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Total 123 results found since Jan 2013.

Quantile Regression Forests to Identify Determinants of Neighborhood Stroke Prevalence in 500 Cities in the USA: Implications for Neighborhoods with High Prevalence
AbstractStroke exerts a massive burden on the US health and economy. Place-based evidence is increasingly recognized as a critical part of stroke management, but identifying the key determinants of neighborhood stroke prevalence and the underlying effect mechanisms is a topic that has been treated sparingly in the literature. We aim to fill in the research gaps with a study focusing on urban health. We develop and apply analytical approaches to address two challenges. First, domain expertise on drivers of neighborhood-level stroke outcomes is limited. Second, commonly used linear regression methods may provide incomplete a...
Source: Journal of Urban Health - September 3, 2020 Category: Health Management Source Type: research

Comparison and Analysis of Epidemiologic Characteristics of Stroke in Sichuan Province, China
In conclusion, the disparity of lower stroke burden in Sichuan than the average China remained, although with the great developments in Sichuan province over all those decades. In addition to traditional modifiable factors, we suggest that unknown or intrinsic differences such as genetic factors might play an important role in geographic disparity, which should be investigated in future studies.
Source: Frontiers in Neurology - August 26, 2020 Category: Neurology Source Type: research

The Difficulty Of Counting the COVID-19 Pandemic ’s Full Death Toll
Sara Wittner had seemingly gotten her life back under control. After a December relapse in her battle with drug addiction, the 32-year-old completed a 30-day detox program and started taking a monthly injection to block her cravings for opioids. She was engaged to be married, working for a local health advocacy group in Colorado, and counseling others about drug addiction. Then the COVID-19 pandemic hit. The virus knocked down all the supports she had carefully built around her: no more in-person Narcotics Anonymous meetings, no talks over coffee with trusted friends or her addiction recovery sponsor. As the virus stressed...
Source: TIME: Health - June 22, 2020 Category: Consumer Health News Authors: Markian Hawryluk / Kaiser Health News Tags: Uncategorized COVID-19 Source Type: news

Snake venom three-finger toxins and their potential in drug development targeting cardiovascular diseases.
Abstract Cardiovascular diseases such as coronary and peripheral artery diseases, venous thrombosis, stroke, hypertension, and heart failure are enormous burden to health and economy globally. Snake venoms have been the sources of discovery of successful therapeutics targeting cardiovascular diseases. For example, the first-in-class angiotensin-converting enzyme inhibitor captopril was designed largely based on bradykinin-potentiating peptides from Bothrops jararaca venom. In the recent years, sensitive and high throughput approaches drive discovery and cataloging of new snake venom toxins. As one of the largest c...
Source: Biochemical Pharmacology - June 20, 2020 Category: Drugs & Pharmacology Authors: Manjunatha Kini R, Yeow Koh C Tags: Biochem Pharmacol Source Type: research

The effect of exposure to long working hours on stroke: A systematic review and meta-analysis from the WHO/ILO Joint Estimates of the Work-related Burden of Disease and Injury.
CONCLUSIONS: We judged the existing bodies of evidence for human evidence as "inadequate evidence for harmfulness" for all exposure categories for stroke prevalence and mortality and for exposure to 41-48 h/week for stroke incidence. Evidence on exposure to 48-54 h/week and ≥55 h/week was judged as "limited evidence for harmfulness" and "sufficient evidence for harmfulness" for stroke incidence, respectively. Producing estimates for the burden of stroke attributable to exposures to working 48-54 and ≥55 h/week appears evidence-based, and the pooled effect estimates presented in this systematic review could be used ...
Source: Environment International - June 2, 2020 Category: Environmental Health Authors: Descatha A, Sembajwe G, Pega F, Ujita Y, Baer M, Boccuni F, Di Tecco C, Duret C, Evanoff BA, Gagliardi D, Godderis L, Kang SK, Kim BJ, Li J, Magnusson Hanson LL, Marinaccio A, Ozguler A, Pachito D, Pell J, Pico F, Ronchetti M, Roquelaure Y, Rugulies R, Sc Tags: Environ Int Source Type: research

Effect of types of ankle-foot orthoses on energy expenditure metrics during walking in individuals with stroke: a systematic review.
Conclusions: An AFO can immediately improve energy expenditure metrics of walking in stroke survivors. There is a need for further well-designed randomized trials to evaluate long-term effect of gait training using AFOs and comparison among the different types of orthoses.IMPLICATIONS FOR REHABILITATIONAn AFO can immediately improve the energy expenditure metrics during walking after stroke.Measurement of energetic parameters of walking wearing a orthotic device such as an AFO can evaluate gait economy in stroke populations. PMID: 32432905 [PubMed - as supplied by publisher]
Source: Disability and Rehabilitation - May 19, 2020 Category: Rehabilitation Authors: Daryabor A, Yamamoto S, Orendurff M, Kobayashi T Tags: Disabil Rehabil Source Type: research

