Query: stroke

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Source: Neurological Research

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Total 184 results found since Jan 2013.

Is air pollution a potential cause of neuronal injury?
CONCLUSION: Gluconeogenesis was induced in human neural cells exposed to fine particles (DEP), in association with cell damage and oxidative stress. These findings suggest that the pathogenesis of cerebrovascular injury due to fine particle pollutant exposure may proceed through derangements in gluconeogenic metabolism. ABBREVIATIONS: DEP: diesel exhaust particles, ICA: intracranial atherosclerosis, ROS: reactive oxygen species. PMID: 31099309 [PubMed - as supplied by publisher]
Source: Neurological Research - May 19, 2019 Category: Neurology Tags: Neurol Res Source Type: research

A new physical-cognitive scale for assessment of frailty in Chinese Han elderly.
CONCLUSIONS: Our study revealed a significantly worse status in frail participants with CI than without. Our new scale shows a stronger correlation between frailty and complications than the classic phenotype. PMID: 31030646 [PubMed - as supplied by publisher]
Source: Neurological Research - May 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Clinical potential of pre-reperfusion hypothermia in ischemic injury.
Authors: Han Y, Rajah GB, Hussain M, Geng X Abstract The damage caused by ischemic stroke is mostly refractory to medical therapies and amounts to a substantial degree of mortality and morbidity in the world. The core tenet of treatment for acute ischemic stroke (AIS) is to save 'reversible' ischemic tissue (ischemic penumbra) as quickly as possible within a limited therapeutic time window. The neuroprotective effect of hypothermia has been proven previously in a large number of animal experiments and clinical trials. Some of these animal and human studies have shown that pre-reperfusion hypothermia can reduce myoc...
Source: Neurological Research - May 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Balloon-mounted versus self-expanding stents for symptomatic intracranial vertebrobasilar artery stenosis combined with poor collaterals.
CONCLUSIONS: Stenting for patients with severe symptomatic intracranial vertebrobasilar arterial stenosis with poor collaterals can be performed safely with efficacy. Patients treated with balloon-mounted stents appear to have shorter operative times and lower re-stenosis rates than treated with self-expanding stents. PMID: 31030623 [PubMed - as supplied by publisher]
Source: Neurological Research - May 1, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Low-dose rt-PA may not decrease the incidence of symptomatic intracranial haemorrhage in patients with high risk of symptomatic intracranial haemorrhage.
CONCLUSIONS: Our study suggests that low-dose intravenous rt-PA for high-risk sICH stroke in Chinese patients may not decrease the incidence of sICH, and concomitant with a poor outcome compared to standard-dose rt-PA. ABBREVIATIONS: rt-PA: recombinant tissue plasminogen activator; AIS: acute ischemic stroke; sICH: symptomatic intracranial haemorrhage. PMID: 30822264 [PubMed - as supplied by publisher]
Source: Neurological Research - March 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotective effects of different frequency preconditioning exercise on neuronal apoptosis after focal brain ischemia in rats.
DISCUSSION: Our findings suggested that three times or more per week of high-intensity preconditioning exercise exert neuroprotective effects through the downregulation of the Bax/Bcl-2 ratio and caspase-3 activation after stroke. ABBREVIATIONS: TUNEL: terminal deoxynucleotidyl transferase-mediated biotinylated dUTP nick and labeling; MCAO:middle cerebral artery occlusion; BAX:Bcl-2-associated X protein; Bcl-2: B-cell lymphoma 2; TTC: 2,3,5-triphenyltetrazorlium chloride. PMID: 30822224 [PubMed - as supplied by publisher]
Source: Neurological Research - March 5, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Expression of telomere repeat binding factor 1 and TRF2 in Alzheimer's disease and correlation with clinical parameters.
CONCLUSION: TRF1 and TRF2 may be both specific to peripheral blood serum of AD, and may be related to the development of AD. PMID: 30761946 [PubMed - as supplied by publisher]
Source: Neurological Research - February 15, 2019 Category: Neurology Tags: Neurol Res Source Type: research

ECAS progression score: a web-based model to predict progression of extracranial carotid artery stenosis.
CONCLUSION: The ECAS progression score is a valid model for predicting the risk of ECAS progression. Further validation of the ECAS-PS in different populations and larger samples is warranted. PMID: 30759062 [PubMed - as supplied by publisher]
Source: Neurological Research - February 15, 2019 Category: Neurology Tags: Neurol Res Source Type: research

