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Nutrition: Calcium

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Total 1776 results found since Jan 2013.

Single Molecule Mechanics and Kinetics of Cardiac Myosin Interacting with Regulated Thin Filaments
Biophys J. 2023 May 10:S0006-3495(23)00306-5. doi: 10.1016/j.bpj.2023.05.008. Online ahead of print.ABSTRACTThe cardiac cycle is a tightly regulated process wherein the heart generates force to pump blood to the body during systole and then relaxes during diastole. Disruption of this finely tuned cycle can lead to a range of diseases including cardiomyopathies and heart failure. Cardiac contraction is driven by the molecular motor myosin, which pulls regulated thin filaments in a calcium-dependent manner. In some muscle and non-muscle myosins, regulatory proteins on actin tune the kinetics, mechanics, and load dependence o...
Source: Biophysical Journal - May 11, 2023 Category: Physics Authors: Sarah R Clippinger Schulte Brent Scott Samantha K Barrick W Tom Stump Thomas Blackwell Michael J Greenberg Source Type: research

Systemic arterial calcium burden in patients with chronic limb-threatening ischemia
CONCLUSIONS: In CLTI patients nearly all arterial territories are severely calcified, suggesting that systemic calcification plays an important role in the poor outcome of this disease.PMID:37150661 | DOI:10.1016/j.jcct.2023.03.003
Source: Atherosclerosis - May 7, 2023 Category: Cardiology Authors: L C D Konijn W P T M Mali H van Overhagen R A P Takx H T C Veger P A de Jong Source Type: research

Quantitative CTA vascular calcification, atherosclerosis burden, and stroke mechanism in patients with ischemic stroke
CONCLUSION: Atherosclerosis calcium volumes in major vessels were significantly higher in LAA compared to non-LAA stroke in younger age.PMID:37148773 | DOI:10.1016/j.jns.2023.120667
Source: Atherosclerosis - May 6, 2023 Category: Cardiology Authors: Takashi Shimoyama Sibaji Gaj Kunio Nakamura Shivakrishna Kovi Shumei Man Ken Uchino Source Type: research

Systemic arterial calcium burden in patients with chronic limb-threatening ischemia
5-year mortality of chronic limb-threatening ischemia (CLTI) is 50 –60% and coronary artery disease (CAD) is the main cause of death of CLTI patients, followed by stroke. The aim of this study is to quantify and qualify the calcium load in different arterial territories in patients with CLTI.
Source: Journal of Cardiovascular Computed Tomography - May 5, 2023 Category: Radiology Authors: L.C.D. Konijn, W.P.T.M. Mali, H. van Overhagen, R.A.P. Takx, H.T.C. Veger, P.A. de Jong Tags: Research paper Source Type: research

CIB2 Is a Novel Endogenous Repressor of Atrial Remodeling
CONCLUSIONS: Our data suggest that CIB2 represents a novel endogenous and atrial-enriched regulator that protects against atrial remodeling and AF under stress conditions. Therefore, CIB2 may represent a new potential target for treating AF.PMID:37128899 | DOI:10.1161/CIRCULATIONAHA.122.062660
Source: Circulation - May 2, 2023 Category: Cardiology Authors: Yihui Wang Jizheng Wang Ling Shi Xiuyu Chen Desheng Li Chen Cui Kai Yang Minjie Lu Jinhua Huang Lei Zhang Fei Li Jinxi Wang Biyi Chen Bin Wang Duane D Hall Zhenwei Pan Jiang Hong Long-Sheng Song Lei Song Shihua Zhao Source Type: research

A New Study Shows How Seriously Air Pollution Can Affect Your Heartbeat
For China’s 1.4 billion people, the simple act of breathing has long been something of a risk. Living in the ninth-dirtiest country in the world in terms of air quality, China’s residents lose an average of 2.6 years of life per capita due to atmospheric pollution alone. The greatest risk, of course, is pulmonary, with air pollution leading to shortness of breath, wheezing, coughing, asthma episodes, and chest pain. But pollution affects the heart too; the U.S. Environmental Protection Agency reports that exposure to fine-particulate matter as well as to nitrogen oxides alone can lead to premature aging in bloo...
Source: TIME: Health - May 1, 2023 Category: Consumer Health News Authors: Jeffrey Kluger Tags: Uncategorized climate change Climate Is Everything Environment healthscienceclimate Source Type: news

Ischemic stroke caused by large-artery atherosclerosis: a red flag for subclinical coronary artery disease
CONCLUSION: The frequency of coronary calcification was higher in subjects with stroke caused by large-artery atherosclerosis than in controls.PMID:37122290 | PMC:PMC10130387 | DOI:10.3389/fneur.2023.1082275
Source: Atherosclerosis - May 1, 2023 Category: Cardiology Authors: Ana Lu íza Vieira de Araújo Raul D Santos Marcio Sommer Bittencourt Roberto Nery Dantas Carlos Andr é Oshiro Cesar Higa Nomura Edson Bor-Seng-Shu Marcelo de Lima Oliveira Claudia da Costa Leite Maria da Gra ça Morais Martin Maramelia Miranda Alves Gis Source Type: research

Quantitative CTA vascular calcification, atherosclerosis burden, and stroke mechanism in patients with ischemic stroke
Vascular calcification is recognized as the advanced stage of atherosclerosis burden. We hypothesized that vascular calcium quantification in CT angiography (CTA) would be helpful to differentiate large artery atherosclerosis (LAA) from other stroke etiology in patients with ischemic stroke.
Source: Journal of the Neurological Sciences - April 28, 2023 Category: Neurology Authors: Takashi Shimoyama, Sibaji Gaj, Kunio Nakamura, Shivakrishna Kovi, Shumei Man, Ken Uchino Source Type: research

Repurposing the K < sub > Ca < /sub > 3.1 Blocker Senicapoc for Ischemic Stroke
Transl Stroke Res. 2023 Apr 24. doi: 10.1007/s12975-023-01152-6. Online ahead of print.ABSTRACTSenicapoc, a small molecule inhibitor of the calcium-activated potassium channel KCa3.1, was safe and well-tolerated in clinical trials for sickle cell anemia. We previously reported proof-of-concept data suggesting that both pharmacological inhibition and genetic deletion of KCa3.1 reduces infarction and improves neurologic recovery in rodents by attenuating neuroinflammation. Here we evaluated the potential of repurposing senicapoc for ischemic stroke. In cultured microglia, senicapoc inhibited KCa3.1 currents with an IC50 of 7...
Source: Cell Research - April 24, 2023 Category: Cytology Authors: Ruth D Lee Yi-Je Chen Hai M Nguyen Latika Singh Connor J Dietrich Benjamin R Pyles Yanjun Cui Jonathan R Weinstein Heike Wulff Source Type: research