Coronavirus Disease 2019 and Stroke: Clinical Manifestations and Pathophysiological Insights
An outbreak of an acute respiratory illness of unknown cause started in Wuhan, Hubei province, China on December 12, 2019.1,2 A new strain of coronavirus, named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was identified in these patients. Subsequently, the identified acute respiratory illness was named coronavirus disease 2019 (COVID-19). Soon thereafter, the COVID-19 epidemic in China became a pandemic with a significant burden on healthcare and the world-wide economy. SARS-CoV-2 has been shown to be a distinct class of the beta coronaviruses (Beta-CoVs) with a 79.5% gene sequence homology to the severe ...
Source: Journal of Stroke and Cerebrovascular Diseases - May 10, 2020 Category: Neurology Authors: Afshin A. Divani, Sasan Andalib, Mario Di Napoli, Simona Lattanzi, M. Shazam Hussain, Jos é Biller, Louise D. McCullough, M. Reza Azarpazhooh, Alina Seletska, Stephan A. Mayer, Michel Torbey Tags: Review Article Source Type: research

Cardiovascular Considerations in Caring for Pregnant Patients: A Scientific Statement From the American Heart Association.
diovascular and Stroke Nursing; and Stroke Council Abstract Cardio-obstetrics has emerged as an important multidisciplinary field that requires a team approach to the management of cardiovascular disease during pregnancy. Cardiac conditions during pregnancy include hypertensive disorders, hypercholesterolemia, myocardial infarction, cardiomyopathies, arrhythmias, valvular disease, thromboembolic disease, aortic disease, and cerebrovascular diseases. Cardiovascular disease is the primary cause of pregnancy-related mortality in the United States. Advancing maternal age and preexisting comorbid conditions have contri...
Source: Circulation - May 3, 2020 Category: Cardiology Authors: Mehta LS, Warnes CA, Bradley E, Burton T, Economy K, Mehran R, Safdar B, Sharma G, Wood M, Valente AM, Santos Volgman A, American Heart Association Council on Clinical Cardiology; Council on Arteriosclerosis, Thrombosis and Vascular Biology; Council on Ca Tags: Circulation Source Type: research

COVID-19 Business Updates Provide Some Clarity
The unknowns still outnumber the knowns, but recent business updates provide some clarity around how the medical device industry is fairing during the COVID-19 pandemic. First and foremost, it is clear that companies are hurting in the areas of elective procedures, which are being deferred. But there may be some silver linings hidden amongst the bad news. Needham & Co. medtech analyst Mike Matson estimates that medical device sales across the industry will continue to drop by an average of 40% to 50% until the economy begins to reopen and hospitals start to resume elective procedures. Matson's e...
Source: MDDI - April 10, 2020 Category: Medical Devices Authors: Amanda Pedersen Tags: COVID-19 Business Source Type: news

Analysis of life expectancy across countries using a decision tree.
Conclusions: Improving these variables may result in significant increases in life expectancy and quality of life. At the country level, appropriate strategies can be developed to improve the quality and performance of health care systems. PMID: 32141591 [PubMed - in process]
Source: Eastern Mediterranean Health Journal - March 8, 2020 Category: Middle East Health Tags: East Mediterr Health J Source Type: research

Gen X Women Get Less Sleep Than Any Other Generation. What ’s Keeping Them Up?
In the middle of the night, I wake up feeling warm. I open the window and pull my hair back into a ponytail and drink some water. Then I glance at my phone, delete a few things, and see some spam. I hit unsubscribe and go back to bed. Then I lie there thinking, What if by opening that spam email I got myself hacked? What if I just sent everyone in my contact list a Burger King ad at two in the morning? Now wide awake, I move on to other concerns: my parents’ health, my stepson’s college tuition, pending deadlines. Hours roll by. I tackle real-life math problems: how many weeks I have before getting my next free...
Source: TIME: Health - January 6, 2020 Category: Consumer Health News Authors: Ada Calhoun Tags: Uncategorized Gen X healthy sleep insomnia Source Type: news