Early microalbuminuria as a clinical marker for acute cerebral small vessel infarction.
CONCLUSIONS: These findings demonstrate that in patients with acute lacunar infarction, slightly increased microalbuminuria seems to be a potential clinical marker for CSVD. The presence of microalbuminuria early may help to differentiate CSVD from stroke subtypes. PMID: 30475173 [PubMed - as supplied by publisher]
Source: Neurological Research - November 27, 2018 Category: Neurology Tags: Neurol Res Source Type: research

The changes of systemic immune responses during the neuroprotection induced by remote ischemic postconditioning against focal cerebral ischemia in mice.
CONCLUSIONS: The present study indicates that there were significant changes of inflammatory responses during the neuroprotection induced by RIPostC in stroke mice. PMID: 30281410 [PubMed - as supplied by publisher]
Source: Neurological Research - October 4, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Influence of hemodynamics on enlarged perivascular spaces in atherosclerotic large vessel disease.
CONCLUSIONS: The number of EPVS was increased in patients with atherosclerotic large vessel disease with hemodynamic compromise and decreased in the presence of a large stroke. EPVS might act as fluid absorbers in a hemodynamically compromised state until the occurrence of an ischemic stroke. PMID: 30156508 [PubMed - as supplied by publisher]
Source: Neurological Research - August 31, 2018 Category: Neurology Tags: Neurol Res Source Type: research

MiR-125b blocks Bax/Cytochrome C/Caspase-3 apoptotic signaling pathway in rat models of cerebral ischemia-reperfusion injury by targeting p53.
CONCLUSION: MiR-125b exerts protective effects on CIR injury through inhibition of Bax/Cytochrome C/Caspase-3signaling pathway via targeting p53, which is likely to be a promising treatment for CIR. ABBREVIATIONS: 3'-UTR: 3-untranslated region; CIR: cerebral ischemia-reperfusion; CIS: cerebral ischemic stroke; PFT-α: Pifithrin-α; PVDF: polyvinylidene fluoride; SD: Sprague-Dawley; TBST: tris buffered saline with tween. TTC staining: Triphenyl tetrazolinm chloride staining; TUNEL: Terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling. PMID: 29956588 [PubMed - as supplied by publisher]
Source: Neurological Research - July 1, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Cerebral ischaemia/reperfusion injury could be managed by using tramadol.
DISCUSSION: Tramadol can ameliorate the histopathological structure of ischaemic tissue in both periods of I/R injury in rat. We suggest further research investigating various dosages with different administration methods of tramadol in stroke should be conducted by adopting different explorative techniques. PMID: 29792388 [PubMed - as supplied by publisher]
Source: Neurological Research - May 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Genistein attenuates brain damage induced by transient cerebral ischemia through up-regulation of Nrf2 expression in ovariectomized rats.
In this study, ovariectomized rats were treated with genistein (10 mg/kg) or vehicle daily for two weeks before they received middle cerebral artery occlusion (MCAO) and reperfusion. After 72 hours of reperfusion, the neurological function was evaluated by Garcia test, infarct volume was detected by 2,3,5-triphenyltetrazolium chloride staining, and neuronal damage was detected by Nissl staining. In addition, ROS production and the expression of Nrf2, NQO1 and cleaved-Caspase3 in the ischemic penumbra were detected. RESULTS: The results showed that genistein treatment significantly improved the neurological outcome, red...
Source: Neurological Research - April 26, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Transcranial direct current stimulation in the modulation of neuropathic pain: a systematic review.
Discussion The shortage of good quality articles, the varying of ramp-on and ramp-off durations, and number of sessions, as well as the diversity of results found did not allow any definite conclusion on the efficacy of the neuromodulating effect of tDCS on NP. PMID: 29600889 [PubMed - as supplied by publisher]
Source: Neurological Research - March 31, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Omega-3 fatty acid supplement reduces activation of NADPH oxidase in intracranial atherosclerosis stenosis.
Conclusions Long-term O3FA dietary supplementation prevents the development of intracranial atherosclerosis. This O3FA effect appears to be mediated by its attenuation of NOX subunit expression and NOX activity, therefore reducing ROS production. O3FA dietary supplement shows promising results in the prevention of ICAS. PMID: 29576013 [PubMed - as supplied by publisher]
Source: Neurological Research - March 27, 2018 Category: Neurology Tags: Neurol Res Source Type: research

