Infectious Disease: Herpes
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Vascular Event Risk After Herpes Zoster
We have read the article by Patterson et al1 published in the April 2019 issue of Mayo Clinic Proceedings. The authors performed an interesting study using propensity score to evaluate the cardiovascular disease risk during the prodromal period and aggregate period of herpes zoster (HZ) infection. The incidence rate calculated according to the time line before and after the index date also provided valuable information on the following cardiovascular risk. Evidence from large population-based studies suggests a transiently increased risk of stroke after HZ.
Source: Mayo Clinic Proceedings - August 1, 2019 Category: Internal Medicine Authors: Yi-Ting Lin, Ping-Hsun Wu Tags: Letter to the Editor Source Type: research
What Causes Facial Nerve Palsy?
Discussion Facial nerve palsy has been known for centuries, but in 1821 unilateral facial nerve paralysis was described by Sir Charles Bell. Bell’s palsy (BP) is a unilateral, acute facial paralysis that is clinically diagnosed after other etiologies have been excluded by appropriate history, physical examination and/or laboratory testing or imaging. Symptoms include abnormal movement of facial nerve. It can be associated with changes in facial sensation, hearing, taste or excessive tearing. The right and left sides are equally affected but bilateral BP is rare (0.3%). Paralysis can be complete or incomplete at prese...
Source: PediatricEducation.org - June 3, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news
Upadacitinib as monotherapy in patients with active rheumatoid arthritis and inadequate response to methotrexate (SELECT-MONOTHERAPY): a randomised, placebo-controlled, double-blind phase 3 study
This study is active but not recruiting and is registered with ClinicalTrials.gov, number NCT02706951.FindingsPatients were screened between Feb 23, 2016, and May 19, 2017 and 648 were randomly assigned to treatment. 598 (92%) completed week 14. At week 14, an ACR20 response was achieved by 89 (41%) of 216 patients (95% CI 35–48) in the continued methotrexate group, 147 (68%) of 217 patients (62–74) receiving upadacitinib 15 mg, and 153 (71%) of 215 patients (65–77) receiving upadacitinib 30 mg (p<0·0001 for both doses vs continued methotrexate). DAS28(CRP) 3·2 or lower was met by 42 (19%) of 216 (95% CI 14–2...
Source: The Lancet - May 25, 2019 Category: General Medicine Source Type: research
Cerebrovascular events after herpes zoster infection: a risk that should be not underestimated
AbstractThe occurrence of a cerebrovascular event after a herpes zoster (HZ) infection represents a nightmare in clinical practice, especially in those patients with concomitant cardiovascular comorbidities/risk factors and disease related per se to a higher risk of zoster infection. Moreover, the absence of a consensus opinion regarding a specific and adequate prevention of cerebrovascular events in these patients further complicates the treatment. Accumulating evidences demonstrated that HZ and HZ ophtalmicus (HZO) increase the risk of cerebrovascular events in the short-and long-term periods. Moreover, patient ’s ages...
Source: Journal of NeuroVirology - May 8, 2019 Category: Neurology Source Type: research
Late-onset Mitochondrial Encephalopathy, Lactic Acidosis, and Stroke-like Episodes Presenting With Auditory Agnosia
Conclusions: MELAS is a disorder with clinical variability. Neuroimaging studies during stroke-like episodes in MELAS can provide significant clues to the underlying disorder. Although patients typically present in childhood, the first stroke-like episode can occur later in life in some patients, potentially related to a lower heteroplasmy level.
Source: The Neurologist - May 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research
Psychosis Polyrisk Score (PPS) for the Detection of Individuals At-Risk and the Prediction of Their Outcomes
Conclusions The combination of risk/protective factors encompassing genetic (PRS) and non-genetic information (PPS) holds promise for overcoming the epidemiological weakness of the CHR-P paradigm. The PPS conceptually and empirically developed here will facilitate future research in this field and hopefully advance our ability to detect individuals at-risk for psychosis and forecast their clinical outcomes. Ethics Statement This study was supported by the King's College London Confidence in Concept award from the Medical Research Council (MRC) (MC_PC_16048) to PF-P. This study also represents independent researc...
