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Infectious Disease: Zika Virus

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February 2019
From A to Zika : Understanding Emerging Diseases Control Your Cholesterol : Protect Yourself from Heart Attack and Stroke Vaping Rises Among Teens Wellness Tips in Spanish Weight Management
Source: NIH News in Health - January 31, 2019 Category: Consumer Health News Source Type: news

Superbugs, Anti-Vaxxers Make WHO ’ s List Of 10 Global Health Threats
(CNN) — From climate change to superbugs, the World Health Organization has laid out 10 big threats to our global health in 2019. And unless these threats get addressed, millions of lives will be in jeopardy. Here’s a snapshot of 10 urgent health issues, according to the United Nations’ public health agency: Not vaccinating when you can One of the most controversial recent health topics in the US is now an international concern. “Vaccine hesitancy — the reluctance or refusal to vaccinate despite the availability of vaccines — threatens to reverse progress made in tackling vaccine-prevent...
Source: WBZ-TV - Breaking News, Weather and Sports for Boston, Worcester and New Hampshire - January 21, 2019 Category: Consumer Health News Authors: Health – CBS Boston Tags: Health News CNN Local TV Source Type: news

How are Malformations of the Cerebral Cortex Grouped?
Discussion Cerebral cortex development is an extremely complex process overall. Our current understanding is incomplete and constantly changing as our understanding of genetics and the processes each gene controls emerges from scientific research. Neural cells are produced in the subventicular zone of the pallial or dorsal germinal epithelium. They then differentiate and migrate radially or tangentially to the cerebral cortex and organize themselves to function. Malformations of cortical development (MCD) is a heterogeneneous group of disorders that cause defective cortical development. These disorders are broadly catego...
Source: PediatricEducation.org - July 23, 2018 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Global Neurology: Navigating Career Possibilities
Semin Neurol 2018; 38: 145-151 DOI: 10.1055/s-0038-1647245Neurology has not typically been associated with international relief work; however, with the growth of chronic cardiovascular disease and stroke associated with unhealthy eating and sedentary ways, the appearance of “new” neurologic diseases, such as the Zika and West Nile viruses, and the high numbers of seizure disorders resulting from neuroinfectious diseases, more opportunities are arising for international and globally oriented neurologists. Multiple opportunities exist for developing a global clinician–educator career pathway, including private institut...
Source: Seminars in Neurology - May 23, 2018 Category: Neurology Authors: Schiess, Nicoline Saylor, Deanna Zunt, Joseph Tags: Review Article Source Type: research

Comment The social sciences, humanities, and health
Humanities and social sciences have had many positive influences on health experiences, care, and expenditure. These include on self-management for diabetes, provision of psychological therapy, handwashing, hospital checklists, the Scottish Government's stroke guidelines, England's tobacco control strategy, the response to the Ebola outbreak in west Africa and Zika virus in Brazil, and many more.1 Researchers have shown time and time again the political, practical, economic, and civic value of education and research in disciplines like anthropology, history, and philosophy.
Source: LANCET - April 13, 2018 Category: General Medicine Authors: Martyn Pickersgill, Sarah Chan, Gill Haddow, Graeme Laurie, Devi Sridhar, Steve Sturdy, Sarah Cunningham-Burley Tags: Comment Source Type: research

Cerebral Infarction and Refractory Seizures in a Neonate with Suspected Zika Virus Infection
This report may impact the evolving definition of congenital Zika syndrome.
Source: The Pediatric Infectious Disease Journal - March 15, 2018 Category: Infectious Diseases Tags: Brief Reports Source Type: research

CDC Director Resigns Amid Reports of Tobacco Stock Trade
The Department of Health and Human Services (HHS) announced on January 31, 2018, that Dr. Brenda Fitzgerald would resign as the Director of the Centers for Disease Control and Prevention (CDC). The statement read, “Dr. Fitzgerald owns certain complex financial interests that have imposed a broad recusal limiting her ability to complete all of her duties as the CDC Director. Due to the nature of these financial interests, Dr. Fitzgerald could not divest from them in a definitive time period.” The decision came a day after Politico reported that she bought stock in a large tobacco company within a month of start...
Source: Public Policy Reports - February 23, 2018 Category: Biology Authors: AIBS Source Type: news