A mini review: garlic extract and vascular diseases.
Authors: Zhu Y, Anand R, Geng X, Ding Y Abstract Vascular diseases refer to medical conditions that narrow blood vessels. Narrowed cardiac or cerebral arteries can lead to myocardial infarction or ischemic stroke. Risk factors including atherosclerosis, hypertension, and diabetes may induce either cardiovascular or cerebral complications. Based on current research, garlic favorably affects atherosclerosis, hypertension and diabetes, and helps decrease the risk of myocardial infarction and ischemic stroke. Garlic has been utilized for hundreds of years as a natural health remedy. New research is emerging regarding i...
Source: Neurological Research - March 23, 2018 Category: Neurology Tags: Neurol Res Source Type: research

U0126 protects hippocampal CA1 neurons against forebrain ischemia-induced apoptosis via the ERK1/2 signaling pathway and NMDA receptors.
CONCLUSION: These findings suggest a novel mechanism by which the ERK1/2 signaling pathway affects the post-I/R apoptosis of CA1 pyramidal neurons, which will provide a therapeutic target for the treatment of stroke. PMID: 29473447 [PubMed - as supplied by publisher]
Source: Neurological Research - February 25, 2018 Category: Neurology Tags: Neurol Res Source Type: research

ECAS score: a web-based risk model to predict moderate and severe extracranial carotid artery stenosis.
Conclusion The ECAS score is a valid model for predicting moderate and severe ECAS. Further validation of the ECAS score in different populations and larger samples is warranted. PMID: 29392984 [PubMed - as supplied by publisher]
Source: Neurological Research - February 4, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Transorbital Doppler with carotid siphon monitoring detects right-to-left shunt effectively.
Conclusion TOD with CS monitoring is able to detect RLS effectively in different populations including healthy subjects, cryptogenic stroke, transient ischemia attack, and migraine patients. In comparing to the TTD with MCA approach, TOD with CS monitoring could detect comparable rate of RLS, but more high grades of RLS. PMID: 29350100 [PubMed - as supplied by publisher]
Source: Neurological Research - January 20, 2018 Category: Neurology Tags: Neurol Res Source Type: research

Neuroanatomical and electrophysiological recovery in the contralateral intact cortex following transient focal cerebral ischemia in rats.
Discussion Focal cerebral ischemia-reperfusion induces time-dependent reduction of dendritic spine density and electrophysiological depression in both the ipsilateral and contralateral cortices and intact brain. This neuroanatomical and electrophysiological evidence suggests that neuroplasticity and functional re-organization in the contralateral cortex is possible following focal cerebral ischemia. PMID: 29262766 [PubMed - in process]
Source: Neurological Research - December 23, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Intraluminal spindle-shaped-head suture induced occlusion of middle cerebral artery in the rats.
CONCLUSION: Our findings indicate that the modified suture induces a more reproducible and stable ischemic stroke following MCAO in SD rats. PMID: 28936922 [PubMed - as supplied by publisher]
Source: Neurological Research - September 24, 2017 Category: Neurology Tags: Neurol Res Source Type: research

The role of high-sensitivity C-reactive protein levels in functional outcomes in patients with large-artery atherosclerosis and small-artery occlusion.
CONCLUSIONS: Patients with LAA with hs-CRP levels <3.215 mg/L and patients with SAO with hs-CRP levels <1.72 mg/L on admission had favorable functional outcomes at 3 months after stroke onset. PMID: 28749740 [PubMed - as supplied by publisher]
Source: Neurological Research - July 29, 2017 Category: Neurology Tags: Neurol Res Source Type: research

CART modulates beta-amyloid metabolism-associated enzymes and attenuates memory deficits in APP/PS1 mice.
CONCLUSION: CART decreases the levels of soluble Aβ in the hippocampus of APP/PS1 mice by modulating the expression of Aβ metabolism-associated enzymes, which may be associated with the MAPK and AKT pathways. PMID: 28743230 [PubMed - as supplied by publisher]
Source: Neurological Research - July 28, 2017 Category: Neurology Tags: Neurol Res Source Type: research

