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Differential Proteomics for Distinguishing Ischemic Stroke from Controls: a Pilot Study of the SpecTRA Project
AbstractA diagnostic blood test for stroke is desirable but will likely require multiple proteins rather than a single “troponin.” Validating large protein panels requires large patient numbers. Mass spectrometry (MS) is a cost-effective tool for this task. We compared differences in the abundance of 147 protein markers to distinguish 20 acute cerebrovascular syndrome (ACVS) patients who presented to the Emergen cy Department of one urban hospital within< 24 h from onset) and from 20 control patients who were enrolled via an outpatient neurology clinic. We targeted proteins from the stroke literature plus cardio...
Source: Translational Stroke Research - January 24, 2018 Category: Neurology Source Type: research
The Burden of Diabetes and the Chance of a Previous Stroke: Thrombolysis for Recurrent Stroke in Diabetics
Intravenous thrombolysis with recombinant tissue plasminogen activator is still not approved by the European Medicines Agency for patients with diabetes mellitus and previous stroke. We assessed functional benefit and potential risk of thrombolysis in patients with diabetes and previous stroke and the influence of age, preexisting diabetic damage, as well as acute and chronic hyperglycemia on outcome, symptomatic intracranial hemorrhage, and in-hospital mortality.
Source: Journal of Stroke and Cerebrovascular Diseases - February 3, 2018 Category: Neurology Authors: Alexandra Filipov, Anne D. Ebert, Eva Neumaier-Probst, Angelika Alonso Source Type: research
Predicting shoulder function after constraint-induced movement therapy: a retrospective cohort study.
Discussion A stantial part of patients with reduced shoulder function reached a level of satisfactory shoulder function after CIMT. Intensive CIMT training, comprising tasks that require both distal and proximal UE function, may increase shoulder function in patients with a potential functional reserve.
PMID: 29473446 [PubMed - as supplied by publisher]
Source: Topics in Stroke Rehabilitation - February 23, 2018 Category: Neurology Authors: Hansen GM, Svendsen SW, Brunner I, Nielsen JF Tags: Top Stroke Rehabil Source Type: research
Infections Diagnosed after Admission to a Stroke Unit and Their Impact on Hospital Mortality in Poland from 1995 to 2015
Implementation of modern stroke unit care might have attenuated the negative effect of infections on stroke outcome. Our aim was to investigate changes in the occurrence of pneumonia and urinary infections diagnosed after admission to experienced Polish stroke center between 1995 and 2015, and their association with hospital mortality.
Source: Journal of Stroke and Cerebrovascular Diseases - March 8, 2018 Category: Neurology Authors: Michal A. Karlinski, Jan P. Bembenek, Anna Baranowska, Iwona Kurkowska-Jastrzebska, Anna Czlonkowska Source Type: research
The Burden of Diabetes and the Chance of a Previous Stroke: Thrombolysis for Recurrent Stroke in Diabetics
Intravenous thrombolysis with recombinant tissue plasminogen activator is still not approved by the European Medicines Agency for patients with diabetes mellitus and previous stroke. We assessed functional benefit and potential risk of thrombolysis in patients with diabetes and previous stroke and the influence of age, preexisting diabetic damage, as well as acute and chronic hyperglycemia on outcome, symptomatic intracranial hemorrhage, and in-hospital mortality.
Source: Journal of Stroke and Cerebrovascular Diseases - February 3, 2018 Category: Neurology Authors: Alexandra Filipov, Anne D. Ebert, Eva Neumaier-Probst, Angelika Alonso Source Type: research
Delays in the Air or Ground Transfer of Patients for Endovascular Thrombectomy Clinical Sciences
Background and Purpose—For suspected large vessel occlusion patients efficient transfer to centers that provide endovascular therapy (ET) is critical to maximizing treatment opportunity. Our objective was to examine associations between transfer time, modes of transfer, ET, and outcomes within a hub-and-spoke telestroke network.Methods—Patients with ischemic stroke were included if transferred to a single hub hospital between January 2011 and October 2015 with National Institutes of Health Stroke Scale>6, onset
Source: Stroke - May 25, 2018 Category: Neurology Authors: Robert W. Regenhardt, Adam P. Mecca, Stephanie A. Flavin, Gregoire Boulouis, Arne Lauer, Kori Sauser Zachrison, James Boomhower, Aman B. Patel, Joshua A. Hirsch, Lee H. Schwamm, Thabele M. Leslie-Mazwi Tags: Revascularization, Quality and Outcomes, Cerebrovascular Disease/Stroke, Cerebrovascular Procedures, Ischemic Stroke Original Contributions Source Type: research
The Serum BDNF Level Offers Minimum Predictive Value for Motor Function Recovery After Stroke
The objective of this study was to investigate the relationship among serum BDNF level, fractional anisotropy (FA), and functional outcome during post-acute stroke rehabilitation. Serum BDNF levels were measured on admission to an acute inpatient rehabilitation hospital. The primary functional outcome was functional independence measure (FIM) motor subscore at discharge. The secondary outcome measures were FIM total score at discharge, FIM motor subscore on admission, length of stay in the hospital, and discharge destination. We investigated the relationship among the level of serum BDNF and FA as well as functional outcom...