Source: Frontiers in Psychiatry - April 17, 2019 Category: Psychiatry Source Type: research
Analysis of Vascular Event Risk After Herpes Zoster From 2007 to 2014 US Insurance Claims Data
To estimate the risk of transient ischemic attack (TIA), stroke, and myocardial infarction in periods covering 4 weeks before to 52 weeks after herpes zoster (HZ) diagnosis in US adults.
Source: Mayo Clinic Proceedings - April 4, 2019 Category: Internal Medicine Authors: Brandon J. Patterson, Debora A. Rausch, Debra E. Irwin, Michael Liang, Songkai Yan, Barbara P. Yawn Tags: Original article Source Type: research
An Association Between Herpes Zoster Vaccination and Stroke Reduction Among Elderly Individuals.
Authors: Klaric JS, Beltran TA, McClenathan BM Abstract Herpes zoster (HZ, shingles) affects individuals (60+ years) by reactivation of varicella virus from primary infection. Approximately one-third of the general population will develop HZ and are at increased risk of stroke. Our objective was describing possible associations between self-reported HZ vaccination and stroke with the Centers for Disease Control and Prevention's Behavioral Risk Factors Surveillance System, a cross-sectional nationwide telephone survey. Non-institutionalized U.S. adults answered items concerning health risk behaviors. 2014 survey dat...
Source: Military Medicine - March 23, 2019 Category: International Medicine & Public Health Tags: Mil Med Source Type: research
Post-Onset Shingles Rx Fails to Cut Ischemic Stroke Risk Post-Onset Shingles Rx Fails to Cut Ischemic Stroke Risk
The higher risk for stroke with herpes zoster was not attenuated by antivirals or Zostavax vaccination in older patients, but that shouldn ' t slow vaccination rates or further study.Medscape Medical News
Source: Medscape Medical News Headlines - February 1, 2019 Category: Consumer Health News Tags: Cardiology News Source Type: news
Cerebrovascular manifestations of herpes simplex virus infection of the central nervous system: a systematic review
Intracerebral hemorrhage and ischemic stroke are increasingly recognized complications of central nervous system (CNS) infection by herpes simplex virus (HSV).
Source: Journal of Neuroinflammation - January 29, 2019 Category: Neurology Authors: Larissa Hauer, Slaven Pikija, Eva C. Schulte, Laszlo K. Sztriha, Raffaele Nardone and Johann Sellner Tags: Research Source Type: research
Central nervous system varicella zoster vasculopathy in an immunocompromised patient
ConclusionThis clinical case and review of the literature highlights the challenges in the diagnosis and management of VZV CNS vasculopathy in immunocompromised patients.
Source: IDCases - December 29, 2018 Category: Infectious Diseases Source Type: research
Dramatic improvement after decompressive craniectomy in a fulminant stroke-like case of herpes simplex encephalitis.
PMID: 30528146 [PubMed - as supplied by publisher]
Source: Presse Medicale - December 7, 2018 Category: General Medicine Authors: Sellier A, Joubert C, Desse N, Bernard C, Faivre A, Dagain A Tags: Presse Med Source Type: research
Increased Risk of Lymphoid Malignancy in Patients with Herpes Zoster: A Longitudinal Follow-up Study Using a National Cohort Study
Conclusion: Our study demonstrates that herpes zoster infection increases the risk of subsequent lymphoid malignancies irrespective of age and gender in the Korean population.DisclosuresNo relevant conflicts of interest to declare.
Source: Blood - November 21, 2018 Category: Hematology Authors: Lee, Y. K., Kim, M., Kim, H. J., Lim, H., Choi, H. G. Tags: 902. Health Services Research-Malignant Diseases: Quality Of Life Studies Source Type: research
Review shows link between herpes and dementia
Authors advocate use of antiherpes antivirals Related items fromOnMedica Anticholinergic drugs may be linked to increased risk of dementia New evidence on benzodiazepine link to Alzheimer ’s Stroke rate higher in HIV patients Single-dose malaria drug eliminates parasite from liver Alzheimer ’s drugs work for more severe forms of disease
Source: OnMedica Latest News - October 19, 2018 Category: UK Health Source Type: news
Diagnosis and Treatment of Squamous Cell Carcinoma in Lower Lip: Case Report
A 67-year-old woman attended the stomatology clinic complaining of a wound on the lip, painful, with an evolution of 3 months. During this period, she was treated by a dermatologist for herpes simplex, but without resolution. Anamnesis indicated systemic arterial hypertension and previous stroke; she denied smoking or performing activities causing sun exposure. A physical examination revealed an exophytic ulcer on the lower lip with a crusted necrotic background, indurated rounded borders, soft base, 1.5 cm in size, and loss of the mucocutaneous line.
