• Filter By:
• Specialty
• Source
• Condition
• Cancer
• Infectious Disease
• Drug
• Training
• Management
• Procedure
• Therapy
• Vaccine
• Nutrition
• Country

Association of Atrial Septal Aneurysm and Shunt Size With Stroke Recurrence
This individual patient data meta-analysis evaluates the association of patent foramen ovale closure on stroke recurrence according to shunt size and/or the presence of an atrial septal aneurysm.
Source: JAMA Neurology - October 10, 2022 Category: Neurology Source Type: research

Broadening Our SCOPE of Understanding Patent Foramen Ovale High-risk Features and Stroke
Paradoxical embolization of a blood clot of presumed venous origin through a patent foramen ovale (PFO) is increasingly recognized as a legitimate cause of otherwise cryptogenic ischemic stroke (CIS). The term PFO-associated stroke has been proposed, as has where and how to classify this entity in the nomenclature of various ischemic stroke subtyping systems. PFOs are common, with prevalence as high as 25% in the general population. The prevalence of PFO is further increased in patients with CIS (overall 2.9 times higher), and especially so in the subset of younger patients (<55 years, 5.1 times higher). One estimate of...
Source: JAMA Neurology - October 10, 2022 Category: Neurology Source Type: research

Perioperative Stroke Risk Reduction in Patients With Patent Foramen Ovale
This Viewpoint considers ischemic stroke risk for patients with a patent foramen ovale.
Source: JAMA Neurology - August 3, 2020 Category: Neurology Source Type: research

Prognosis of Cryptogenic Stroke With Patent Foramen Ovale at Older Ages and Implications for Trials
This systematic review and meta-analysis examines the recurrence of ischemic stroke and possible use of patent foramen ovale closure in patients aged 60 years or older.
Source: JAMA Neurology - July 6, 2020 Category: Neurology Source Type: research

Nomenclature and Potential Causation Classification of Patent Foramen Ovale –Associated Stroke
This Special Communication describes new information on strokes associated with patent foramen ovale from randomized clinical trials and meta-analyses and proposes a new clinical approach to the categorization of such strokes.
Source: JAMA Neurology - April 13, 2020 Category: Neurology Source Type: research

Left Atrial Enlargement Could Be Detected on Extended Computed Tomography Angiography —Reply
In Reply We agree with Popkirov that left atrial volume is a better marker of incident atrial fibrillation than atrial diameter; however, we did not have these data available at all of the sites participating in the New Approach Rivaroxaban Inhibition of Factor Xa in a Global Trial Versus ASA to Prevent Embolism in Embolic Stroke of Undetermined Source (NAVIGATE-ESUS) trial. Recently completed and ongoing studies will help determine if our observation has a clinical role and may provide additional data on left atrial size and function. Once all of these data are available, guidelines committees will likely make recommendat...
Source: JAMA Neurology - November 11, 2019 Category: Neurology Source Type: research

Additional Factors in Considering Patent Foramen Ovale Closure to Prevent Recurrent Ischemic Stroke
To the Editor In his Viewpoint, Kamel addresses some issues with the randomized clinical trials (RCTs) of patent foramen ovale (PFO) closure for preventing recurrent stroke and urges a judicious and evidence-based approach for patient selection. I would like to point out additional factors that further demonstrate need for extreme caution in selecting patients to undergo this procedure.
Source: JAMA Neurology - May 14, 2018 Category: Neurology Source Type: research

Additional Factors in Considering Patent Foramen Ovale Closure to Prevent Recurrent Ischemic Stroke —Reply
In Reply Powers raises several important issues that I did not address in detail in my Viewpoint about managing patent foramen ovale in patients with ischemic stroke. These additional points further highlight that many patients who are fully informed about the available data will reasonably choose medical therapy rather than patent foramen ovale closure.
Source: JAMA Neurology - May 14, 2018 Category: Neurology Source Type: research

Evidence-Based Management of Patent Foramen Ovale in Patients With Ischemic Stroke
This Viewpoint describes the results of 5 randomized clinical trials of devices that occlude patent foramen ovale, discusses the cerebrovascular outcomes associated with treatment, and outlines judicious use of closure procedures.
Source: JAMA Neurology - December 26, 2017 Category: Neurology Source Type: research

Migraine and the Risk of Carotid Artery Dissection
Stroke incidence is increasing among patients aged 40 to 60 years —faster than in older age cohorts. Preliminary evidence suggests that ischemic stroke—not hemorrhage or subarachnoid hemorrhage—accounts for the increase. Many speculate that increasing incidences of classic vascular risk factors among young patients contribute to the increased incidence of st roke. Certainly, we are all aware of the obesity epidemic and continued prevalence of smoking, leading to premature atherosclerosis. Furthermore, equally relevant causes of stroke in the young include migraine, drug abuse, cervical arterial dissections, patent fo...
Source: JAMA Neurology - March 6, 2017 Category: Neurology Source Type: research