What ’s the Big Deal about Data in Medtech?
Discussion, “Top 5 Things You Need to Know about the Implantable Internet of Things." Brian Chapman, partner and leader of ZS’s medtech practice of ZS, attributes today’s focus on data to the intersection of two important things: "A general recognition that understanding more and connecting actions with outcomes will provide feedback and understanding that will drive standards of care. This is not new, but as capabilities rise in data collection, aggregation, and synthesize rise, and coupled with machine learning, the promise of data in healthcare is becoming even more ...
Source: MDDI - December 20, 2019 Category: Medical Devices Authors: Daphne Allen Tags: Digital Health Source Type: news

How to Keep Alzheimer ’s From Bringing About the Zombie Apocalypse
I tried to kill my father for years. To be fair, I was following his wishes. He’d made it clear that when he no longer recognized me, when he could no longer talk, when the nurses started treating him like a toddler, he didn’t want to live any longer. My father was 58 years old when he was diagnosed with Alzheimer’s disease. He took the diagnosis with the self-deprecating humor he’d spent a lifetime cultivating, constantly cracking jokes about how he would one day turn into a zombie, a walking corpse. We had a good 10 years with him after the diagnosis. Eventually, his jokes came true. Seven years ...
Source: TIME: Health - November 20, 2019 Category: Consumer Health News Authors: Jay Newton-Small Tags: Uncategorized Alzheimer's Disease Source Type: news

12 Innovations That Will Change Health Care and Medicine in the 2020s
Pocket-size ultrasound devices that cost 50 times less than the machines in hospitals (and connect to your phone). Virtual reality that speeds healing in rehab. Artificial intelligence that’s better than medical experts at spotting lung tumors. These are just some of the innovations now transforming medicine at a remarkable pace. No one can predict the future, but it can at least be glimpsed in the dozen inventions and concepts below. Like the people behind them, they stand at the vanguard of health care. Neither exhaustive nor exclusive, the list is, rather, representative of the recasting of public health and medic...
Source: TIME: Health - October 25, 2019 Category: Consumer Health News Authors: TIME Staff Tags: Uncategorized HealthSummit19 technology Source Type: news

‘Salty’ Concern: Tackling High Salt Consumption in China
Veena S. Kulkarni, Associate Professor, Department of Criminology, Sociology and Geography, Arkansas State University, USA; and Raghav Gaiha, (Hon.) Professorial Research Fellow, Global Development Institute, University of Manchester, England.By Veena S. Kulkarni and Raghav GaihaNEW DELHI, India and JONESBORO, US, Oct 7 2019 (IPS) China’s almost meteoric transition from a being a low income to a middle income country within a span of four decades is often perceived as a miracle analogous to the post Second World War Japanese economic development experience. China’s GDP rose from $200 current United States dollars (US$ ...
Source: IPS Inter Press Service - Health - October 7, 2019 Category: International Medicine & Public Health Authors: Veena Kulkarni and Raghav Gaiha Tags: Asia-Pacific Development & Aid Economy & Trade Food & Agriculture Food Sustainability Globalisation Headlines Health Labour TerraViva United Nations Barilla Center for Food and Nutrition Foundation (BCFN) Source Type: news

Harnessing Unruly Digital Health Data
As medical devices and digital apps increasingly merge, patients, healthcare professionals, and medtech companies find themselves armed with more and richer data. Digitally-enabled medical devices can record data which, if used properly, facilitates more personalized care and drives better outcomes for patients. These advanced devices also provide medtech companies with the information they need to do two important things: continually optimize product performance and prove to key stakeholders the efficacy and value of their products. And more of these devices are on the way. Let’s consider two examples. A...
Source: MDDI - September 3, 2019 Category: Medical Devices Authors: Dan Schulman and Piotr Kula Tags: Digital Health Source Type: news

Burden of smoking in Brazil and potential benefit of increasing taxes on cigarettes for the economy and for reducing morbidity and mortality.
In conclusion, the burden of disease and economic losses associated with smoking is high in Brazil, and tax increases are capable of averting deaths, illness, and costs to society. PMID: 31483047 [PubMed - in process]
Source: Cadernos de Saude Publica - August 28, 2019 Category: International Medicine & Public Health Authors: Pinto M, Bardach A, Palacios A, Biz A, Alcaraz A, Rodriguez B, Augustovski F, Pichon-Riviere A Tags: Cad Saude Publica Source Type: research

