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Source: Lancet Neurology
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Total 215 results found since Jan 2013.
In Context Hemiplegic migraine and stroke in Mary Shelley
Mary Wollstonecraft Godwin Shelley (1797 –1851) was the author of Frankenstein; or, the Modern Prometheus. In 1839, she had recurrent, severe headaches whose severity, location, and duration were variable.1 These headaches were associated with dizziness; pain in the legs, right hand, and right eye; and episodes of transient partial paral ysis of the right leg and hand, with tremors, convulsive seizures, and severe pain on the top of the head.2 She was diagnosed with psychosomatic illness in 1842, “functional derangement in the nerves or brain” in 1845, and back pain and “neuralgia of the heart” in 1846.
Source: Lancet Neurology - March 14, 2018 Category: Neurology Authors: Philippe Charlier, Otto Appenzeller, Saudamini Deo, Antonio Perciaccante, Raffaella Bianucci Tags: In Context Source Type: research
In Context Yogeshwar Kalkonde
Yogeshwar Kalkonde is a neurologist and a public health researcher working at the Society for Education, Action and Research in Community Health in Gadchiroli, India. His research focuses on stroke as a public health problem in rural India, and he is currently investigating community-based interventions to reduce stroke mortality.
Source: Lancet Neurology - March 14, 2018 Category: Neurology Tags: In Context Source Type: research
Correspondence The SeLECT score is useful to predict post-stroke epilepsy
We read with interest Josef Finsterer's Comment1 on our Article2 on the SeLECT score as a prognostic model for prediction of late seizures after ischaemic stroke. He does not take into account three major points about prognostic modelling3 and the differences from aetiological research.4 First, for a prognostic model to be clinically useful, the entry data have to be routinely and widely available and easily applicable in the clinical setting. Second, for a model to be relevant, it must provide outcome information satisfying the needs of the user at, or soon after, the event.
Source: Lancet Neurology - February 15, 2018 Category: Neurology Authors: Marian Galovic, Nico D öhler, Mark R Keezer, John S Duncan, Josemir W Sander, Matthias J Koepp, Barbara Tettenborn, SeLECT Score Collaborators Tags: Correspondence Source Type: research
In Context Expecting exoskeletons for more than spinal cord injury
Exoskeletons that can help the paralysed to walk are available now. But they might also help patients with stroke damage, cerebral palsy, multiple sclerosis, or Parkinson's disease. So when might they be ready to take home? Adrian Burton investigates.
Source: Lancet Neurology - February 13, 2018 Category: Neurology Authors: Adrian Burton Tags: In Context Source Type: research
Comment The SeLECT score is inappropriate to predict post-stroke epilepsy
Causes of post-stroke epilepsy are manifold and not just restricted to the stroke itself (primary post-stroke epilepsy). These causes range from premorbid conditions already present before the stroke, to morbidity that develops after the stroke, either as a complication of, or independent of, the stroke. Seizures associated with a pre-existing disposition (eg, meningitis, head trauma, or encephalopathy caused by, for example, diabetes or hypertension) can be triggered by stroke or by co-pathologies developing after a stroke (secondary post-stroke epilepsy).
Source: Lancet Neurology - January 18, 2018 Category: Neurology Authors: Josef Finsterer Tags: Comment Source Type: research
Articles Prediction of late seizures after ischaemic stroke with a novel prognostic model (the SeLECT score): a multivariable prediction model development and validation study
This easily applied instrument was shown to be a good predictor of the risk of late seizures after stroke in three external validation cohorts and is freely available as a smartphone app. The SeLECT score has the potential to identify individuals at high risk of seizures and is a step towards more personalised medicine. It can inform the selection of an enriched population for antiepileptogenic treatment trials and will guide the recruitment for biomarker studies of epileptogenesis.
Source: Lancet Neurology - January 18, 2018 Category: Neurology Authors: Marian Galovic, Nico D öhler, Barbara Erdélyi-Canavese, Ansgar Felbecker, Philip Siebel, Julian Conrad, Stefan Evers, Michael Winklehner, Tim J von Oertzen, Hans-Peter Haring, Anna Serafini, Giorgia Gregoraci, Mariarosaria Valente, Francesco Janes, Gian Tags: Articles Source Type: research
2017 Round-up Stroke research in 2017: surgical progress and stem-cell advances
To show that progress has been made in stroke intervention, it is possible to cite several substantial advances over the past year. Beginning with a clinical highlight: three randomised trials1 –3 that tested the safety and efficacy of patent foramen ovale (PFO) closure after a cryptogenic stroke reported their results simultaneously. The CLOSE trial1 enrolled patients who had a recent PFO-attributed stroke associated with either an atrial septal aneurysm or a large, right-to-left intera trial shunt.
