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Infectious Disease: Cytomegalovirus

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Total 23 results found since Jan 2013.

Quantification of biological age as a determinant of age-related diseases in the Rotterdam Study: a structural equation modeling approach
AbstractChronological age alone is not a sufficient measure of the true physiological state of the body. The aims of the present study were to: (1) quantify biological age based on a physiological biomarker composite model; (2) and evaluate its association with death and age-related disease onset in the setting of an elderly population. Using structural equation modeling we computed biological age for 1699 individuals recruited from the first and second waves of the Rotterdam study. The algorithm included nine physiological parameters (c-reactive protein, creatinine, albumin, total cholesterol, cytomegalovirus optical dens...
Source: European Journal of Epidemiology - April 13, 2019 Category: Epidemiology Source Type: research

Cytomegalovirus encephalitis radiographically mimicking lateral medullary stroke
Cytomegalovirus encephalitis may demonstrate unique MRI characteristics that allow for earlier diagnosis and treatment.
Source: Neurology Clinical Practice - December 10, 2018 Category: Neurology Authors: Li, D., van Gaal, S. Tags: MRI, Encephalitis, Viral infections, HIV, All Cerebrovascular disease/Stroke Case Source Type: research

Cytomegalovirus Infection in Cardiovascular Diseases
AbstractAtherosclerosis underlies the development of many cardiovascular diseases that continue to hold a leading place among the causes of death in developed countries. The role of activated immune cells in atherosclerosis progression has been convincingly demonstrated, but the mechanism of their action remains poorly investigated. Since atherosclerosis is associated with chronic inflammatory response, involvement of viral and bacterial infections in atherogenesis has been examined. A special place among the infectious agents is held by human herpesviruses as the most common persistent viruses in human population coupled ...
Source: Biochemistry (Moscow) - December 1, 2018 Category: Biochemistry Source Type: research

Elevated serum human cytomegalovirus IgM levels in the acute phase of ischemic stroke are associated with increased risk of death and major disability.
CONCLUSIONS: Elevated serum HCMV IgM levels in the acute phase of ischemic stroke were correlated with increased risk of combined outcome of death and major disability, indicating that serum HCMV IgM could be an important predictive factor for poor prognosis of ischemic stroke. PMID: 30468129 [PubMed - as supplied by publisher]
Source: Current Neurovascular Research - November 23, 2018 Category: Neurology Authors: Zhang C, Huang P, Zhang P, Zhou M, Gao Y, Zhang Y, Guo Y, Lv L, Xu T Tags: Curr Neurovasc Res Source Type: research

Trypanosoma cruzi seroprevalence among solid organ donors in Ceará State, Brazil
CONCLUSIONS: There was a high prevalence of CD and other coinfections among potential solid organ donors in Ceará, and statistical tests have shown that these individuals are at increased ri sk of stroke when compared to potential non-reactive donors. This work highlights the importance of screening DC infection in potential donors.
Source: Revista da Sociedade Brasileira de Medicina Tropical - October 8, 2018 Category: Tropical Medicine Source Type: research

What Causes Microcephaly?
Discussion Microcephaly is usually defined as an occipitofrontal head circumference (OFC) more than 2 standard deviations (SD) below the mean for sex, age and ethnicity. Severe microcephaly is used for OFC < 3 standard deviations. Rates of microcephaly range from 0.5-12 patients/10,000 live births. The OFC should be measured at every well child visit and at other opportunities and plotted on standard growth charts. The OFC is measured using a nonelastic tape measure around the largest part of the head with the tape measure held above the eyebrows and ears. It is a highly reproducible measurement. There are several diff...
Source: PediatricEducation.org - September 25, 2017 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Maternal levels of Epstein-Barr virus IgG antibodies and risk of multiple sclerosis in offspring in the Finnish Maternity Cohort (S44.006)
Conclusions:Elevated maternal levels of VCA IgG are associated with an increased risk of MS in the offspring. Further studies are needed to elucidate potential biological mechanisms.Study Supported by: This study was funded by the National Institute of Neurological Disorders and Stroke (NIH R01 NS073633, PI: Ascherio).Disclosure: Dr. Munger has nothing to disclose. Dr. Zhang has nothing to disclose. Dr. Aivo has nothing to disclose. Dr. Hongell has nothing to disclose. Dr. Soilu-Hanninen has nothing to disclose. Dr. Surcel has nothing to disclose. Dr. Ascherio has received personal compensation for activities with Almirall...
Source: Neurology - April 17, 2017 Category: Neurology Authors: Munger, K., Zhang, Z., Aivo, J., Hongell, K., Soilu-Hanninen, M., Surcel, H.-M., Ascherio, A. Tags: MS Risk Factors and Modifications Source Type: research

