Query: stroke

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Source: Neurological Research

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Total 184 results found since Jan 2013.

Collateral circulation alters downstream hemodynamic stress caused by intracranial atherosclerotic stenosis.
CONCLUSION: An anatomically severe (70-99%) symptomatic ICAS lesion may generate significant hemodynamic stress downstream as assessed by the indicator FF, particularly in patients with poor collateral circulation. Further, good collateralization may mitigate this hemodynamic impact, partially explaining the protective effect of collateral circulation against recurrent stroke in such patients. PMID: 28436268 [PubMed - as supplied by publisher]
Source: Neurological Research - April 25, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Ulinastatin downregulates TLR4 and NF-kB expression and protects mouse brains against ischemia/reperfusion injury.
CONCLUSION: These results showed that UTI protected the brain against ischemic injury which may be due to the alleviation of inflammation reaction in early stage through downregulating TLR4 and NF-κB expression. PMID: 28191863 [PubMed - as supplied by publisher]
Source: Neurological Research - February 15, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Plasma protein profiling for potential biomarkers in the early diagnosis of Alzheimer's disease.
DISCUSSION: Our results suggest that altered expression levels of these proteins in plasma may yield candidate biomarkers for the early diagnosis of AD. ABBREVIATIONS: AD, Alzheimer's disease; FAST, Functional Assessment Staging; 2D-DIGE, two-dimensional differential gel electrophoresis; MALDI-TOF/TOF/MS, matrix-assisted laser desorption ionization time-of-flight tandem mass spectrometry; CSF, cerebrospinal fluid; Aβ, amyloid beta; MMSE, Mini Mental State Examination; MRI, magnetic resonance imaging; NINCDS-ADRDA, National Institute for Neurological Diseases and Stroke/Alzheimer's Disease and Related Disorders Associa...
Source: Neurological Research - January 23, 2017 Category: Neurology Tags: Neurol Res Source Type: research

The association between hyperglycemia and the prognosis of acute spontaneous intracerebral hemorrhage.
CONCLUSION: Hyperglycemia was associated with neurological severity of sICH, but not with 90-day outcomes. PMID: 28019142 [PubMed - as supplied by publisher]
Source: Neurological Research - December 27, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Effect of Fluosol-DA and hetastarch on local cerebral blood flow, cortical O2 availability and computerized EEG data during cerebral ischaemia.
This study was designed to assess the effects of volume expansion with Fluosol-DA and hetastarch on local cerebral blood flow (CBF), cortical O2 availability (O2a) and computerized EEG power data during cerebral ischaemia in a primate stroke model. Focal cerebral ischaemia was produced in 20 anaesthetized Macaca monkeys by right unilateral middle cerebral artery (MCA) occlusion by the transorbital technique. Following occlusion of the right MCA, monkeys were randomized into one of the following treatment groups: Group A - Fluosol-DA 15 ml kg(-1) i.v. + 40% O2; Group B - Fluosol-DA 15 ml kg(-1) i.v. + 100% O2; Group C-hetas...
Source: Neurological Research - November 10, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Carotid artery disease and low cerebral perfusion pressure: symptomatology, operative risk and outcome.
Authors: Schroeder T, Utzon NP, Aabech J, Sillesen H, Sørensen PS, Engell HC Abstract Direct internal carotid artery blood pressure measurements in patients undergoing carotid endarterectomy identified 49 patients, among 239 consecutive cases (21%), who had a reduction in perfusion pressure of 20% or more. The clinical history, objective findings and angiographic data were compared with those of a control group of a further 49 patients selected from the remaining patients operated on over the same period. The two groups were compared for short- and long-term outcome of surgery. We were unable to delineate a sympto...
Source: Neurological Research - November 10, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Transesophageal echocardiography in patients less than 60 years of age without obvious cardiac source of embolism.
Authors: Nighoghossian N, Perinetti M, Barthelet M, Adeleine P, Trouillas P Abstract Minor potential cardioembolic sources of stroke such as atrial septal aneurysms (ASA) or patent foramen ovale (PFO) are important risk factors for cryptogenic stroke. We aim to determine the prevalence of these abnormalities through an exhaustive etiological workup including transesophageal echocardiography and cervical arteries assessment in stroke patients younger than 60 years of age who had no evidence of a significant source of embolism. We classified 118 stroke patients into four groups according to transesophageal echocardio...
Source: Neurological Research - November 10, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Electrical stimulation of cerebellar fastigial nucleus protects against cerebral ischemic injury by PPAR γ upregulation.
CONCLUSION: Our results as described above suggested that FNS confers neuroprotection by upregulated PPARγ. PMID: 27819182 [PubMed - as supplied by publisher]
Source: Neurological Research - November 9, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Association of promoter polymorphism -857C/T (rs1799724) in tumor necrosis factor gene with intracerebral hemorrhage in Korean males.
CONCLUSION: These results suggest that promoter polymorphism of TNF gene, -857C/T, may be involved in the susceptibility of ICH in males. PMID: 27809686 [PubMed - as supplied by publisher]
Source: Neurological Research - November 6, 2016 Category: Neurology Tags: Neurol Res Source Type: research

