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Total 103 results found since Jan 2013.

Efficacy and Safety of High-intensity Statins in Patients with Acute Myocardial Infarction: An Asian Perspective
ConclusionsAMI patients in Taiwan with HIS had similar clinical outcomes to those with non-HIS. Using HIS for effective reduction of low-density lipoprotein cholesterol is safe in Taiwan.
Source: Canadian Journal of Cardiology - November 2, 2019 Category: Cardiology Source Type: research

How to continue lipid-lowering therapy in patients with coronary heart disease and severe liver dysfunction?: A case report of plaque regression by a combination of Chinese and Western Medicine
Rationale: Atherosclerotic cardiovascular disease (ASCVD), including coronary heart disease (CHD), atherosclerotic stroke and peripheral vascular disease, has become the most deadly chronic noncommunicable disease throughout the world in recent decades, while plaque regression could reduce the occurrence of ASCVD. Traditional Chinese Medicine (TCM) has been widely used for prevention and treatment of these diseases. In the perspective of TCM, phlegm and blood stasis are considered to be leading pathogenesis for CHD. Hence, activating blood circulation and dissipating phlegm, which is of great benefit to regress plaque, h...
Source: Medicine - October 1, 2019 Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research

Molecules, Vol. 24, Pages 3274: Therapeutic Potential of Pien-Tze-Huang: A Review on Its Chemical Composition, Pharmacology, and Clinical Application
ingqing Huang Pien-Tze-Huang (PTH) is a famous and commonly used traditional Chinese medicine formula in China. It was first formulated by a royal physician of the Ming Dynasty (around 1555 AD). Recently, PTH has attracted attention worldwide due to its beneficial effects against various diseases, especially cancer. This paper systematically reviewed the up-to-date information on its chemical composition, pharmacology, and clinical application. A range of chemical compounds, mainly ginsenosides and bile acids, have been identified and quantified from PTH. Pharmacological studies indicated that PTH has beneficial effect...
Source: Molecules - September 9, 2019 Category: Chemistry Authors: Lili Huang Yiping Zhang Xiaoqin Zhang Xiuping Chen Yitao Wang Jinjian Lu Mingqing Huang Tags: Review Source Type: research

Erratum: The burden of hepatitis C infection in a Southern Brazilian State
In this report, we present a series of three cases of snakebites that evolved with hemorrhagic stroke due to delays in the access to antivenom in the Brazilian Amazon, being fundamental for diagnosis to validate the clinical suspicion and make decisions that would improve the treatment and prognosis of the patients.
Source: Revista da Sociedade Brasileira de Medicina Tropical - August 2, 2019 Category: Tropical Medicine Source Type: research

Are waste pickers at risk for hepatitis B and C infections because of poverty or environmental exposures?
In this report, we present a series of three cases of snakebites that evolved with hemorrhagic stroke due to delays in the access to antivenom in the Brazilian Amazon, being fundamental for diagnosis to validate the clinical suspicion and make decisions that would improve the treatment and prognosis of the patients.
Source: Revista da Sociedade Brasileira de Medicina Tropical - July 18, 2019 Category: Tropical Medicine Source Type: research

Drug-Drug Interactions in Hepatitis Patients: Do these Interactions Matter in Clinical Perspectives?
CONCLUSION: We observed hepatitis patients presented with a considerable number of clinically relevant pDDIs. Attention should be given to widespread major-pDDIs and their potential adverse outcomes. Clinically relevant parameters, such as labs and signs/symptoms should be monitored particularly in high risk patients having polypharmacy, prolong hospitalization, and stroke as comorbidity. PMID: 31208626 [PubMed - in process]
Source: Annals of Hepatology - June 20, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

A 41-year-old female with progressive multifocal leukoencephalopathy after liver transplant
We report a patient who received liver transplantation due to liver failure resulting from autoimmune hepatitis and advanced PML presenting with aphasia. A 41-year-old female with a history of liver transplantation who received a usual immunosuppression regimen was admitted with a stroke attack resulting in right hemiplegia 2  months after liver transplantation. Surprisingly, she gradually developed dysarthria and left central facial paresis. A brain MRI showed an abnormal multifocal area with a high T2/flair signal in the deep subcortical white matter of the left hemisphere as well as the splenium of the corpus callosu m...
Source: Journal of NeuroVirology - May 28, 2019 Category: Neurology Source Type: research