Source: Translational Stroke Research - August 3, 2018 Category: Neurology Source Type: research
Trends in Interhospital Transfers and Mechanical Thrombectomy for United States Acute Ischemic Stroke Inpatients
Objective: Stroke care in the US is increasingly regionalized. Many patients undergo interhospital transfer to access specialized, time-sensitive interventions such as mechanical thrombectomy. Methods: Using a stratified survey design of the US Nationwide Inpatient Sample (2009-2014) we examined trends in interhospital transfers for ischemic stroke resulting in mechanical thrombectomy. International Classification of Disease —Ninth Revision (ICD-9) codes were used to identify stroke admissions and inpatient procedures within endovascular-capable hospitals.
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2019 Category: Neurology Authors: Benjamin P. George, Thomas A. Pieters, Christopher G. Zammit, Adam G. Kelly, Kevin N. Sheth, Tarun Bhalla Source Type: research
Mortality and Predictors of Death Poststroke: Data from a Multicenter Prospective Cohort of Lebanese Stroke Patients
We examined mortality rates during the first year after acute stroke and the major short-term (1-month) and long-term (1-year) mortality predictors. Methods: Data were collected prospectively on hospitalized stroke patients from 8 hospitals in Beirut during a 1-year period. Patients were followed up for 1-year or until death.
Source: Journal of Stroke and Cerebrovascular Diseases - January 9, 2019 Category: Neurology Authors: Rachel Abdo, Halim Abboud, Pascale Salameh, Taghrid El Hajj, Hassan Hosseini Source Type: research
Nicardipine Associated Risk of Short-Term Mortality in Critically Ill Patients with Ischemic Stroke
This study aimed to determine all-cause in-hospital mortality, medication-related hypotensive episodes, development of hospital acquired infections and hospital length of stay between nicardipine and labetalol use for the management of hypertension after acute ischemic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - January 22, 2019 Category: Neurology Authors: Mahsa Sadeghi, Hamidreza Saber, Azara Singh, Claudia Hanni, Dennis Parker, Aaron Desai, Wazim Mohamed Source Type: research
The Influence of Stroke Location on Cognitive and Mood Impairment. A Voxel-Based Lesion-Symptom Mapping Study
Background and purpose: The role of stroke location as a determinant of mood and cognitive symptoms is still a matter of debate. The aim of this study was to identify the predictive value of ischemic stroke location, on a voxel basis, for mood and cognitive outcome. Materials and methods: A prospective monocentric study including patients with a supratentorial ischemic stroke was conducted. A 3 Tesla brain MRI was performed at baseline. Mood and cognition were assessed using Hospital Anxiety and Depression scale (HAD), apathy inventory (AI), and Montreal Cognitive Assessment scale subscores, performed at 3 months poststroke.
Source: Journal of Stroke and Cerebrovascular Diseases - February 1, 2019 Category: Neurology Authors: Sharmila Sagnier, Fanny Munsch, Antoine Bigourdan, Sabrina Debruxelles, Mathilde Poli, Pauline Renou, St éphane Olindo, François Rouanet, Vincent Dousset, Thomas Tourdias, Igor Sibon Source Type: research
Clinical Characteristics and Emergent Therapeutic Interventions in Patients Evaluated through the In-hospital Stroke Alert Protocol
Background and Purpose: Emergent evaluation of inpatients with suspected acute ischemic stroke faces difficulty of symptoms recognition, false alarms, and high rate of contraindications to reperfusion therapies. We aim to assess the clinical characteristics and therapeutic interventions implemented in patients evaluated though the in-hospital Stroke Alert Protocol. Methods: We analyzed 4 years-worth of Stroke Alert cases at a university hospital. Demographics, clinical presentation, final diagnosis, and acute interventions were compared between inpatients and those presenting to the emergency department.
Source: Journal of Stroke and Cerebrovascular Diseases - March 3, 2019 Category: Neurology Authors: Victor J. Del Brutto, Agnieszka Ardelt, Andrea Loggini, Zachary Bulwa, Faten El-Ammar, Raisa C. Martinez, James Brorson, Fernando Goldenberg Source Type: research
Letter to Editor on “Lacunar Stroke in Cryptococcal Meningitis: Clinical and Radiographic Features”
We read with much pleasure the article “Lacunar Stroke in Cryptococcal Meningitis: Clinical and Radiographic Features” by Vela et al published in the Journal of Stroke and Cerebrovascular Disease.1 Authors have done a commendable job at describing the clinical and radiographical details of stroke in a cohort of patients with cryptoco ccal meningitis. Authors have collected extensive data over 18years from the University of Colorado Hospital, and have identified 42 patients. Among these, 32 (76%) of the patients had available neuroimaging.
Source: Journal of Stroke and Cerebrovascular Diseases - March 14, 2019 Category: Neurology Authors: Ajay K. Mishra, Anu A. George, Kamal K. Sahu, Amos Lal, Cijoy K. Kuriakose Tags: Letter to the Editor Source Type: research
Factors Associated with Leukoaraiosis Severity in Acute Stroke Patients
Objective: Age-related cerebral white matter abnormalities, commonly termed leukoaraiosis (LA), are frequent manifestation of cerebral microvascular disease. Aging and hypertension are well linked to LA. We compared additional vascular risk factors and socioeconomic factors with LA severity in acute stroke patients. Methods: We analyzed 271 patients with acute ischemic or hemorrhagic stroke from a hospital registry. We collected clinical and socioeconomic data prospectively with a standardized questionnaire during acute stroke hospitalization.
Source: Journal of Stroke and Cerebrovascular Diseases - April 24, 2019 Category: Neurology Authors: Kishore Vedala, Arun K. Nagabandi, Stephen Looney, Askiel Bruno Source Type: research
