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P 164 Parietal stroke mimicking the Heidenhain variant of Creutzfeldt-Jakob Disease
The Heidenhain variant of Creutzfeldt-Jakob disease (CJD) is a rapidly progressive neurodegenerative disease with an occipito-parietal focus.It initially presents with visual disturbances such as visual agnosia or cortical blindness (Kropp et al., 1999).After presentation of early visual symptoms, rapid progression of dementia and death follows.While the Heidenhain variant matches neuropathological criteria of CJD, differential diagnosis from other neurological disorders using biomarkers from electroencephalography (EEG), magnetic resonance imaging (MRI), and cerebrospinal fluid (CSF) reveal low sensitivity and specificity...
Source: Clinical Neurophysiology - September 8, 2017 Category: Neuroscience Authors: D. Becker, D. Kramer, W. M üllges, K. Boelmans Tags: Poster Source Type: research

EP 4. Recruitment of premotor cortices in subacute stroke patients – A longitudinal fMRI study
In order to investigate changes in functional representation of hand movement after stroke we used functional magnetic resonance imaging (fMRI) during an active motor task of the affected hand before and after a three week comprehensive motor training.
Source: Clinical Neurophysiology - August 5, 2016 Category: Neuroscience Authors: U. Horn, S. Roschka, K. Eyme, A.D. Walz, T. Platz, M. Lotze Source Type: research

Reply to “The usefulness of diffusion tensor tractography for estimating the state of corticobulbar tract in stroke patients”
Diffusion tensor imaging (DTI) is an advanced magnetic resonance imaging technique used to demonstrate the structural integrity of white matter tracts. DTI has a unique advantage in visualizing the neural fiber tracts in the proximity of cerebral infarction by use of constructing three-dimensional images of white matter fiber tracts (Mori and van Zijl, 2002). A diffusion tensor tractography (DTT) study by Dr Jang investigated the injury of the corticobulbar tract (CBT) in stroke patients with dysarthria, and suggested that the evaluation of the CBT using DTT provides important information in stroke patients with bulbar sym...
Source: Clinical Neurophysiology - May 3, 2016 Category: Neuroscience Authors: Juan Du, Fang Yang, Xinfeng Liu Tags: Letter to the Editor Source Type: research

P 117. Can cerebellar theta burst stimulation improve recovery of cerebellar stroke patients?
Conclusion: These preliminary results provide novel evidence that cerebellar TBS can be used to promote functional recovery of patients with cerebellar stroke. These clinical improvement could be related to long-lasting changes in the excitability of cerebello-thalamo-cortical pathways.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: V. Ponzo, S. Bonnı̀, C. Caltagirone, G. Koch Tags: Society Proceedings Source Type: research

IS 39. Enhanced visuo-spatial and language learning with tDCS
Efficacy and effectiveness of training in conditions like chronic post-stroke aphasia or neglect, or neurodegenerative disorders like mild cognitive impairment (MCI) and Alzheimer’s disease, remain moderate only. Thus, novel strategies to enhance training success and overall behavioural outcome are urgently needed. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation tool that is now being widely used in neuroscientific and clinical research in humans, modulating cortical excitability by application of weak electrical currents in the form of direct current brain polarization.In a series of st...
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: A. Flöel, W. Suttorp, M. Meinzer, C. Breitenstein Tags: Society Proceedings Source Type: research

IS 23. Testing cortical connectivity with multifocal TMS
Multifocal transcranial magnetic stimulation (TMS) has been recently investigated as a powerful method able to detect, within a millisecond time scale, direct information on the causal connectivity between distant cortical areas. A conditioning stimulus (CS) is first used to activate putative pathways to the motor cortex from, for example, the posterior parietal cortex or the premotor cortex, while a second, test stimulus (TS), delivered over the M1 a few milliseconds later probes any changes in excitability that are produced by the CS. When tested at rest, the activation of these cortico-cortical projections may induce ei...
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: G. Koch Tags: Society Proceedings Source Type: research

