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Coronary flow velocity reserve predicts adverse prognosis in women with angina and no obstructive coronary artery disease: results from the iPOWER study
Conclusion  Assessment of CFVR by echocardiography is feasible and predictive of adverse outcome in women with angina and no obstructive CAD. Results support a more aggressive preventive management of these patients and underline the need for trials targeting CMD.
Source: European Heart Journal - December 1, 2020 Category: Cardiology Source Type: research

Gone with wind: a novel biodegradable occluder for percutaneous closure of patent foramen ovale
A 42-year-old man with a history of cryptogenic stroke and sequela free after medical therapy was found to have a patent foramen ovale (PFO) by transoesophageal echocardiography (TEE,Panel A, arrowhead indicates the PFO; Ao, aorta; LA, left atrium; RA, right atrium). Given a RoPE score of 7, he was referred for percutaneous PFO closure. A 24  mm × 24 mm fully biodegradable occluder (Pancy® occluder, ChiCTR1900024036,Panel E, arrowhead indicates marker) was delivered and deployed via a 10-Fr sheath (Mallow® delivery system) under florescent angiography and TEE (Panel B, arrowhead indicates the marker on occluder while ...
Source: European Heart Journal - October 2, 2020 Category: Cardiology Source Type: research

Clinical impact of direct stenting and interaction with thrombus aspiration in patients with ST-segment elevation myocardial infarction undergoing percutaneous coronary intervention: Thrombectomy Trialists Collaboration
ConclusionDirect stenting rates were higher in patients randomized to thrombus aspiration. Clinical outcomes and myocardial reperfusion measures did not differ significantly between DS and conventional stenting and there was no interaction with thrombus aspiration.
Source: European Heart Journal - April 21, 2018 Category: Cardiology Source Type: research

Modern prevention: genetic testing, vascular imaging, machine learning, and drug safety
Traditionally, prevention has been divided into primary and secondary prevention. While the former focused on individuals considered healthy, the latter was designed to avoid future events in those who already had coronary artery disease, myocardial infarction, or stroke.1 However, this distinction is no longer useful, as many asymptomatic individuals do have atherosclerotic lesions such as plaques and calcifications upon modern imaging, and not all subjects with suspected symptoms have atherosclerotic vascular disease.2 –4 This Focus Issue on Prevention addresses these important issues. In a firstCurrent Opinion entitle...
Source: European Heart Journal - June 13, 2017 Category: Cardiology Source Type: research

Gut microbiota-dependent trimethylamine N-oxide in acute coronary syndromes: a prognostic marker for incident cardiovascular events beyond traditional risk factors
Conclusion</div>Plasma TMAO levels among patients presenting with chest pain predict both near- and long-term risks of incident cardiovascular events, and may thus provide clinical utility in risk stratification among subjects presenting with suspected ACS.</span>
Source: European Heart Journal - January 10, 2017 Category: Cardiology Source Type: research

Effective anti-thrombotic therapy without stenting: intravascular optical coherence tomography-based management in plaque erosion (the EROSION study)
Conclusion</div>For patients with ACS caused by plaque erosion, conservative treatment with anti-thrombotic therapy without stenting may be an option.</span>
Source: European Heart Journal - August 29, 2016 Category: Cardiology Source Type: research

Coronary microcirculatory pathophysiology: can we afford it to remain a black box?
<span class="paragraphSection"><div class="boxTitle">Abstract</div>Coronary microvascular networks play the key role in determining blood flow distribution in the heart. Matching local blood supply to tissue metabolic demand entails continuous adaptation of coronary vessels via regulation of smooth muscle tone and structural dilated vessel diameter. The importance of coronary microcirculation for relevant pathological conditions including angina in patients with normal or near-normal coronary angiograms [microvascular angina (MVA)] and heart failure with preserved ejection fraction (HFpEF) is increasingly...
Source: European Heart Journal - February 1, 2016 Category: Cardiology Source Type: research

Elastin fragmentation in atherosclerotic mice leads to intraplaque neovascularization, plaque rupture, myocardial infarction, stroke, and sudden death
Conclusions Elastin fragmentation plays a key role in plaque destabilization and rupture. ApoE–/–Fbn1C1039G+/– mice represent a unique model of acute plaque rupture with human-like complications.
Source: European Heart Journal - May 1, 2015 Category: Cardiology Authors: Van der Donckt, C., Van Herck, J. L., Schrijvers, D. M., Vanhoutte, G., Verhoye, M., Blockx, I., Van Der Linden, A., Bauters, D., Lijnen, H. R., Sluimer, J. C., Roth, L., Van Hove, C. E., Fransen, P., Knaapen, M. W., Hervent, A.-S., De Keulenaer, G. W., B Tags: BASIC SCIENCE Source Type: research