The role of microRNA in neuronal inflammation and survival in the post ischemic brain: a review.
Authors: Li WA, Efendizade A, Ding Y Abstract Each year, more than 790 000 people in the United States suffer from a stroke. Although progress has been made in diagnosis and treatment of ischemic stroke (IS), new therapeutic interventions to protect the brain during an ischemic insult is highly needed. MicroRNAs (miRNAs) are small, non-coding RNAs that regulate gene expression post-transcriptionally. Growing evidence suggests that miRNAs have a profound impact on ischemic stroke progression and are potential targets of novel treatments. Notably, inflammatory pathways play an important role in the pathogenesis of i...
Source: Neurological Research - May 31, 2017 Category: Neurology Tags: Neurol Res Source Type: research

The 15-LO-1/15-HETE system promotes angiogenesis by upregulating VEGF in ischemic brains.
DISCUSSION: The results indicate that the 15-LO-1/15-HETE system promotes angiogenesis in ischemic brains by upregulation of VEGF, representing a potential target for improving neurobehavioral recovery after cerebral ischemic stroke. PMID: 28460604 [PubMed - as supplied by publisher]
Source: Neurological Research - May 5, 2017 Category: Neurology Tags: Neurol Res Source Type: research

CT perfusion in predicting the morbidity and prognosis of hypoxic-ischemic encephalopathy after off-pump coronary artery bypass grafting.
CONCLUSION: The difference in occipital lobe rTTP on CTA perfusion may be a potential predictor of HIE. Furthermore, abnormal CT and rTTP may be used for predicting the prognosis in HIE patients. Three principal components (F1 as a reflection of CBF, F2 as reflection of TTP, F3 as a reflection of MTT) can be used to generally describe perfusion parameters. PMID: 28454490 [PubMed - as supplied by publisher]
Source: Neurological Research - May 1, 2017 Category: Neurology Tags: Neurol Res Source Type: research

Comparison of carotid atherosclerotic plaque characteristics between patients with first-time and recurrent acute ischaemic stroke using B-mode ultrasound.
CONCLUSION: Stroke recurrence is related to advanced atherosclerosis defined by carotid plaque and its characteristics. PMID: 26100248 [PubMed - as supplied by publisher]
Source: Neurological Research - June 24, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Association study between C-reactive protein polymorphisms and ischaemic stroke.
CONCLUSIONS: There is no association between rs1130864 or rs3093059 and ischaemic stroke in Chinese Han population. PMID: 26039816 [PubMed - as supplied by publisher]
Source: Neurological Research - June 4, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Thrombolytic treatment decreases glutamate/GABA ratio in serum during acute ischaemic stroke: a pilot study.
Authors: Kurzepa J, Szpetnar M, Hordyjewska A, Wątroba S, Gołąb P, Boguszewska-Czubara A Abstract There is no information about possible effect of recombinant tissue plasminogen activator (rtPA) therapy on excitotoxic/neuroprotective amino acids during acute phase of ischaemic stroke (IS). Our purpose was to evaluate iv thrombolytic treatment on glutamate (Glu) and gamma-aminobutyric acid (GABA) serum levels during acute IS. Eleven thrombolytic (rtPA group) and 12 non-thrombolytic (non-rtPA group) patients with acute IS were enrolled. The serum samples were obtained at three time-points for rtPA group (time-poin...
Source: Neurological Research - May 26, 2015 Category: Neurology Tags: Neurol Res Source Type: research

C-reactive protein gene polymorphisms and gene-environment interactions in ischaemic stroke.
Authors: Chen Z, Yu D, Xu ZW, Li SS, Li XF, Li J, Yang X Abstract Ischaemic stroke is a heterogeneous, multifactorial disease caused by the combination of certain risk factors and genetic factors. Several single nucleotide polymorphisms (SNPs) of C-reactive protein (CRP) have been reported to be associated with serum CRP levels. However, genetic association studies have produced conflicting results regarding the association between these SNPs and ischaemic stroke. In this paper, we conducted a population-based case-control study to determine whether two SNPs of CRP (rs1800947 and rs3093059) are associated with isch...
Source: Neurological Research - May 26, 2015 Category: Neurology Tags: Neurol Res Source Type: research