Health system challenges affecting rehabilitation services in South Africa.
This article presents challenges and solutions to ensure that South Africa can meet WHO 2030 Rehabilitation Goals for equitable provision of effective public rehabilitation services using the WHO's health system building block framework. IMPLICATIONS FOR REHABILITATION To meet the challenge of providing rehabilitation for those in need requires country-specific, strategic, evidence-informed, and planned decisions in terms of best investment for highest return. Whilst there is sound international evidence for best-practice rehabilitation care, country-specific strategies are required to identify and address local barriers t...
Source: Disability and Rehabilitation - August 2, 2019 Category: Rehabilitation Authors: Morris LD, Grimmer KA, Twizeyemariya A, Coetzee M, Leibbrandt DC, Louw QA Tags: Disabil Rehabil Source Type: research

NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance
Conclusion and Perspectives Gliomas are the most prevalent primary brain cancer in adults and include a broad category of tumors including astrocytoma, oligodendroglioma, and GBM. Regardless of tumor aggressiveness, malignancy, and infiltration, these glia-derived tumors rarely exceed a median survival time of 12–14 months. Driven by the infiltrative nature of these tumors, the clinical approach is difficult and relapses often occur with fatal consequences. These unsuccessful attempts to control glioma's fate have fostered research looking for more effective therapies. (GSCs) are a small subset of CD133&#...
Source: Frontiers in Oncology - May 2, 2019 Category: Cancer & Oncology Source Type: research

The Outcome of Status Epilepticus and Long-Term Follow-Up
Conclusion: This study highlights the importance of regular care and patient follow-up. Introduction Status epilepticus (SE) is a condition and most extreme form of epilepsy (1), which leads to abnormal and prolonged seizure (at least 5 min). In case SE persists over 30 min, it may have severe long-term consequences (2). Referring to the new classification scheme of SE, there are two operational dimensions of the definition: time point 1 (T1) is associated with abnormally prolonged seizure, when therapy should be initiated, while time point 2 (T2) is related to the time of on-going seizure activity involving a risk...
Source: Frontiers in Neurology - April 25, 2019 Category: Neurology Source Type: research

A Copernican Approach to Brain Advancement: The Paradigm of Allostatic Orchestration
The objective of this presentation is to explore historical, scientific, interventional, and other differences between the two paradigms, so that innovators, researchers, practitioners, policy-makers, patients, end-users, and others can gain clarity with respect to both the explicit and implicit assumptions associated with brain advancement agendas of any kind. Over the course of three decades, a series of brain-centric, evolution-inspired insights have been articulated with increasing refinement, as principles of allostasis (Sterling and Eyer, 1988; Sterling, 2004, 2012, 2014). Allostasis recognizes that the role of the ...
Source: Frontiers in Human Neuroscience - April 25, 2019 Category: Neuroscience Source Type: research

Influence of Combined Transcranial Direct Current Stimulation and Motor Training on Corticospinal Excitability in Children With Unilateral Cerebral Palsy
Conclusion This proof-of-principle study evaluated the influence of cathodal contralesional tDCS on corticospinal excitability in pediatric participants with UCP. A hypothesized decrease in contralesional excitability was noted in participants in the Active+CIMT group, however, the efficacy of tDCS to modulate corticospinal excitability was not statistically different than the Sham+CIMT group. A more detailed understanding of how tDCS impacts M1 neurophysiology will be essential to inform future clinical trials on the optimal dosing parameters, based on individual brain circuitry, to explore the potential functional benef...
Source: Frontiers in Human Neuroscience - April 23, 2019 Category: Neuroscience Source Type: research

Influence of Sex on Stroke Prognosis: A Demographic, Clinical, and Molecular Analysis
Conclusion Our data suggest that women who suffer from IS present with a poorer functional outcome than men at 3-months, regardless of other preclinical and clinical factors during the acute phase. These relationships seem to be mediated by atrial dysfunction and inflammation. The inflammatory response is slightly higher in women; however, there are no sex differences in their functional behavior. There is a probable relationship between the molecular marker of atrial dysfunction NT-proBNP and worse functional outcome in women, and the connection seems to be more important in cardioembolic stroke patients. In patients wi...
Source: Frontiers in Neurology - April 16, 2019 Category: Neurology Source Type: research

WHO/ILO work-related burden of disease and injury: Protocol for systematic reviews of exposure to occupational noise and of the effect of exposure to occupational noise on cardiovascular disease.
aga JU Abstract BACKGROUND: The World Health Organization (WHO) and the International Labour Organization (ILO) are developing a joint methodology for estimating the national and global work-related burden of disease and injury (WHO/ILO joint methodology), with contributions from a large network of experts. In this paper, we present the protocol for two systematic reviews of parameters for estimating the number of deaths and disability-adjusted life years from cardiovascular disease attributable to exposure to occupational noise, to inform the development of the WHO/ILO joint methodology. OBJECTIVES: We aim t...
Source: Environment International - January 22, 2019 Category: Environmental Health Authors: Teixeira LR, Azevedo TM, Bortkiewicz A, Corrêa da Silva DT, de Abreu W, de Almeida MS, de Araujo MAN, Gadzicka E, Ivanov ID, Leppink N, Macedo MRV, de S Maciel EMG, Pawlaczyk-Łuszczyńska M, Pega F, Prüss-Üstün AM, Siedlecka J, Stevens GA, Ujita Y, B Tags: Environ Int Source Type: research

