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Investigation of therapeutic effects of calcium dobesilate in cerebral hypoxia/ reperfusion injury in rats
CONCLUSION: From these results, it was observed that CD treatment could reduce neuronal necrosis and create anti-inflammatory, anti-edema, anti-oxidant, anti-apoptotic, and anti-autophagic effects in hypoxia/reperfusion injury in rats.PMID:36548871 | DOI:10.1080/01616412.2022.2159109
Source: Neurological Research - December 22, 2022 Category: Neurology Authors: Alemiddin Ozdemir Mustafa Ogden Bahar Kartal Asli Fahriye Ceylan Ulas Yuksel Bulent Bakar Source Type: research

Dihydromyricetin alleviates cerebral ischemia-reperfusion injury by attenuating apoptosis and astrogliosis in peri-infarct cortex
This study investigates the potential of DHM, given postreperfusion in middle cerebral artery occlusion (MCAo) model of stroke in rats.METHODS: MCAo surgery was performed in male Wistar rats. Reperfusion was performed after 90 min of ischemia. DHM (50 and 100 mg/kg) was administered 10-15 min and 2 h postreperfusion followed by daily dosing for 2 more days. Neurobehavioral parameters and infarct size (TTC staining) were assessed after 72 h. The effective dose (100 mg/kg) was then used to study reduction in infarct size (measured by MRI) and effect on apoptosis (evaluated by protein expression of Bax, Bcl-2 and cleaved casp...
Source: Neurological Research - December 9, 2021 Category: Neurology Authors: Himika Wasan Devendra Singh Balu Joshi Deepti Upadhyay Uma Sharma Amit Kumar Dinda K H Reeta Source Type: research

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