Peripheral arterial disease and critical limb ischaemia: still poor outcomes and lack of guideline adherence
Conclusion Regardless of recent advances in PAD treatment, current outcomes remain poor especially in CLI. Despite overwhelming evidence for reduction of limb loss by revascularization, CLI patients still received significantly less angiographies and revascularizations.
Source: European Heart Journal - April 14, 2015 Category: Cardiology Authors: Reinecke, H., Unrath, M., Freisinger, E., Bunzemeier, H., Meyborg, M., Luders, F., Gebauer, K., Roeder, N., Berger, K., Malyar, N. M. Tags: Peripheral artery disease Source Type: research

Management of venous thrombo-embolism: an update
Venous thrombo-embolism is the third most frequent acute cardiovascular syndrome after myocardial infarction and stroke. Recently published landmark trials paved the way for significant progress in the management of the disease and provided the evidence for the ESC Pulmonary Embolism (PE) Guidelines 2014 update. Risk stratification strategies for non-high-risk PE continue to evolve, with an increasing emphasis on clinical prediction rules and right ventricular (RV) assessment on computed tomographic pulmonary angiography. In the field of anticoagulation treatment, pharmacogenetic testing for vitamin K antagonists on top of...
Source: European Heart Journal - November 1, 2014 Category: Cardiology Authors: Konstantinides, S., Torbicki, A. Tags: Frontiers in cardiovascular medicine Source Type: research

Coronary artery disease severity and aortic stenosis: clinical outcomes according to SYNTAX score in patients undergoing transcatheter aortic valve implantation
Conclusions Severity of CAD appears to be associated with impaired clinical outcomes at 1 year after TAVI. Patients with SS >22 receive less complete revascularization and have a higher risk of cardiovascular death, stroke, or MI than patients without CAD or low SS.
Source: European Heart Journal - October 1, 2014 Category: Cardiology Authors: Stefanini, G. G., Stortecky, S., Cao, D., Rat-Wirtzler, J., O'Sullivan, C. J., Gloekler, S., Buellesfeld, L., Khattab, A. A., Nietlispach, F., Pilgrim, T., Huber, C., Carrel, T., Meier, B., Juni, P., Wenaweser, P., Windecker, S. Tags: Valvular heart disease Source Type: research

Ticagrelor vs. clopidogrel in patients with non-ST-elevation acute coronary syndrome with or without revascularization: results from the PLATO trial
Conclusion In patients with NSTE-ACS, benefit of ticagrelor over clopidogrel in reducing ischaemic events and total mortality was consistent with the overall PLATO trial, independent of actually performed revascularization during the initial 10 days.
Source: European Heart Journal - August 14, 2014 Category: Cardiology Authors: Lindholm, D., Varenhorst, C., Cannon, C. P., Harrington, R. A., Himmelmann, A., Maya, J., Husted, S., Steg, P. G., Cornel, J. H., Storey, R. F., Stevens, S. R., Wallentin, L., James, S. K. Tags: Acute coronary syndromes Source Type: research

Prognostic value of choline and betaine depends on intestinal microbiota-generated metabolite trimethylamine-N-oxide
Conclusion Elevated plasma levels of choline and betaine are each associated with incident MACE risk independent of traditional risk factors. However, high choline and betaine levels are only associated with higher risk of future MACE with concomitant increase in TMAO.
Source: European Heart Journal - April 7, 2014 Category: Cardiology Authors: Wang, Z., Tang, W. H. W., Buffa, J. A., Fu, X., Britt, E. B., Koeth, R. A., Levison, B. S., Fan, Y., Wu, Y., Hazen, S. L. Tags: BASIC SCIENCE Source Type: research

Long-term impact on healthcare resource utilization of statin treatment, and its cost effectiveness in the primary prevention of cardiovascular disease: a record linkage study
Conclusion Five years' primary prevention treatment of middle-aged men with a statin significantly reduces healthcare resource utilization, is cost saving, and increases QALYs. Treatment of even younger, lower risk individuals is likely to be cost-effective.
Source: European Heart Journal - February 1, 2014 Category: Cardiology Authors: McConnachie, A., Walker, A., Robertson, M., Marchbank, L., Peacock, J., Packard, C. J., Cobbe, S. M., Ford, I. Tags: Prevention and epidemiology Source Type: research

Urinary excretion of kynurenine and tryptophan, cardiovascular events, and mortality after elective coronary angiography
Conclusion A novel urinary inflammation marker, KTR, is strongly associated with adverse prognosis in patients with suspected stable CAD. Underlying pathomechanisms should be further elucidated.
Source: European Heart Journal - September 7, 2013 Category: Cardiology Authors: Pedersen, E. R., Svingen, G. F. T., Schartum-Hansen, H., Ueland, P. M., Ebbing, M., Nordrehaug, J. E., Igland, J., Seifert, R., Nilsen, R. M., Nygard, O. Tags: Coronary artery disease Source Type: research