Palm oil and dietary change: Application of an integrated macroeconomic, environmental, demographic, and health modelling framework for Thailand
Publication date: Available online 18 January 2019Source: Food PolicyAuthor(s): Henning Tarp Jensen, Marcus R. Keogh-Brown, Bhavani Shankar, Wichai Aekplakorn, Sanjay Basu, Soledad Cuevas, Alan D. Dangour, Shabbir H. Gheewala, Rosemary Green, Edward J.M. Joy, Nipa Rojroongwasinkul, Nalitra Thaiprasert, Richard D. SmithAbstractPalm oil is a cooking oil and food ingredient in widespread use in the global food system. However, as a highly saturated fat, palm oil consumption has been associated with negative effects on cardiovascular health, while large scale oil palm production has been linked to deforestation. We construct a...
Source: Food Policy - January 20, 2019 Category: Food Science Source Type: research

Application of Muse Cell Therapy to Stroke.
Authors: Niizuma K, Borlongan CV, Tominaga T Abstract Stroke is defined as a sudden onset of neurologic deficits arising from cerebrovascular complications. It is the second common cause of death around the world and the major cause of disability. Because brain is an organ with complicated neural networks and neurons are highly differentiated, it has been traditionally considered to possess a limited potential for regeneration. The number of stroke patients is increasing, and stroke represents a serious problem from the viewpoint of the national medical economy. Even with the current sophisticated treatments, more ...
Source: Advances in Experimental Medicine and Biology - November 30, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research

‘ Meat Taxes ’ Would Save Lives And Cut Health Care Costs, Study Says
(CNN) — It would drive up the price of your barbecue but a global “meat tax” could save 220,000 lives and cut health care bills by $41 billion each year, according to a new study. The numbers are based on evidence that links meat consumption to increased risk of heart disease, cancer, stroke and diabetes. Three years ago, the World Health Organization declared red meat such as beef, lamb and pork to be carcinogenic when eaten in processed forms, including sausages, bacon and beef jerky. Health officials have also declared that unprocessed red meat like steak and burgers are “probably” carcinog...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - November 7, 2018 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health Offbeat Local TV Meat Source Type: news

Did post-Soviet Russians drink themselves to death?
By Vladimir Popov and Jomo Kwame SundaramMOSCOW and KUALA LUMPUR, Oct 23 2018 (IPS)Although initially obscured by The Economist, among others, the sudden and unprecedented increase in Russian adult male mortality during 1992-1994 is no longer denied. Instead, the debate is now over why?Having advocated ‘shock therapy’, a ‘big bang’, ‘sudden’ or rapid post-Soviet transition, Jeffrey Sachs and others have claimed that the sudden collapse in Russian adult male life expectancy was due to a sudden increase in alcohol consumption, playing into popular foreign images of vodka-binging Russian men. In Russia, vodka is a...
Source: IPS Inter Press Service - Health - October 23, 2018 Category: International Medicine & Public Health Authors: Vladimir Popov and Jomo Kwame Sundaram Tags: Development & Aid Economy & Trade Europe Global Governance Headlines Health TerraViva United Nations Source Type: news

Zero Hunger: our actions today are our future tomorrow
This article is part of a series of opinion pieces to mark World Food Day October 16   José Graziano da Silva is Director-General of the Food and Agriculture Organization of the United NationsThe post Zero Hunger: our actions today are our future tomorrow appeared first on Inter Press Service.
Source: IPS Inter Press Service - Health - October 15, 2018 Category: International Medicine & Public Health Authors: Jose Graziano da Silva Tags: Development & Aid Economy & Trade Editors' Choice Featured Food & Agriculture Global Headlines Health Poverty & SDGs TerraViva United Nations World Food Day 2018 Source Type: news