Source: Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics - September 1, 2018 Category: ENT & OMF Authors: Rayane Velloso De Almeida, Miriam Beatriz Jord ão Moreira Sarruf, Ana Flávia Schuler De Assumpção Leite, Adriana Terezinha Neves Novellino Alves, Simone De Queiroz Chaves Lourenço, Jacqueline Tavares Silva Fernandes, Josiane Costa Rodrigues De Sá Tags: Oral and Maxillofacial Pathology Source Type: research
Herpes Simplex Laryngitis Presenting as Airway Obstruction in a Stroke Patient
We present the second confirmed report of HSV laryngitis in an adult stroke patient, resulting in complicated airway management issues. This rare presentation of laryngeal HSV in a stroke patient can interfere with speech, language, and swallowing functions and confounds the etiology of these issues, which can impact subsequent management.
Source: IDCases - August 23, 2018 Category: Infectious Diseases Source Type: research
In this issue of JNO, Drs. M. Tariq Bhatti and Mark L. Moster discuss the following 6 articles: 1. Hitomi E, Simpkins AN, Luby M, Latour LL, Leigh RJ, Leigh R. Blood-ocular barrier disruption in patients with acute stroke. Neurology. 2018;90:e915–e923.2. Karaa A, Haas R, Goldstein A, Vockley J, Weaver WD, Cohen BH. Randomized dose-escalation trial of elamipretide in adults with primary mitochondrial myopathy. Neurology. 2018;90:e1212–e1221.3. Maggi P, Absinta M, Grammatico M, Vuolo L, Emmi G, Carlucci G, Spagni G, Barilaro A, Repice AM, Emmi L, Prisco D, Martinelli V, Scotti R, Sadeghi N, Perrotta G, Sati P, Dachy B, ...
Source: Journal of Neuro-Ophthalmology - August 18, 2018 Category: Opthalmology Tags: Literature Commentary: PDF Only Source Type: research
Clinical Efficacy of Platelet-Rich Plasma in the Treatment of Neurotrophic Corneal Ulcer.
Conclusions: Autologous platelet-rich plasma is a blood-based product which seems efficient in the treatment of neurotrophic keratopathy. PMID: 30026985 [PubMed]
Source: Journal of Ophthalmology - July 23, 2018 Category: Opthalmology Tags: J Ophthalmol Source Type: research
Clinical presentation, management, and pathophysiology of neuropathic itch
Publication date: August 2018Source: The Lancet Neurology, Volume 17, Issue 8Author(s): Martin Steinhoff, Martin Schmelz, Imre Lőrinc Szabó, Anne Louise OaklanderSummaryUnlike conventional itch, neuropathic itch develops in normal skin from excess peripheral firing or dampened central inhibition of itch pathway neurons. Neuropathic itch is a symptom of the same central and peripheral nervous system disorders that cause neuropathic pain, such as sensory polyneuropathy, radiculopathy, herpes zoster, stroke, or multiple sclerosis, and lesion location affects symptoms more than aetiology. The causes of neuropathic itch are h...
Source: The Lancet Neurology - July 19, 2018 Category: Neurology Source Type: research
Comment on ischemic stroke after herpes zoster
Journal of Medical Virology,Volume 0, Issue ja, -Not available-.
Source: Journal of Medical Virology - July 11, 2018 Category: Virology Authors: GiulianaGalassiMD , MaurilioGenoveseMD , MarisaMeacciPhD , MarcellaMalagoliMD Source Type: research
Magnetic resonance imaging of arterial stroke mimics: a pictorial review
AbstractAcute ischaemic stroke represents the most common cause of new sudden neurological deficit, but other diseases mimicking stroke happen in about one-third of the cases. Magnetic resonance imaging (MRI) is the best technique to identify those ‘stroke mimics’. In this article, we propose a diagnostic approach of those stroke mimics on MRI according to an algorithm based on diffusion-weighted imaging (DWI), which can be abnormal or normal, followed by the results of other common additional MRI sequences, such as T2 with gradient recall ed echo weighted imaging (T2-GRE) and fluid-attenuated inversion recovery (FLAIR...
