Infectious Disease: Candida
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Total 17 results found since Jan 2013.
Aspergillus fumigatus endocarditis in a splenectomized patient with no risk factors
Publication date: Available online 9 January 2020Source: IDCasesAuthor(s): Abhimanyu Aggarwal,, Karen Hogan,, Armando Paez,AbstractAspergillus endocarditis is a rare cause of culture-negative fungal endocarditis, after Candida endocarditis. Typical risk factors include intravenous drug use, immunosuppression, prior cardiac surgery or presence of prosthetic heart valves, hematopoietic stem cell or solid organ transplantation. Common presentations include signs and symptoms consistent with endocarditis but with negative bacterial blood cultures. Here, we present a case report of a 49-year-old male without known risk factors ...
Source: IDCases - January 9, 2020 Category: Infectious Diseases Source Type: research
Antifungal Activity and Potential Mechanism of N-Butylphthalide Alone and in Combination With Fluconazole Against Candida albicans
This study demonstrated that n-butylphthalide exhibited antifungal activity against Candida albicans with minimum inhibitory concentrations of 128μg/mL and n-butylphthalide combined with fluconazole showed synergistic antifungal effects against resistant Candida albicans, resulting in a decrease in the minimum inhibitory concentrations of fluconazole from>512 to 0.25-1μg/mL. Time-killing curves verified the antifungal activity in dynamic. Besides, n-butylphthalide exhibited anti-biofilm activity against Candida albicans biofilms preformed
Source: Frontiers in Microbiology - July 1, 2019 Category: Microbiology Source Type: research
Isolation of Antimicrobial Compounds From Cnestis ferruginea Vahl ex. DC (Connaraceae) Leaves Through Bioassay-Guided Fractionation
Conclusion In conclusion, aqueous extracts of C. ferruginea leaves showed antimicrobial activity due to the presence of hydroquinone and caffeic acid methyl ester. This supports its traditional use for infections and confirmed that the active molecules are water-soluble. Author Contributions KK, SP, LVP, and WL conceived and designed the experiments. SP, KK, M-RY, and J-GL performed the experiments. SP, LVP, WL, M-RY, J-GL, and Z-HJ analyzed the data. WL and Z-HJ contributed reagents, materials, and analysis tools. KK, SP, WL, M-RY, Z-HJ, and LVP contributed to the writing of the manuscript. All authors contributed to m...
Source: Frontiers in Microbiology - April 10, 2019 Category: Microbiology Source Type: research
Acute ischemic stroke treated with mechanical thrombectomy and fungal endocarditis: a case report and systematic review of the literature
We report a case of an acute ischemic stroke treated by mechanical thrombectomy, with the histopathological analysis of the retrieved clot followed by the confirmation of fungal endocarditis. An extensive review of the literature has been proposed and three key points concerning the fungal endocarditis predisposing factors, the relation between thrombolysis and hemorrhagic risk and, finally, the importance of clot analysis have been discussed.
Source: Journal of Neuroradiology - April 3, 2019 Category: Radiology Source Type: research
Repair of Thoracic and Thoracoabdominal Mycotic Aneurysms and Infected Aortic Grafts Using Allograft
ConclusionsRadical resection and in situ reconstruction with CPA avoids placing prosthetic material in an infected field and provides good early and midterm outcomes. However, early postoperative imaging is necessary given the risk of pseudoaneurysm formation.
Source: The Annals of Thoracic Surgery - September 21, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research
Oral Health Interventions Using Chlorhexidine—Effects on the Prevalence of Oral Opportunistic Pathogens in Stroke Survivors: A Randomized Clinical Trial
ConclusionOral hygiene intervention using a powered tooth brush and 1% chlorhexidine oral gel was effective in reducing the prevalence of oral opportunistic pathogens.
Source: Journal of Evidence Based Dental Practice - July 10, 2018 Category: Dentistry Source Type: research
Neuroinfections caused by fungi
ConclusionAlthough the number of fungal species causing CNS mycosis is increasing, only some possess well-defined treatment standards (e.g., cryptococcal meningitis and CNS aspergillosis). The early diagnosis of fungal infection, accompanied by identification of the etiological factor, is needed to allow the selection of effective therapy in patients with FIs-CNS and limit their high mortality.
Source: Infection - May 21, 2018 Category: Infectious Diseases Source Type: research
Repair of Thoracic and Thoracoabdominal Mycotic Aneurysms and Infected Aortic Grafts Using Allograft
Conclusions Radical resection and in-situ reconstruction with CPA avoids placing prosthetic material in an infected field and provides good early and mid-term outcomes. However, early postoperative imaging is necessary given the risk of pseudoaneurysm formation.
Source: The Annals of Thoracic Surgery - May 17, 2018 Category: Cardiovascular & Thoracic Surgery Source Type: research
Repair of Thoracic and Thoracoabdominal Mycotic Aneurysms and Infected Aortic Grafts Using Allograft.