Vaccine safety in HIV-infected adults within the Vaccine Safety Datalink Project.
CONCLUSIONS: Routinely administered vaccines are generally safe for HIV-infected adults. PMID: 31064675 [PubMed - as supplied by publisher]
Source: Vaccine - May 4, 2019 Category: Allergy & Immunology Authors: Hechter RC, Qian L, Tartof SY, Sy LS, Klein NP, Weintraub E, Mercado C, Naleway A, McLean HQ, Jacobsen SJ Tags: Vaccine Source Type: research

Neurological Involvement in Primary Systemic Vasculitis
Conclusion Neurological involvement is a common complication of PSV (Table 1), and neurologists play an important role in the identification and diagnosis of PSV patients with otherwise unexplained neurological symptoms as their chief complaint. This article summarizes the neurological manifestations of PSV and hopes to improve neuroscientists' understanding of this broad range of diseases. TABLE 1 Table 1. Common CNS and PNS involvements of primary systemic vasculitis. Author Contributions SZ conceived the article and wrote the manuscript. DY and GT reviewed and edited the manuscript. All authors ...
Source: Frontiers in Neurology - April 26, 2019 Category: Neurology Source Type: research

Increasing Upstream Chromatin Long –Range Interactions May Favor Induction of Circular RNAs in LysoPC-Activated Human Aortic Endothelial Cells
We examined the sponging potential of all significantly changed circRNAs using the CircInteractome database (Montefiori et al., 2018), recording two miRNAs with four or more predicted binding sites in a single circRNA transcript, a threshold above which meaningful sponging activity is likely to occur Memczak et al. (2013). Another four significantly changed circRNAs are experimentally shown to sponge miRNAs (Dudekula et al., 2016; Chen et al., 2017; Yan et al., 2017; Wang et al., 2018), for six total circRNAs with miRNA sponging activity including miR125, miR143, miR1272, miR153, miR515-5p, and miR196a-5p (Table 4). In Fig...
Source: Frontiers in Physiology - April 18, 2019 Category: Physiology Source Type: research

The Paradoxical Protective Effect of Liver Steatosis on Severity and Functional Outcome of Ischemic Stroke
Conclusions: Our study shows that a higher burden of liver steatosis seems to be associated with less severe stroke and better functional outcome after ischemic stroke or TIA. Introduction Non-alcoholic fatty liver disease (NAFLD) is a spectrum of diseases from simple steatosis to steatohepatitis with varying degree of fibrosis, and liver cirrhosis (1, 2). NAFLD is becoming the most common chronic liver disease worldwide including Korea, affecting approximately 25% of the general population (3, 4). NAFLD is closely associated with obesity, insulin resistance, and type 2 diabetes mellitus, and is even recognized as ...
Source: Frontiers in Neurology - April 12, 2019 Category: Neurology Source Type: research

Isolation of Antimicrobial Compounds From Cnestis ferruginea Vahl ex. DC (Connaraceae) Leaves Through Bioassay-Guided Fractionation
Conclusion In conclusion, aqueous extracts of C. ferruginea leaves showed antimicrobial activity due to the presence of hydroquinone and caffeic acid methyl ester. This supports its traditional use for infections and confirmed that the active molecules are water-soluble. Author Contributions KK, SP, LVP, and WL conceived and designed the experiments. SP, KK, M-RY, and J-GL performed the experiments. SP, LVP, WL, M-RY, J-GL, and Z-HJ analyzed the data. WL and Z-HJ contributed reagents, materials, and analysis tools. KK, SP, WL, M-RY, Z-HJ, and LVP contributed to the writing of the manuscript. All authors contributed to m...
Source: Frontiers in Microbiology - April 11, 2019 Category: Microbiology Source Type: research