Association of HIV and Opportunistic Infections With Incident Stroke: A Nationwide Population-Based Cohort Study in Taiwan
Conclusions: Patients with HIV had an increased risk of stroke, particularly those with cryptococcal meningitis, cytomegalovirus, or P. marneffei infection.
Source: JAIDS Journal of Acquired Immune Deficiency Syndromes - January 12, 2017 Category: Infectious Diseases Tags: Epidemiology Source Type: research

Carotid intima media thickness and blood biomarkers of atherosclerosis in patients after stroke or myocardial infarction.
CONCLUSIONS: Our study supports linear correlations between CIMT and IC and hs-CRP levels. However, these associations seem to depend on the type of vascular burden. PMID: 28051279 [PubMed - in process]
Source: Croatian Medical Journal - December 31, 2016 Category: Journals (General) Authors: Kurkowska-Jastrzebska I, Karlinski MA, Błazejewska-Hyzorek B, Sarzynska-Dlugosz I, Filipiak KJ, Czlonkowska A Tags: Croat Med J Source Type: research

Human Cytomegalovirus Increases the Risk of Future Hemorrhagic But Not Ischemic Stroke  - A Nested Case-Control Study.
CONCLUSIONS: Seropositivity for HCMV DNA was positively associated with total and hemorrhagic but not ischemic stroke, which persisted after controlling for other cardiovascular factors. PMID: 27499027 [PubMed - as supplied by publisher]
Source: Circulation Journal - August 8, 2016 Category: Cardiology Authors: Zheng L, Sun Z, Sun Z, Zhang X, Jing K, Li J, Hu D, Sun Y Tags: Circ J Source Type: research

French Intensive Care Society, International congress - Réanimation 2016.
C, Sauneuf B, Verrier P, Pottier V, Orabona M, Samba D, Viquesnel G, Lermuzeaux M, Hazera P, Hanouz JL, Parienti JJ, Du Cheyron D, Demoule A, Clavel M, Rolland-Debord C, Perbet S, Terzi N, Kouatchet A, Wallet F, Roze H, Vargas F, Guérin C, Dellamonica J, Jaber S, Similowski T, Quenot JP, Binquet C, Vinsonneau C, Barbar SD, Vinault S, Deckert V, Lemaire S, Hssain AA, Bruyère R, Souweine B, Lagrost L, Adrie C, Jung B, Daurat A, De Jong A, Chanques G, Mahul M, Monnin M, Molinari N, Lheureux O, Trepo E, Hites M, Cotton F, Wolff F, Surin R, Créteur J, Vincent JL, Gustot T, Jacobs F, Taccone FS, Neuville M, Timsit JF, El-Hel...
Source: Australian Family Physician - June 1, 2016 Category: Primary Care Authors: Jaillette E, Girault C, Brunin G, Zerimech F, Chiche A, Broucqsault-Dedrie C, Fayolle C, Minacori F, Alves I, Barrailler S, Robriquet L, Delaporte E, Thellier D, Delcourte C, Duhamel A, Nseir S, Valette X, Desmeulles I, Savary B, Masson R, Seguin A, Daubi Tags: Ann Intensive Care Source Type: research