Source: Insights into Imaging - June 22, 2018 Category: Radiology Source Type: research
Neurological Disorders Associated with Human Alphaherpesviruses.
Authors: Kawada JI Abstract Herpes simplex virus (HSV) encephalitis is the most common cause of sporadic fatal encephalitis worldwide, and central nervous system (CNS) involvement is observed in approximately one-third of neonatal HSV infections . In recent years, single-gene inborn errors of innate immunity have been shown to be associated with susceptibility to HSV encephalitis . Temporal lobe abnormalities revealed by magnetic resonance imaging-the most sensitive imaging method for HSV encephalitis-are considered strong evidence for the disease. Detection of HSV DNA in the cerebrospinal fluid by polymerase chain...
Source: Advances in Experimental Medicine and Biology - June 15, 2018 Category: Research Tags: Adv Exp Med Biol Source Type: research
Correlation between herpes zoster and stroke —A case–control study
Journal of Medical Virology, EarlyView.
Source: Journal of Medical Virology - May 25, 2018 Category: Virology Authors: HadisehHosamirudsariMD , ParisaRashedMD , FarhadAfsariMD , SamanehAkbarpourPhD , AliasgharBagherzadehMD Source Type: research
Risk of Stroke/Transient Ischemic Attack or Myocardial Infarction with Herpes Zoster: A Systematic Review and Meta-Analysis
Accumulating evidence indicates that herpes zoster (HZ) may increase the risk of stroke/transient ischemic attack (TIA) or myocardial infarction (MI), but the results are inconsistent. We aim to explore the relationship between HZ and risk of stroke/TIA or MI and between herpes zoster ophthalmicus (HZO) and stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - May 10, 2017 Category: Neurology Authors: Yanting Zhang, Ganfeng Luo, Yuanwei Huang, Qiuyan Yu, Li Wang, Ke Li Source Type: research
Misdiagnosis of CADASIL: A single Medical Center experience (P1.251)
Conclusions:CADASIL is the most prevalent monogenic cerebral small-vessel arteriopathy. Despite wide availability of genetic testing, misdiagnosis and delay diagnosis are common. We encourage for enhanced awareness of CADASIL among patients with migraines with aura, recurrent TIAs or subcortical ischemic strokes, and mood disorder, in order to provide appropriate multidisciplinary treatment, psychological support and genetic counselingStudy Supported by: n/aDisclosure: Dr. Ortiz-Garcia has nothing to disclose. Dr. Orjuela has nothing to disclose. Dr. Sweis has nothing to disclose. Dr. Biller has received personal compensat...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Ortiz-Garcia, J., Orjuela, K., Sweis, R., Biller, J. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research
Stroke Associated With Varicella Zoster Vasculopathy: A Clinicoradiological Profile of 3 Patients
Conclusions: VZ associated vasculopathy may have diverse clinical profile and neuroimaging features. It should be considered as an important and treatable cause of stroke in appropriate clinical settings.
Source: The Neurologist - March 1, 2017 Category: Neurology Tags: Case Report/Case Series Source Type: research
Herpes Zoster and the Risk of Stroke in Patients With Autoimmune Diseases
ConclusionIn patients with autoimmune diseases, incident HZ was associated with as much as a 2‐fold increased risk of stroke in the subsequent few months. These data underscore the urgency of developing strategies for reducing the risk of varicella‐zoster virus.
Source: Arthritis and Rheumatism - January 28, 2017 Category: Rheumatology Authors: Leonard H. Calabrese, Fenglong Xie, Huifeng Yun, Kevin L. Winthrop, John W. Baddley, Cassandra Calabrese, Jeffrey R. Curtis Tags: Autoimmune Disease Source Type: research
Carotid intima media thickness and blood biomarkers of atherosclerosis in patients after stroke or myocardial infarction.
