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Infectious Disease: Syphilis

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Total 25 results found since Jan 2013.

Infectious Etiologies of Stroke
Semin Neurol 2019; 39: 482-494 DOI: 10.1055/s-0039-1687915Central nervous system (CNS) infections are a frequently underappreciated potential etiology of cerebrovascular disease. Highlighted in this review are a selection of infectious agents that lead to cerebrovascular complications through various mechanisms including multifocal vasculopathy, focal infiltrative vasculitis and vasospasm, and direct vessel wall invasion and thrombus formation. Diagnosis of stroke due to underlying CNS infection requires a high index of clinical suspicion and careful consideration of neuroimaging, serum, and cerebrospinal fluid studies in ...
Source: Seminars in Neurology - September 18, 2019 Category: Neurology Authors: Shulman, Julie G. Cervantes-Arslanian, Anna M. Tags: Review Article Source Type: research

What Causes Facial Nerve Palsy?
Discussion Facial nerve palsy has been known for centuries, but in 1821 unilateral facial nerve paralysis was described by Sir Charles Bell. Bell’s palsy (BP) is a unilateral, acute facial paralysis that is clinically diagnosed after other etiologies have been excluded by appropriate history, physical examination and/or laboratory testing or imaging. Symptoms include abnormal movement of facial nerve. It can be associated with changes in facial sensation, hearing, taste or excessive tearing. The right and left sides are equally affected but bilateral BP is rare (0.3%). Paralysis can be complete or incomplete at prese...
Source: PediatricEducation.org - June 3, 2019 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Isolation of Antimicrobial Compounds From Cnestis ferruginea Vahl ex. DC (Connaraceae) Leaves Through Bioassay-Guided Fractionation
Conclusion In conclusion, aqueous extracts of C. ferruginea leaves showed antimicrobial activity due to the presence of hydroquinone and caffeic acid methyl ester. This supports its traditional use for infections and confirmed that the active molecules are water-soluble. Author Contributions KK, SP, LVP, and WL conceived and designed the experiments. SP, KK, M-RY, and J-GL performed the experiments. SP, LVP, WL, M-RY, J-GL, and Z-HJ analyzed the data. WL and Z-HJ contributed reagents, materials, and analysis tools. KK, SP, WL, M-RY, Z-HJ, and LVP contributed to the writing of the manuscript. All authors contributed to m...
Source: Frontiers in Microbiology - April 11, 2019 Category: Microbiology Source Type: research

Neurosyphilis prevalence at a Portuguese stroke unit care.
CONCLUSION: We observed a low prevalence of NS (0.31%), but this result was surprisingly higher than what was expected in an elderly population. PMID: 30343380 [PubMed - as supplied by publisher]
Source: Aging Clinical and Experimental Research - October 20, 2018 Category: Geriatrics Authors: Pintado Maury I, Alves M, Fonseca T Tags: Aging Clin Exp Res Source Type: research

Stroke and syphilis: A retrospective study of 53 patients.
CONCLUSION: A diagnosis of syphilitic stroke should be suspected in young patients as a manifestation of syphilis, and tests for neurosyphilis should be routine in neurology departments to make a prompt diagnosis, thereby preventing psychological sequelae. PMID: 29631855 [PubMed - as supplied by publisher]
Source: Revue Neurologique - April 13, 2018 Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

Prothrombotic factors do not increase the risk of recurrent ischemic events after cryptogenic stroke at young age: the FUTURE study
ConclusionsThe prevalence of prothrombotic factors and preceding infections did not significantly differ between stroke patients with a cryptogenic versus an identified cause of stroke and neither is significantly associated with an increased risk of recurrent ischemic events after cryptogenic stroke.
Source: Journal of Thrombosis and Thrombolysis - February 26, 2018 Category: Hematology Source Type: research

What Causes Microcephaly?
Discussion Microcephaly is usually defined as an occipitofrontal head circumference (OFC) more than 2 standard deviations (SD) below the mean for sex, age and ethnicity. Severe microcephaly is used for OFC < 3 standard deviations. Rates of microcephaly range from 0.5-12 patients/10,000 live births. The OFC should be measured at every well child visit and at other opportunities and plotted on standard growth charts. The OFC is measured using a nonelastic tape measure around the largest part of the head with the tape measure held above the eyebrows and ears. It is a highly reproducible measurement. There are several diff...
Source: PediatricEducation.org - September 25, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Neurosyphilis in Africa: A systematic review
DiscussionThis is the first systematic review of the literature on neurosyphilis in Africa since the beginning of the HIV epidemic. Neurosyphilis continues to be reported as a manifestation of both early and late syphilis, but the methodological quality of the majority of the included studies was poor. Future well-designed prospective studies are needed to better delineate the incidence and clinical spectrum of neurosyphilis in Africa and to better define interactions with HIV in this setting.
Source: PLoS Neglected Tropical Diseases - August 31, 2017 Category: Tropical Medicine Authors: Michael Marks Source Type: research