What Genetics are Associated with Multiple Sclerosis?
Discussion Multiple sclerosis (MS) is “a chronic degenerative, often episodic disease of the central nervous system marked by patchy destruction of the myelin that surrounds and insulates nerve fibers, usually appearing in young adulthood and manifested by one or more mild to severe neural and muscular impairments, as spastic weakness in one or more limbs, local sensory losses, bladder dysfunction, or visual disturbances.” It is a chronic disease and therefore symptoms must occur more than once. The first episode is called an acute demyelinating attack. Fifteen to forty-five percent of children with their first...
Source: PediatricEducation.org - April 4, 2016 Category: Pediatrics Authors: pediatriceducationmin Tags: Uncategorized Source Type: news

Herpesvirus Infections and Childhood Arterial Ischemic Stroke: Results of the VIPS Study.
CONCLUSIONS: -Herpesviruses may act as a trigger for childhood AIS, even if the infection is subclinical. Antivirals like acyclovir might have a role in the prevention of recurrent stroke if further studies confirm a causal relationship. PMID: 26813104 [PubMed - as supplied by publisher]
Source: Circulation - January 26, 2016 Category: Cardiology Authors: Elkind MS, Hills NK, Glaser CA, Lo WD, Amlie-Lefond C, Dlamini N, Kneen R, Hod EA, Wintermark M, deVeber GA, Fullerton HJ, VIPS Investigators Tags: Circulation Source Type: research

Biological Plausibility of a Link Between Arterial Ischemic Stroke and Infection with Varicella-Zoster Virus or Herpes Simplex Virus.
Abstract There are now 9 human herpesviruses; the increase from 8 to 9 was caused by a recent decision to split human herpesvirus (HHV) strains 6A and 6B into distinct species. The 9 species are subdivided into three subfamilies, called alpha: herpes simplex virus (HSV) types 1 and 2 and varicella-zoster virus (VZV); beta: cytomegalovirus (CMV), HHV6A, HHV6B and HHV7; gamma: Epstein-Barr virus (EBV) and Kaposi's sarcoma-associated herpesvirus (sometimes called HHV8). These same herpesviruses have evolved with humankind around the world since the great migration of modern humans across the Mandeb Strait out of Afri...
Source: Circulation - January 26, 2016 Category: Cardiology Authors: Grose C Tags: Circulation Source Type: research

CMV seropositivity and T‐cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study
Summary Although chronic infection with cytomegalovirus (CMV) is known to drive T lymphocytes toward a senescent phenotype, it remains controversial whether and how CMV can cause coronary heart disease (CHD). To explore whether CMV seropositivity or T‐cell populations associated with immunosenescence were informative for adverse cardiovascular outcome in the very old, we prospectively analyzed peripheral blood samples from 751 octogenarians (38% males) from the Newcastle 85+ study for their power to predict survival during a 65‐month follow‐up (47.3% survival rate). CMV‐seropositive participants showed a higher pre...
Source: Aging Cell - December 22, 2015 Category: Cytology Authors: Ioakim Spyridopoulos, Carmen Martin‐Ruiz, Catharien Hilkens, Mohammad E. Yadegarfar, John Isaacs, Carol Jagger, Tom Kirkwood, Thomas Zglinicki Tags: Short Take Source Type: research

Donor risk factors in orthotopic liver transplant: analysis of the OPTN/UNOS registry.
This study of the United Network for Organ Sharing registry data analyzed reputed donor factors using the post-MELD data and evaluated them further in HCV positive and HCV negative recipients with hepatic cirrhosis to develop a modified DRI (mDRI). We found that HCV negative cirrhotic recipients have generally higher tolerance against inferior qualities of donors than HCV positive cirrhotic patients. In addition, the results revealed the post-MELD prognostic factors that should be considered in the donor procurement processes. The group of "all recipients" and the subset of HCV positive cirrhotic recipients showed a simila...
Source: Clinical Transplants - November 20, 2015 Category: Transplant Surgery Tags: Clin Transpl Source Type: research