CONCLUSIONS: Our study supports linear correlations between CIMT and IC and hs-CRP levels. However, these associations seem to depend on the type of vascular burden. PMID: 28051279 [PubMed - in process]
Source: Croatian Medical Journal - December 31, 2016 Category: Journals (General) Authors: Kurkowska-Jastrzebska I, Karlinski MA, Błazejewska-Hyzorek B, Sarzynska-Dlugosz I, Filipiak KJ, Czlonkowska A Tags: Croat Med J Source Type: research
Risk of Stroke in Patients with Herpes Zoster: A Systematic Review and Meta-Analysis
Several observational studies suggest that herpes zoster (HZ) may increase the risk of stroke, but the results are inconsistent. Our study was designed to assess the association between HZ and the risk of stroke through a meta-analysis of cohort studies.
Source: Journal of Stroke and Cerebrovascular Diseases - October 31, 2016 Category: Neurology Authors: Sheng-Ye Yang, Hong-Xing Li, Xin-Hao Yi, Guang-Liang Han, Qiang Zong, Ming-Xing Wang, Xiao-Xiao Peng Source Type: research
Herpes Zoster and the Risk for Stroke in Patients with Autoimmune Diseases
Conclusion: In patients with autoimmune diseases, incident HZ was associated with up to a two‐fold increased risk for stroke in the subsequent few months. These data provide urgency for developing strategies to reduce the risk of VZV. This article is protected by copyright. All rights reserved.
Source: Arthritis and Rheumatism - September 2, 2016 Category: Rheumatology Authors: L.H. Calabrese, F. Xie, H. Yun, K. Winthrop, J.W. Baddley, C. Calabrese, J.R. Curtis Tags: Full Length Source Type: research
Shingles associated with short-term increased risk of stroke.
Authors: Abstract The varicella zoster virus causes varicella, or chickenpox, before becoming latent in neurones. As immunity decreases in older and immunocompromised individuals, the virus reactivates to produce herpes zoster, or shingles. More than 95% of the world's adult population is infected and up to one third will develop shingles in their lifetime. PMID: 27029983 [PubMed - in process]
Source: Nursing Older People - March 31, 2016 Category: Nursing Tags: Nurs Older People Source Type: research
Herpesvirus Infections and Childhood Arterial Ischemic Stroke: Results of the VIPS Study.
CONCLUSIONS: -Herpesviruses may act as a trigger for childhood AIS, even if the infection is subclinical. Antivirals like acyclovir might have a role in the prevention of recurrent stroke if further studies confirm a causal relationship. PMID: 26813104 [PubMed - as supplied by publisher]
Source: Circulation - January 26, 2016 Category: Cardiology Authors: Elkind MS, Hills NK, Glaser CA, Lo WD, Amlie-Lefond C, Dlamini N, Kneen R, Hod EA, Wintermark M, deVeber GA, Fullerton HJ, VIPS Investigators Tags: Circulation Source Type: research
Biological Plausibility of a Link Between Arterial Ischemic Stroke and Infection with Varicella-Zoster Virus or Herpes Simplex Virus.
Abstract There are now 9 human herpesviruses; the increase from 8 to 9 was caused by a recent decision to split human herpesvirus (HHV) strains 6A and 6B into distinct species. The 9 species are subdivided into three subfamilies, called alpha: herpes simplex virus (HSV) types 1 and 2 and varicella-zoster virus (VZV); beta: cytomegalovirus (CMV), HHV6A, HHV6B and HHV7; gamma: Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (sometimes called HHV8). These same herpesviruses have evolved with humankind around the world since the great migration of modern humans across the Mandeb Strait out of Afri...
Source: Circulation - January 26, 2016 Category: Cardiology Authors: Grose C Tags: Circulation Source Type: research
Well: After Shingles, Higher Risk of Heart Attack or Stroke
Researchers found that in the first week after a herpes zoster diagnosis, patients were more susceptible to cardiovascular events.
Source: NYT Health - December 16, 2015 Category: Consumer Health News Authors: NICHOLAS BAKALAR Tags: Heart Shingles (Disease) Stroke Live Featured Aging Source Type: news
Medical News Today: Shingles may lead to stroke and heart attack
The herpes zoster virus causes chickenpox and shingles; following shingles, there appears to be a higher risk of acute cardiovascular events such as stroke or myocardial infarction
Source: Health News from Medical News Today - December 15, 2015 Category: Consumer Health News Tags: Infectious Diseases / Bacteria / Viruses Source Type: news
Risk of Stroke and Myocardial Infarction After Herpes Zoster in Older Adults in a US Community Population
To assess the risk of stroke and myocardial infarction (MI) after herpes zoster in a US community population of older adults.