A dynamic stroke treatment paradigm.
Authors: Hussain M, Liu L, Ding Y PMID: 25992871 [PubMed - as supplied by publisher]
Source: Neurological Research - May 21, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Music-supported therapy (MST) in improving post-stroke patients' upper-limb motor function: a randomised controlled pilot study.
This study supports that MST, when combined with conventional treatment, is effective for the recovery of motor skills in post-stroke patients. Additionally, it suggests that apart from the repetitive practices of MST, music may play a unique role in improving upper-limb motor function for post-stroke patients. PMID: 25916420 [PubMed - as supplied by publisher]
Source: Neurological Research - April 29, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Association between polyvascular atherosclerosis and estimated glomerular filtration rate in patients with ischaemic stroke: data analysis of the patients in the Chinese National Stroke Registry.
This study evaluated the prevalence of chronic kidney disease (CKD) in ischemic stroke (IS) patients with polyvascular disease (PolyVD) and analysed the relationship between PolyVD and estimated glomerular filtration rate (eGFR) in IS patients. METHODS: Data from 9152 consecutive IS patients from the China National Stroke Registry were analysed. PolyVD was defined as patients with IS and coronary artery disease (CAD) and/or peripheral arterial disease (PAD). Chronic kidney disease was defined as eGFR < 60 mL/minute/1.73 m(2).The prevalence of CKD in IS patients with PolyVD was calculated. Logistic regression w...
Source: Neurological Research - April 22, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Is serum total bilirubin useful to differentiate cardioembolic stroke from other stroke subtypes?
CONCLUSIONS: Serum TB level was independently associated with cardioembolic stroke. The combination of clinical data and serum TB may be a feasible strategy to diagnose cardioembolic stroke in the acute phase. PMID: 25891436 [PubMed - as supplied by publisher]
Source: Neurological Research - April 22, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Quantitative assessment and correlation analysis of cerebral microbleed distribution and leukoaraiosis in stroke outpatients.
DISCUSSION: Cerebral microbleed incidence increased with age. Mixed CMB type displayed the highest incidence. The severity and number of CMBs at any location correlated with LA severity. These results suggested interactions between hypertension and CAA during LA progression. PMID: 25875577 [PubMed - as supplied by publisher]
Source: Neurological Research - April 17, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Recent advances in atrial fibrillation and stroke.
Authors: David Spence J PMID: 25875354 [PubMed - as supplied by publisher]
Source: Neurological Research - April 17, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Acute recanalization of carotid stenosis is not proper: an experimental ischaemic stroke study.
CONCLUSIONS: Our study suggests that the optimal time to open the CCA stenosis complicating cerebral infarction is at or after 7 days of CCA stenosis. PMID: 25830557 [PubMed - as supplied by publisher]
Source: Neurological Research - April 3, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Primary stroke prevention in China - a new approach.
Authors: Feigin VL, Wang W, Fu H, Liu L, Krishnamurthi R, Bhattacharjee R, Parmar P, Hussein T, Barker-Collo S Abstract The growing burden of stroke in China, along with the increasing cost of health care calls for new, more effective strategies for stroke prevention. These strategies should include increasing awareness of stroke symptoms, awareness of risk factors, and provision of easily available information on means of modifying risk factors. The Stroke Riskometer App is exactly such a tool, available in Mandarin, for adult individuals to calculate their risk of stroke over the next 5 and 10 years, and to ide...
Source: Neurological Research - March 31, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Enhanced beneficial effects of mild hypothermia by phenothiazine drugs in stroke therapy.
This study combined mild hypothermia with phenothiazine drugs to enhance its neuroprotective effects, thus potentially avoiding side effects. METHODS: Fifty-four male Sprague-Dawley rats were induced with a 2-hour right middle cerebral artery (MCA) occlusion using an intraluminal filament. Five groups were tested: the stroke group without treatment (anal temperature 37.8-38.3°C), the mild hypothermia group (anal temperature 35.0°C), the drugs group (1 mg/kg chlorpromazine and 1 mg/kg promethazine, anal temperature at 37.8-38.3°C), combination therapy with the mild hypothermia and drugs group and the normal contr...
Source: Neurological Research - March 31, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Neuroprotection by peripheral nerve electrical stimulation and remote postconditioning against acute experimental ischaemic stroke.
DISCUSSION: Peripheral nerve ES appears to have a neuroprotective effect in a rat dMCAO model. This effect may indicate a neural protective mechanism underlying beneficial effect of RIPostC. PMID: 25819636 [PubMed - as supplied by publisher]
Source: Neurological Research - March 31, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Weight loss: indication of brain damage and effect of combined normobaric oxygen and ethanol therapy after stroke.
DISCUSSION: Degree of weight loss after stroke is largely associated with severity of infarction as well as damage reduction after treatment administration. PMID: 25819503 [PubMed - as supplied by publisher]
Source: Neurological Research - March 31, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Factors impact the adherence rate of prophylaxis for deep venous thrombosis in acute ischaemic stroke patients: an analysis of the China National Stroke Registry.
We examined the factors that impact the adherence rate of DVT prophylaxis in stroke patients from the China National Stroke Registry (CNSR). METHOD: Records of 12 173 acute ischaemic stroke patients with follow-up admitted to 132 hospitals in CNSR from September 1, 2007 to August 30, 2008 were reviewed. Data from 4643 patients eligible for DVT prophylaxis were analysed. Generalised estimating equations were used to identify the patient's and hospital's factors that impact the practice of DVT prophylaxis. RESULTS: Among 4643 acute ischaemic stroke patients eligible for DVT prophylaxis, the overall adherence rate of ...
Source: Neurological Research - March 31, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Cilostazol may prevent cardioembolic stroke in patients undergoing antiplatelet therapy.
CONCLUSIONS: Cilostazol may prevent cardioembolic stroke in patients undergoing antiplatelet therapy. This could be a novel strategy for cardioembolic stroke prevention potentially by affecting cardiac remodelling, in contrast to secondary anticoagulant therapy. PMID: 25798683 [PubMed - as supplied by publisher]
Source: Neurological Research - March 24, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Association of C677T polymorphism in the methylenetetrahydrofolate reductase gene (MTHFR gene) with ischemic stroke: a meta-analysis.
Conclusion: The present study results suggest that MTHFR C677T genetic polymorphism is a probable risk of ischemic stroke. PMID: 25591425 [PubMed - as supplied by publisher]
Source: Neurological Research - January 18, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Influence of internal carotid artery stenosis, blood pressure, glycated hemoglobin, and hemoglobin level on fMRI signals of stroke patients.
Conclusion: It is suggested that both ICA stenosis and arterial BP could influence BOLD signal, while HbA1c and hemoglobin level had no effect on BOLD signal. PMID: 25591421 [PubMed - as supplied by publisher]
Source: Neurological Research - January 18, 2015 Category: Neurology Tags: Neurol Res Source Type: research