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: Yilong Wang, Yongjun Wang Tags: 2017 Round-up Source Type: research
Comment HERMES: a helpful messenger in the anaesthesia for thrombectomy debate?
The effectiveness of endovascular treatment in patients with anterior circulation ischaemic stroke due to large artery occlusion is firmly established, although optimal anaesthesia for the procedure remains contentious. Studies have suggested that endovascular treatment under general anaesthesia (GA) is associated with a worse outcome than when treatment is done without GA. However, because patients with more severe stroke and comorbidities are more likely to receive GA, there is potential for confounding by indication.
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: Judith Dinsmore Tags: Comment Source Type: research
Articles Effect of general anaesthesia on functional outcome in patients with anterior circulation ischaemic stroke having endovascular thrombectomy versus standard care: a meta-analysis of individual patient data
Worse outcomes after endovascular thrombectomy were associated with GA, after adjustment for baseline prognostic variables. These data support avoidance of GA whenever possible. The procedure did, however, remain effective versus standard care in patients treated under GA, indicating that treatment should not be withheld in those who require anaesthesia for medical reasons.
Source: Lancet Neurology - December 16, 2017 Category: Neurology Authors: Bruce C V Campbell, Wim H van Zwam, Mayank Goyal, Bijoy K Menon, Diederik W J Dippel, Andrew M Demchuk, Serge Bracard, Philip White, Antoni D ávalos, Charles B L M Majoie, Aad van der Lugt, Gary A Ford, Natalia Pérez de la Ossa, Michael Kelly, Romain Bo Tags: Articles Source Type: research
In Context Telestroke: India's solution to a public health-care crisis
Stroke is a leading cause of morbidity and mortality in India. Yet much of the country is composed of rural, low-income and middle-income communities that lack access to essential neurological care. Telemedicine is helping to tackle this important problem. Jacquelyn Corley investigates.
Source: Lancet Neurology - November 29, 2017 Category: Neurology Authors: Jacquelyn Corley Tags: In Context Source Type: research
In Context Sonja Scholz
Sonja Scholz is a neurologist –scientist specialised in neurodegenerative diseases. She obtained her medical doctorate from the Medical University Innsbruck, Austria and her PhD in neurogenomics from University College London, UK. She trained as a postdoctoral fellow in neurogenetics before completing an internship and neurolo gy residency training at Johns Hopkins University, USA. In 2015, she joined the National Institute of Neurological Disorders and Stroke (Bethesda, USA) as an Assistant Clinical Investigator to study neurodegenerative diseases using modern genomic technologies.
Source: Lancet Neurology - November 15, 2017 Category: Neurology Tags: In Context Source Type: research
In Context Trying to change the stroke landscape in Nigeria
The dearth of stroke awareness and specialised medical services in Nigeria leaves plenty for new NGOs to do. But the problems they face, including their own capacity building, are many. Can their efforts turn the tide? Adrian Burton investigates.
Source: Lancet Neurology - October 11, 2017 Category: Neurology Authors: Adrian Burton Tags: In Context Source Type: research
In Context Journey in an unknown country
In a garden, an old woman who has experienced a stroke approaches tentatively some snow on the ground. When prompted to define what she sees, at first she is unable to give it a name. Yet, when she takes some in her hand, the word “snow” suddenly materialises in her mind. The woman then tries to explain what is happening in her mind: “If I pick this…stuff up in my hand, then…I know its name. I didn't have to pick it up to know…what it was.”
Source: Lancet Neurology - October 10, 2017 Category: Neurology Authors: Marco De Ambrogi Tags: In Context Source Type: research
Global Health Metrics Global, regional, and national burden of neurological disorders during 1990 –2015: a systematic analysis for the Global Burden of Disease Study 2015
Neurological disorders are an important cause of disability and death worldwide. Globally, the burden of neurological disorders has increased substantially over the past 25 years because of expanding population numbers and ageing, despite substantial decreases in mortality rates from stroke and communicable neurological disorders. The number of patients who will need care by clinicians with expertise in neurological conditions will continue to grow in coming decades. Policy makers and health-care providers should be aware of these trends to provide adequate services.
Source: Lancet Neurology - September 17, 2017 Category: Neurology Authors: GBD 2015 Neurological Disorders Collaborator Group Tags: Global Health Metrics Source Type: research