Source: Mayo Clinic Proceedings - December 15, 2015 Category: Internal Medicine Authors: Barbara P. Yawn, Peter C. Wollan, Maria A. Nagel, Don Gilden Tags: Original article Source Type: research
Stroke risk rose in autoimmune disease patients after herpes zoster
Stroke risk was 50% higher in the month after patients with autoimmune diseases developed herpes zoster, compared with the next 2-6 years, according to Dr. Leonard H. Calabrese. “These data provide urgency for developing strategies to reduce the risk of varicella zoster virus in vulnerable...
Source: Skin and Allergy News - November 8, 2015 Category: Dermatology Source Type: news
Herpes Simplex Virus Type 2 Encephalitis as a Cause of Ischemic Stroke: Case Report and Systematic Review of the Literature
Our objective is to describe a patient who developed an ischemic stroke as a complication of herpes simplex virus type 2 (HSV-2) encephalitis and to review the literature.
Source: Journal of Stroke and Cerebrovascular Diseases - November 2, 2015 Category: Neurology Authors: Panagiotis Zis, Panagiota Stritsou, Panagiotis Angelidakis, Antonios Tavernarakis Source Type: research
Pilot study of antibodies against varicella zoster virus and human immunodeficiency virus in relation to the risk of developing stroke, nested within a rural cohort in Uganda
ConclusionsThis is the first prospective study to examine a biological measure of exposure to VZV prior to diagnosis of stroke and although we identified no significant association, in this small pilot, with limited characterisation of cases, we cannot exclude the possibility that the virus is causal for a subset. The impact of HIV on risk of stroke has not been well characterised and warrants further study.
Source: Tropical Medicine and International Health - July 23, 2015 Category: Tropical Medicine Authors: Gershim Asiki, Lisa Stockdale, Ivan Kasamba, Tobias Vudriko, Grace Tumwekwase, Tom Johnston, Pontiano Kaleebu, Anatoli Kamali, Janet Seeley, Robert Newton Tags: Original Article Source Type: research
Pilot study of antibodies against Varicella Zoster Virus (VZV) and human immunodeficiency virus (HIV) in relation to the risk of developing stroke, nested within a rural cohort in Uganda
ConclusionsThis is the first prospective study to examine a biological measure of exposure to VZV prior to diagnosis of stroke and although we identified no significant association, in this small pilot, with limited characterisation of cases, we cannot exclude the possibility that the virus is causal for a subset. The impact of HIV on risk of stroke has not been well characterised and warrants further study.This article is protected by copyright. All rights reserved.
Source: Tropical Medicine and International Health - June 17, 2015 Category: Tropical Medicine Authors: Gershim Asiki, Lisa Stockdale, Ivan Kasamba, Tobias Vudriko, Grace Tumwekwase, Tom Johnston, Pontiano Kaleebu, Anatoli Kamali, Janet Seeley, Robert Newton Tags: Original Article Source Type: research
The relationship between herpes zoster and stroke.
Abstract Varicella zoster virus (VZV) infects >95 % of the world population. Typically, varicella (chickenpox) results from primary infection. The virus then becomes latent in ganglionic neurons along the entire neuraxis. In immunocompromised individuals, VZV reactivates and causes herpes zoster (shingles), pain, and rash in 1-2 dermatomes. Multiple case reports showed a link between stroke and zoster, and recent studies have emerged which reveal that VZV infection of the cerebral arteries directly causes pathological vascular remodeling and stroke (VZV vasculopathy). In the past few years, several large epide...
Source: Herpes - February 26, 2015 Category: Infectious Diseases Authors: Nagel MA, Gilden D Tags: Curr Neurol Neurosci Rep Source Type: research
The Relationship Between Herpes Zoster and Stroke
Abstract Varicella zoster virus (VZV) infects >95 % of the world population. Typically, varicella (chickenpox) results from primary infection. The virus then becomes latent in ganglionic neurons along the entire neuraxis. In immunocompromised individuals, VZV reactivates and causes herpes zoster (shingles), pain, and rash in 1–2 dermatomes. Multiple case reports showed a link between stroke and zoster, and recent studies have emerged which reveal that VZV infection of the cerebral arteries directly causes pathological vascular remodeling and stroke (VZV vasculopathy). In the past few years, several large ep...
