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Total 1776 results found since Jan 2013.
Vitamin D intake and all-cause and cause-specific mortality in Japanese men and women: the Japan Public Health Center-based prospective study
Eur J Epidemiol. 2023 Jan 31. doi: 10.1007/s10654-023-00968-8. Online ahead of print.ABSTRACTWhile higher circulating 25-hydroxyvitamin D concentrations have been reported to be associated with decreased risk of all-cause mortality, evidence on dietary vitamin D intake is limited and inconsistent. We investigated whether vitamin D intake is associated with all-cause and cause-specific mortality among Japanese adults. Participants were 42,992 men and 50,693 women who responded to the second survey of the Japan Public Health Center-based Prospective Study (1995-1998) and who were followed up for mortality through 2018. Dieta...
Source: Cancer Control - January 31, 2023 Category: Cancer & Oncology Authors: Akiko Nanri Tetsuya Mizoue Atsushi Goto Mitsuhiko Noda Norie Sawada Shoichiro Tsugane Japan Public Health Center-based Prospective Study Group Source Type: research
Epigenetics and stroke: role of DNA methylation and effect of aging on blood-brain barrier recovery
This study aimed to evaluate the epigenetic and transcriptional profile of cerebral microvessels after thromboembolic (TE) stroke to define potential causes of limited BBB recovery. RNA-sequencing and reduced representation bisulfite sequencing (RRBS) analyses were performed using microvessels isolated from young (6 months) and old (18 months) mice seven days poststroke compared to age-matched sham controls. DNA methylation profiling of poststroke brain microvessels revealed 11287 differentially methylated regions (DMR) in old and 9818 DMR in young mice, corresponding to annotated genes. These DMR were enriched in genes en...
Source: Cell Research - January 30, 2023 Category: Cytology Authors: Chelsea Phillips Svetlana Stamatovic Richard Keep Anuska Andjelkovic Source Type: research
Carotid dysfunction in senescent female mice is mediated by increased α < sub > 1A < /sub > -adrenoceptor activity and COX-derived vasoconstrictor prostanoids
In conclusion, senescence intensifies vasoconstriction mediated by a1A-adrenergic signaling in the carotid of female mice by mechanisms involving increased iCa+2 and release of cyclooxygenase-derived prostanoids.PMID:36705993 | DOI:10.1152/ajpheart.00495.2022
Source: American Journal of Physiology. Heart and Circulatory Physiology - January 27, 2023 Category: Physiology Authors: Tiago J Costa Paula R Barros Diego A Duarte J úlio A Silva-Neto Sara Cristina Hott Thamyris Santos-Silva Claudio M Costa-Neto Felipe V Gomes Eliana H Akamine Cameron G McCarthy Francesc Jim énez-Altayó Ana Paula Dantas Rita C Tostes Source Type: research
The effect of regulating MCU expression on experimental ischemic brain injury
Exp Neurol. 2023 Jan 23:114329. doi: 10.1016/j.expneurol.2023.114329. Online ahead of print.ABSTRACTMitochondrial calcium uniporter (MCU) is a critical channel for Ca2+ influx into mitochondria. The present study aimed to determine if MCU knockdown has beneficial effects on ischemic brain injury and to explore the underlying mechanisms. The present study demonstrated that MCU knockdown but not total knockout (KO) attenuated ischemia infarction volume and primary cortical neuronal cells' ischemic damage. MCU knockdown maintained mitochondrial ultrastructure, alleviated calcium overload, and reduced mitochondrial apoptosis. ...
Source: Experimental Neurology - January 26, 2023 Category: Neurology Authors: Jin Qin Lijuan Liu Lin Liu Zhou Zhou Yicong Zhou Kun Zhang Binbin Wang Honglin Lu Jina Ran Tianzhao Ma Yingzhen Zhang Zhongzhong Li Xiaoyun Liu Source Type: research
Inter and intracellular mitochondrial transfer: Future of mitochondrial transplant therapy in Parkinson's disease
Biomed Pharmacother. 2023 Jan 20;159:114268. doi: 10.1016/j.biopha.2023.114268. Online ahead of print.ABSTRACTParkinson's disease (PD) is marked by the gradual degeneration of dopaminergic neurons and the intracellular build-up of Lewy bodies rich in α-synuclein protein. This impairs various aspects of the mitochondria including the generation of ROS, biogenesis, dynamics, mitophagy etc. Mitochondrial dynamics are regulated through the inter and intracellular movement which impairs mitochondrial trafficking within and between cells. This inter and intracellular mitochondrial movement plays a significant role in maintainin...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - January 22, 2023 Category: Drugs & Pharmacology Authors: Rachit Jain Nusrat Begum Kamatham Pushpa Tryphena Shashi Bala Singh Saurabh Srivastava Sachchida Nand Rai Emanuel Vamanu Dharmendra Kumar Khatri Source Type: research
Toll-Like Receptor 4 Signaling in Neurons Mediates Cerebral Ischemia/Reperfusion Injury
AbstractIn microglia, Toll-like receptor 4 (TLR4) is well known to contribute to neuroinflammatory responses following brain ischemia. TLR4 is also expressed in neurons and can mediate the conduction of calcium (Ca2+) influx, but the mechanistic link between neuronal TLR4 signaling and brain ischemic injury is still poorly understood. Here, primary neuronal cell cultures from TLR4 knockout mice and mice with conditional TLR4 knockout in glutamatergic neurons (TLR4cKO) were used to establish ischemic models in vitro and in vivo, respectively. We found that deleting TLR4 would reduce the neuronal death and intracellular Ca2+...
Source: Molecular Neurobiology - January 19, 2023 Category: Neurology Source Type: research