An update on physical health and economic consequences of overweight and obesity
Publication date: Available online 5 May 2018Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Dinh-Toi Chu, Nguyen Thi Minh Nguyet, Thien Chu Dinh, Nguyen Vu Thai Lien, Khanh-Hoang Nguyen, Vo Truong Nhu Ngoc, Yang Tao, Le Hoang Son, Duc-Hau Le, Vu Bich Nga, Adam Jurgoński, Quoc-Hung Tran, Pham Van Tu, Van-Huy PhamAbstractOverweight and obesity (OW and OB) have been on the increase globally and posed health risks to the world’s population of all ages, including pre-born babies, children, adolescents, adults and elderly people, via their comorbid conditions. Excellent examples of comorbidities ...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - July 10, 2018 Category: Endocrinology Source Type: research

Is Working Remotely Bad for Your Health?
Imagine rolling out of bed in the morning and, rather than racing to get out the door and into morning traffic, you could go for a run or make yourself breakfast. It’s the kind of daydream every chained-to-his-desk office worker has now and then. And for many, that daydream has become a reality. Following the Great Recession and the rise of the app-driven gig economy, more and more American workers have found themselves jettisoned from traditional office spaces and thrust into jobs that require them to work remotely, at least some of the time. A 2016 study from Harvard and Princeton found that the percentage of the ...
Source: TIME: Health - July 9, 2018 Category: Consumer Health News Authors: Markham Heid Tags: Uncategorized healthytime Research Source Type: news

An update on physical health and economic consequences of overweight and obesity
Publication date: Available online 5 May 2018Source: Diabetes & Metabolic Syndrome: Clinical Research & ReviewsAuthor(s): Dinh-Toi Chu, Nguyen Thi Minh Nguyet, Thien Chu Dinh, Nguyen Vu Thai Lien, Khanh-Hoang Nguyen, Vo Truong Nhu Ngoc, Yang Tao, Le Hoang Son, Duc-Hau Le, Vu Bich Nga, Adam Jurgoński, Quoc-Hung Tran, Pham Van Tu, Van-Huy PhamAbstractOverweight and obesity (OW and OB) have been on the increase globally and posed health risks to the world’s population of all ages, including pre-born babies, children, adolescents, adults and elderly people, via their comorbid conditions. Excellent examples of comorbidities ...
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews - July 5, 2018 Category: Endocrinology Source Type: research

Biomechanical mechanisms underlying exosuit-induced improvements in walking economy after stroke RESEARCH ARTICLE
This study elucidates the biomechanical mechanisms underlying exosuit-induced reductions in metabolic power. We evaluated the relationships between exosuit-induced changes in the body center of mass (COM) power generated by each limb, individual joint power and metabolic power. Compared with walking with an exosuit unpowered, exosuit assistance produced more symmetrical COM power generation during the critical period of the step-to-step transition (22.4±6.4% more symmetric). Changes in individual limb COM power were related to changes in paretic (R2=0.83, P=0.004) and non-paretic (R2=0.73, P=0.014) ankle power. Inte...
Source: Journal of Experimental Biology - March 7, 2018 Category: Biology Authors: Bae, J., Awad, L. N., Long, A., O'Donnell, K., Hendron, K., Holt, K. G., Ellis, T. D., Walsh, C. J. Tags: Comparative biomechanics of movement RESEARCH ARTICLE Source Type: research

Associations between Ischemic Stroke Follow-Up, Socioeconomic Status, and Adherence to Secondary Preventive Drugs in Southern Sweden: Observations from the Swedish Stroke Register (Riksstroke)
Conclusions: The use of secondary preventive drugs decreases over the first year after stroke and remains suboptimal. Specific reasons for nonadherence warrant further study.Neuroepidemiology 2017;48:32-38
Source: Neuroepidemiology - February 24, 2017 Category: Epidemiology Source Type: research

Non-invasive brain stimulation to enhance stroke recovery – towards patient-tailored strategies
Stroke is the leading cause of serious long-term disability with growing impact on actual and future health economy. The resulting deficits of a stroke, e.g., of the upper extremity or language, have great impact on activities of daily life, social as well as professional.
Source: BRAIN STIMULATION: Basic, Translational, and Clinical Research in Neuromodulation - February 15, 2017 Category: Neurology Authors: F.C. Hummel Source Type: research

Alterations in Aerobic Exercise Performance and Gait Economy Following High-Intensity Dynamic Stepping Training in Persons With Subacute Stroke
Conclusions: High-intensity stepping training may elicit significant improvements in O2submax, whereas changes in both peak capacity and economy better reflect gains in walking function. Providing high-intensity training to improve locomotor and aerobic exercise performance may increase the efficiency of rehabilitation sessions. Video Abstract available for more insights from the authors (see Supplemental Digital Content, http://links.lww.com/JNPT/A142 ).
Source: Journal of Neurologic Physical Therapy - September 24, 2016 Category: Physiotherapy Tags: Research Articles Source Type: research