Zika associated Guillain-Barre syndrome in the United States (P2.327)
Conclusions:Zika can induce GBS after a brief viral illness. Neuropathy can be a mixture of demyelinating and axonal. Dysautonomia may also be present including severe dysphagia, orthostatics and retention.Zika RNA has a short detection window in serum and CSF making a diagnosis time sensitive. Serological assays using IgM and IgG cross-react with other flaviviruses making them unable to differentiate between recent Zika exposure and cross reactivity with Dengue and Chikungunya. Our pt likely had prior exposure to Dengue, being from an endemic area. Prior Dengue exposure may possibly modulate the response to Zika via antib...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Tantillo, G., Sclar, G., Vasa, C., Shin, S., Sivak, M. Tags: Zika, Chikungunya, West Nile Virus, and Other Viral Infections I Source Type: research

Trends and Characteristics of Tuberculous Meningitis in the United States, 1993-2013 (S30.007)
Conclusions:Over the past two decades, the incidence and mortality of TBM in the US have steadily declined, but neurological complications are increasing.Study Supported by:This work was supported by the National Institute of Neurological Disorders [grant numbers K23NS082367, R01NS097443-01 to H.K.] and the Michael Goldberg Stroke Research Fund to [H.K.].Disclosure: Dr. Merkler has nothing to disclose. Dr. Chatterjee has nothing to disclose. Dr. Gialdini has nothing to disclose. Dr. Reynolds has nothing to disclose. Dr. Morris has nothing to disclose. Dr. Murthy has nothing to disclose. Dr. Thakur has received personal com...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Merkler, A., Chatterjee, A., Gialdini, G., Reynolds, A., Morris, N., Murthy, S., Thakur, K., Kamel, H. Tags: Infectious Disease: HIV, Syphilis, Borrelia, TB, Cysticercosis, and Other Infections Source Type: research

A Rare Case of Central Nervous System Tuberculosis Presenting as Transient Splenial Lesion: Case Report and Literature Review (P1.320)
Conclusions:Based on literature review, the transient splenial lesion of corpus callosum has never been reported in patients with CNS tuberculosis. The mechanisms underlying transient splenial lesions may due to intramyelinic edema and inflammatory cell infiltration. This hypothesis supported by the MR spectroscopy findings in our patient. Since early diagnosis and treatment can reduce mortality and morbidity, patients with isolated splenial lesion warrant diagnostic tests for CNS tuberculosis.Study Supported by:The authors report no disclosures relevant to the manuscript.Disclosure: Dr. Wu has nothing to disclose. Dr. Che...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Wu, J.-W., Chen, S. Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research

Burden of Cerebrovascular Disease and its association in the clinical characteristics, Incidence and outcomes in the hospitalized patients with Community-Acquired Pneumonia in Louisville, KY (P1.321)
Conclusions:This study documents worse clinical outcomes and significantly increased mortality in the hospitalized patients with community acquired pneumonia and associated cerebrovascular disease.Disclosure: Dr. SirDeshpande has nothing to disclose. Dr. Kolikonda has nothing to disclose. Dr. Peyrani has nothing to disclose. Dr. Ramirez has nothing to disclose. Dr. Arnold has nothing to disclose. Dr. Wiemken has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: SirDeshpande, P., Kolikonda, M., Peyrani, P., Ramirez, J., Arnold, F., Wiemken, T. Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research

Streptococcus pneumoniae meningitis and intracranial vasculopathy: Clinical correlation with improving transcranial Doppler hemodynamics (P1.322)
Conclusions:Antibiotic treatment for S. pneumoniae meningitis correlated with improvement in clinical status and TCD hemodynamics. Serial TCDs may be a potentially useful strategy in the management of bacterial meningitis.Disclosure: Dr. Idris has nothing to disclose. Dr. Tai has nothing to disclose. Dr. Tan has nothing to disclose. Dr. Tan has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Idris, M. I., Tai, S. M. L., Tan, C. T., Tan, K. S. Tags: Autoimmunity with Infection, Syphilis, Lyme, Tuberculosis, and other Bacteria Source Type: research