Insomnia as an Independent Predictor of Incident Cardiovascular Disease in HIV: Data From the Veterans Aging Cohort Study
Background: Insomnia is associated with increased cardiovascular disease (CVD) risk in the general population and is highly prevalent in people with HIV. The CVD risk conferred by insomnia in the HIV population is unknown. Methods: Using the Veterans Aging Cohort Study Survey Cohort, insomnia symptoms were measured and dummy coded with the item, “Difficulty falling or staying asleep?” (5-point scale from no difficulty to bothers a lot). Incident CVD event ICD-9 codes (acute myocardial infarction, stroke, or coronary artery revascularization) were identified with the Department of Veterans Affairs (VA) and Medicare...
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - April 9, 2019 Category: Infectious Diseases Tags: Clinical Science Source Type: research

Stroke Characteristics, Risk Factors, and Outcomes in Transgender Adults: A Case Series
Conclusions: Understanding unique vulnerabilities of the transgender community for cerebrovascular events is essential to provide culturally appropriate counseling for harm reduction.
Source: The Neurologist - March 1, 2019 Category: Neurology Tags: Case Report/Case Series Source Type: research

N-Acetylcysteine (NAC) for the Prevention of Liver Failure in Heat Injury-Mediated Ischemic Hepatitis.
Authors: Will JS, Snyder CJ, Westerfield KL Abstract Exertional Heat Illness with associated ischemic hepatitis (IH) is a common occurrence among military trainees; however, few specific therapies exist if unresponsive to appropriate supportive measures. A 27-year-old basic combat trainee presented with altered mental status, renal insufficiency, rhabdomyolysis, and a core temp of 107.9 °F after collapsing during a run, leading to the diagnosis of heat stroke. While the patient's azotemia and creatinine kinase levels rapidly improved with aggressive intravenous hydration, transaminases continued to increase to nea...
Source: Military Medicine - March 1, 2019 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Genetic variation of matrix metalloproteinase enzyme in HIV-associated neurocognitive disorder.
Abstract Matrix metalloproteinases (MMPs) play a key role in several diseases such as rheumatoid arthritis, HIV-associated neurological diseases (HAND), multiple sclerosis, osteoporosis, stroke, Alzheimer's disease, certain viral infections of the central nervous system, cancer, and hepatitis C virus. MMPs have been explained with regards to extracellular matrix remodeling, which occurs throughout life and ranges from tissue morphogenesis to wound healing in various processes. MMP are inhibited by endogenous tissue inhibitors of metalloproteinases (TIMPs). Matrix metalloproteases act as an interface between host's...
Source: Gene - February 27, 2019 Category: Genetics & Stem Cells Authors: Singh H, Nain S, Krishnaraj A, Lata S, Dhole TN Tags: Gene Source Type: research

Drug-Drug Interactions in Hepatitis Patients: Do these Interactions Matter in Clinical Perspectives?
CONCLUSION: We observed hepatitis patients presented with a considerable number of clinically relevant pDDIs. Attention should be given to widespread major-pDDIs and their potential adverse outcomes. Clinically relevant parameters, such as labs and signs/symptoms should be monitored particularly in high risk patients having polypharmacy, prolong hospitalization, and stroke as comorbidity. PMID: 30600298 [PubMed - in process]
Source: Annals of Hepatology - January 3, 2019 Category: Gastroenterology Tags: Ann Hepatol Source Type: research

Chronic Kidney Disease (CKD) in the U.S. Hemophilia Population: A Cohort Study
Conclusions: In this interim analysis of an ongoing national prospective cohort study, older men with moderate to severe hemophilia commonly report risk factors for CKD, including HTN (51.5%), DM, viral infection, and potential renal damaging medication use. Only 11.6% had CVD. Urological symptoms were also common, including hematuria and obstructive symptoms with urination.In our cohort, 11.4% met the definition of CKD, defined as the presence of either kidney damage or GFR < 60 ml/min/1.73 m2 for ≥ 3 months. The distribution of GFR values appeared similar to the general population. As with risk factors associated w...
Source: Blood - November 21, 2018 Category: Hematology Authors: Sood, S. L., Cheng, D., Shapiro, A., Kessler, C. M., Key, N. S., Quon, D., Eyster, M. E., Manco-Johnson, M. J., Kempton, C. L., Cuker, A., Ragni, M. V., Kuriakose, P., von Drygalski, A., Kouides, P. A., Escobar, M. A., Wheeler, A. P., Wang, T.-F., Leissin Tags: 322. Disorders of Coagulation or Fibrinolysis: Poster II Source Type: research

