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Efficacy and safety of rivaroxaban compared with warfarin in patients with peripheral artery disease and non-valvular atrial fibrillation: insights from ROCKET AF
Conclusion Patients with PAD in ROCKET AF did not have a statistically significant higher risk of stroke or systemic embolism than patients without PAD, and there were similar efficacy outcomes in patients treated with rivaroxaban and warfarin. In PAD patients, there was a higher risk of major bleeding or NMCR bleeding with rivaroxaban when compared with warfarin (interaction P = 0.037). Further investigation is warranted to validate this subgroup analysis and determine the optimal treatment in this high-risk cohort of AF patients with PAD.
Source: European Heart Journal - January 21, 2014 Category: Cardiology Authors: Jones, W. S., Hellkamp, A. S., Halperin, J., Piccini, J. P., Breithardt, G., Singer, D. E., Fox, K. A. A., Hankey, G. J., Mahaffey, K. W., Califf, R. M., Patel, M. R. Tags: Atrial fibrillation Source Type: research

Heterogeneous impact of classic atherosclerotic risk factors on different arterial territories: the EPIC-Norfolk prospective population study
Conclusion The heterogeneity in the risk factor–CVD associations supports the concept of pathophysiological differences between atherosclerotic CVD manifestations and could have implications for CVD prevention.
Source: European Heart Journal - March 14, 2016 Category: Cardiology Authors: Stoekenbroek, R. M., Boekholdt, S. M., Luben, R., Hovingh, G. K., Zwinderman, A. H., Wareham, N. J., Khaw, K.-T., Peters, R. J. G. Tags: Prevention and epidemiology Source Type: research

Genetic predisposition to smoking in relation to 14 cardiovascular diseases
ConclusionThis MR study supports a causal association between smoking and a broad range of CVDs, in particular, coronary artery disease, heart failure, abdominal aortic aneurysm, ischaemic stroke, transient ischaemic attack, peripheral arterial disease, and arterial hypertension.
Source: European Heart Journal - April 16, 2020 Category: Cardiology Source Type: research

CardioPulse Articles * Andreas Gruntzig's beginnings started in peripheral arteries * Developments in the treatment of aortic aneurysms in 2014 * Interventional treatment of venous thromboembolism * From academia to industry * Working in industry requires wanting to make medicines * STEMI and stroke: distant cousins at best
Source: European Heart Journal - March 7, 2015 Category: Cardiology Tags: CardioPulse Source Type: research

Prevalence, incidence, and outcomes across cardiovascular diseases in homeless individuals using national linked electronic health records
Conclusion  CVD in homeless individuals has high prevalence, incidence, and 1-year mortality risk post-diagnosis with earlier onset, and high burden of risk factors. Inclusion health and social care strategies should reflect this high preventable and treatable burden, which is increasingly important in the current COVID-19 context.
Source: European Heart Journal - September 10, 2020 Category: Cardiology Source Type: research