A modified method to reduce variable outcomes in a rat model of four-vessel arterial occlusion.
CONCLUSIONS: In conclusion, this modified model provides a reliable tool for ischemic stroke research. PMID: 27796195 [PubMed - as supplied by publisher]
Source: Neurological Research - November 1, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotective effect of ischemic preconditioning via modulating the expression of cerebral miRNAs against transient cerebral ischemia in diabetic rats.
In this study, we aimed to evaluate the effect of the Ischemic preconditioning (IPreC) on the expression profile of cerebral miRNAs against stroke by induced transient middle cerebral artery occlusion (MCAo) in diabetic rats. METHODS: Eighty male Spraque Dawley rats were allocated to eight groups. In order to evaluate the expression profile of miRNAs, we induced transient MCAo seven days after STZ-induced diabetes (DM). Also we performed IPreC 72 h before transient MCAo to assess whether IPreC could have a neuroprotective effect against ischemia-reperfusion injury. RESULTS: The general characteristics of STZ-treat...
Source: Neurological Research - September 18, 2016 Category: Neurology Tags: Neurol Res Source Type: research

A new clinically relevant model for intracranial atherosclerosis in rats.
CONCLUSIONS: A rat model of intracranial atherosclerosis was effectively developed by high-cholesterol diet and L-NAME administration. This clinically relevant model would be beneficial for studying ICAS. PMID: 27477859 [PubMed - as supplied by publisher]
Source: Neurological Research - August 3, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Association of platelet-to-lymphocyte ratio with silent brain infarcts in patients with paroxysmal atrial fibrillation.
In this study, we aimed to evaluate whether the inflammation as measured by increased platelet to lymphocyte ratio (PLR) predispose to silent infarcts in patients with paroxysmal atrial fibrillation (PAF). METHODS: The present study investigated a total of 48 new diagnosed patients with PAF who had no signs of stroke. PLR, which was calculated as the ratio of the platelet count to the lymphocyte count, C-reactive protein and erythrocyte sedimentation rate were measured due to evaluate inflammatory state. Magnetic resonance imaging (MRI) was performed to evaluate the presence of silent brain infarcts (SBIs) in patients....
Source: Neurological Research - July 28, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Intra- and extracranial atherosclerotic disease: casting a new light on emerging trends.
Authors: Ding J, Wang X Abstract Intra- and extracranial atherosclerotic stenosis has been shown to be associated with an increased risk of secondary stroke mortality. Advances in invasive and non-invasive imaging modalities have improved analysis of hemodynamic changes and allowed better delineation of the integrity of intracranial collateralization and plague morphology in patients with artery stenosis. This review focuses on new imaging modalities and clinical applications of currently available techniques, and provides significant insight into future directions in comprehensive analysis of intra- and extracrani...
Source: Neurological Research - July 3, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Diagnostic accuracy of somatosensory evoked potential and electroencephalography during carotid endarterectomy.
CONCLUSION: The diagnostic accuracy of multimodality IONM during CEA is higher than an approach using single modality IONM. Simultaneous EEG and SSEP monitoring improves the likelihood of detecting periprocedural strokes after CEA. Neuro protective therapies to prevent periprocedural strokes can be based on changes in SSEP and EEG during CEA. PMID: 27342607 [PubMed - as supplied by publisher]
Source: Neurological Research - June 29, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Local cerebral hypothermia induced by selective infusion of cold lactated ringer's: a feasibility study in rhesus monkeys.
CONCLUSION: Local infusion of ice-cold lactated Ringer's solution via micro-catheter is a safe and effective method for selective cerebral hypothermia. This cooling method could potentially be developed as a new treatment in acute ischemic stroke. PMID: 27320250 [PubMed - in process]
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