Acute ischemic stroke in a young female: a novel presentation of anti-GAD autoimmunity (P3.272)
Conclusions:Restricted diffusion, seen typically in ischemia, indicates cytotoxic oedema and irreversible cell damage. In this patient, we postulate a mechanism of severe CNS inflammation with cellular toxicity and small vessel vasculitis. Anti-GAD autoimmunity should be considered in young patients presenting with stroke-like episodes, particularly when accompanied by positive phenomenon.Disclosure: Dr. Neo has nothing to disclose. Dr. Lee has nothing to disclose. Dr. Lee has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Neo, X. S., Lee, K. E., Lee, R. Tags: Cerebrovascular Disease Case Reports II Source Type: research

Epidemiology of Acquired Immune Deficiency Syndrome and Cerebrovascular Disease in a Post Antiretroviral Era
People with acquired immune deficiency syndrome (AIDS) develop ischemic stroke through distinct mechanisms. These include infections such as syphilis, tuberculosis, varicella, and other conditions such as cocaine abuse, endocarditis, and hypercoagulability. The effect of improved awareness, detection, and treatment with highly active antiretroviral therapy (HAART) on the incidence and outcome of AIDS patients with stroke is unknown.
Source: Journal of Stroke and Cerebrovascular Diseases - February 8, 2017 Category: Neurology Authors: Phillip Kucab, Pratik Bhattacharya Source Type: research

Scanning electron microscopy of the adhesion of Treponema pallidum subspecies pallidum (Nichol strain) to human brain microvascular endothelial cells in vitro
This article is protected by copyright. All rights reserved.
Source: Journal of the European Academy of Dermatology and Venereology - September 29, 2016 Category: Dermatology Authors: Fan Wu, Jing ‐Ping Zhang, Qian‐Qiu Wang Tags: Letter to Editor Source Type: research

Diagnostic value of color-coded duplex sonography in patients with ischemic stroke and congenital changes in the circle of Willis
Publication date: Available online 11 February 2016 Source:Cor et Vasa Author(s): I. Staikov, I. Stoyanov, M. Staneva, N. Neykov, G. Kirova, P. Polomski, I. Petrov The circle of Willis (CoW) forms the main circulatory system in the human brain. A large number of variations of the CoW is known, and also their association with ischemic stroke. Three cases of young patients with combination of ischemic stroke and anomalies in the CoW are presented, and the value of the color-coded duplex sonography (CCDS) is compared to other imaging diagnostics such as magnetic resonance angiography (MRA) and digital subtraction ang...
Source: Cor et Vasa - February 23, 2016 Category: Cardiology Source Type: research

Serum TRSUT Titer ≥1: 16 Is a Predictor for Neurosyphilis Among HIV-Infected Patients With Concurrent Syphilis and No Neurological Symptoms
Abstract: Investigating the predictors for lumbar puncture to diagnose the asymptomatic neurosyphilis among HIV and syphilis co-infected patients in Shanghai, China. Respectively, screening the medical records from August 1, 2009 to June 30, 2015. Those HIV-infected patients with concurrent syphilis who had received lumbar puncture were selected and their clinical and demographic data were recorded. Participants comprised symptomatic and asymptomatic patients. The latter ones could be further divided into 3 groups: late syphilis, early syphilis with anti-syphilis treatment failure, and early syphilis with serum toludine re...
Source: Medicine - November 1, 2015 Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research

The Most Unusual Deaths By State, In One Map
What are the most distinctive deaths by state? Researcher Francis Boscoe of the New York State Cancer Registry set out to answer that question by analyzing the deaths in each state from 2001 to 2010. Out of a total 136 causes of death, Boscoe pinpointed the number one reason people in different states died that was distinct from the United States’ general population. Now keep in mind that these aren’t the most common deaths in each state. Instead, think of these deaths as the ones that a state had in a disproportionately high number compared to the national average. The map, Boscoe explained, is a good way to illu...
Source: Science - The Huffington Post - May 19, 2015 Category: Science Source Type: news