Infectious Burden and Cognitive Decline in the Northern Manhattan Study
ConclusionA quantitative stroke risk‐weighted measure of IB explained variability in baseline executive function performance and associated with decline in memory. Past exposure to common infections may contribute to vascular cognitive impairment and warrants further study.
Source: Journal of the American Geriatrics Society - August 20, 2015 Category: Geriatrics Authors: Clinton B. Wright, Hannah Gardener, Chuanhui Dong, Mitsuhiro Yoshita, Charles DeCarli, Ralph L. Sacco, Yaakov Stern, Mitchell S. V. Elkind Tags: Clinical Investigations Source Type: research

Concentration Dependent Inhibitory Effect of a Nucleoside-based Analog Against Human Herpesvirus-6 Replication (P6.304)
Human herpesvirus-6 (HHV-6) is associated with a number neurological disorders including multiple sclerosis (MS). To test the hypothesis of HHV-6 association in MS, certain approved human herpesvirus therapies have been investigated for treatment against HHV-6 in MS patients. However, antiviral therapies specific for HHV-6 do not exist. Therefore, antivirals that primarily targert other β-herpesviruses such as human cytomegalovirus (HCMV) are often used in these trials but with minimal efficacy. Recently, a subset of nucleoside-based analogs was reported with improved efficacy against herpesviruses. Therefore, our goa...
Source: Neurology - April 8, 2015 Category: Neurology Authors: Lee, N., Leibovitch, E., Jacobson, S. Tags: HTLV and Other Viral Infections Source Type: research

Cytomegalovirus proctitis mimicking rectal cancer in an immunocompetent elderly patient: a case report
Conclusion: This raised some several interesting points; firstly that we must revise our approach to investigating the immunocompetent elderly patient, secondly, could chronic Cytomegalovirus infection have contributed to the presentation of stroke in this patient and lastly what are the existing evidence for treatment in this population? We use this opportunity to try and address some of these questions and feel that this would be of benefit to the wider audience.We discuss the risk factors for disease in immune-competent patients and also a brief overview of the benefits of treatment in this population.
Source: BMC Research Notes - November 15, 2014 Category: Research Authors: Sathyavani SubbaraoAnthony O¿SullivanTolu AdesinaAdam GwozdzJulia ReesGiovanni Satta Source Type: research

Neurological Consequences of Cytomegalovirus Infection
Cytomegalic Inclusion Body Disease (CIBD or CMV) information sheet compiled by NINDS, the National Institute of Neurological Disorders and Stroke.
Source: NINDS Disorders: National Institute of Neurological Disorders and Stroke - October 26, 2014 Category: Neurology Source Type: research

Growth of newborn babies' brains tracked
Conclusion This study has mapped out the growth rate of the major structures of the brain in 87 apparently healthy neonates from within a week of birth up to 90 days. A study of this nature can help our understanding of the growth and development of the brain and our ability to monitor brain development over time. The fact the investigation had no apparent side effects is also welcome. However, as the authors point out, the relatively small size of the study means the results cannot be used as a reference for normal development. Larger and more ethnically diverse studies would be required. The goal of establishing data ...
Source: NHS News Feed - August 12, 2014 Category: Consumer Health News Tags: Pregnancy/child Source Type: news

A study on the association between infectious burden and Alzheimer's disease
ConclusionsIB consisting of CMV, HSV‐1, B. burgdorferi, C. pneumoniae and H. pylori is associated with AD. This study supports the role of infection/inflammation in the etiopathogenesis of AD.
Source: European Journal of Neurology - June 9, 2014 Category: Neurology Authors: X.‐L. Bu, X.‐Q. Yao, S.‐S. Jiao, F. Zeng, Y.‐H. Liu, Y. Xiang, C.‐R. Liang, Q.‐H. Wang, X. Wang, H.‐Y. Cao, X. Yi, B. Deng, C.‐H. Liu, J. Xu, L.‐L. Zhang, C.‐Y. Gao, Z.‐Q. Xu, M. Zhang, L. Wang, X.‐L. Tan, X. Xu, H.‐D. Zhou, Y. Tags: Original Article Source Type: research