The correlation of D-dimer levels with patient outcomes in acute ischemic cerebrovascular disease complicating coronary heart disease.
CONCLUSIONS: AICVD patients complicating CHD is very common in clinical practice. The AICVD patients that complicating CHD showed worse outcomes within 90 days after initial onset of stroke. The D-dimer levels of patients with AICVD complicating CHD were higher. Patients in the CHD group, whose D-dimer levels were higher than the normal standard, had worst outcomes. Paying close attention to the stage of the coronary artery disease and indicators of the coagulation-fibrinolysis is beneficial in the optimization of the clinical treatment for AICVD patients. Maybe the results of this study could provide some reference for s...
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Multi-mode CT in the evaluation of leptomeningeal collateral flow and the related factors: comparing with digital subtraction angiography.
DISCUSSION: Our data showed that multi-mode CT score has a high value in predicting leptomeningeal collateral flow in ischemic stroke. PMID: 27320244 [PubMed - in process]
Source: Neurological Research - June 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Internal maxillary artery to intracranial artery bypass: a case series of 31 patients with chronic internal carotid/middle cerebral arterial-sclerotic steno-occlusive disease.
CONCLUSIONS: By supplying an adequate flow to a larger flow territory of chronically stenotic/occlusive major cerebral arteries, IMA bypass surgery is efficient for restoring hemodynamics in selected patients and improving their neurological deficits. PMID: 27122096 [PubMed - as supplied by publisher]
Source: Neurological Research - April 30, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Animal models of spontaneous intracerebral hemorrhage.
CONCLUSIONS: While all of the spontaneous ICH models have some advantages, the disadvantages include the sporadic time of onset of ICH and variability in size and location of ICH. Since there are no known efficacious treatments for ICH, it is not known if findings in the animal models will find treatments that are effective in humans. PMID: 27098341 [PubMed - as supplied by publisher]
Source: Neurological Research - April 22, 2016 Category: Neurology Tags: Neurol Res Source Type: research

The role of Akt (protein kinase B) and protein kinase C in ischemia-reperfusion injury.
Authors: Zhao EY, Efendizade A, Cai L, Ding Y Abstract Stroke is a leading cause of long-term disability and death in the United States. Currently, tissue plasminogen activator (tPA), is the only Food and Drug Administration-approved treatment for acute ischemic stroke. However, the use of tPA is restricted to a small subset of acute stroke patients due to its limited 3-h therapeutic time window. Given the limited therapeutic options at present and the multi-factorial progression of ischemic stroke, emphasis has been placed on the discovery and use of combination therapies aimed at various molecular targets contrib...
Source: Neurological Research - April 21, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Normobaric hyperoxia retards the evolution of ischemic brain tissue toward infarction in a rat model of transient focal cerebral ischemia.
Conclusions: Our results demonstrate that NBO treatment given during cerebral ischemia retards the evolution of ischemic brain tissue toward infarction and NBO-preserved cortical tissue survives better than NBO-preserved striatal tissue during the phase of reperfusion. PMID: 27078693 [PubMed - as supplied by publisher]
Source: Neurological Research - April 16, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Cortical and subcortical vascular hypointensity on T2* weighted imaging in moyamoya disease.
CONCLUSION: CSVH on T2* WI may be a useful tool for diagnosing and evaluating the extent of moyamoya disease. Our small series study shows that revascularization surgery can decrease the number of CSVH. PMID: 26901097 [PubMed - as supplied by publisher]
Source: Neurological Research - February 25, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotection by combination of resveratrol and enriched environment against ischemic brain injury in rats.
DISCUSSION: Altogether, the combined therapy of RV and EE showed a clearly enhanced neuroprotective effect, compared to RV or EE monotherapy, which might be a new strategy for the treatment of ischemic brain injury. PMID: 26883584 [PubMed - as supplied by publisher]
Source: Neurological Research - February 19, 2016 Category: Neurology Tags: Neurol Res Source Type: research