Rapid Decline in Kidney Function in Sickle Cell Disease
Conclusion:Rapid decline in eGFR is common in SCD. Use of ACE-I/ARB and history of stroke are associated with rapid decline in renal function. Rapid decline in eGFR is associated with an increased risk of death in SCD. Long-term studies are required to determine if therapies that may reduce loss of kidney function may decrease mortality in SCD.DisclosuresAtaga: Pfizer: Research Funding; Bioverativ: Honoraria, Membership on an entity's Board of Directors or advisory committees; Novartis Pharmaceuticals: Honoraria; Modus Therapeutics: Honoraria; Global Blood Therapeutics: Honoraria, Membership on an entity's Board of Directo...
Source: Blood - November 21, 2018 Category: Hematology Authors: Derebail, V. K., Ciccone, E. J., Zhou, Q., Cai, J., Ataga, K. I. Tags: 114. Hemoglobinopathies, Excluding Thalassemia-Clinical: Poster I Source Type: research

Liver Injury Associated with Sporting Activities
Semin Liver Dis 2018; 38: 357-365 DOI: 10.1055/s-0038-1670656Exertional heat stroke most commonly develops following prolonged levels of aerobic activity in a warm or humid environment. Hypoperfusion of the vital organs along with activation of the inflammasome can lead to progressive and potentially fatal multiorgan failure including acute liver failure. In the United States, herbal and dietary supplements that are marketed to improve performance, strength, and weight loss are increasingly being used by both amateur and professional athletes. Consumption of bodybuilding supplements that contain androgenic anabolic steroid...
Source: Seminars in Liver Disease - October 24, 2018 Category: Gastroenterology Authors: Hassan, Ammar Fontana, Robert J. Tags: Review Article Source Type: research

Trypanosoma cruzi seroprevalence among solid organ donors in Ceará State, Brazil
CONCLUSIONS: There was a high prevalence of CD and other coinfections among potential solid organ donors in Ceará, and statistical tests have shown that these individuals are at increased ri sk of stroke when compared to potential non-reactive donors. This work highlights the importance of screening DC infection in potential donors.
Source: Revista da Sociedade Brasileira de Medicina Tropical - October 8, 2018 Category: Tropical Medicine Source Type: research

Woman, 71, develops hepatitis after taking turmeric supplements to prevent a stroke
The unnamed 71-year-old, believed to be from Arizona, suffered no symptoms but was referred to a specialist when a check-up found she had abnormally high enzyme levels in her liver.
Source: the Mail online | Health - September 18, 2018 Category: Consumer Health News Source Type: news

Risk of gallstones in patients with obstructive sleep apnea: a nationwide observational cohort study
ConclusionThe study shows a strong association between OSA and gallstones. Moreover, our findings suggest the requirement for survey and health education for gallstones in OSA and further studies to verify whether the treatment of OSA can reduce the risk of gallstones.
Source: Sleep and Breathing - July 7, 2018 Category: Respiratory Medicine Source Type: research

Risk of gallstones in patients with obstructive sleep apnea: a nationwide observational cohort study.
CONCLUSION: The study shows a strong association between OSA and gallstones. Moreover, our findings suggest the requirement for survey and health education for gallstones in OSA and further studies to verify whether the treatment of OSA can reduce the risk of gallstones. PMID: 29980983 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - July 7, 2018 Category: Sleep Medicine Authors: Chen CH, Lin CL, Hsu CY, Kao CH Tags: Sleep Breath Source Type: research