Cerebral infarction due to Zika virus
We read with great interest the letter by Anne Landais and colleagues entitled, “ZIKA vasculitis: A new cause of stroke in children.” [1] The article presents a case of an acute left middle cerebral artery infarct in an eight-month old boy within a few days of symptomatic Zika infection. He had positive Zika PCR in serum followed a few months later by positive Zika IgG and negative Zika IgM. The authors report this as the first case of cerebral infarction associated with Zika infection, broadening the clinical neurologic spectrum of Zika infection.
Source: Journal of the Neurological Sciences - February 3, 2018 Category: Neurology Authors: Sarah B. Mulkey, Roberta L. DeBiasi, Adre J. du Plessis Tags: Letter to the Editor Source Type: research

10 Global Health Issues to Watch in 2018
January 19, 2018It ’s notallbad news.When we set out to compile our annual list of global health issues to watch this year, it seemed like all bad news. And true, that ’s often what we deal with in global health—the problems that need tackling, the suffering we can help alleviate.But then stories and columns likethis one cheer us up. They remind us that no matter how complicated and frustrating our work may get, fighting back against poverty and inequality works.There are and always will be global health challenges to face. But there ’s boundless hope, too. And a field full of determined health workers and other hu...
Source: IntraHealth International - January 19, 2018 Category: International Medicine & Public Health Authors: mnathe Source Type: news

New spectrum of the neurologic consequences of Zika
Zika virus infection represents a new neuropathological agent with association to a wide spectrum of neurological complications: a) Congenital Zika Syndrome by affecting the neural stem cells of the human fetal brain; b) Guillain-Barr é Syndrome by an autoimmune response against peripheral myelin and/or axonal components or probable direct inflammatory reaction; c) Encephalitis/meningoencephalitis and myelitis by a direct viral inflammatory process on the central nervous system; d) Sensory neuropathy by infecting directly the pe ripheral neurons and causing substantial cell death and pathogenic transcriptional dysregulati...
Source: Journal of the Neurological Sciences - October 31, 2017 Category: Neurology Authors: Marco T. Medina, Marco Medina-Montoya Tags: Editorial Source Type: research

ZIKA vasculitis: A new cause of stroke in children?
Viral infectious vasculitis is a cause of stroke in children. Zika virus infection is often asymptomatic. Neurological complications have however been reported: Guillain-Barr é, ADEM, meningoencephalitis, myelitis, microcephaly in the fetus of infected mothers. We discuss the case of a child presenting acute infection with ZIKV that was associated with a stroke. A 10-months-old boy without medical history presented after 2days of fever and cutaneous rash, conjunctivitis on day 5, a right hemiparesis on day 6.
Source: Journal of the Neurological Sciences - October 27, 2017 Category: Neurology Authors: Anne Landais, Audrey C ésaire, Manuel Fernandez, Sébastien Breurec, Cécile Herrmann, Fréderique Delion, Philippe Desprez Tags: Letter to the Editor Source Type: research

Better ‘mini brains’ could help scientists identify treatments for Zika-related brain damage
UCLA researchers have developed an improved technique for creating simplified human brain tissue from stem cells. Because these so-called “mini brain organoids” mimic human brains in how they grow and develop, they’re vital to studying complex neurological diseases.In a study published in the journal Cell Reports, the researchers used the organoids to better understand how Zika infects and damages fetal brain tissue, which enabled them to identify drugs that could prevent the virus ’s damaging effects.The research, led by senior author Ben Novitch, could lead to new ways to study human neurological and neurodevelop...
Source: UCLA Newsroom: Health Sciences - October 10, 2017 Category: Universities & Medical Training Source Type: news

What Causes Microcephaly?
Discussion Microcephaly is usually defined as an occipitofrontal head circumference (OFC) more than 2 standard deviations (SD) below the mean for sex, age and ethnicity. Severe microcephaly is used for OFC < 3 standard deviations. Rates of microcephaly range from 0.5-12 patients/10,000 live births. The OFC should be measured at every well child visit and at other opportunities and plotted on standard growth charts. The OFC is measured using a nonelastic tape measure around the largest part of the head with the tape measure held above the eyebrows and ears. It is a highly reproducible measurement. There are several diff...
Source: PediatricEducation.org - September 25, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Hopkins Nursing—Dean on Chronic Disease / Pediatrics
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Source: Johns Hopkins University and Health Systems Archive - July 27, 2017 Category: Nursing Source Type: news