Protective effect of telmisartan on neurovascular unit and inflammasome in stroke-resistant spontaneously hypertensive rats.
Discussion: These results suggest that telmisartan comprehensively protected the NVU components by reducing inflammatory reactions relative to AD in hypertensive rats, which could also preclude the risk of AD under hypertension. PMID: 25591419 [PubMed - as supplied by publisher]
Source: Neurological Research - January 18, 2015 Category: Neurology Tags: Neurol Res Source Type: research

A pharmacoeconomic assessment of recombinant tissue plasminogen activator therapy for acute ischemic stroke in a tertiary hospital in China.
Conclusions: Intravenous rt-PA was associated with lower patients' disabilities, fewer in-hospital days, and comparable total costs compared to conservative therapy for the management of AIS. PMID: 25297471 [PubMed - as supplied by publisher]
Source: Neurological Research - December 2, 2014 Category: Neurology Tags: Neurol Res Source Type: research

Preexisting dual antiplatelet treatment increases the risk of post-thrombolysis intracranial hemorrhage in Chinese stroke patients.
DISCUSSION: The risk of developing sICH is low when thrombolysis is given to patients who are on ASA alone. However, there is potential increased risk of sICH if a patient is on dual AP treatment. PMID: 24861494 [PubMed - in process]
Source: Neurological Research - December 2, 2014 Category: Neurology Tags: Neurol Res Source Type: research

APOE ϵ 2 allele is an independent risk factor for vulnerable carotid plaque in ischemic stroke patients.
CONCLUSIONS: This study suggests that ϵ 2 allele is an independent risk factor for echolucent and ulcerated carotid plaque. PMID: 24846706 [PubMed - in process]
Source: Neurological Research - December 2, 2014 Category: Neurology Tags: Neurol Res Source Type: research