Unique MicroRNAs Signature of Lymphocyte of Yang and Yin Syndromes in Acute Ischemic Stroke Patients
ConclusionThese results offered insight into the molecular basis underlying the different pathogenesis of yang or yin syndrome, providing clues for the individualized therapeutic strategies of acute ischemic stroke.
Source: Chinese Journal of Integrative Medicine - June 20, 2018 Category: Internal Medicine Source Type: research

IJERPH, Vol. 15, Pages 513: Association between Inflammatory Bowel Disease and Cholelithiasis: A Nationwide Population-Based Cohort Study
g Kao We assessed the subsequent risk of cholelithiasis development in patients with inflammatory bowel diseases (IBDs) such as Crohn’s disease (CD) or ulcerative colitis (UC). We identified 8186 patients who aged ≥20 years and were diagnosed with IBD between 2000 and 2010 as the study cohort. A total of 8186 patients without IBD were selected by frequency-matching according to age, sex, comorbidities, and the index date of diagnosis, and they were identified as the control cohort. To measure the incidence of cholelithiasis, all patients were followed up until the end of 2011. The risk of developing cholelithiasis,...
Source: International Journal of Environmental Research and Public Health - March 14, 2018 Category: Environmental Health Authors: Chien-Hua Chen Cheng-Li Lin Chia-Hung Kao Tags: Article Source Type: research

The Unraveled Link Between Antiviral Therapy and Heart Failure Hospitalization in Chronic Hepatitis C Virus Infection  - A Nationwide Cohort Study.
CONCLUSIONS: AVT for chronic HCV infection might offer protection against HF hospitalizations, critical vascular events, and cardiovascular death beyond known beneficial effects. PMID: 29503408 [PubMed - as supplied by publisher]
Source: Circulation Journal - March 2, 2018 Category: Cardiology Authors: Lin MS, Chung CM, Chang ML, Chen MY, Chang ST, Chu PH, Chen TH, Lin WY, Huang TJ, Lin YS Tags: Circ J Source Type: research

Ischemic stroke in liver cirrhosis: epidemiology, risk factors, and in-hospital outcomes
Conclusion Ischemic stroke was often observed in patients with cirrhosis, and it significantly increased the in-hospital mortality. The association of inflammation, coagulation disorders, and viral hepatitis with development of ischemic stroke in liver cirrhosis should be further evaluated in prospective cohort studies.
Source: European Journal of Gastroenterology and Hepatology - January 17, 2018 Category: Gastroenterology Tags: Original Articles: Liver Cirrhosis Source Type: research

Characteristics and Performance of Unilateral Kidney Transplants from Deceased Donors.
CONCLUSIONS: A large number of discarded kidneys were procured from donors whose contralateral kidneys were transplanted with good post-transplant outcomes. PMID: 29217537 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - December 7, 2017 Category: Urology & Nephrology Authors: Husain SA, Chiles MC, Lee S, Pastan SO, Patzer RE, Tanriover B, Ratner LE, Mohan S Tags: Clin J Am Soc Nephrol Source Type: research

Prognostic value of viral eradication for major adverse cardiovascular events in hepatitis C cirrhotic patients
Conclusion In patients with compensated HCV-related cirrhosis, Asian ethnic origin, arterial hypertension, smoking and low serum albumin are independent predictive factors of cardiovascular events, while a sustained virological response is associated with a decreased rate of cardiovascular events.
Source: American Heart Journal - November 9, 2017 Category: Cardiology Source Type: research

Direct medical costs associated with the extrahepatic manifestations of hepatitis C virus infection in France
ConclusionExtrahepatic manifestations of HCV infection substantially add to the overall economic burden of the disease in France. HCV cure after anti‐viral therapy is expected to significantly reduce the total costs of managing these manifestations in France.
Source: Alimentary Pharmacology and Therapeutics - October 18, 2017 Category: Drugs & Pharmacology Authors: P. Cacoub, M. Vautier, A. C. Desbois, D. Saadoun, Z. Younossi Tags: ORIGINAL ARTICLE Source Type: research