The Changing Epidemiology of Stroke in Acquired Immune Deficiency Syndrome (AIDS). (I7-1A)
Conclusions:There is an increased frequency of AIDS among stroke patients, possibly due to the increased detection of AIDS. In the HAART era, the median age of incident stroke in AIDS has increased. Whether HAART can reduce the incidence and improve survival of stroke needs to be explored.Disclosure: Dr. Kucab has received personal compensation for activities with Bayer HealthCare as an advisory board participant. Dr. Bhattacharya has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kucab, P., Bhattacharya, P. Tags: The Global Burden of Neurological Infections: Epidemiology, Treatment, and Prevention Data Blitz Presentations Source Type: research

The Changing Epidemiology of Stroke in Acquired Immune Deficiency Syndrome (AIDS). (P1.089)
Conclusions:There is an increased frequency of AIDS among stroke patients, possibly due to the increased detection of AIDS. In the HAART era, the median age of incident stroke in AIDS has increased. Whether HAART can reduce the incidence and improve survival of stroke needs to be explored.Disclosure: Dr. Kucab has received personal compensation for activities with Bayer HealthCare as an advisory board participant. Dr. Bhattacharya has nothing to disclose.
Source: Neurology - April 8, 2015 Category: Neurology Authors: Kucab, P., Bhattacharya, P. Tags: Neuroepidemiology: Cerebrovascular Disease Source Type: research

Syphilis on the Rise: Diagnosis, Treatment, and Prevention
This article focuses on identifying high-risk patients and diagnosis and treatment options for syphilis infection.
Source: The Journal for Nurse Practitioners - January 1, 2015 Category: Nursing Authors: Jennifer Klein, Mary McLaud, Deanna Rogers Tags: Feature Article Source Type: research

The Great Imitator—Still Today! A Case of Meningovascular Syphilis Affecting the Posterior Circulation
We describe clinical features and imaging studies of a 50-year-old patient with Parinaud syndrome and a syphilitic dorsal midbrain infarction. Brain magnetic resonance imaging indicated vasculitis of the posterior circulation. The diagnosis of meningovascular syphilis was established by serum and cerebrospinal fluid examinations. Although rare, because of the high impact on treatment, clinicians should always be aware of meningovascular syphilis in the differential diagnosis of stroke, particularly in young and male patients with cryptogenic stroke.
Source: Journal of Stroke and Cerebrovascular Diseases - October 2, 2014 Category: Neurology Authors: Jochen Bäuerle, Anna Zitzmann, Karl Egger, Stephan Meckel, Cornelius Weiller, Andreas Harloff Tags: Case Report Source Type: research

One night with venus, a lifetime with mars
I present a case of neurosyphilis presenting as acute stroke in a 44-year-old male; I review the current literature, with a particular emphasis on diagnostics and the pitfalls of serological testing. Neurosyphilis is an imprecise term and subsumes meningitic, meningovascular, parenchymatous and gummatous syphilis. Of these, meningovascular syphilis is most commonly associated with large vessel arteritis and stroke, particularly of the middle cerebral artery. Although syphilis rates have increased since the latter part of the 20th century, neurosyphilis remains a rare disease and epidemiological estimates are marred by impr...
Source: Journal of Neurology, Neurosurgery and Psychiatry - September 9, 2014 Category: Neurosurgery Authors: Johnson, J. Tags: Abstracts Source Type: research

Cerebral small-vessel disease associated with COL4A1 and COL4A2 gene duplications
A nonsmoking woman, aged 44 years, presented with transient right-sided hemiparesis. CT showed leukoencephalopathy without infarction (figure). Blood pressure was normal. Blood count, plasma glucose levels, C-reactive protein, renal/liver function tests, cardiac enzymes, atrial natriuretic factor, HIV/syphilis/hepatitis B and C serology, and lactic acid levels were normal. Low-density lipoprotein (LDL) cholesterol levels were slightly elevated (1.25 g/L). Screening tests for prothrombotic disorders (serum fibrinogen, D-dimer, fibrin degradation products, antithrombin III level, protein C and S level, factor V Leiden, proth...
Source: Neurology - September 8, 2014 Category: Neurology Authors: Renard, D., Mine, M., Pipiras, E., Labauge, P., Delahaye, A., Benzacken, B., Tournier-Lasserve, E. Tags: Stroke in young adults, MRI, All Cerebrovascular disease/Stroke, Infarction, All Genetics CLINICAL/SCIENTIFIC NOTES Source Type: research