Alterations in Aerobic Exercise Performance and Gait Economy Following High-Intensity Dynamic Stepping Training in Persons With Subacute Stroke.
CONCLUSIONS: High-intensity stepping training may elicit significant improvements in (Equation is included in full-text article.)O2submax, whereas changes in both peak capacity and economy better reflect gains in walking function. Providing high-intensity training to improve locomotor and aerobic exercise performance may increase the efficiency of rehabilitation sessions.Video Abstract available for more insights from the authors (see Supplemental Digital Content, http://links.lww.com/JNPT/A142). PMID: 27632078 [PubMed - in process]
Source: Physical Therapy - September 19, 2016 Category: Physiotherapy Authors: Leddy AL, Connolly M, Holleran CL, Hennessy PW, Woodward J, Arena RA, Roth EJ, Hornby TG Tags: J Neurol Phys Ther Source Type: research

Economy Class Syndrome, patent foramen ovale and stroke
Whether or not air travel in a patient with patent foramen ovale (PFO) is a risk factor for cerebral embolism is unresolved. This is illustrated by a recent case report of the Massachusetts General Hospital in the New England Journal of Medicine of deep venous thrombosis and stroke associated with air travel. The discussant concluded that because of the relatively short flight “it seems unlikely that air travel was a major risk factor” 1. This may well be true for deep venous thrombosis per se, the risk of which has been shown to increase with duration of the flight 2.
Source: The American Journal of Cardiology - August 1, 2016 Category: Cardiology Authors: Franz H. Messerli, Stefano F. Rimoldi, Urs Scherrer Source Type: research

Rheumatic Valve Disease and Stroke. A Public Health Problem in Countries in Way of Develop (P1.288)
Conclusions: In our population RVD with or without AF is the main cause of cerebral ischemia, just preceded by thrombosis of large arteries, affecting young and productive people, which severely impacts the economy of families and country that walking towards development. Mexico along with other emerging countries needs to implement public health programs in the early diagnosis and treatment of this health problem.Disclosure: Dr. Mendez-Dominguez has nothing to disclose. Dr. Arias-Fernandez has nothing to disclose. Dr. Aguirre-Delfin has nothing to disclose.
Source: Neurology - April 3, 2016 Category: Neurology Authors: Mendez-Dominguez, A., Arias-Fernandez, J., Aguirre-Delfin, M. Tags: Global Health: Infectious Disease, Capacity Building, and Other Source Type: research

Stroke in Commercial Flights Brief Reports
Conclusions— We found a low incidence of stroke in the setting of air travel. Economy class stroke syndrome and arterial dissection were well represented in our sample. However, the main pathogenesis was atherothrombosis with a high proportion of patients with high carotid stenosis.
Source: Stroke - March 27, 2016 Category: Neurology Authors: Alvarez-Velasco, R., Masjuan, J., DeFelipe, A., Corral, I., Estevez-Fraga, C., Crespo, L., Alonso-Canovas, A. Tags: Epidemiology, Risk Factors, Ischemic Stroke, Transient Ischemic Attack (TIA) Brief Reports Source Type: research

Differences in the distribution of risk factors for stroke among the high‐risk population in urban and rural areas of Eastern China
ConclusionAmong the population at high risk of stroke, there were significant differences in the distribution of the following risk factors between the urban and rural groups: hypertension, atrial fibrillation, dyslipidemia, lack of physical exercise, and a previous stroke. As the Chinese lifestyle has changed rapidly with the growth of economy and society during the past 3 decades, the incidence of risk factors for stroke in China has become similar to that in the Western countries. Hypertension, diabetes, hypercholesterolemia, smoking, atrial fibrillation, physical inactivity, obesity, and stroke family history are the ...
Source: Brain and Behavior - February 29, 2016 Category: Neurology Authors: Te Mi, Shangwen Sun, Yifeng Du, Shougang Guo, Lin Cong, Mingfeng Cao, Qinjian Sun, Yi Sun, Chuanqiang Qu Tags: Original Research Source Type: research

Prevention and follow-up in thromboembolic ischemic stroke: Do we need to think out of the box?
Stroke is one of the most debilitating thrombotic diseases, and world-wide it is estimated that by, 2030 23 million people will be affected. Except for the impact on the individual families, the world economy is also affected adversely. Although the medical treatment and knowledge of stroke are both increasing and well-researched, we still do not see a light in the tunnel. Currently various diagnostic tests are employed to determine the specific type of ischemic stroke as classified by the TOAST criteria.
Source: Thrombosis Research - November 4, 2015 Category: Hematology Authors: Albe C. Swanepoel, Etheresia Pretorius Tags: Review Article Source Type: research