Source: Current Neurology and Neuroscience Reports - February 25, 2015 Category: Neuroscience Source Type: research
Herpes Zoster Oticus
Herpes zoster oticus information page compiled by NINDS, the National Institute of Neurological Disorders and Stroke.
Source: NINDS Disorders: National Institute of Neurological Disorders and Stroke - October 26, 2014 Category: Neurology Source Type: research
GLUTAMATE RECEPTOR ANTIBODIES IN NEUROLOGICAL DISEASES: Anti-AMPA-GluR3 antibodies, Anti-NMDA-NR1 antibodies, Anti-NMDA-NR2A/B antibodies, Anti-mGluR1 antibodies or Anti-mGluR5 antibodies are present in subpopulations of patients with either: Epilepsy, Encephalitis, Cerebellar Ataxia, Systemic Lupus Erythematosus (SLE) and Neuropsychiatric SLE, Sjogren's syndrome, Schizophrenia, Mania or Stroke. These autoimmune anti-glutamate receptor antibodies can bind neurons in few brain regions, activate glutamate receptors, decrease glutamate receptor's expression, impair glutamate-induced signaling and function, activate Blood Brain Barrier endothelial cells, kill neurons, damage the brain, induce behavioral/psychiatric/cognitive abnormalities and Ataxia in animal models, and can be removed or silenced in some patients by immunotherapy.
Abstract Glutamate is the major excitatory neurotransmitter of the Central Nervous System (CNS), and it is crucially needed for numerous key neuronal functions. Yet, excess glutamate causes massive neuronal death and brain damage by excitotoxicity-detrimental over activation of glutamate receptors. Glutamate-mediated excitotoxicity is the main pathological process taking place in many types of acute and chronic CNS diseases and injuries. In recent years, it became clear that not only excess glutamate can cause massive brain damage, but that several types of anti-glutamate receptor antibodies, that are present in ...
Source: Herpes - August 1, 2014 Category: Infectious Diseases Authors: Levite M Tags: J Neural Transm Source Type: research
Herpes zoster as a risk factor for stroke and TIA: A retrospective cohort study in the UK
Conclusion: HZ is an independent risk factor for vascular disease in the UK population, particularly for stroke, TIA, and MI in subjects affected before the age of 40 years. In older subjects, better ascertainment of vascular risk factors and earlier intervention may explain the reduction in risk of stroke after HZ infection.
Source: Neurology - July 7, 2014 Category: Neurology Authors: Breuer, J., Pacou, M., Gautier, A., Brown, M. M. Tags: CORRECTED AND REPUBLISHED ARTICLES Source Type: research
Meningeal Disease Masquerading as Transient Ischemic Attack
Conclusions: Our study confirmed that serious meningeal disease could present as TIA, but this disease was relatively uncommon among patients treated in a TIA clinic. The findings highlight the diagnostic value of MRI in patients with suspected TIA.
Source: Journal of Stroke and Cerebrovascular Diseases - April 25, 2014 Category: Neurology Authors: Line Cuinat, Nathalie Nasr, Jeanine Manuela Kamsu, Frédéric Tanchoux, Fabrice Bonneville, Vincent Larrue Tags: Case Reports Source Type: research
Shingles May Portend Stroke, But Antivirals Lower Risk (FREE)
By Joe Elia The risk for stroke increases significantly in the weeks after the onset of herpes zoster, especially cases of zoster affecting the distribution of the trigeminal nerve, according to a Clinical Infectious …
Source: Physician's First Watch current issue - April 4, 2014 Category: Primary Care Source Type: news
Herpes Zoster Linked Again to Increased Stroke, MIHerpes Zoster Linked Again to Increased Stroke, MI
The vaccine that reduces herpes zoster might also cut risks for vascular events, including stroke, transient ischemic attack, and myocardial infarction, researchers speculate. Medscape Medical News
Source: Medscape Cardiology Headlines - January 2, 2014 Category: Cardiology Tags: Neurology & Neurosurgery News Source Type: news