Clinical features and outcomes in 154 patients with haemorrhagic moyamoya disease: comparison of conservative treatment and surgical revascularization.
CONCLUSIONS: Age at the initial bleeding is a risk factor for rebleeding in haemorrhagic MMD. Although surgical revascularization showed the tendency to decrease the rebleeding rate, there was no statistical difference between direct revascularization, indirect revascularization, combined revascularization and conservative treatment in preventing rebleeding. Further study is needed to determine whether surgical revascularization is effective in select population or with certain techniques. PMID: 26159234 [PubMed - as supplied by publisher]
Source: Neurological Research - July 12, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Trains of electrical stimulation of the trapezius muscles redistribute the frequencies of body oscillations during stance.
Authors: Nhouvannasak V, Clément S, Manto M Abstract We investigated the postural effects of trains of electrical stimulation (TES) applied unilaterally or bilaterally on the trapezius muscle in 20 healthy subjects (mean age: 23.1 ± 1.33 years; F/M: 8/12). The anterior-posterior (AP) displacements (AP axis), medio-lateral displacements (ML axis) and total travelled distances (TTW) of the centre of pressure (COP) remained unchanged with TES. However, detailed spectral analysis of COP oscillations revealed a marked decrease of the magnitudes of peak power spectral density (peak PSD) following application of T...
Source: Neurological Research - May 26, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Aetiological diagnosis of middle-aged and elderly cryptogenic ischaemic cerebral vascular disease.
Authors: Dong J, Elmadhoun O, Ma X Abstract Although tremendous efforts have been made to explore the potential aetiologies of cryptogenic ischaemic cerebral vascular disease (CICVD), it remains a great challenge for neurologists to get a comprehensive picture of CICVD across the world. Part of the reason why is that the vast majority of studies have focussed on CICVD in young stroke patients while the underlying causes of CICVD in middle-aged or elderly stroke population have not been fully investigated. The focus of this paper has been dedicated to review the different studies that explore the aetiologies of CICV...
Source: Neurological Research - May 26, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Motor outcome of deep intracerebral haemorrhage in diffusion tensor imaging: comparison of data from different locations along the corticospinal tract.
DISCUSSION: Clinical motor outcome of ICH within 2 weeks can be identified with a statistically significant decrease in rFA at the corona radiata. PMID: 26003992 [PubMed - as supplied by publisher]
Source: Neurological Research - May 26, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Predictors of neurological deterioration during hospitalization: results from the Chinese Intracranial Atherosclerosis (CICAS) Study.
DISCUSSION: Patients with watershed infarcts and MCA or BA stenosis or occlusion should be monitored closely, and various therapeutic strategies should be administered simultaneously to prevent pneumonia during hospitalisation. PMID: 25917464 [PubMed - as supplied by publisher]
Source: Neurological Research - April 29, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Cerebral venous sinus thrombosis may be associated with hepatitis B virus infection: a preliminary finding.
Conclusion: Hepatitis B virus infection may be a risk factor for CVST. PMID: 25591420 [PubMed - as supplied by publisher]
Source: Neurological Research - January 18, 2015 Category: Neurology Tags: Neurol Res Source Type: research

The effect of a microcatheter-based selective intra-arterial hypothermia on hemodynamic changes following transient cerebral ischemia.
Conclusion: Cold saline, when infused directly into the ischemic brain region, can confer robust neuroprotection by reducing immediate post-ischemic hyperperfusion and delayed post-ischemic hypoperfusion. PMID: 25310355 [PubMed - as supplied by publisher]
Source: Neurological Research - December 2, 2014 Category: Neurology Tags: Neurol Res Source Type: research

A comparison of rt-PA thrombolysis guidelines between China and the USA: are changes needed?
CONCLUSIONS: Onset to IV time is critical for reducing mortality and improving favorable outcomes. We suggest Chinese acute ischemic stroke treatment guidelines be revised to include an increase in the age limit of 80 years, removing contraindications such as a history of previous sever heart, liver, and kidney dysfunction, and placing more emphasis on physician expertise. PMID: 24981554 [PubMed - in process]
Source: Neurological Research - December 2, 2014 Category: Neurology Tags: Neurol Res Source Type: research

The effect of recombinant tissue plasminogen activator on MMP-2 and MMP-9 activities in vitro.
In conclusion, this study showed that rtPA can increase the biological activity of MMP-2 and MMP-9 on posttranslational level. PMID: 24963695 [PubMed - in process]
Source: Neurological Research - December 2, 2014 Category: Neurology Tags: Neurol Res Source Type: research

The effect of cilostazol and aspirin pre-treatment against subsequent transient focal cerebral ischemia in rat.
We examined whether 7 days of oral administration of cilostazol protects against subsequent cerebral ischemia, and whether or not the effect of combination therapy with aspirin is more protective. METHODS: We used Sprague-Dawley (SD) rats and assigned them to four groups: vehicle, aspirin, cilostazol, and aspirin plus cilostazol combination therapy. After oral administration of anti-platelets for 7 days, we performed transient middle cerebral artery occlusion (MCAO) for 90 minutes, and examined infarct volume, neurological symptoms, and regional cerebral blood flow (rCBF). Immunostaining of Bax, Bcl-2, TUNEL, 4-HNE, 8-...
Source: Neurological Research - December 2, 2014 Category: Neurology Tags: Neurol Res Source Type: research