Effects of handrail hold and light touch on energetics, step parameters, and neuromuscular activity during walking after stroke
Conclusion: Handrail hold, but not light touch, altered step parameters and was accompanied by a global reduction in muscle activity, with improved timing constancy. This suggests that the use of a handrail allows for a more economic step pattern that requires less muscular activation without resulting in substantial neuromuscular re-organization. Handrail use may thus have beneficial effects on gait economy after stroke, which cannot be accomplished through enhanced somatosensory input alone.
Source: Journal of NeuroEngineering and Rehabilitation - August 23, 2015 Category: Rehabilitation Authors: T. IJmkerC. LamothH. HoudijkM. TolsmaL. van der WoudeA. DaffertshoferP. Beek Source Type: research

Correspondence The future of stroke therapy must not be mired by past arguments
Stroke is the leading cause of disability and the fifth leading cause of death in the UK, costing the UK economy more than £7 billion per year.1 At present, the only therapeutic approved by the UK National Institute for Health and Care Excellence (NICE) for the treatment of ischaemic stroke is thrombolysis using recombinant tissue-type plasminogen activator (rtPA). However, rtPA is only effective in patients who present within 4·5 h of stroke onset, with a number needed to treat for benefit of 3·6 before 90 min, rising to 5·9 between 3 h and 4·5 h.
Source: LANCET - August 14, 2015 Category: Journals (General) Authors: Alastair M Buchan, Hasneen G Karbalai, Brad A Sutherland Tags: Correspondence Source Type: research

O-002 developing an interventional stroke service: improving clinical outcomes and reducing cost and delivering great cost saving benefits to health economy
ConclusionMechanical Thrombectomy has shown benefit in improving clinical outcomes with significant cost saving benefit to our institution and the community care. If the cost saving benefits is extrapolated to the stroke population of the United Kingdom or any other western country with a similar healthcare structure, this will lead to major savings to the healthcare economy. For this to materialize, there needs to a larger government initiative to streamline stroke pathways and provide adequate funding to develop this service uniformly across the country.DisclosuresS. Nayak: None.
Source: Journal of NeuroInterventional Surgery - July 26, 2015 Category: Neurosurgery Authors: Nayak, S. Tags: SNIS 12th Annual Meeting Oral Abstracts Source Type: research

Stroke rehabilitation at home before and after discharge reduced disability and improved quality of life: A randomised controlled trial.
CONCLUSION: Early home-based rehabilitation reduced disability and increased quality of life. Compared to standard care, home-based stroke rehabilitation was more cost-effective. PMID: 25758941 [PubMed - as supplied by publisher]
Source: Clinical Rehabilitation - March 10, 2015 Category: Rehabilitation Authors: Rasmussen RS, Østergaard A, Kjær P, Skerris A, Skou C, Christoffersen J, Seest LS, Poulsen MB, Rønholt F, Overgaard K Tags: Clin Rehabil Source Type: research

The One-Year Attributable Cost of Post-stroke Dysphagia
This study sought to address this issue by examining the 1-year cost associated with a diagnosis of dysphagia post-stroke in South Carolina. Furthermore, this study investigated whether ethnicity and residence differences exist in the cost of dysphagia post-stroke. Data on 3,200 patients in the South Carolina Medicare database from 2004 who had ICD-9 codes for ischemic stroke, 434 and 436, were retrospectively included in this study. Differences between persons with and without dysphagia post-stroke were compared with respect to age, gender, ethnicity, mortality, length of stay, comorbidity, rurality, discharge disposition...
Source: Dysphagia - September 27, 2014 Category: Speech Therapy Source Type: research

Stroke in Asia: a global disaster
Although stroke is a world‐wide problem, the burden of stroke is particularly serious in Asia; its mortality is higher than in Europe or North America. The situation in Asia is dichotomized. Stroke mortality and case fatality has been declining in northern‐eastern countries such as Korea, Japan, Taiwan, and urbanized areas of China. This is attributed to both the risk factor control and stroke care improvement. However, declining stroke incidence is rarely observed, which is in part due to rapidly aging population. As a result, there is an increase in the number of stroke survivors who require long‐term, costly care....
Source: International Journal of Stroke - September 18, 2014 Category: Neurology Authors: Jong S. Kim Tags: Leading opinion Source Type: research