3 Reasons to Feel Good About Drinking Coffee on National Coffee Day
People often think about their relationship with coffee as a bad habit: maybe they splurge too frequently on $4 lattes (free coffee deals only come around once a year), or they’re so dependent on their morning pot of coffee that they can’t function without it. While there is a case to be made for not overdoing it, there are also plenty of reasons to embrace your daily coffee ritual without guilt. Yes, there’s the taste, the aroma, and the way coffee brings those fuzzy mornings into focus. But in recent years, research has also suggested that coffee has real health perks—and that for many people, the...
Source: TIME.com: Top Science and Health Stories - September 29, 2017 Category: Consumer Health News Authors: Amanda MacMillan Tags: Uncategorized Diet/Nutrition is coffee good for you National Coffee Day Source Type: news

Hemorrhagic Stroke in a Young Healthy Male Following Use of Pre-Workout Supplement Animal Rage XL.
Authors: Harris BF, Winn C, Ableman TB Abstract So-called "pre-workout" supplements are substances marketed as natural dietary supplements with claims of helping athletes achieve more focused and intense workouts. The use of such products remains popular among American youth as a whole, but is especially high among active duty service members. Supplements are minimally regulated by the Food and Drug Administration (FDA), and unlike pharmaceuticals, supplements are often brought to market without any testing to show neither efficacy nor safety. Several case reports have documented serious adverse events and raise th...
Source: Military Medicine - September 10, 2017 Category: International Medicine & Public Health Tags: Mil Med Source Type: research

Hepatitis B virus infection and decreased risk of stroke: a meta-analysis.
Authors: Wang Y, Xiong J, Chen X, Niu M, Chen X, Guan Y, Zheng K, Xu K Abstract Several studies have reported that hepatitis B virus (HBV) infection may decrease the risk of stroke. However, its association is controversial. Thus, we conducted a systematic review and meta-analysis to investigate the relationship between hepatitis B virus (HBV) infection and the risk of stroke. Relevant studies published before May 2017 were identified by searching PubMed, EMBASE, and ISI Web of Science. The relationships between HBV infection and the risk of stroke were assessed using odds ratio (OR)/risk ratio (RR) values and the ...
Source: Oncotarget - August 6, 2017 Category: Cancer & Oncology Tags: Oncotarget Source Type: research

DIS-17-0023 The Enduring Health Challenges of Afghan Immigrants and Refugees in Iran: A Systematic Review
This article does not contain any studies with human participants or animals performed by the author. Data Availability All national (MagIran, Science Information Database (SID) and Iranmedex) and international (PubMed, Scopus) databases were searched from November 2010 to November 2016 using keywords both in English and Persian: Afghan immigrants, Afghan refugees, Iran, infectious diseases, tuberculosis, HIV, Hepatitis B and C, non-communicable disease, food security, mental health, barriers, health insurance, access to health service. All related websites and webpages were also searched by Google with the same keywords ...
Source: PLOS Currents Disasters - July 21, 2017 Category: International Medicine & Public Health Authors: nasim Source Type: research

The Enduring Health Challenges of Afghan Immigrants and Refugees in Iran: A Systematic Review
This article does not contain any studies with human participants or animals performed by the author. Data Availability All national (MagIran, Science Information Database (SID) and Iranmedex) and international (PubMed, Scopus) databases were searched from November 2010 to November 2016 using keywords both in English and Persian: Afghan immigrants, Afghan refugees, Iran, infectious diseases, tuberculosis, HIV, Hepatitis B and C, non-communicable disease, food security, mental health, barriers, health insurance, access to health service. All related websites and webpages were also searched by Google with the same keywords ...
Source: PLOS Currents Disasters - July 21, 2017 Category: International Medicine & Public Health Authors: nasim Source Type: research

Heartburn drugs linked to premature death
Conclusion This larger set of observational data finds that PPI drugs are associated with an increase in the risk of early death compared with either H2 blockers or no acid suppression drugs. This was the case for participants both with and without gastrointestinal problems. It also appears as though the longer the PPIs drugs are taken, the greater the risk of death. Considering that these drugs are widely used in the UK, these findings may cause concern. But the research has a number of important limitations: The study was conducted in a population of mostly white, older US male veterans, which might limit the ability...
Source: NHS News Feed - July 4, 2017 Category: Consumer Health News Tags: Medication Source Type: news

