, diabetes appears to be one of the few cases that put rich and poor societies at equal footing. In either case, diabetes is caused by wrong, dangerous to health nutritional habits. In fact, people in industrialised countries tend to consume the so-called “junk food”, while in poor nations diabetes is caused by malnutrition and undernourishment. And it is a seriously worrying health problem. In fact, globally, an estimated 422 million adults were living with diabetes as of 2014, compared to 108...
Source: IPS Inter Press Service - Health - November 12, 2021 Category: International Medicine & Public Health Authors: Bruno Kappa Tags: Global Headlines Health Source Type: news

Endothelial Cell CD36 Reduces Atherosclerosis and Controls Systemic Metabolism
Front Cardiovasc Med. 2021 Nov 23;8:768481. doi: 10.3389/fcvm.2021.768481. eCollection 2021.ABSTRACTHigh-fat Western diets contribute to tissue dysregulation of fatty acid and glucose intake, resulting in obesity and insulin resistance and their sequelae, including atherosclerosis. New therapies are desperately needed to interrupt this epidemic. The significant idea driving this research is that the understudied regulation of fatty acid entry into tissues at the endothelial cell (EC) interface can provide novel therapeutic targets that will greatly modify health outcomes and advance health-related knowledge. Dysfunctional ...
Source: Atherosclerosis - December 10, 2021 Category: Cardiology Authors: Umar R Rekhi Mohamed Omar Maria Alexiou Cole Delyea Linnet Immaraj Shokrollah Elahi Maria Febbraio Source Type: research

Could "cellular exercise" be the missing ingredient in a healthy life? Diets, caloric restriction, and exercise-induced hormesis
Nutrition. 2022 Feb 7;99-100:111629. doi: 10.1016/j.nut.2022.111629. Online ahead of print.ABSTRACTOvernutrition is a poor dietary habit that has been correlated with increased health risks, especially in the developed world. This leads to an imbalance between energy storage and energy breakdown. Many biochemical processes involving hormones are involved in conveying the excess of energy into pathologic states, mainly atherosclerosis, hypertension, cardiovascular diseases, and diabetes. Diverse modalities of regular exercise have been shown to be beneficial, to varying extents, in overcoming the overnutrition comorbidities...
Source: Atherosclerosis - April 30, 2022 Category: Cardiology Authors: Iv John L Pinches Yiuing L Pinches John O Johnson Natasha C Haddad Myriam G Boueri Luc M Oke Georges E Haddad Source Type: research

The Truth About Fasting and Type 2 Diabetes
Most fad diets don’t live up to the hype, let alone serious scientific scrutiny. But intermittent fasting seems to be an exception. These plans involve going without caloric foods or drinks for an extended period of time—anywhere from 16 hours to several days—and they have become increasingly popular. Research has also found them to be effective for weight loss. Doctors often advise people with Type 2 diabetes to lose weight, which can have beneficial effects on blood glucose and insulin sensitivity, as well as on the progression of the disease. For this and other reasons, experts are actively looking at ...
Source: TIME: Health - June 16, 2022 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized Diet & Nutrition freelance healthscienceclimate Source Type: news

Anti-Diabesity Middle Eastern Medicinal Plants and Their Action Mechanisms
Evid Based Complement Alternat Med. 2022 Jul 18;2022:2276094. doi: 10.1155/2022/2276094. eCollection 2022.ABSTRACTOver the last four decades, the escalation in diabetes and obesity rates has become epidemic all over the world. Diabesity describes the strong link between T2D and obesity. It correlates deeper with the elevated risks of developing cardiovascular disease hypertension, stroke, and several malignancies. Therapeutic usage of medicinal plants and natural products in the treatment of diabetes and obesity has long been known to physicians of Greco-Arab and Islamic medicine. Improved versions of their abundant medici...
Source: Evidence-based Complementary and Alternative Medicine - July 28, 2022 Category: Complementary Medicine Authors: Bashar Saad Abdalsalam Kmail Sameena Z H Haq Source Type: research