Zika associated Guillain-Barre syndrome in the United States (P2.327)
Conclusions:Zika can induce GBS after a brief viral illness. Neuropathy can be a mixture of demyelinating and axonal. Dysautonomia may also be present including severe dysphagia, orthostatics and retention.Zika RNA has a short detection window in serum and CSF making a diagnosis time sensitive. Serological assays using IgM and IgG cross-react with other flaviviruses making them unable to differentiate between recent Zika exposure and cross reactivity with Dengue and Chikungunya. Our pt likely had prior exposure to Dengue, being from an endemic area. Prior Dengue exposure may possibly modulate the response to Zika via antib...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Tantillo, G., Sclar, G., Vasa, C., Shin, S., Sivak, M. Tags: Zika, Chikungunya, West Nile Virus, and Other Viral Infections I Source Type: research

Neurological involvement in Chikangunya Virus infection (S40.007)
Conclusions:Chikangunya fever is frequently associated with neurological symptoms, especially alteration in sensorium, neutrophilia and hyponatremia in more than two-thirds of the patients, sepsis and hepatorenal dysfunction in almost one third of the patients, CSF lymphocytosis with raised proteins and topographically involves temporal and frontal lobes predominantly.Disclosure: Dr. Anand has nothing to disclose. Dr. Kasundra has nothing to disclose. Dr. Prasad has nothing to disclose. Dr. Handa has nothing to disclose.
Source: Neurology - April 17, 2017 Category: Neurology Authors: Anand, R., Kasundra, G., Prasad, A., Handa, R. Tags: Infectious Disease: The Neurology of Zika, Chikungunya, and Acute Flaccid Myelitis Source Type: research

December blogs digest: the health benefits of nuts, sequencing the Iberian lynx genome, the importance of pets and more
How can we measure health behavior theories mathematically? William Riley looks at whether Social Cognitive Theory (SCT) could be expressed mathematically. He reports on his article published in Translational Behavioral Medicine in which he and co-authors developed a dynamic computational model for SCT. Magnesium deficiency and its multiple health outcomes Getting enough magnesium in your diet? A study published in BMC Medicine last month found that increased dietary magnesium is associated with a reduced risk of heart failure, stroke, diabetes, and all-cause mortality. The study was the largest of its kind to date, using ...
Source: BioMed Central Blog - January 6, 2017 Category: Journals (General) Authors: Davy Falkner Tags: Biology Health Medicine Open Access blogs digest Source Type: blogs

Identification and genetic characterization of Zika virus isolated from an imported case in China.
In this study, we reported the complete genomic sequence of Zika virus strain ZKC2/2016 from an imported case in China, in February 2016. The virus was isolated and virus characteristics were identified by cytopathic effect, quantitative real time-PCR, immunofluorescence assay and electronic microscopy. Next generation sequencing (NGS) technique and 5' and 3' Rapid Amplification cDNA Ends (RACE) PCR were used to sequence the complete genome. The genome length of this newly obtained Zika virus strain is 10,807base pairs (bp). Genetic analysis showed that ZKC2/2016, along with other Chinese Zika virus strains in 2016, formed...
Source: Infection, Genetics and Evolution - October 31, 2016 Category: Genetics & Stem Cells Authors: Liu L, Zhang S, Wu, Song J, Li A, Zhang H, Wu W, Tan Q, Li C, Zhang Q, Zhou H, Liang M, Ke C, Li D Tags: Infect Genet Evol Source Type: research

Zika Virus Emergence and Expansion: Lessons Learned from Dengue and Chikungunya May Not Provide All the Answers.
Abstract Following the emergence of Zika in the past decade, there are lessons to be learned from similar emergence events of dengue (DENV) and chikungunya (CHIKV). Specifically, as Zika emerges in the Americas there is a natural tendency to apply the knowledge base of DENV and CHIKV to mitigation and control of a virus with such a similar transmission system. However, there are marked differences that may preclude such broad stroke application of this knowledge base without making potentially faulty assumptions. Herein, Zika virus (ZIKV) transmission is reviewed, and the commonalities among these three arboviruse...
Source: The American Journal of Tropical Medicine and Hygiene - February 22, 2016 Category: Tropical Medicine Authors: Christofferson RC Tags: Am J Trop Med Hyg Source Type: research