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Total 1776 results found since Jan 2013.

Mechanism of Hypoxia-Mediated Smooth Muscle Cell Proliferation Leading to Vascular Remodeling
Biomed Res Int. 2022 Dec 24;2022:3959845. doi: 10.1155/2022/3959845. eCollection 2022.ABSTRACTVascular remodeling refers to changes in the size, contraction, distribution, and flow rate of blood vessels and even changes in vascular function. Vascular remodeling can cause cardiovascular and cerebrovascular diseases. It can also lead to other systemic diseases, such as pulmonary hypertension, pulmonary atherosclerosis, chronic obstructive pulmonary disease, stroke, and ascites of broilers. Hypoxia is one of the main causes of vascular remodeling. Prolonged hypoxia or intermittent hypoxia can lead to loss of lung ventilation,...
Source: Biomed Res - January 3, 2023 Category: Research Authors: Xiaojuan Huang Elif Ece Akg ün Khalid Mehmood Hui Zhang Zhaoxin Tang Ying Li Source Type: research

Pollutants In Your Salt!?
Your doctor, the media, and the medical establishment continue to warn that flavoring your food with salt will kill you. They link sodium consumption to a higher risk of high blood pressure, stroke – and of course, heart disease. As usual, the powers that be are missing the real picture… You see, salt has been part of human life for thousands of years – long before these chronic diseases became as common as they are today. Humans started adding salt to their food for more than 5,000 years. It was the most effective way to preserve food. Some historians even go as far as to credit salt for the development of human civ...
Source: Al Sears, MD Natural Remedies - December 23, 2022 Category: Complementary Medicine Authors: Jacob Tags: Anti-Aging Health Source Type: news

Investigation of therapeutic effects of calcium dobesilate in cerebral hypoxia/ reperfusion injury in rats
CONCLUSION: From these results, it was observed that CD treatment could reduce neuronal necrosis and create anti-inflammatory, anti-edema, anti-oxidant, anti-apoptotic, and anti-autophagic effects in hypoxia/reperfusion injury in rats.PMID:36548871 | DOI:10.1080/01616412.2022.2159109
Source: Neurological Research - December 22, 2022 Category: Neurology Authors: Alemiddin Ozdemir Mustafa Ogden Bahar Kartal Asli Fahriye Ceylan Ulas Yuksel Bulent Bakar Source Type: research

Downregulation of mitochondrial calcium uptake family 3 attenuates secondary brain injury after intracerebral hemorrhage in rats
In conclusion, MICU3 is expected to be a molecular marker and a potential therapeutic target for ICH.PMID:36549422 | DOI:10.1016/j.expneurol.2022.114302
Source: Experimental Neurology - December 22, 2022 Category: Neurology Authors: Jiahe Wang Siyuan Yang Haiying Li Haitao Shen Xiaocheng Lu Xiang Li Gang Chen Source Type: research

Transient receptor potential ion channels and cerebral stroke
ConclusionsAlthough the precise mechanism of transient receptor potential ion channels in cerebral stroke is still unclear, it has the potential to be a therapeutic target for patients with stroke if developed appropriately. Hence, more research is needed to prove its efficacy in this context.
Source: Brain and Behavior - December 17, 2022 Category: Neurology Authors: Qin'yi Xu, Yan Zou, Zeng'li Miao, Lei Jiang, Xu'dong Zhao Tags: REVIEW Source Type: research

Acetate suppresses myocardial contraction via the short-chain fatty acid receptor GPR43
The heart has high energy requirements, with an estimated 40%–60% of myocardial ATP production derived from the oxidation of fatty acids under physiological conditions. However, the effect of short-chain fatty acids on myocardial contraction remains controversial, warranting further research. The present study sought to investigate the effects and mechanisms of acetate, a short-chain fatty acid, on myocardial contraction in rat ventricular myocytes. Echocardiography and Langendorff heart perfusion were used to evaluate cardiac function. Cell shortening and calcium transient were measured in isolated cardiomyocytes. The p...
Source: Frontiers in Physiology - December 16, 2022 Category: Physiology Source Type: research

The association of admission ionized calcium with outcomes of thrombolysed patients with anterior circulation ischemic stroke
ConclusionThe current results found that ionized calcium might be associated with early neurological improvement, but had no association with 3 months' outcome in anterior circulation AIS patients after IVT.
Source: Brain and Behavior - December 7, 2022 Category: Neurology Authors: Yan ‐Li Qi, Qiong Wu, Xiao‐Qiu Li, Zhong‐He Zhou, Cheng Xia, Xin‐Hong Wang, Hui‐Sheng Chen Tags: ORIGINAL ARTICLE Source Type: research

Optogenetic Stimulation Array for Confocal Microscopy Fast Transient Monitoring
Optogenetics is an emerging discipline with multiple applications in neuroscience, allowing to study neuronal pathways or serving for therapeutic applications such as in the treatment of anxiety disorder, autism spectrum disorders (ASDs), or Parkinson's disease. More recently optogenetics is opening its way also to stem cell-based therapeutic applications for neuronal regeneration after stroke or spinal cord injury. The results of optogenetic stimulation are usually evaluated by immunofluorescence or flow cytometry, and the observation of transient responses after stimulation, as in cardiac electrophysiology studies...
Source: IEEE Transactions on Biomedical Circuits and Systems - December 1, 2022 Category: Biomedical Engineering Source Type: research