CONCLUSIONS: Radical resection and in-situ reconstruction with CPA avoids placing prosthetic material in an infected field and provides good early and mid-term outcomes. However, early postoperative imaging is necessary given the risk of pseudoaneurysm formation. PMID: 29777669 [PubMed - as supplied by publisher]
Source: The Annals of Thoracic Surgery - May 16, 2018 Category: Cardiovascular & Thoracic Surgery Authors: Corvera JS, Blitzer D, Copeland H, Murphy D, Hess PJ, Pillai ST, Fehrenbacher JW Tags: Ann Thorac Surg Source Type: research
Oral Health Interventions Using Chlorhexidine —Effects on the Prevalence of Oral Opportunistic Pathogens in Stroke Survivors: A Randomized Clinical Trial
Conclusion Oral hygiene intervention using a powered tooth brush and 1% chlorhexidine oral gel was effective in reducing the prevalence of oral opportunistic pathogens.
Source: Journal of Evidence Based Dental Practice - September 14, 2017 Category: Dentistry Source Type: research
Oral health interventions using chlorhexidine - effects on the prevalence of oral opportunistic pathogens in stroke survivors: a randomized clinical trial
Conclusion Oral hygiene intervention, using a powered tooth brush and 1% Chlorhexidine oral gel was effective in reducing the prevalence of oral opportunistic pathogens. (187 words)
Source: Journal of Evidence Based Dental Practice - August 17, 2017 Category: Dentistry Source Type: research
Enzymatic and solid-phase synthesis of new donepezil-based L- and d-glutamic acid derivatives and their pharmacological evaluation in models related to Alzheimer's disease and cerebral ischemia.
Abstract Previously, we have described N-Bz-L-Glu[NH-2-(1-benzylpiperidin-4-yl)ethyl]-O-nHex (IQM9.21, L-1) as an interesting multifunctional neuroprotective compound for the potential treatment of neurodegenerative diseases. Here, we describe new derivatives and different synthetic routes, such as chemoenzymatic and solid-phase synthesis, aiming to improve the previously described route in solution. The lipase-catalysed amidation of L- and D-Glu diesters with N-benzyl-4-(2-aminoethyl)piperidine has been studied, using Candida antarctica and Mucor miehei lipases. In all cases, the α-amidated compound was obtained...
Source: European Journal of Medicinal Chemistry - February 21, 2017 Category: Chemistry Authors: Monjas L, Arce MP, León R, Egea J, Pérez C, Villarroya M, López MG, Gil C, Conde S, Rodríguez-Franco MI Tags: Eur J Med Chem Source Type: research
Oral health status in patients with acquired brain injury: a systematic review
Conclusion Stroke was the most predominant brain injury condition studied in the literature with few publications focusing on other form of brain injury diseases. Overall, oral health has been noted to be poor in patients with ABI, but oral hygiene, and OHrQoL, has been found to be improved when oral hygiene interventions are provided to the patients.
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology - November 10, 2016 Category: ENT & OMF Source Type: research
Fungal Infections of the Central Nervous System
This article summarizes current knowledge on the epidemiology, clinical presentations, diagnosis, and management of selected fungal infections of the central nervous system (CNS). Key syndromes, differential diagnoses, and therapeutic interventions according to host immune status and exposure are reviewed. Recent Findings:: Advancements in imaging of the brain and spinal cord, and molecular DNA and antigen-based laboratory diagnostics afford improved sensitivity for CNS mycoses. Newer therapeutic strategies may improve outcomes if provided early and host immunosuppression is abrogated. Adjunctive corticosteroid use for dis...
Source: CONTINUUM - December 1, 2015 Category: Neurology Tags: Review Articles Source Type: research
Thrombosis in Fontan patient on apixaban
We report a case of large thrombus in a 24-year-old male born with double inlet left ventricle in the lateral tunnel Fontan while on apixaban.
Source: International Journal of Cardiology - December 27, 2014 Category: Cardiology Authors: Candida Pinto, Bennett P. Samuel, Christopher Ratnasamy, Joseph J. Vettukattil Source Type: research
Arterial spin labeling‐fast imaging with steady‐state free precession (ASL‐FISP): a rapid and quantitative perfusion technique for high‐field MRI
Arterial spin labeling (ASL) is a valuable non‐contrast perfusion MRI technique with numerous clinical applications. Many previous ASL MRI studies have utilized either echo‐planar imaging (EPI) or true fast imaging with steady‐state free precession (true FISP) readouts, which are prone to off‐resonance artifacts on high‐field MRI scanners. We have developed a rapid ASL‐FISP MRI acquisition for high‐field preclinical MRI scanners providing perfusion‐weighted images with little or no artifacts in less than 2 s. In this initial implementation, a flow‐sensitive alternating inversion recovery (FAIR) ASL prep...
Source: NMR in Biomedicine - June 3, 2014 Category: Radiology Authors: Ying Gao, Candida L. Goodnough, Bernadette O. Erokwu, George W. Farr, Rebecca Darrah, Lan Lu, Katherine M. Dell, Xin Yu, Chris A. Flask Tags: Rapid communication Source Type: research