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Evaluation of a Novel Synthetic Peptide Derived from Cytolytic Mycotoxin Candidalysin
Toxins (Basel). 2022 Oct 11;14(10):696. doi: 10.3390/toxins14100696.ABSTRACTThe importance of neuroinflammation in neurology is becoming increasingly apparent. In addition to neuroinflammatory diseases such as multiple sclerosis, the role of neuroinflammation has been identified in many non-inflammatory neurological disorders such as stroke, epilepsy, and cancer. The immune response within the brain involves the presence of CNS resident cells; mainly glial cells, such as microglia, the CNS resident macrophages. We evaluated the peptide Ca-MAP1 bioinspired on the C. albicans immature cytolytic toxin candidalysin to develop ...
Source: Cancer Control - October 26, 2022 Category: Cancer & Oncology Authors: Pedro Henrique de Oliveira Cardoso Ana Paula de Ara újo Boleti Patr ícia Souza E Silva Lincoln Takashi Hota Mukoyama Alexya Sandim Guindo Luiz Filipe Ramalho Nunes de Moraes Caio Fernando Ramalho de Oliveira Maria Ligia Rodrigues Macedo Cristiano Marcel Source Type: research

New sequence types of Acinetobacter baumannii in two emergency hospitals in the Central-West region of Brazil
In this report, we present a series of three cases of snakebites that evolved with hemorrhagic stroke due to delays in the access to antivenom in the Brazilian Amazon, being fundamental for diagnosis to validate the clinical suspicion and make decisions that would improve the treatment and prognosis of the patients.
Source: Revista da Sociedade Brasileira de Medicina Tropical - July 18, 2019 Category: Tropical Medicine Source Type: research

Challenge to the Intestinal Mucosa During Sepsis
Conclusion The impact of sepsis on the gut is manifold, e.g., sepsis mediated alteration of the gut-blood barrier and increase in the intestinal permeability, which may correlate with the phenomena of bacterial translocation and lymphatic activation (“toxic-lymph”). Systemic consequences of sepsis are widespread and concern to the coagulative system, the microbiome as well as enzymes, such as pancreatic proteases, MMPs and IAPs. Nevertheless, the therapeutic approaches for modulating the mucosal immune system are still rarely effective in daily routine. Recent published studies showing that treatment with ...
Source: Frontiers in Immunology - April 29, 2019 Category: Allergy & Immunology Source Type: research

Microbiological Etiologies of Pneumonia Complicating Stroke Clinical Sciences
Conclusions—Although the analysis was limited by small and heterogeneous study populations, limiting determination of microbiological causality, this review suggests aerobic Gram-negative bacilli and Gram-positive cocci are frequently associated with pneumonia complicating stroke. This supports the need for appropriately designed studies to determine microbial cause and a consensus-based approach in antibiotic usage and further targeted antibiotic treatment trials for enhanced antibiotic stewardship.
Source: Stroke - June 25, 2018 Category: Neurology Authors: Amit K. Kishore, Andy Vail, Adam R. Jeans, Angel Chamorro, Mario Di Napoli, Lalit Kalra, Peter Langhorne, Christine Roffe, Willeke Westendorp, Paul J. Nederkoorn, Javier Garau, Diederik van de Beek, Joan Montaner, Mark Woodhead, Andreas Meisel, Craig J. S Tags: Complications, Meta Analysis, Cerebrovascular Disease/Stroke, Intracranial Hemorrhage, Ischemic Stroke Original Contributions Source Type: research