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Bypassing Closest Stroke Center for Intracerebral Hemorrhage
Prehospital stroke triage protocols focus on enabling rapid access to 2 proven time-sensitive short-term treatments: intravenous thrombolysis for all eligible patients with disabling acute ischemic stroke and endovascular therapy (EVT) for select patients with acute ischemic stroke from large vessel occlusion (LVO). As EVT is a particularly powerful treatment with an estimated number needed to treat of 2 to 3, prehospital screening tools and protocols have been developed that prioritize identifying potential patients with LVO in the field and preferentially transporting them to EVT-capable centers, even if this means bypas...
Source: JAMA Neurology - August 21, 2023 Category: Neurology Source Type: research

Development and Validation of a Postprocedural Model to Predict Outcome After Endovascular Treatment for Ischemic Stroke
This prognostic study investigates the effectiveness of a prognostic tool to predict the functional outcome of individual patients after endovascular treatment for ischemic stroke.
Source: JAMA Neurology - July 31, 2023 Category: Neurology Source Type: research

Association Between Thrombectomy and Functional Outcomes in Pediatric Patients With Acute Ischemic Stroke From LVO
This case-control study evaluates whether pediatric patients with acute large vessel occlusion (LVO) stroke who undergo thrombectomy have better clinical outcomes than matched patients managed conservatively.
Source: JAMA Neurology - July 24, 2023 Category: Neurology Source Type: research

Efficacy and Safety of Butylphthalide in Patients With Acute Ischemic Stroke
This randomized clinical trial assesses the efficacy and safety of DL-3-n-butylphthalide in patients with acute ischemic stroke receiving reperfusion therapy of intravenous thrombolysis and/or endovascular treatment.
Source: JAMA Neurology - June 26, 2023 Category: Neurology Source Type: research

Safety and Efficacy of ApTOLL in Patients With Ischemic Stroke Undergoing Endovascular Treatment
This randomized clinical trial investigates the safety and efficacy of ApTOLL as a neuroprotectant drug for patients with ischemic stroke when given in combination with endovascular treatment.
Source: JAMA Neurology - June 20, 2023 Category: Neurology Source Type: research

Symptomatic Intracranial Hemorrhage With Tenecteplase vs Alteplase in Patients With Acute Ischemic Stroke
This cohort study evaluates rates of symptomatic intracranial hemorrhage following stroke with tenecteplase vs alteplase.
Source: JAMA Neurology - May 30, 2023 Category: Neurology Source Type: research

Dual Thrombolytic Therapy With Mutant Prourokinase and Small Bolus Alteplase for Ischemic Stroke
This randomized clinical trial of individuals with ischemic stroke assesses the safety and efficacy of treatment with a dual plasminogen activator vs usual treatment with intravenous alteplase.
Source: JAMA Neurology - May 22, 2023 Category: Neurology Source Type: research

Association of Mortality and Risk of Epilepsy With Type of Acute Symptomatic Seizure After Ischemic Stroke
This cohort study examines data for patients with acute ischemic stroke to compare the risk of poststroke mortality and epilepsy between different types of acute symptomatic seizures.
Source: JAMA Neurology - April 10, 2023 Category: Neurology Source Type: research

Outcomes After Endovascular Therapy With Procedural Sedation vs General Anesthesia in Acute Ischemic Stroke
This randomized clinical trial evaluates whether general anesthesia or procedural sedation for anterior circulation large-vessel occlusion acute ischemic stroke thrombectomy are associated with a difference in periprocedural complications and 3-month functional outcome.
Source: JAMA Neurology - April 3, 2023 Category: Neurology Source Type: research

Quantification of Penumbral Volume in Association With Time From Stroke Onset in Acute Ischemic Stroke
This cross-sectional study examines changes in the penumbral and core volumes over time to imaging in patients with acute ischemic stroke.
Source: JAMA Neurology - March 20, 2023 Category: Neurology Source Type: research

Association Between Magnitude of Differential Blood Pressure Reduction and Secondary Stroke Prevention
This meta-analysis and meta-regression of randomized clinical trials evaluates the association of magnitude of differential blood pressure reduction and recurrent stroke in patients with stroke or transient ischemic attack.
Source: JAMA Neurology - March 20, 2023 Category: Neurology Source Type: research

Multimodal Neuroimaging of Intimal Flap in a Basilar Artery Dissection
This case report describes a spontaneous dissection of the basilar artery in a 53-year-old man presenting with ischemic stroke.
Source: JAMA Neurology - March 13, 2023 Category: Neurology Source Type: research

Error in Byline, Affiliations, and Table 1
This article was corrected online.
Source: JAMA Neurology - February 6, 2023 Category: Neurology Source Type: research

Building Evidence on Safety of Thrombolysis for Patients Receiving Direct Oral Anticoagulants
Nearly 20% of patients with acute ischemic stroke (AIS) are undergoing direct oral anticoagulant (DOAC) treatment at the time of their stroke. Common indications for DOACs among these patients include stroke prevention from atrial fibrillation, treatment of venous and pulmonary thrombosis, and coronary and peripheral atherosclerotic disease. Novel indications for DOAC use are expected to emerge and may increase the proportion of patients with AIS who are undergoing treatment with DOACs. Current US and European acute stroke treatment guidelines recommend withholding intravenous thrombolysis (thrombolysis), a morbidity- and ...
Source: JAMA Neurology - January 3, 2023 Category: Neurology Source Type: research

Intravenous Thrombolysis in Patients With Ischemic Stroke and Recent Ingestion of Direct Oral Anticoagulants
This cohort study evaluates the risk of symptomatic intracranial hemorrhage associated with use of intravenous thrombolysis in patients with recent direct oral anticoagulant ingestion.
Source: JAMA Neurology - January 3, 2023 Category: Neurology Source Type: research

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