IS 30. Predicting recovery of motor function after stroke-an essential role for TMS
Conclusions: TMS is a useful tool for predicting recovery of upper limb function after stroke, particularly in combination with clinical and imaging measures, as part of the PREP algorithm. The clinical benefits of tailoring rehabilitation based on the individual’s capacity for motor recovery will be discussed.
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: C. Stinear, S.J. Ackerley, M.A. Petoe, P.A. Barber, W.D. Byblow Tags: Society Proceedings Source Type: research

IS 12. Plasticity in stroke patients: Why brain stimulation may (not) work
Advances in brain imaging techniques allow us to study not just what the brain looks like but how it works. When applied to people who have suffered a stroke this technology has demonstrated reorganization of the way surviving brain regions function. These findings give hope to the idea that new treatments can be designed and more effectively targeted towards individual patients.So how can we measure these changes in organization in the human brain? Brain imaging techniques such as functional magnetic resonance imaging (fMRI) have developed to the point where a detailed appreciation of the damage to brain structures and th...
Source: Clinical Neurophysiology - September 19, 2013 Category: Neuroscience Authors: N. Ward Tags: Society Proceedings Source Type: research

P 117. Can cerebellar theta burst stimulation improve recovery of cerebellar stroke patients?
Conclusion: These preliminary results provide novel evidence that cerebellar TBS can be used to promote functional recovery of patients with cerebellar stroke. These clinical improvement could be related to long-lasting changes in the excitability of cerebello-thalamo-cortical pathways.
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: V. Ponzo, S. Bonnı̀, C. Caltagirone, G. Koch Tags: Society Proceedings Source Type: research

IS 30. Predicting recovery of motor function after stroke-an essential role for TMS
Conclusions: TMS is a useful tool for predicting recovery of upper limb function after stroke, particularly in combination with clinical and imaging measures, as part of the PREP algorithm. The clinical benefits of tailoring rehabilitation based on the individual’s capacity for motor recovery will be discussed.
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: C. Stinear, S.J. Ackerley, M.A. Petoe, P.A. Barber, W.D. Byblow Tags: Society Proceedings Source Type: research

IS 39. Enhanced visuo-spatial and language learning with tDCS
Efficacy and effectiveness of training in conditions like chronic post-stroke aphasia or neglect, or neurodegenerative disorders like mild cognitive impairment (MCI) and Alzheimer’s disease, remain moderate only. Thus, novel strategies to enhance training success and overall behavioural outcome are urgently needed. Transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation tool that is now being widely used in neuroscientific and clinical research in humans, modulating cortical excitability by application of weak electrical currents in the form of direct current brain polarization.In a series of st...
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: A. Flöel, W. Suttorp, M. Meinzer, C. Breitenstein Tags: Society Proceedings Source Type: research

IS 12. Plasticity in stroke patients: Why brain stimulation may (not) work
Advances in brain imaging techniques allow us to study not just what the brain looks like but how it works. When applied to people who have suffered a stroke this technology has demonstrated reorganization of the way surviving brain regions function. These findings give hope to the idea that new treatments can be designed and more effectively targeted towards individual patients.So how can we measure these changes in organization in the human brain? Brain imaging techniques such as functional magnetic resonance imaging (fMRI) have developed to the point where a detailed appreciation of the damage to brain structures and th...
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: N. Ward Tags: Society Proceedings Source Type: research

IS 23. Testing cortical connectivity with multifocal TMS
Multifocal transcranial magnetic stimulation (TMS) has been recently investigated as a powerful method able to detect, within a millisecond time scale, direct information on the causal connectivity between distant cortical areas. A conditioning stimulus (CS) is first used to activate putative pathways to the motor cortex from, for example, the posterior parietal cortex or the premotor cortex, while a second, test stimulus (TS), delivered over the M1 a few milliseconds later probes any changes in excitability that are produced by the CS. When tested at rest, the activation of these cortico-cortical projections may induce ei...
Source: Clinical Neurophysiology - September 1, 2013 Category: Neuroscience Authors: G. Koch Tags: Society Proceedings Source Type: research