Impact of aging on neurocognitive performance in previously antiretroviral-naive HIV-infected individuals on their first suppressive regimen
Conclusion: Despite continued virologic suppression and neurocognitive improvement in the cohort as a whole, older individuals were more likely to have neurocognitive impairment than younger individuals.
Source: AIDS - June 30, 2017 Category: Infectious Diseases Tags: Clinical Science Source Type: research

Medicaid waiver program helped public hospitals improve care to California ’s most needy
A five-year Medicaid waiver program that infused billions of dollars into public hospitals prompted significant improvements in health care to California ’s neediest population — the poor and uninsured, according to an extensiveevaluation by the UCLA Center for Health Policy Research.Seventeen designated public hospitals participated in the $3.3 billion “pay-for-performance” experiment, including five University of California hospital systems and 12 county‐owned-and‐operated hospital systems. Collectively, these facilities serve more than 2 million patients every year, including most of the state’s Medi-Cal p...
Source: UCLA Newsroom: Health Sciences - June 28, 2017 Category: Universities & Medical Training Source Type: news

HIV/HCV coinfection and the risk of cardiovascular disease: A meta ‐analysis
In conclusion, individuals with HIV/HCV coinfection had an increased CVD risk compared to those with HIV monoinfection. More research is needed to further examine the nature of this association, and response to traditional risk‐reduction therapies.
Source: Journal of Viral Hepatitis - June 23, 2017 Category: Infectious Diseases Authors: O. Osibogun, O. Ogunmoroti, E. D. Michos, E. S. Spatz, B. Olubajo, K. Nasir, P. Madhivanan, W. Maziak Tags: ORIGINAL ARTICLE Source Type: research

Stroke in HIV-infected individuals with and without HCV coinfection in Spain in the combination antiretroviral therapy era
by Alejandro Alvaro-Meca, Juan Berenguer, Asunci ón Díaz, Dariela Micheloud, Teresa Aldámiz-Echevarría, Chiara Fanciulli, Salvador Resino The incidence of stroke in human immunodeficiency virus (HIV)–infected individuals has been well analyzed in recent epidemiological studies. However, little is known about the specific contribution of hepatitis C virus (HCV) infection to stroke among HIV-infected individuals. The aims of this st udy were to analyze trends in the incidence rates of stroke in HIV-infected individuals during the combination antiretroviral (cART) era in Spain and to categorize them by the presence or ...
Source: PLoS One - June 15, 2017 Category: Biomedical Science Authors: Alejandro Alvaro-Meca Source Type: research

Purinoreceptors and VZV Vasculopathy (P1.263)
Conclusions:Overall, VZV infection caused a transient rise in extracellular ATP. Importantly, we found that aside from its known antiplatelet effects, P2Y12 antagonist clopidogrel also inhibits VZV infection, independent of downstream inhibition of glycoprotein IIB/IIIA, and may serve as an alternative antiviral therapy for VZV vasculopathy.Disclosure: Dr. Wyborny has nothing to disclose. Dr. Choe has nothing to disclose. Dr. Totaro has received personal compensation for activities with Bayer Schering Pharma, Biogen Idec, Merck Serono, Novartis, Sanofi-Aventis, and Teva as a speaker. Dr. Gerasimovskaya has nothing to discl...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Wyborny, A., Choe, A., Traktinskiy, I., Gerasimovskaya, E., Gilden, D., Nagel, M. Tags: Genetic Stroke Syndromes, Biomarkers, and Translational/Basic Research Source Type: research

Association of hepatitis B virus infection with decreased ischemic stroke
ConclusionHBV was correlated with a reduced risk of AIS development. Although a decrease in AIS risk was noted in the patients with HBV, preventing the development of AIS in this population warrants further attention.
Source: Acta Neurologica Scandinavica - December 21, 2015 Category: Neurology Authors: C.‐H. Tseng, C.‐H. Muo, C.‐Y. Hsu, C.‐H. Kao Tags: Original Article Source Type: research

Reversing the effects of the new anti-clotting drugs
The oral anticoagulant warfarin (Coumadin) became available for prescription in 1954. This anti-clotting drug commanded national attention when President Dwight Eisenhower received the drug as part of his treatment following a heart attack. No other oral anticoagulant was successfully developed and marketed in the United States until 2010. Warfarin is a dangerous drug. Along with insulin, it is responsible for the most emergency hospitalizations due to adverse drug reactions. Whereas insulin causes low blood sugar, warfarin is notorious for the complication of major bleeding. Warfarin is plagued by hundreds of drug-drug an...
Source: New Harvard Health Information - December 9, 2015 Category: Consumer Health News Authors: Samuel Z. Goldhaber, MD Tags: Drugs and Supplements Health Heart Health Hypertension and Stroke anti-clotting coumadin deep-vein-thrombosis DVT Source Type: news

Stroke in HIV-infected African Americans: a retrospective cohort study
Abstract The risk of having a first stroke is nearly twice as high among African Americans compared to Caucasians. HIV/AIDS is an independent risk factor for stroke. Our study aimed to report the risk factors and short-term clinical outcomes of African Americans with HIV infection and new-onset stroke admitted at the Johns Hopkins Hospitals (2000–2012). Multivariate linear regression was used to examine the association between potential predictors and odds of an unfavorable outcome, defined as a higher modified Rankin Scale (mRS) score on hospital discharge. African Americans comprised 105/125 (84 %) of HIV-inf...
Source: Journal of NeuroVirology - July 9, 2015 Category: Neurology Source Type: research

Correspondence Infectious causes of stroke
Although the causality of hepatitis C virus in stroke is not conclusive, some clinical studies have shown an increased risk of stroke in patients with chronic hepatitis C. In their Review, Jennifer Fugate and colleagues1 propose several interesting hypotheses to explain the link between chronic infection and stroke that might also be applied to the association of hepatitis C virus infection with stroke. Accumulating evidence shows the metabolic manifestations of hepatitis C virus, and provides a strong link between hepatitis C virus clearance and a decrease in the risk of stroke.
Source: The Lancet Infectious Diseases - May 18, 2015 Category: Infectious Diseases Authors: Ching-Sheng Hsu Tags: Correspondence Source Type: research

EBN resources page
SIGN Apps for iPhone and iPad http://itunes.com/apps/signguidelines, https://play.google.com/store/apps/details?id=com.rootcreative.sign The SIGN app has recently been updated and now contains quick reference guides (QRGs) for:SIGN 136 Management of chronic pain SIGN 135 Management of epithelial ovarian cancer SIGN 134 Treatment of primary breast cancer SIGN 133 Management of hepatitis C The SIGN app has also had a complete re-design and now features:Optimisation for the latest operating systems Re-designed for improved legibility Send pdf button feature Split screen feature (ipad) Prevention of stroke in patients with atr...
Source: Evidence-Based Nursing - June 17, 2014 Category: Nursing Tags: Liver disease, General practice / family medicine, Hepatitis and other GI infections, Drugs: cardiovascular system, Pain (neurology), Stroke, Diet, Pregnancy, Reproductive medicine, Breast cancer, Gynecological cancer, Lung cancer (oncology), Radiotherapy Source Type: research

World Health Assembly approves resolution on hepatitis and mechanism to coordinate noncommunicable disease response
22 May 2014 -- The World Health Assembly approved a resolution to improve the prevention, diagnosis and treatment of viral hepatitis and proposals to improve global coordination of efforts to address noncommunicable diseases like diabetes, cancers, heart disease and stroke.
Source: WHO news - May 22, 2014 Category: Global & Universal Tags: cancer [subject], Diabetes, heart disease, Hepatitis, hepatitis [subject], leprosy [subject], NCDs, noncommunicable disease [subject], Press release [doctype], stroke, WHA67, Audio, Fact Sheets, media center, media centre, Notes for the Press, Photographs Source Type: news